071006-神经生物学
083100-生物医学工程
080300-光学工程

光学显微成像、神经光学
神经血管耦合、脑血流调控
生物物理建模

2015-06--2019-12   哈佛医学院/麻省总医院   博士后
2009-01--2014-08   蒙特利尔大学工学院   博士

   

2020-01~现在, 中国科学院深圳先进技术研究院, 副研究员
2015-06~2019-12,哈佛医学院/麻省总医院, 博士后
2009-01~2014-08,蒙特利尔大学工学院, 博士

   

（ 1 ） 一种多功能双光子显微成像系统, 2023, 第 1 作者, 专利号: CN115702777A

   

（1） Cortical microvascular blood flow velocity mapping by combining dynamic light scattering optical coherence tomography and two-photon microscopy, JOURNAL OF BIOMEDICAL OPTICS, 2023, 第 5 作者
（2） Differential reductions in the capillary red-blood-cell flux between retina and brain under chronic global hypoperfusion, NEUROPHOTONICS, 2023, 第 1 作者  通讯作者
（3） Measurements of cerebral microvascular blood flow, oxygenation, and morphology in a mouse model of whole-brain irradiation-induced cognitive impairment by two-photon microscopy and optical coherence tomography: evidence for microvascular injury in the cerebral white matter, GEROSCIENCE, 2023, 第 1 作者
（4） Aerobic exercise reverses aging-induced depth-dependent decline in cerebral microcirculation, ELIFE, 2023, 第 11 作者
（5） Baseline oxygen consumption decreases with cortical depth, PLOS BIOLOGY, 2022, 第 11 作者
（6） Optical coherence tomography of arteriolar diameter and capillary perfusion during spreading depolarizations, JOURNAL OF CEREBRAL BLOOD FLOW & METABOLISM, 2021, 第 2 作者
（7） Quantification of Capillary Perfusion in an Animal Model of Acute Intracranial Hypertension, JOURNAL OF NEUROTRAUMA, 2021, 第 2 作者
（8） Hypertension accelerates cerebral tissue PO2 disruption in Alzheimer���s disease, NEUROSCIENCE LETTERS, 2020, 第 3 作者
（9） Voluntary exercise increases brain tissue oxygenation and spatially homogenizes oxygen delivery in a mouse model of Alzheimer's disease, NEUROBIOLOGY OF AGING, 2020, 第 3 作者
（10） Label-free assessment of hemodynamics in individual cortical brain vessels using third harmonic generation microscopy, BIOMEDICAL OPTICS EXPRESS, 2020, 第 3 作者
（11） Atherosclerosis is associated with a decrease in cerebral microvascular blood flow and tissue oxygenation, PLOS ONE, 2019, 第 1 作者
（12） A Pilot Study Investigating Changes in Capillary Hemodynamics and Its Modulation by Exercise in the APP-PS1 Alzheimer Mouse Model, FRONTIERS IN NEUROSCIENCE, 2019, 第 3 作者
（13） More homogeneous capillary flow and oxygenation in deeper cortical layers correlate with increased oxygen extraction, ELIFE, 2019, 第 1 作者
（14） Two-photon microscopic imaging of capillary red blood cell flux in mouse brain reveals vulnerability of cerebral white matter to hypoperfusion, JOURNAL OF CEREBRAL BLOOD FLOW & METABOLISM, 2019, 第 1 作者
（15） Awake mouse imaging: from 2-photon microscopy to BOLD fMRI, BIOLOGICAL PSYCHIATRY. COGNITIVE NEUROSCIENCE AND NEUROIMAGING, 2018, 第 8 作者
（16） Shear-induced diffusion of red blood cells measured with dynamic light scattering-optical coherence tomography, JOURNAL OF BIOPHOTONICS, 2018, 第 3 作者
（17） Impact of temporal resolution on estimating capillary RBC-flux with optical coherence tomography, JOURNAL OF BIOMEDICAL OPTICS, 2017, 第 1 作者  通讯作者
（18） Development of a new bioactivatable fluorescent probe for quantification of apolipoprotein A-I proteolytic degradation invitro and invivo, ATHEROSCLEROSIS, 2017, 第 2 作者
（19） Contribution of low- and high-flux capillaries to slow hemodynamic fluctuations in the cerebral cortex of mice, JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2016, 第 1 作者  通讯作者
（20） Hybrid FMT-MRI applied to in vivo atherosclerosis imaging, BIOMEDICAL OPTICS EXPRESS, 2014, 第 1 作者  通讯作者
（21） Ultrasound guided fluorescence molecular tomography with improved quantification by an attenuation compensated born-normalization and in vivo preclinical study of cancer, REVIEW OF SCIENTIFIC INSTRUMENTS, 2014, 第 1 作者  通讯作者
（22） Low-cost three-dimensional imaging system combining fluorescence and ultrasound, JOURNAL OF BIOMEDICAL OPTICS, 2011, 第 1 作者

   

（ 1 ） 基20220158 多物种全脑快速脑结构图谱绘制方案研究, 负责人, 地方任务, 2023-02--2026-02
（ 2 ） 多模态多尺度脑图谱技术和平台研究, 参与, 国家任务, 2022-08--2026-02
（ 3 ） 中国科学院“****”项目, 负责人, 中国科学院计划, 2022-01--2024-12
（ 4 ） 重2021N015 高性能多光子激光扫描显微成像系统关键技术研发, 参与, 地方任务, 2021-07--2024-07
（ 5 ） 脑功能环路研究的新技术方法和工具的研发与转化, 参与, 地方任务, 2019-01--2021-12

（1）Two-photon microscopic imaging of capillary red blood cell flux in mouse brain reveals vulnerability of cerebral white matter to hypoperfusion   2019-04-11
（2）Two-photon microscopic imaging of capillary red blood cell flux in mouse brain reveals vulnerability of cerebral white matter to hypoperfusion   2019-02-02
（3）Two-photon microscopy imaging of capillary red blood cell flux in mouse brain reveals vulnerability of white matter to hypoperfusion   2018-10-03
（4）Cortical depth specific capillary blood flow homogenization facilitates resting state brain oxygen delivery   2018-07-08
（5）Cerebral oxygenation and blood flow distributions along the capillary path in awake mice   2018-01-27
（6）Cerebral oxygenation and blood flow distributions along the capillary path in awake mice   2017-11-11
（7）Investigation of the red blood cells flux change during hypercapnia in the rat brain with optical coherence tomography   2015-02-07
（8）MRI-guided fiber-based fluorescence molecular tomography for preclinical atherosclerosis imaging   2014-05-28
（9）Ultrasound guided fluorescence tomography   2012-06-06
（10）A Low Cost Fluorescence/Ultrasound Multimodal imaging System   2011-09-07