基本信息
戴辉雄  男  博导  中国科学院上海药物研究所
email: hxdai@simm.ac.cn
address: 上海市浦东新区祖冲之路555号
postalCode:

招生信息

   
招生专业
100701-药物化学
070303-有机化学
招生方向
药物化学

教育背景

2004-09--2007-07   中国科学院上海有机化学研究所   博士
2001-09--2004-07   南开大学   硕士
1997-09--2001-07   南昌大学   学士

工作经历

   
工作简历
2012-07~2016-02,中国科学院上海有机化学研究所, 副研究员
2009-12~2012-07,美国Scipps研究所, 研究助理
2007-12~2009-12,美国德州大学, 博士后
2004-09~2007-07,中国科学院上海有机化学研究所, 博士
2001-09~2004-07,南开大学, 硕士
1997-09~2001-07,南昌大学, 学士

教授课程

高等有机化学

专利与奖励

   
奖励信息
(1) 上海市优秀青年学术带头人, , 市地级, 2019
(2) 上海市科技系统青年五四奖章, 市地级, 2019
(3) 中国科学院卢嘉锡青年人才奖, 院级, 2015
(4) Thieme Chemistry Journals Award, 其他, 2015
(5) 中科院青年创新促进会会员, 院级, 2014
专利成果
( 1 ) 内酰胺类化合物及其制备方法, 2017, 第 2 作者, 专利号: CN106831522A

