071010-生物化学与分子生物学

大分子结构
流感病毒
冠状病毒

2007-10--2011-07   University of Bristol   PhD
2004-10--2007-07   University of Bristol   BSc (Hons)

   

2020-08~现在, 中国科学院广州生物医药与健康研究院, 研究员
2018-05~2020-08,MRC Laboratory of Molecular Biology, Postdoctoral Scientist
2016-10~2018-04,University of Washington, Senior Fellow
2015-01~2016-09,The Francis Crick Institute, Career Development Fellow
2011-03~2014-12,MRC National Institute for Medical Research, Career Development Fellow

2020-07-31-今,Nature Structural and Molecular Biology 杂志, 审稿人

   

[1] Haisheng Yu, Banghui Liu, Yudi Zhang, Xijie Gao, Qian Wang, Haitao Xiang, Xiaofang Peng, Caixia Xie, Yaping Wang, Peiyu Hu, Jingrong Shi, Quan Shi, Pingqian Zheng, Chengqian Feng, Guofang Tang, Xiaopan Liu, Liliangzi Guo, Xiumei Lin, Jiaojiao Li, Chuanyu Liu, Yaling Huang, Naibo Yang, Qiuluan Chen, Zimu Li, Mengzhen Su, Qihong Yan, Rongjuan Pei, Xinwen Chen, Longqi Liu, Fengyu Hu, Dan Liang, Bixia Ke, Changwen Ke, Feng Li, Jun He, Meiniang Wang, Ling Chen, Xiaoli Xiong, Xiaoping Tang. Somatically hypermutated antibodies isolated from SARS-CoV-2 Delta infected patients cross-neutralize heterologous variants. NATURE COMMUNICATIONS[J]. 2023, 14(1): 1-14, https://doaj.org/article/9b9eeb66b96c4be0aef6038b90a860fc.
[2] He, Ping, Liu, Banghui, Gao, Xijie, Yan, Qihong, Pei, Rongjuan, Sun, Jing, Chen, Qiuluan, Hou, Ruitian, Li, Zimu, Zhang, Yanjun, Zhao, Jincun, Sun, Hao, Feng, Bo, Wang, Qian, Yi, Haisu, Hu, Peiyu, Li, Pingchao, Zhang, Yudi, Chen, Zhilong, Niu, Xuefeng, Zhong, Xiaolin, Jin, Liang, Liu, Xiaofeng, Qu, Kun, Ciazynska, Katarzyna A, Carter, Andrew P, Briggs, John A G, Chen, Jizheng, Liu, Jinsong, Chen, Xinwen, He, Jun, Chen, Ling, Xiong, Xiaoli. SARS-CoV-2 Delta and Omicron variants evade population antibody response by mutations in a single spike epitope. NATURE MICROBIOLOGY[J]. 2022, 7(10): 1635-+, http://dx.doi.org/10.1038/s41564-022-01235-4.
[3] Sauer, Maximilian M, Tortorici, M Alejandra, Park, YoungJun, Walls, Alexandra C, Homad, Leah, Acton, Oliver J, Bowen, John E, Wang, Chunyan, Xiong, Xiaoli, de van der Schueren, Willem, Quispe, Joel, Hoffstrom, Benjamin G, Bosch, BerendJan, McGuire, Andrew T, Veesler, David. Structural basis for broad coronavirus neutralization. NATURE STRUCTURAL & MOLECULAR BIOLOGY[J]. 2021, 28(6): 478-+, http://dx.doi.org/10.1038/s41594-021-00596-4.
[4] Baxendale Helen E, Wells David, Gronlund Jessica, Nadesalingham Angalee, Paloniemi Mina, Carnell George, Tonks Paul, CeronGutierrez Lourdes, Ebrahimi Soraya, Sayer Ashleigh, Briggs John AG, Ziong Xiaoli, Nathan James A, Grice Guinevere, James Leo C, Luptak Jakub, Pai Sumita, Heeney Jonathan L, Lear Sara, Doffinger Rainer. Critical Care Workers Have Lower Seroprevalence of SARS-CoV-2 IgG Compared with Non-patient Facing Staff in First Wave of COVID19. THE JOURNAL OF CRITICAL CARE MEDICINE[J]. 2021, 7(3): 199-210, https://doaj.org/article/a3ea9ee6b7f042ecbcf2d643eff68365.
