基本信息
王杰  男  博导  中国科学院广州生物医药与健康研究院
电子邮件: wang_jie01@gibh.ac.cn
通信地址: 广州市黄埔区开源大道190号
邮政编码:

研究领域

课题组围绕器官再生的表观组学和生物信息学主要进行以下几方面的研究:(1)通过单细胞测序等高通量技术手段检测疾病与器官再生的各种组学图谱,建立相关数据库。(2)开发统计建模、机器学习、网络重构等生物信息学分析方法。(3)揭示疾病与器官再生相关的表观调控机制,确定疾病治疗与器官再生的潜在作用靶点。(4)构建疾病发生与器官再生的多维数学模型,并进行相应的模拟与预测。


招生信息

   
招生专业
071010-生物化学与分子生物学
0710J3-生物信息学
0710Z1-基因组学
招生方向
器官再生的表观组学与生物信息学研究
组学数据分析与算法开发

教育背景

2009-09--2014-07   中国科学院上海生命科学研究院   博士
2005-09--2009-07   重庆大学   学士

工作经历

   
工作简历
2020-12~现在, 中国科学院广州生物医药与健康研究院, 研究员
2014-12~2020-11,Johns Hopkins University, 博士后

专利与奖励

   
奖励信息
(1) Wilmer杰出博士后奖, 一等奖, 研究所(学校), 2018

出版信息

   
发表论文
[1] Dapeng Sun, Xiaojie Gan, Lei Liu, Yuan Yang, Dongyang Ding, Wen Li, Junyao Jiang, Wenbin Ding, Linghao Zhao, Guojun Hou, Jian Yu, Jie Wang, Fu Yang, Shengxian Yuan, Weiping Zhou. DNA hypermethylation modification promotes the development of hepatocellular carcinoma by depressing the tumor suppressor gene ZNF334. Cell Death and Disease[J]. 2022, 13(5): 1-12, [2] Ma, Ding, Zhan, Daqian, Fu, Yi, Wei, Shuang, Lal, Bachchu, Wang, Jie, Li, Yunqing, LopezBertoni, Hernando, Yalcin, Fatih, Dzaye, Omar, Eberhart, Charles G, Laterra, John, Wilson, Mary Ann, Ying, Mingyao, Xia, Shuli. Mutant IDH1 promotes phagocytic function of microglia/macrophages in gliomas by downregulating ICAM1. CANCER LETTERS[J]. 2021, 517: 35-45, http://dx.doi.org/10.1016/j.canlet.2021.05.038.
[3] Thanh Hoang, Wang, Jie, Boyd, Patrick, Wang, Fang, Santiago, Clayton, Jiang, Lizhi, Yoo, Sooyeon, Lahne, Manuela, Todd, Levi J, Jia, Meng, Saez, Cristian, Keuthan, Casey, Palazzo, Isabella, Squires, Natalie, Campbell, Warren A, Rajaii, Fatemeh, Parayil, Trisha, Trinh, Vickie, Kim, Dong Won, Wang, Guohua, Campbell, Leah J, Ash, John, Fischer, Andy J, Hyde, David R, Qian, Jiang, Blackshaw, Seth. Gene regulatory networks controlling vertebrate retinal regeneration. SCIENCE[J]. 2020, 370(6519): 934-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000594441500042.
[4] Wang, Lei, Kaya, Koray D, Kim, Sujung, Brooks, Matthew J, Wang, Jie, Xin, Ying, Qian, Jiang, Swaroop, Anand, Handa, James T. Retinal pigment epithelium transcriptome analysis in chronic smoking reveals a suppressed innate immune response and activation of differentiation pathways. FREE RADICAL BIOLOGY AND MEDICINE[J]. 2020, 156: 176-189, http://dx.doi.org/10.1016/j.freeradbiomed.2020.06.004.
[5] Kallman, Alyssa, Capowski, Elizabeth E, Wang, Jie, Kaushik, Aniruddha M, Jansen, Alex D, Edwards, Kimberly L, Chen, Liben, Berlinicke, Cynthia A, Phillips, M Joseph, Pierce, Eric A, Qian, Jiang, Wang, TzaHuei, Gamm, David M, Zack, Donald J. Investigating cone photoreceptor development using patient-derived NRL null retinal organoids. COMMUNICATIONS BIOLOGY[J]. 2020, 3(1): 1-13, https://doaj.org/article/db517a6b8b0b4b128d88c83365b08645.
