Biochemistry and molecular biology, Interested in the research on macromolecular structure, influenza virus, coronavirus etc.

2020-08 to current, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences,  Principal Investigator
2018-05~2020-08,MRC Laboratory of Molecular Biology, Postdoctoral Scientist
2016-10~2018-04,University of Washington, Senior Fellow
2015-01~2016-09,The Francis Crick Institute, Career Development Fellow
2011-03~2014-12,MRC National Institute for Medical Research, Career Development Fellow

（1） New structural insights into the multifunctional influenza A matrix protein 1, Febs Letters, 2021, the 2nd author
（2） Hemagglutinin Structure and Activities, COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, 2021, the 3rd author
（3） Germline IGHV3-53-encoded RBD-targeting neutralizing antibodies are commonly present in the antibody repertoires of COVID-19 patients, EMERGING MICROBES & INFECTIONS, 2021, the 19th author
（4） SARS-CoV-2 Spike Protein Stabilized in the Closed State Induces Potent Neutralizing Responses, JOURNAL OF VIROLOGY, 2021, the 4th author
（5） Structural basis for broad coronavirus neutralization, NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2021, the 9th author
（6） Critical Care Workers Have Lower Seroprevalence of SARS-CoV-2 IgG Compared with Non-patient Facing Staff in First Wave of COVID19, The Journal of Critical Care Medicine, 2021, 
（7） Hemagglutinin Traits Determine Transmission of Avian A/H10N7 Influenza Virus between Mammals, CELL HOST & MICROBE, 2020, the 13th author
（8） Structures and distributions of SARS-CoV-2 spike proteins on intact virions, NATURE, 2020, the 13th author
（9） Enhancing Neuraminidase Immunogenicity of Influenza A Viruses by Rewiring RNA Packaging Signals, JOURNAL OF VIROLOGY, 2020, the 3rd author
（10） A thermostable, closed SARS-CoV-2 spike protein trimer, NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2020, the corresponding author
（11） Combined Point-of-Care Nucleic Acid and Antibody Testing for SARS-CoV-2 following Emergence of D614G Spike Variant, CELL REPORTS MEDICINE, 2020, the 14th author
（12） The native structure of the assembled matrix protein 1 of influenza A virus, NATURE, 2020, the corresponding author
（13） Unexpected Receptor Functional Mimicry Elucidates Activation of Coronavirus Fusion, CELL, 2019,the 2nd author
（14） Glycan Shield and Fusion Activation of a Deltacoronavirus Spike Glycoprotein Fine-Tuned for Enteric Infections, JOURNAL OF VIROLOGY, 2018, the 1st author
（15） Tectonic conformational changes of a coronavirus spike glycoprotein promote membrane fusion, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, the 4th author
（16） Structures of complexes formed by H5 influenza hemagglutinin with a potent broadly neutralizing human monoclonal antibody, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, the 1st author
（17） Enhanced human receptor binding by H5 haemagglutinins, VIROLOGY, 2014, the 1st author
（18） Receptor Binding Properties of the Influenza Virus Hemagglutinin as a Determinant of Host Range, INFLUENZA PATHOGENESIS AND CONTROL - VOL I, 2014, the 1st author
（19） Recent evolution of equine influenza and the origin of canine influenza, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014,the 7th author
（20） Receptor binding by H10 influenza viruses, NATURE, 2014, 第 2 作者
（21） Receptor binding by an H7N9 influenza virus from humans, NATURE, 2013, the 1st author
（22） Recognition of sulphated and fucosylated receptor sialosides by A/Vietnam/1194/2004 (H5N1) influenza virus, VIRUS RESEARCH, 2013, 
（23） Receptor binding by a ferret-transmissible H5 avian influenza virus, NATURE, 2013,the 1st author
（24） H1N1 2009 Pandemic Influenza Virus: Resistance of the I223R Neuraminidase Mutant Explained by Kinetic and Structural Analysis, PLOS PATHOGENS, 2012, the 4th author
（25） Evolution of the receptor binding properties of the influenza A(H3N2) hemagglutinin, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, the 2nd author
（26） Structural insights into quinolone antibiotic resistance mediated by pentapeptide repeat proteins: conserved surface loops direct the activity of a Qnr protein from a Gram-negative bacterium, NUCLEIC ACIDS RESEARCH, 2011, the 1st author

The students

Yi Zhao, Doctoral student, 071010-Biochemistry and Molecular Biology 

Hang Yuan, Doctoral student, 100103-Pathogenic Biology

Jiacheng Gui, Master student, 071008-Developmental Biology

Zexuan Li, Master student, 071009-Cell Biology

Shujuan Yan, Doctoral student, 071009-Cell Biology

Luyao Pan, Doctoral student, 071010-Biochemistry and Molecular Biology

2020-07-31 to current, Nature Structural and Molecular Biology, Junal Reviewer