[5] Julia Peukes, Xiaoli Xiong, John A G Briggs. New structural insights into the multifunctional influenza A matrix protein 1. FEBS LETTERS. 2021, 595(20): 2535-2543, [6] Gamblin, Steven J, Vachieri, Sebastien G, Xiong, Xiaoli, Zhang, Jie, Martin, Stephen R, Skehel, John J. Hemagglutinin Structure and Activities. COLD SPRING HARBOR PERSPECTIVES IN MEDICINE[J]. 2021, 11(10): http://dx.doi.org/10.1101/cshperspect.a038638.
[7] Yan, Qihong, He, Ping, Huang, Xiaohan, Luo, Kun, Zhang, Yudi, Yi, Haisu, Wang, Qian, Li, Feng, Hou, Ruitian, Fan, Xiaodi, Li, Pingchao, Liu, Xinglong, Liang, Huan, Deng, Yijun, Chen, Zhaoming, Chen, Yunfei, Mo, Xiaoneng, Feng, Liqiang, Xiong, Xiaoli, Li, Song, Han, Jian, Qu, Linbing, Niu, Xuefeng, Chen, Ling. Germline IGHV3-53-encoded RBD-targeting neutralizing antibodies are commonly present in the antibody repertoires of COVID-19 patients. EMERGING MICROBES & INFECTIONS[J]. 2021, 10(1): 1097-1111, http://dx.doi.org/10.1080/22221751.2021.1925594.
[8] Carnell, George W, Ciazynska, Katarzyna A, Wells, David A, Xiong, Xiaoli, Aguinam, Ernest T, McLaughlin, Stephen H, Mallery, Donna, Ebrahimi, Soraya, CeronGutierrez, Lourdes, Asbach, Benedikt, Einhauser, Sebastian, Wagner, Ralf, James, Leo C, Doffinger, Rainer, Heeney, Jonathan L, Briggs, John A G. SARS-CoV-2 Spike Protein Stabilized in the Closed State Induces Potent Neutralizing Responses. JOURNAL OF VIROLOGY[J]. 2021, 95(15): http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000708632900016.
[9] Herfst, Sander, Zhang, Jie, Richard, Mathilde, McBride, Ryan, Lexmond, Pascal, Bestebroer, Theo M, Spronken, Monique I J, de Meulder, Dennis, van den Brand, Judith M, Rosu, Miruna E, Martin, Stephen R, Gamblin, Steve J, Xiong, Xiaoli, Peng, Wenjie, Bodewes, Rogier, van der Vries, Erhard, Osterhaus, Albert D M E, Paulson, James C, Skehel, John J, Fouchier, Ron A M. Hemagglutinin Traits Determine Transmission of Avian A/H10N7 Influenza Virus between Mammals. CELL HOST & MICROBE[J]. 2020, 28(4): 602-+, http://dx.doi.org/10.1016/j.chom.2020.08.011.
[10] Ke, Zunlong, Oton, Joaquin, Qu, Kun, Cortese, Mirko, Zila, Vojtech, McKeane, Lesley, Nakane, Takanori, Zivanov, Jasenko, Neufeldt, Christopher J, Cerikan, Berati, Lu, John M, Peukes, Julia, Xiong, Xiaoli, Krausslich, HansGeorg, Scheres, Sjors H W, Bartenschlager, Ralf, Briggs, John A G. Structures and distributions of SARS-CoV-2 spike proteins on intact virions. NATURE[J]. 2020, 588(7838): 498-+, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7116492/.
[11] Zheng, Allen, Sun, Weina, Xiong, Xiaoli, Freyn, Alec W, Peukes, Julia, Strohmeier, Shirin, Nachbagauer, Raffael, Briggs, John A G, Krammer, Florian, Palese, Peter. Enhancing Neuraminidase Immunogenicity of Influenza A Viruses by Rewiring RNA Packaging Signals. JOURNAL OF VIROLOGY[J]. 2020, 94(16): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7394900/.