[6] Liu, Jiadong, Gao, Mingwei, Xu, Shuyang, Chen, Yaping, Wu, Kaixin, Liu, He, Wang, Jie, Yang, Xuejie, Wang, Junwei, Liu, Weiwei, Bao, Xichen, Chen, Jiekai. YTHDF2/3 Are Required for Somatic Reprogramming through Different RNA Deadenylation Pathways. CELL REPORTS[J]. 2020, 32(10): http://dx.doi.org/10.1016/j.celrep.2020.108120.
[7] Blackshaw, Seth, Hoang, Thanh, Wang, Jie, Lahne, Manuela, Todd, Levi, Santiago, Clayton, Squires, Nathalie, Boyd, Patrick, Ash, John D, Fischer, Andrew J, Qian, Jiang, Hyde, David R. Comparative transcriptomic and epigenomic analysis identifes regulators of neurogenic competence in retinal Muller glia. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE[J]. 2018, 59(9): https://www.webofscience.com/wos/woscc/full-record/WOS:000442912502255.
[8] Santiago, Clayton, Hooper, Marcus, Thanh Hoang, Wang, Jie, Qian, Jiang, Blackshaw, Seth, Ash, John D. Muller cell transcriptional unit to regulate stress induced LIF expression. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE[J]. 2018, 59(9): 479-484, https://www.webofscience.com/wos/woscc/full-record/WOS:000442912507192.
[9] Hyde, David R, Boyd, Patrick, Lahne, Manuela, Thanh Hoang, Wang, Jie, Santiago, Clayton, Blackshaw, Seth, Qian, Jiang, Ash, John D, Fischer, Andy. Transcriptomics analysis of Muller glia in response to different damage paradigms in the adult zebrafish retina. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE[J]. 2018, 59(9): https://www.webofscience.com/wos/woscc/full-record/WOS:000442912502256.
[10] Newmann, Elizabeth A, Kim, Dong Won, Wan, Jun, Wang, Jie, Qian, Jiang, Blackshaw, Seth. Foxd1 is required for terminal differentiation of anterior hypothalamic neuronal subtypes. DEVELOPMENTAL BIOLOGY[J]. 2018, 439(2): 102-111, https://www.webofscience.com/wos/woscc/full-record/WOS:000434003600006.
[11] Jie Wang, Cristina Zibetti, Peng Shang, Srinivasa R Sripathi, Pingwu Zhang, Marisol Cano, Thanh Hoang, Shuli Xia, Hongkai Ji, Shannath L Merbs, Donald J Zack, James T Handa, Debasish Sinha, Seth Blackshaw, Jiang Qian. ATAC-Seq analysis reveals a widespread decrease of chromatin accessibility in age-related macular degeneration. NATURE COMMUNICATIONS[J]. 2018, 9(1): https://doaj.org/article/0f18f4981da94ca68e6f36c5fb7554b0.
[12] Shuang Wei, Jie Wang, Olutobi Oyinlade, Ding Ma, Shuyan Wang, Lisa Kratz, Bachchu Lal, Qingfu Xu, Senquan Liu, Sagar R Shah, Hao Zhang, Yunqing Li, Alfredo QuionesHinojosa, Heng Zhu, Zhiyong Huang, Linzhao Cheng, Jiang Qian, Shuli Xia. Heterozygous IDH1 R132H created by "single base editing" inhibits human astroglial cell growth by downregulating YAP. Oncogene[J]. 2018, 37(38): 5160-5174, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590918/.
