Synthetic Biology, Metabolic Engineering, Applied Microbiology, Directed Genome Evolution

2012.09 – 2015.12 Doctor of Science (D. Sc) in Biochemical Engineering, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences

2009.09 – 2012.07 Master of Science (M.S.) in Botany, Shandong Agricultural University

2005.09 – 2009.07 Bachelor of Science (BS) in Biological Science, Shandong Agricultural University

   

2022.10 – present Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Investigator

2021.06 – 2022.09 Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Associate Investigator

​Selected publications

Wang X, Xu Z, Shi Z, Rong W, He H, Zhou H, Liu L, Liu Z, Sui W*, Wang G*, Ma Y. (2026) Evolving natural yeast to protein-rich micro-grain adaptable for non-sterile low-carbon biomanufacturing. Bioresource Technology, 453, 134634.

Zhou H^#, Wang D^#, He H^#, Shi Z, Chen H, Qi X, Yu H, Yuan Q, Ma H, Liao X*, Wang G*. (2026). Elucidating the metabolic landscape of p-coumaric acid to deepen biological implication and enhance biomanufacturing. ACS Synthetic Biology.

Rong W^#, Wang X^#, Xiao P, Zhu Z*, & Wang G*. (2026). Customizing microbial protein to supply a sustainable solution for precision nutrition. The Innovation Life, 100180.

Rong W, Wang X, Shi Z, Liu L, Zhang Z, Fang Y, Sun J, Lin L*, Wang G*. (2025). Systematic engineering of Komagataella phaffii for efficient production of sweet-tasting protein brazzein. Biotechnology Journal, 20(6), e70046

Shi Z^#, Xu Z^#, Rong W, Sun H, Zhou H, Yuan Q, Xiao A, Ma H, Cai T*, Wang G*, Ma Y*. (2025) Reprogramming yeast metabolism for customized starch-rich micro-grain through low-carbon microbial manufacturing, Nature Communications, 6(1), 2784.

Pan Z, Guo Y, Rong W, Cui K, Cai W, Shi Z, Wang G*, Guo K* (2025) Single-Cell Protein Production from CO2 and Electricity with A Recirculating Anaerobic-Aerobic Bioprocess. Environmental Science and Ecotechnology, 100525.

Liu L, Rong W, Du X, Yuan Q, Xu Z, Yu C, Lu H, Wang Y*, Zhu Y, Liu Z, Wang G*. (2024) Integrating experimental and computational analyses of yeast protein profiles for optimizing the production of high-quality microbial proteins. Applied Biochemistry and Biotechnology.

10.1007/s12010-024-04995-3

Rong W^#, Lin L^#; Wang G*. (2024) Nitroplasts suggest the creation of artificial nitrogen-fixing eukaryotes. Trends in Biotechnology. 42, 946-948 10.1016/j.tibtech.2024.06.002

Shi Z, Wang G. Chapter 15 - Reprogramming microbial cell factories to overproduce plant natural products through directed genome evolution. In Engineering Biology for Microbial Biosynthesis of Plant-Derived Bioactive Compounds, Wei, Y.; Ji, X.-J.; Cao, M., Eds. Academic Press: 2024; pp 315-343.

Wang G*, Wu X*, Yin Y*. (2022) Synthetic biology-driven customization of functional feed resources. Trends in Biotechnololy. 40 (7): 777-780. 

Wang G, Tavares A, Schmitz S, Franca L, Almeida H, Cavalheiro J, Carolas A, Ozmerih S, Blank LM, Ferreira BS^*, Borodina I^*. (2022) An integrated yeast-based process for cis,cis-muconic acid production. Biotechnology Bioengineering. 119, 376-387

Wang G^*, Olofsson-Dolk M, Hansson FG, Donati S, Li X, Chang H, Cheng J, Dahlin J, Borodina I^*. (2021) Engineering yeast Yarrowia lipolytica for methanol assimilation. ACS Synthetic Biology. 10, 3537-3550