[12] Xiong, Xiaoli, Qu, Kun, Ciazynska, Katarzyna A, Hosmillo, Myra, Carter, Andrew P, Ebrahimi, Soraya, Ke, Zunlong, Scheres, Sjors H W, Bergamaschi, Laura, Grice, Guinevere L, Zhang, Ying, Nathan, James A, Baker, Stephen, James, Leo C, Baxendale, Helen E, Goodfellow, Ian, Doffinger, Rainer, Briggs, John A G, Bradley, John, Lyons, Paul A, Smith, Kenneth G C, Toshner, Mark, Elmer, Anne, Ribeiro, Carla, Kourampa, Jenny, Jose, Sherly, Kennet, Jane, Rowlands, Jane, Meadows, Anne, OBrien, Criona, Rastall, Rebecca, Crucusio, Cherry, Hewitt, Sarah, Price, Jane, Calder, Jo, Canna, Laura, Bucke, Ashlea, Tordesillas, Hugo, Harris, Julie, Ruffolo, Valentina, Domingo, Jason, Graves, Barbara, Butcher, Helen, Caputo, Daniela, Le Gresley, Emma, Dunmore, Benjamin J, Martin, Jennifer, Legchenko, Ekaterina, Treacy, Carmen, Huang, Christopher, Wood, Jennifer, Sutcliffe, Rachel, Hodgson, Josh, Shih, Joy, Graf, Stefan, Tong, Zhen, Mescia, Federica, Tilly, Tobias, ODonnell, Ciara, Hunter, Kelvin, Pointon, Linda, Pond, Nicole, Wylot, Marta, Jones, Emma, Fawke, Stuart, Bullman, Ben, Bergamaschi, Laura, Turner, Lori, Jarvis, Isobel, Omarjee, Ommar, De Sa, Aloka, Marsden, Joe, Betancourt, Ariana, Perera, Marianne, Epping, Maddie, Richoz, Nathan, Bower, Georgie, Sharma, Rahul, Nice, Francesca, Huhn, Oisin, Stark, Hannah, Walker, Neil, Stirrups, Kathy, Ovington, Nigel, Dewhust, Eleanor, Li, Emily, Papadia, Sofia, CITIIDNIHR COVID19 BioResource C. A thermostable, closed SARS-CoV-2 spike protein trimer. NATURE STRUCTURAL & MOLECULAR BIOLOGY[J]. 2020, 27(10): 934-+, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7116388/.
[13] Mlcochova, Petra, Collier, Dami, Ritchie, Allyson, Assennato, Sonny M, Hosmillo, Myra, Goel, Neha, Meng, Bo, Chatterjee, Krishna, Mendoza, Vivien, Temperton, Nigel, Kiss, Leo, James, Leo C, Ciazynska, Katarzyna A, Xiong, Xiaoli, Briggs, John A G, Nathan, James A, Mescia, Federica, Bergamaschi, Laura, Zhang, Hongyi, Barmpounakis, Petros, Demeris, Nikos, Skells, Richard, Lyons, Paul A, Bradley, John, Baker, Steven, Allain, Jean Pierre, Smith, Kenneth G C, Bousfield, Rachel, Wilson, Michael, Sparkes, Dominic, Amoroso, Glenn, GkraniaKlotsas, Effrosyni, Hardwick, Susie, Boyle, Adrian, Goodfellow, Ian, Gupta, Ravindra K, Cambridge Inst Therapeutic Immunol. Combined Point-of-Care Nucleic Acid and Antibody Testing for SARS-CoV-2 following Emergence of D614G Spike Variant. CELL REPORTS MEDICINE[J]. 2020, 1(6): 100099-100099, http://dx.doi.org/10.1016/j.xcrm.2020.100099.
[14] Peukes, Julia, Xiong, Xiaoli, Erlendsson, Simon, Qu, Kun, Wan, William, Calder, Leslie J, Schraidt, Oliver, Kummer, Susann, Freund, Stefan M, V, Krausslich, HansGeorg, Briggs, John A G. The native structure of the assembled matrix protein 1 of influenza A virus. NATURE[J]. 2020, 587(7834): 495-+, http://dx.doi.org/10.1038/s41586-020-2696-8.
