基本信息
熊晓犁  男  博导  中国科学院广州生物医药与健康研究院
电子邮件: xiong_xiaoli@gibh.ac.cn
通信地址: 广州市黄埔区开发区开源大道190号
邮政编码:

招生信息

   
招生专业
071010-生物化学与分子生物学
招生方向
大分子结构
流感病毒
冠状病毒

教育背景

2007-10--2011-07   University of Bristol   PhD
2004-10--2007-07   University of Bristol   BSc (Hons)

工作经历

   
工作简历
2020-08~现在, 中国科学院广州生物医药与健康研究院, 研究员
2018-05~2020-08,MRC Laboratory of Molecular Biology, Postdoctoral Scientist
2016-10~2018-04,University of Washington, Senior Fellow
2015-01~2016-09,The Francis Crick Institute, Career Development Fellow
2011-03~2014-12,MRC National Institute for Medical Research, Career Development Fellow
2007-10~2011-07,University of Bristol, PhD
2004-10~2007-07,University of Bristol, BSc (Hons)
社会兼职
2020-07-31-今,Nature Structural and Molecular Biology 杂志, 审稿人

出版信息

   
发表论文
(1) New structural insights into the multifunctional influenza A matrix protein 1, Febs Letters, 2021, 第 2 作者
(2) Hemagglutinin Structure and Activities, COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, 2021, 第 3 作者
(3) Germline IGHV3-53-encoded RBD-targeting neutralizing antibodies are commonly present in the antibody repertoires of COVID-19 patients, EMERGING MICROBES & INFECTIONS, 2021, 第 19 作者
(4) SARS-CoV-2 Spike Protein Stabilized in the Closed State Induces Potent Neutralizing Responses, JOURNAL OF VIROLOGY, 2021, 第 4 作者
(5) Structural basis for broad coronavirus neutralization, NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2021, 第 9 作者
(6) Critical Care Workers Have Lower Seroprevalence of SARS-CoV-2 IgG Compared with Non-patient Facing Staff in First Wave of COVID19, The Journal of Critical Care Medicine, 2021, 
(7) Hemagglutinin Traits Determine Transmission of Avian A/H10N7 Influenza Virus between Mammals, CELL HOST & MICROBE, 2020, 第 13 作者
(8) Structures and distributions of SARS-CoV-2 spike proteins on intact virions, NATURE, 2020, 第 13 作者
(9) Enhancing Neuraminidase Immunogenicity of Influenza A Viruses by Rewiring RNA Packaging Signals, JOURNAL OF VIROLOGY, 2020, 第 3 作者
(10) A thermostable, closed SARS-CoV-2 spike protein trimer, NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2020, 通讯作者
(11) Combined Point-of-Care Nucleic Acid and Antibody Testing for SARS-CoV-2 following Emergence of D614G Spike Variant, CELL REPORTS MEDICINE, 2020, 第 14 作者
(12) The native structure of the assembled matrix protein 1 of influenza A virus, NATURE, 2020, 通讯作者
(13) Unexpected Receptor Functional Mimicry Elucidates Activation of Coronavirus Fusion, CELL, 2019, 第 2 作者
(14) Glycan Shield and Fusion Activation of a Deltacoronavirus Spike Glycoprotein Fine-Tuned for Enteric Infections, JOURNAL OF VIROLOGY, 2018, 第 1 作者
(15) Tectonic conformational changes of a coronavirus spike glycoprotein promote membrane fusion, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 第 4 作者
(16) Structures of complexes formed by H5 influenza hemagglutinin with a potent broadly neutralizing human monoclonal antibody, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 第 1 作者
(17) Enhanced human receptor binding by H5 haemagglutinins, VIROLOGY, 2014, 第 1 作者
(18) Receptor Binding Properties of the Influenza Virus Hemagglutinin as a Determinant of Host Range, INFLUENZA PATHOGENESIS AND CONTROL - VOL I, 2014, 第 1 作者
(19) Recent evolution of equine influenza and the origin of canine influenza, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 第 7 作者
(20) Receptor binding by H10 influenza viruses, NATURE, 2014, 第 2 作者
(21) Receptor binding by an H7N9 influenza virus from humans, NATURE, 2013, 第 1 作者
(22) Recognition of sulphated and fucosylated receptor sialosides by A/Vietnam/1194/2004 (H5N1) influenza virus, VIRUS RESEARCH, 2013, 
(23) Receptor binding by a ferret-transmissible H5 avian influenza virus, NATURE, 2013, 第 1 作者
(24) H1N1 2009 Pandemic Influenza Virus: Resistance of the I223R Neuraminidase Mutant Explained by Kinetic and Structural Analysis, PLOS PATHOGENS, 2012, 第 4 作者
(25) Evolution of the receptor binding properties of the influenza A(H3N2) hemagglutinin, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 第 2 作者
(26) Structural insights into quinolone antibiotic resistance mediated by pentapeptide repeat proteins: conserved surface loops direct the activity of a Qnr protein from a Gram-negative bacterium, NUCLEIC ACIDS RESEARCH, 2011, 第 1 作者

科研活动

   
科研项目
( 1 ) 病原微生物致病机理的研究, 负责人, 研究所自选, 2020-09--2025-09
( 2 ) 解析分枝杆菌重要生理过程及结核分枝杆菌免疫逃逸 中关键蛋白质机器的分子基础, 负责人, 国家任务, 2021-12--2026-11
( 3 ) 刺突蛋白病毒样颗粒的生产方法, 负责人, 地方任务, 2021-01--2024-01
( 4 ) 国家高层次人才青年项目, 负责人, 国家任务, 2021-05--2024-04