Wang G^*, Kell DB, Borodina I^*. (2021) Harnessing the yeast Saccharomyces cerevisiae for the production of fungal secondary metabolites. Essays in Biochemistry. 65, 277-291

Wang G, Hansen IM, Babaei M, D'ambrosio V, Christensen HB, Darbani B, Jensen MK, Borodina I^*. (2021) Transportome-wide engineering of Saccharomyces cerevisiae. Metabolic Engineering. 64:52-63

Sáez-Sáez J, Wang G^*, Marella ER, Sudarsan S, Pastor MC, Borodina I^*. (2020) Engineering the oleaginous yeast Yarrowia lipolytica for high-level resveratrol production. Metabolic Engineering, 62:51-61

Wang G, Ozmerih S, Guerreiro R, Meireles AC, Milne N, Jensen MK, Ferreira BS, Borodina I^*. (2020) Improvement of cis,cis-muconic acid production in Saccharomyces cerevisiae through biosensor-aided engineering, ACS Synthetic Biology, 9 (3): 634-646

Wang G, Bjork S, Huang M, Liu Q, Campbell K, Nielsen J, Jonsson H^*, Petranovic D^*. (2019) RNAi expression tuning, microfluidic screening, and genome recombineering for improved protein production in Saccharomyces cerevisiae, Proceedings of the National Academy of Sciences, 116(19), 9324-9332.

Wang G, Jia W, Chen N, Zhang K, Wang L, Lv P, He R, Wang M, Zhang D^*. (2018) A GFP-fusion coupling FACS platform for advancing the metabolic engineering of filamentous fungi, Biotechnology for Biofuels; 11:232

Wang G^#, Huang M^#, Nielsen J^*. (2017) Exploring the potential of Saccharomyces cerevisiae for biopharmaceutical protein production, Current Opinion in Biotechnology; 48:77-84

Wang G, Xiong X, Ghogare R, Wang P, Meng Y, Chen S^*. (2016) Exploring fatty alcohol-producing capability of Yarrowia lipolytica. Biotechnology for Biofuels; 9:107.

Wang G, Lv P, He R, Wang H, Wang L, Zhang D^*, Chen S^*. (2015) Protein disulfide isomerase homolog TrPDI2 contributing to cellobiohydrolase production in Trichoderma reesei. Enzyme and Microbial Technology; 77:21-28.

Wang G, Wang H, Xiong X, Chen S, Zhang D^*. (2015) Mitochondria thioredoxin's backup role in oxidative stress resistance in Trichoderma reesei. Microbiological Research; 171:32-38.

Wang G, Zhang D, Chen S^*. (2014) Effect of earlier unfolded protein response and efficient protein disposal system on cellulase production in Rut C30. World Journal of Microbiology & Biotechnology; 30:2587-2595.

Wang G, Zhang M, Gong J, Guo Q, Feng Y, Wang W^*. (2012) Increased gibberellin contents contribute to accelerated growth and development of transgenic tobacco overexpressing a wheat ubiquitin gene. Plant Cell Rep 31 (12):2215-2227.

Synthetic biology-driven customization of functional nutritional resources

Our team aims to leverage the magic power of synthetic biology and metabolic engineering to customize cell factories to

i) stably supply high-quality protein resources to the rapidly growing global population;

ii) efficiently produce active plant natural products to ensure the health of humans and economic animals.

To achieve this goal, we develop advanced technologies to genetically edit and high-throughput screen strains and identify the genotype-to-phenotype relationship. We decompose and reprogram the complex biological machinery, iteratively generating superior yeast cell factories that efficiently convert renewable feedstock to functional nutritional resources.

已指导学生

周弘艺  硕士研究生  086000-生物与医药  

史智慧  博士研究生  071010-生物化学与分子生物学  

现指导学生

MD Abuhena Ph.D student 071005-微生物学  

刘松奇  硕士研究生  086000-生物与医药  

段世睿  硕士研究生  071005-微生物学