[15] Walls, Alexandra C, Xiong, Xiaoli, Park, YoungJun, Tortorici, M Alejandra, Snijder, Joost, Quispe, Joel, Cameroni, Elisabetta, Gopal, Robin, Dai, Mian, Lanzavecchia, Antonio, Zambon, Maria, Rey, Felix A, Corti, Davide, Veesler, David. Unexpected Receptor Functional Mimicry Elucidates Activation of Coronavirus Fusion. CELL[J]. 2019, 176(5): 1026-+, http://dx.doi.org/10.1016/j.cell.2018.12.028.
[16] Xiong, Xiaoli, Tortorici, M Alejandra, Snijder, Joost, Yoshioka, Craig, Walls, Alexandra C, Li, Wentao, McGuire, Andrew T, Rey, Felix A, Bosch, BerendJan, Veesler, David. Glycan Shield and Fusion Activation of a Deltacoronavirus Spike Glycoprotein Fine-Tuned for Enteric Infections. JOURNAL OF VIROLOGY[J]. 2018, 92(4): http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000423580900019.
[17] Walls, Alexandra C, Tortorici, M Alejandra, Snijder, Joost, Xiong, Xiaoli, Bosch, BerendJan, Rey, Felix A, Veesler, David. Tectonic conformational changes of a coronavirus spike glycoprotein promote membrane fusion. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2017, 114(42): 11157-11162, https://www.webofscience.com/wos/woscc/full-record/WOS:000413237900052.
[18] Xiong, Xiaoli, Corti, Davide, Liu, Junfeng, Pinna, Debora, Foglierini, Mathilde, Calder, Lesley J, Martin, Stephen R, Lin, Yi Pu, Walker, Philip A, Collins, Patrick J, Monne, Isabella, Suguitan, Amorsolo L, Jr, Santos, Celia, Temperton, Nigel J, Subbarao, Kanta, Lanzavecchia, Antonio, Gamblin, Steven J, Skehel, John J. Structures of complexes formed by H5 influenza hemagglutinin with a potent broadly neutralizing human monoclonal antibody. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2015, 112(30): 9430-9435, http://dx.doi.org/10.1073/pnas.1510816112.
[19] Xiong, Xiaoli, Xiao, Haixia, Martin, Stephen R, Coombs, Peter J, Liu, Junfeng, Collins, Patrick J, Vachieri, Sebastien G, Walker, Philip A, Lin, Yi Pu, McCauley, John W, Gamblin, Steven J, Skehel, John J. Enhanced human receptor binding by H5 haemagglutinins. VIROLOGY[J]. 2014, 456(100): 179-187, http://dx.doi.org/10.1016/j.virol.2014.03.008.
[20] Xiong, Xiaoli, McCauley, John W, Steinhauer, David A, Compans, RW, Oldstone, MBA. Receptor Binding Properties of the Influenza Virus Hemagglutinin as a Determinant of Host Range. INFLUENZA PATHOGENESIS AND CONTROL - VOL Inull. 2014, 385: 63-91, https://www.webofscience.com/wos/woscc/full-record/WOS:000348980900004.
[21] Collins, Patrick J, Vachieri, Sebastien G, Haire, Lesley F, Ogrodowicz, Roksana W, Martin, Stephen R, Walker, Philip A, Xiong, Xiaoli, Gamblin, Steven J, Skehel, John J. Recent evolution of equine influenza and the origin of canine influenza. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2014, 111(30): 11175-11180, https://www.webofscience.com/wos/woscc/full-record/WOS:000339500200068.