[13] Yuan, Shengxian, Wang, Jie, Yang, Yuan, Zhang, Jin, Liu, Hui, Xiao, Juanjuan, Xu, Qingguo, Huang, Xinhui, Xiang, Bangde, Zhu, Shaoliang, Li, Lequn, Liu, Jingfeng, Liu, Lei, Zhou, Weiping. The Prediction of Clinical Outcome in Hepatocellular Carcinoma Based on a Six-Gene Metastasis Signature. CLINICAL CANCER RESEARCH[J]. 2017, 23(1): 289-297, http://dx.doi.org/10.1158/1078-0432.CCR-16-0395.
[14] Han, Xiaomei, Wang, Jenny, Wang, Jie, Liu, Sheng, Hu, Jianfei, Zhu, Heng, Qian, Jiang. ScaPD: a database for human scaffold proteins. BMC BIOINFORMATICS[J]. 2017, 18(11): 87-91, http://dx.doi.org/10.1186/s12859-017-1806-6.
[15] Jie Wang, Shuli Xia, Brian Arand, Heng Zhu, Raghu Machiraju, Kun Huang, Hongkai Ji, Jiang Qian. Single-Cell Co-expression Analysis Reveals Distinct Functional Modules, Co-regulation Mechanisms and Clinical Outcomes. PLOS COMPUTATIONAL BIOLOGY[J]. 2016, 12(4): https://doaj.org/article/12e4f84d74c94a379817675912e30874.
[16] Yuan, Shengxian, Wang, Jie, Yang, Fu, Tao, Qifei, Zhang, Jin, Wang, Lili, Yang, Yuan, Liu, Hui, Wang, Zhenguang, Xu, Qingguo, Fan, Jia, Liu, Lei, Sun, Shuhan, Zhou, Weiping. Long Noncoding RNA DANCR Increases Stemness Features of Hepatocellular Carcinoma by Derepression of CTNNB1. HEPATOLOGY[J]. 2016, 63(2): 499-511, https://www.webofscience.com/wos/woscc/full-record/WOS:000373296800008.
[17] Fu, HanHsuan, Fu, Jie, Wang, Jie, Jones, Richard J, Fuchs, Ephraim, Levitsky, Hyam. Post-transplantation cyclophosphamide depletes vaccine primed donor T cells and compromises graft-versus-tumor effects in alloBMT model. CANCER RESEARCHnull. 2015, 75: https://www.webofscience.com/wos/woscc/full-record/WOS:000371578502389.
[18] Xinlu Yuan, Jie Wang, Xiaoyan Tang, Yixue Li, Pu Xia, Xin Gao. Berberine ameliiorates nonalcoholic fatty liver disease by a global modulation of hepatic mRNA and IncRNA expression profiles.. Journal of Translational Medicine[J]. 2015, 13(1): 1-11, https://pubmed.ncbi.nlm.nih.gov/25623289.
[19] Yuan, ShengXian, Tao, QiFei, Wang, Jie, Yang, Fu, Liu, Lei, Wang, LiLi, Zhang, Jin, Yang, Yuan, Liu, Hui, Wang, Fang, Sun, ShuHan, Zhou, WeiPing. Antisense long non-coding RNA PCNA-AS1 promotes tumor growth by regulating proliferating cell nuclear antigen in hepatocellular carcinoma. CANCER LETTERS[J]. 2014, 349(1): 87-94, http://dx.doi.org/10.1016/j.canlet.2014.03.029.
[20] Jie Wang, Yu Wang, Zhuo Wang, Lei Liu, Xin-Guang Zhu, Xiaotu Ma. Synchronization of cytoplasm and transferred mitochondrial ribosomal protein gene espression in land plants is linked to telo-box motif enrichment. BMC Evolutionary Biology[J]. 2011, 11(1): 1-15, https://pubmed.ncbi.nlm.nih.gov/21668973/.

科研活动

   
科研项目
( 1 ) 肝再生与肝纤维化的表观组学研究, 主持, 市地级, 2020-12--2024-12