基本信息
李宝强  男  博导  中国科学院深圳先进技术研究院
email: bq.li@siat.ac.cn
address: 广东省深圳市南山区西丽深圳大学城学苑大道1068号
postalCode:

招生信息

   
招生专业
071006-神经生物学
083100-生物医学工程
080300-光学工程
招生方向
光学显微成像、神经光学
神经血管耦合、脑血流调控
生物物理建模

教育背景

2015-06--2019-12   哈佛医学院/麻省总医院   博士后
2009-01--2014-08   蒙特利尔大学工学院   博士

工作经历

   
工作简历
2020-01~现在, 中国科学院深圳先进技术研究院, 副研究员
2015-06~2019-12,哈佛医学院/麻省总医院, 博士后
2009-01~2014-08,蒙特利尔大学工学院, 博士

专利与奖励

   
专利成果
( 1 ) 一种多功能双光子显微成像系统, 2023, 第 1 作者, 专利号: CN115702777A

出版信息

   
发表论文
(1) Cortical microvascular blood flow velocity mapping by combining dynamic light scattering optical coherence tomography and two-photon microscopy, JOURNAL OF BIOMEDICAL OPTICS, 2023, 第 5 作者
(2) Differential reductions in the capillary red-blood-cell flux between retina and brain under chronic global hypoperfusion, NEUROPHOTONICS, 2023, 第 11 作者
(3) Measurements of cerebral microvascular blood flow, oxygenation, and morphology in a mouse model of whole-brain irradiation-induced cognitive impairment by two-photon microscopy and optical coherence tomography: evidence for microvascular injury in the cerebral white matter, GEROSCIENCE, 2023, 第 1 作者
(4) Aerobic exercise reverses aging-induced depth-dependent decline in cerebral microcirculation, ELIFE, 2023, 第 11 作者
(5) Baseline oxygen consumption decreases with cortical depth, PLOS BIOLOGY, 2022, 第 0 作者
(6) Optical coherence tomography of arteriolar diameter and capillary perfusion during spreading depolarizations, JOURNAL OF CEREBRAL BLOOD FLOW & METABOLISM, 2021, 第 2 作者
(7) Hypertension accelerates cerebral tissue PO2 disruption in Alzheimer���s disease, NEUROSCIENCE LETTERS, 2020, 第 3 作者
(8) Voluntary exercise increases brain tissue oxygenation and spatially homogenizes oxygen delivery in a mouse model of Alzheimer's disease, NEUROBIOLOGY OF AGING, 2020, 第 3 作者
(9) Label-free assessment of hemodynamics in individual cortical brain vessels using third harmonic generation microscopy, BIOMEDICAL OPTICS EXPRESS, 2020, 第 3 作者
(10) Atherosclerosis is associated with a decrease in cerebral microvascular blood flow and tissue oxygenation, PLOS ONE, 2019, 第 1 作者
(11) A Pilot Study Investigating Changes in Capillary Hemodynamics and Its Modulation by Exercise in the APP-PS1 Alzheimer Mouse Model, FRONTIERS IN NEUROSCIENCE, 2019, 第 3 作者
(12) More homogeneous capillary flow and oxygenation in deeper cortical layers correlate with increased oxygen extraction, ELIFE, 2019, 第 1 作者
(13) Two-photon microscopic imaging of capillary red blood cell flux in mouse brain reveals vulnerability of cerebral white matter to hypoperfusion, JOURNAL OF CEREBRAL BLOOD FLOW & METABOLISM, 2019, 第 1 作者
(14) Awake mouse imaging: from 2-photon microscopy to BOLD fMRI, BIOLOGICAL PSYCHIATRY. COGNITIVE NEUROSCIENCE AND NEUROIMAGING, 2018, 第 8 作者
(15) Shear-induced diffusion of red blood cells measured with dynamic light scattering-optical coherence tomography, JOURNAL OF BIOPHOTONICS, 2018, 第 3 作者
(16) Impact of temporal resolution on estimating capillary RBC-flux with optical coherence tomography, JOURNAL OF BIOMEDICAL OPTICS, 2017, 第 11 作者
(17) Development of a new bioactivatable fluorescent probe for quantification of apolipoprotein A-I proteolytic degradation invitro and invivo, ATHEROSCLEROSIS, 2017, 第 2 作者
(18) Contribution of low- and high-flux capillaries to slow hemodynamic fluctuations in the cerebral cortex of mice, JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2016, 第 11 作者
(19) Hybrid FMT-MRI applied to in vivo atherosclerosis imaging, BIOMEDICAL OPTICS EXPRESS, 2014, 第 11 作者
(20) Ultrasound guided fluorescence molecular tomography with improved quantification by an attenuation compensated born-normalization and in vivo preclinical study of cancer, REVIEW OF SCIENTIFIC INSTRUMENTS, 2014, 第 11 作者
(21) Low-cost three-dimensional imaging system combining fluorescence and ultrasound, JOURNAL OF BIOMEDICAL OPTICS, 2011, 第 1 作者

科研活动

   
科研项目
( 1 ) 基20220158 多物种全脑快速脑结构图谱绘制方案研究, 负责人, 地方任务, 2023-02--2026-02
( 2 ) 多模态多尺度脑图谱技术和平台研究, 参与, 国家任务, 2022-08--2026-02
( 3 ) 中国科学院“****”项目, 负责人, 中国科学院计划, 2022-01--2024-12
( 4 ) 重2021N015 高性能多光子激光扫描显微成像系统关键技术研发, 参与, 地方任务, 2021-07--2024-07
( 5 ) 脑功能环路研究的新技术方法和工具的研发与转化, 参与, 地方任务, 2019-01--2021-12
参与会议
(1)Two-photon microscopic imaging of capillary red blood cell flux in mouse brain reveals vulnerability of cerebral white matter to hypoperfusion   2019-04-11
(2)Two-photon microscopic imaging of capillary red blood cell flux in mouse brain reveals vulnerability of cerebral white matter to hypoperfusion   2019-02-02
(3)Two-photon microscopy imaging of capillary red blood cell flux in mouse brain reveals vulnerability of white matter to hypoperfusion   2018-10-03
(4)Cortical depth specific capillary blood flow homogenization facilitates resting state brain oxygen delivery   2018-07-08
(5)Cerebral oxygenation and blood flow distributions along the capillary path in awake mice   2018-01-27
(6)Cerebral oxygenation and blood flow distributions along the capillary path in awake mice   2017-11-11
(7)Investigation of the red blood cells flux change during hypercapnia in the rat brain with optical coherence tomography   2015-02-07
(8)MRI-guided fiber-based fluorescence molecular tomography for preclinical atherosclerosis imaging   2014-05-28
(9)Ultrasound guided fluorescence tomography   2012-06-06
(10)A Low Cost Fluorescence/Ultrasound Multimodal imaging System   2011-09-07