Jie Wang, Ph.D. in Bioinformatics

  • Professional: Principal Investigator
    • Email:

Research Areas

Dr. Wang focuses on epigenomics of diseases and tissue regeneration. Dr. Wang developed integrative analysis of multi-omics and regulatory network reconstruction, uncovered epigenomic regulations of retinal degeneration and regeneration, and partially realized retinal regeneration in mammals. 


2009.9 – 2014.7: Shanghai Institutes for Biological Sciences, CAS / Ph.D. in Bioinformatics

2005.9 – 2009.7: Chongqing University, Bioengineering College / Bachelor


2020.12 – now: Guangzhou Institutes of Biomedicine and Health, CAS / Principal Investigator

2014.12 – 2020.11: Johns Hopkins University, School of Medicine / Postdoctoral fellow


1.      Hoang T#Wang J#, Boyd P, Wang F, Santiago C, Jiang L, Yoo S, Lahne M, Todd LJ, Jia M, Saez C, Keuthan C, Palazzo I, Squires N, Campbell WA, Rajaii F, Payail T, Trinh V, Kim DW, Wang G, Campbell LJ, Ash J, Fischer AJ, Hyde DR*, Qian J*, Blackshaw S*. Gene regulatory networks controlling vertebrate retinal regeneration. Science 370, 934 (2020). #co-first author, *corresponding author.

2.      Wang J#, Zibetti C#, Shang P, Sripathi SR, Zhang P, Cano M, Hoang T, Xia S, Ji H, Merbs S, Zack D, Handa JT, Sinha D, Blackshaw S*, Qian J*. ATAC-Seq analysis reveals a widespread decrease of chromatin accessibility in age-related macular degeneration. Nature Communications 9, 1364 (2018).

3.      Yuan S#Wang J#*, Yang Y, Zhang J, Liu H, Xiao J, Xu Q, Huang X, Xiang B, Zhu S, Li L*, Liu J*, Liu L*, Zhou W*The prediction of clinical outcome in hepatocellular carcinoma based on a six-gene metastasis signatureClinical Cancer Research 23, 289-97 (2017).

4.      Yuan S#Wang J#, Yang F#, Tao Q#, Wang L, Yang Y, Zheng H, Wang Z, Xu Q, Wang F, Liu L*, Sun S* and Zhou W*. Long noncoding RNA DANCR increases stemness features of hepatocellular carcinoma by derepression of CTNNB1Hepatology 63, 499-511 (2016). ESI Highly Cited Paper (> 200 citations).

5.      Wang JXia S, Arand B, Zhu H, Machiraju R, Huang K, Ji H, Qian J*Single-cell co-expression analysis reveals distinct functional modules, co-regulation mechanisms and clinical outcomesPLOS Computational Biology 12, e1004892 (2016).



周广琦  硕士研究生  071009-细胞生物学  

汤杪庥  硕士研究生  071010-生物化学与分子生物学  

李金连  博士研究生  071010-生物化学与分子生物学  

梁嫣然  硕士研究生  086000-生物与医药  

蒋熙平  硕士研究生  071009-细胞生物学