Kuanqing Liu PhD Investigator

Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences

32 West 7th Avenue, Tianjin Airport Economic Area, Tianjin 300308, China

Research Areas

  1. Microbial Biosynthesis
  2. Metabolic Engineering
  3. Molecular Biology and Biochemistry


  • 2015.05. PhD in Molecular Virology and Microbiology (Baylor College of Medicine)                 

  • 2009.07. MS in Food Science (Pennsylvania State University)        

  • 2007.07. BE in Bioengineering (China Agricultural University)                                                      




  1. Scarborough AM, Flaherty JN, Hunter OV, Liu K, Kumar A, Xing C, Tu BP, Conrad NK. (2021) SAM homeostasis is regulated by CFIm-mediated splicing of MAT2A. Elife 10, e64930.
  2. Liu K, Santos DA, Hussmann JA, Wang Y, Sutter BM, Weissman JS, Tu BP. (2021) Regulation of translation by methylation multiplicity of 18S rRNA. Cell Reports 34(10), 108825.
  3. Liu K, Sutter BM, Tu BP. (2021) Autophagy sustains glutamate and aspartate synthesis in Saccharomyces cerevisiae during nitrogen starvation. Nature Communications 12, 57. 
  4. Anderson BW, Liu K, Wolak C, Dubiel K, She F, Satyshur KA, Keck JL, Wang JD. (2019) Evolution of (p)ppGpp-HPRT regulation through diversification of an allosteric oligomeric interaction. eLife 25;8. pii: e47534. 
  5. Weiss CA, Hoberg JA, Liu K, Tu BP, Winkler WC. (2019) Single cell microscopy reveals that levels of cyclic di-GMP vary among Bacillus subtilis subpopulations. Journal of Bacteriology 00247-19.
  6. Orr MW, Weiss CA, Severin GB, Turdiev H, Kim SK, Turdiev A, Liu K, Tu BP, Waters CM, Winkler WC, Lee VT. (2018) A subset of exoribonucleases serve as degradative enzymes for pGpG in c-di-GMP signaling. Journal of Bacteriology 200(24), e00300-18.
  7. Pendleton KE, Chen B, Liu K, Hunter OV, Xie Y, Tu BP, Conrad NK. (2017) The U6 snRNA m6A methyltransferase METTL16 regulates SAM synthetase intron retention. Cell 18;169(5):824-835. 
  8. Li W, Bouveret E, Zhang Y, Liu K, Wang JD, Weisshaar JC. (2016) Effects of amino acid starvation on RelA diffusive behavior in live Escherichia coli. Molecular Microbiology 99(3):571-585.
  9. Gaca AO, Colomer-Winter C, Kudrin P, Beljantseva J, Liu K, Anderson BW, Wang JD, Potrykus K, Cashel M, Hauryliuk V, Lemos JA. (2015) From (p)ppGpp to (pp)pGpp: Characterization of a new magic spot produced by the small alarmone synthase RelQ of Enterococcus faecalis. Journal of Bacteriology 197(18):2908-2919.
  10. Liu K, Myers AR, Pisithkul T, Claas KR, Satyshur KA, Amador-Noguez D, Keck JL, Wang JD. (2015) Molecular mechanism and evolution of guanylate kinase regulation by (p)ppGpp. Molecular Cell 57, 735-749.
  11. Liu K*, Bittner AN*, Wang JD. (2015) Diversity in (p)ppGpp metabolism and effectors. Current Opinion in Microbiology 24:72-79. (*equal contribution)
  12. Gaca AO, Kajfasz JK, Miller JH, Liu K, Wang JD, Abranches J, Lemos JA. (2013) Basal levels of (p)ppGpp in Enterococcus faecalis: the magic beyond the stringent response. mBio 4(5):e00646-13.
  13. Kriel A, Bittner AN, Kim SH, Liu K, Tehranchi AK, Zou WY, Rendon S, Chen R, Tu BP, Wang JD. (2012) Direct regulation of GTP homeostasis by (p)ppGpp: a critical component of viability and stress resistance. Molecular Cell 48, 231–241.
  14. Hartzell A, Chen C, Lewis C, Liu K, Reynolds S, Dudley EG. (2011Escherichia coli O157:H7 of genotype lineage-specific polymorphism assay 211111 and Clade 8 are common clinical isolates within Pennsylvania. Foodborne Pathogens and Disease 8(7): 763-768.
  15. Liu K, Knabel SJ, Dudley EG. (2009rhs genes are potential markers for multilocus sequence typing of Escherichia coli O157:H7 strains. Applied and Environmental Microbiology 75(18): 5853-5862.
  16. Tian H, Wan H, Liu K, Shan L, Li Y, Yuan Y. (2006) Study on characteristics of Lactobacillus bulgaricus on the preparing of yoghourt starter by the technology of lyophilization. China Dairy Industry 34(12): 4-6.
  17. Hao Y, Zhu B, Luan C, Liu K, Luo Y. (2006) Cloning and identification of sunflower seed-specific promoter Ha ds10 G1. Journal of Agricultural Biotechnology 14(6): 922-925.

Research Interests


  • 2020.12. Biochemistry Department Seminar UT Southwestern Medical Center, Dallas, Texas, USA (virtual) 

  • 2020.10. EMBL Symposium: The Complex Life of RNA (virtual) 

  • 2015.09. Welch Conference on Chemical Research, Houston, Texas, USA 

  • 2014.08. Molecular Genetics of Bacteria and Phages, Madison, Wisconsin, USA 

  • 2013.08. Molecular Genetics of Bacteria and Phages, Madison, Wisconsin, USA 

  • 2013.06. American Society for Microbiology General Meeting, Denver, Colorado, USA 

  • 2009.06. American Society for Microbiology General Meeting, Philadelphia, Pennsylvania, USA