[22] Vachieri, Sebastien G, Xiong, Xiaoli, Collins, Patrick J, Walker, Philip A, Martin, Stephen R, Haire, Lesley F, Zhang, Ying, McCauley, John W, Gamblin, Steven J, Skehel, John J. Receptor binding by H10 influenza viruses. NATURE[J]. 2014, 511(7510): 475-+, http://dx.doi.org/10.1038/nature13443.
[23] Xiong, Xiaoli, Martin, Stephen R, Haire, Lesley F, Wharton, Stephen A, Daniels, Rodney S, Bennett, Michael S, McCauley, John W, Collins, Patrick J, Walker, Philip A, Skehel, John J, Gamblin, Steven J. Receptor binding by an H7N9 influenza virus from humans. NATURE[J]. 2013, 499(7459): 496-+, http://dx.doi.org/10.1038/nature12372.
[24] Xiong, X, Tuzikov, A, Coombs, P J, Martin, S R, Walker, P A, Gamblin, S J, Bovin, N, Skehel, J J. Recognition of sulphated and fucosylated receptor sialosides by A/Vietnam/1194/2004 (H5N1) influenza virus. VIRUS RESEARCHnull. 2013, 178(1): 12-14, http://dx.doi.org/10.1016/j.virusres.2013.08.007.
[25] Xiong, Xiaoli, Coombs, Peter J, Martin, Stephen R, Liu, Junfeng, Xiao, Haixia, McCauley, John W, Locher, Kathrin, Walker, Philip A, Collins, Patrick J, Kawaoka, Yoshihiro, Skehel, John J, Gamblin, Steven J. Receptor binding by a ferret-transmissible H5 avian influenza virus. NATURE[J]. 2013, 497(7449): 392-+, http://dx.doi.org/10.1038/nature12144.
[26] van der Vries, Erhard, Collins, Patrick J, Vachieri, Sebastien G, Xiong, Xiaoli, Liu, Junfeng, Walker, Philip A, Haire, Lesley F, Hay, Alan J, Schutten, Martin, Osterhaus, Albert D M E, Martin, Steve R, Boucher, Charles A B, Skehel, John J, Gamblin, Steve J. H1N1 2009 Pandemic Influenza Virus: Resistance of the I223R Neuraminidase Mutant Explained by Kinetic and Structural Analysis. PLOS PATHOGENS[J]. 2012, 8(9): https://doaj.org/article/b7d5f67f66c34811b64f6ffdbd9cd721.
[27] Lin, Yi Pu, Xiong, Xiaoli, Wharton, Stephen A, Martin, Stephen R, Coombs, Peter J, Vachieri, Sebastien G, Christodoulou, Evangelos, Walker, Philip A, Liu, Junfeng, Skehel, John J, Gamblin, Steven J, Hay, Alan J, Daniels, Rodney S, McCauley, John W. Evolution of the receptor binding properties of the influenza A(H3N2) hemagglutinin. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2012, 109(52): 21474-21479, http://dx.doi.org/10.1073/pnas.1218841110.
[28] Xiong, Xiaoli, Bromley, Elizabeth H C, Oelschlaeger, Peter, Woolfson, Derek N, Spencer, James. Structural insights into quinolone antibiotic resistance mediated by pentapeptide repeat proteins: conserved surface loops direct the activity of a Qnr protein from a Gram-negative bacterium. NUCLEIC ACIDS RESEARCH[J]. 2011, 39(9): 3917-3927, https://www.webofscience.com/wos/woscc/full-record/WOS:000290589500041.

   

（ 1 ） 病原微生物致病机理的研究, 负责人, 研究所自选, 2020-09--2025-09
（ 2 ） 解析分枝杆菌重要生理过程及结核分枝杆菌免疫逃逸 中关键蛋白质机器的分子基础, 负责人, 国家任务, 2021-12--2026-11
（ 3 ） 刺突蛋白病毒样颗粒的生产方法, 负责人, 地方任务, 2021-01--2024-01
（ 4 ） 国家高层次人才青年项目, 负责人, 国家任务, 2021-05--2024-04

现指导学生

赵逸  博士研究生  071010-生物化学与分子生物学  

袁航  博士研究生  100103-病原生物学  

桂嘉诚  硕士研究生  071008-发育生物学  

李泽萱  硕士研究生  071009-细胞生物学  

颜淑娟  博士研究生  071009-细胞生物学  

潘路遥  博士研究生  071010-生物化学与分子生物学