( 2 ) 一种制备3-亚氨基异吲哚啉酮类化合物的方法, 2016, 第 2 作者, 专利号: CN105294536A

出版信息

   
发表论文
(1) Fused-ring α-pyrones from intramolecular C–H activation and their lipids-lowering activity associated with LXR-IDOL-LDLR axis regulation, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 通讯作者
(2) 铑催化吲哚C(4)—H选择性活化构建氮杂-螺4,5吲哚骨架, Construction of Aza-spiro4,5indole Scaffolds via Rhodium-Catalyzed Regioselective C(4)—H Activation of Indole, 化学学报, 2022, 第 5 作者
(3) Functionalized styrene synthesis via palladium-catalyzed C-C cleavage of aryl ketones, TETRAHEDRON LETTERS, 2022, 通讯作者
(4) Enones as Alkenyl Reagents via Ligand-Promoted C-C Bond Activation, ACS CATALYSIS, 2022, 通讯作者
(5) Rhodium-Catalyzed C-H Activation of Indoles for the Construction of Spiroindole Scaffolds, SYNTHESIS-STUTTGART, 2022, 通讯作者
(6) Homologation of aryl ketones to long-chain ketones and aldehydes via C–C bond cleavage, ISCIENCE, 2022, 第 5 作者
(7) Palladium-Catalyzed Alkynylation of Enones with Alkynylsilanes via C-C Bond Activation, JOURNAL OF ORGANIC CHEMISTRY, 2022, 通讯作者
(8) Palladium-catalyzed diarylative dearomatization of indoles with aryl thioesters, Palladium-catalyzed diarylative dearomatization of indoles with aryl thioesters, CHINESE CHEMICAL LETTERS, 2021, 通讯作者
(9) Construction of 2-alkynyl aza-spiro4,5indole scaffolds via sequential C-H activations for modular click chemistry libraries, CHEMICAL COMMUNICATIONS, 2021, 通讯作者
(10) C3-Arylation of indoles with aryl ketones via C-C/C-H activations, CHEMICAL COMMUNICATIONS, 2021, 通讯作者
(11) Copper-mediated ortho C-H primary amination of anilines, TETRAHEDRON LETTERS, 2021, 通讯作者
(12) Palladium/Norbornene-Catalyzed Decarbonylative Difunctionalization of Thioesters, JACS AU, 2021, 第 10 作者
(13) Pd-Catalyzed Asymmetric Dearomatization of Indoles via Decarbonylative Heck-Type Reaction of Thioesters, ORGANIC LETTERS, 2021, 通讯作者
(14) Mizoroki-Heck Reaction of Unstrained Aryl Ketones via Ligand-Promoted C-C Bond Olefination, ORGANIC LETTERS, 2021, 通讯作者
(15) Ligand-Promoted Alkynylation of Aryl Ketones: A Practical Tool for Structural Diversity in Drugs and Natural Products, ACS CATALYSIS, 2021, 通讯作者
(16) Copper-Mediated ortho-C-H Amination Using DMF as the Amine Source, ORGANIC LETTERS, 2021, 通讯作者
(17) Enones as Alkenyl Reagents via Ligand-Promoted C-C Bond Activation, ACS CATALYSIS, 2021, 第 6 作者
(18) Arylketones as Aryl Donors in Palladium-Catalyzed Suzuki-Miyaura Couplings, ORGANIC LETTERS, 2021, 通讯作者
(19) Pd-Catalyzed Asymmetric Acyl-Carbamoylation of an Alkene to Construct an alpha-Quaternary Chiral Cycloketone, ORGANIC LETTERS, 2021, 通讯作者
(20) Copper mediated C(sp(2))-H amination and hydroxylation of phosphinamides, CHEMICAL COMMUNICATIONS, 2020, 通讯作者
(21) Copper-mediated C-H thiolation of (hetero)arenes using weakly coordinating directing group, TETRAHEDRON LETTERS, 2020, 通讯作者
(22) Palladium-catalyzed meta-CsbndH bond iodination of arenes with I2, CHINESE CHEMICAL LETTERS, 2020, 通讯作者
(23) Palladium-Catalyzed, Copper(I)-Promoted Methoxycarbonylation of Arylboronic Acids with O-Methyl S-Aryl Thiocarbonates, JOURNAL OF ORGANIC CHEMISTRY, 2020, 通讯作者
(24) Cu(II) Mediated beta-C-H Alkynylation of Acrylamides with Terminal Alkynes, CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2020, 通讯作者
(25) Synthesis of Trifluoromethylarenes via Nickel-Mediated C-O Bond Activation of Phenol Derivatives, CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2020, 通讯作者
(26) 铜参与的烯基酰胺β-碳氢键与端炔的炔基化反应(英文), 有机化学, 2020, 第 5 作者
(27) 铜参与的烯基酰胺β-碳氢键与端炔的炔基化反应, Cu(II)-Mediatedβ-C—H Alkynylation of Acrylamides with Terminal Alkynes, 有机化学, 2020, 第 5 作者
(28) Transformations of Aryl Ketones via Ligand-Promoted C-C Bond Activation, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2020, 通讯作者
(29) Synthesis of Axially Chiral Olefin-Oxazoline Ligands via Pd-Catalyzed Multiple C-H Functionalization, ORGANIC LETTERS, 2020, 通讯作者
(30) Copper-mediated CsbndH thiolation of (hetero)arenes using weakly coordinating directing group, TETRAHEDRON LETTERS, 2020, 通讯作者
(31) Palladium-catalyzed fluoroacylation of (Hetero)arylboronic acid with fluorothioacetates at ambient temperature, TETRAHEDRON LETTERS, 2020, 通讯作者
(32) Palladium-catalyzed meta-C—H bond iodination of arenes with I2, Palladium-catalyzed meta-C-H bond iodination of arenes with I-2, CHINESE CHEMICAL LETTERS, 2020, 通讯作者
(33) Copper-Catalyzed Oxalamide-Directed ortho-C-H Amination of Anilines with Alkylamines, ORGANIC LETTERS, 2020, 通讯作者
(34) 镍介导的苯酚衍生物碳氧键活化合成三氟甲基芳烃, Synthesis of Trifluoromethylarenes via Nickel-Mediated C-O Bond Activation of Phenol Derivatives, 有机化学, 2020, 第 2 作者
(35) Remote Para-C-H Acetoxylation of Electron-Deficient Arenes, ORGANICLETTERS, 2019, 通讯作者
(36) Palladium-catalyzed intramolecular CsbndH acylation of indoles with thioester, TETRAHEDRON LETTERS, 2019, 通讯作者
(37) Copper-catalyzedα-selective C–H trifluoromethylation of acrylamides with TMSCF3, Copper-catalyzed α-selective C–H trifluoromethylation of acrylamides with TMSCF3, 中国化学快报:英文版, 2019, 通讯作者
(38) Copper-catalyzed alpha-selective C-H trifluoromethylation of acrylamides with TMSCF3, CHINESE CHEMICAL LETTERS, 2019, 通讯作者
(39) coppercatalyzedselectivechtrifluoromethylationofacrylamideswithtmscf3, CHINESECHEMICALLETTERS, 2019, 通讯作者
(40) Palladium-Catalyzed Remote meta-C-H Bond Deuteration of Arenes Using a Pyridine Template, ORGANIC LETTERS, 2019, 通讯作者
(41) Efficient Synthesis of Spirooxindole Pyrrolones by a Rhodium(III)-Catalyzed C-H Activation/Carbene Insertion/Lossen Rearrangement Sequence, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2019, 通讯作者
(42) Cu-Mediated C-H Thioetherification of Arenes at Room Temperature, ORGANIC LETTERS, 2019, 通讯作者
(43) Palladium-catalyzed intramolecular C-H acylation of indoles with thioester, TETRAHEDRON LETTERS, 2019, 通讯作者
(44) Copper-Mediated Diastereoselective C-H Thiolation of Ferrocenes, ORGANOMETALLICS, 2018, 通讯作者
(45) 基于C—H键官能团化合成芳香伯胺的研究进展, Progress in the Synthesis of Primary Anilines via C—H Bond Functionalization, 有机化学, 2018, 第 4 作者
(46) Progress in the Synthesis of Primary Anilines via C-H Bond Functionalization, CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2018, 通讯作者
(47) Ligand-enabled ortho-C-H olefination of phenylacetic amides with unactivated alkenes, CHEMICAL SCIENCE, 2018, 通讯作者
(48) Rapid Syntheses of Heteroaryl-Substituted Imidazo1,5-aindole and Pyrrolo1,2-cimidazole via Aerobic C2-H Functionalizations, ORGANIC LETTERS, 2018, 通讯作者
(49) Copper mediated c-h amination with oximes: en route to primary anilines, CHEMICAL SCIENCE, 2018, 通讯作者
(50) Identification of monodentate oxazoline as a ligand for copper-promoted ortho-c-h hydroxylation and amination, CHEMICAL SCIENCE, 2017, 通讯作者
(51) Copper-Mediated Late-Stage Functionalization of Heterocycle-Containing Molecules, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2017, 通讯作者
(52) Pd-Catalyzed alpha-Selective C-H Functionalization of Olefins: En Route to 4-Imino-beta-Lactams, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2016, 通讯作者
(53) Recent progress on copper-mediated directing-group-assisted c(sp(2))-h activation, SYNTHESIS-STUTTGART, 2016, 通讯作者
(54) Pd-Catalyzed α-Selective C-H Functionalization of Olefins: En Route to 4-Imino-β-Lactams, J. Am. Chem. Soc, 2016, 通讯作者
(55) Cu(ii)-mediated c(sp(2))-h hydroxylation, JOURNAL OF ORGANIC CHEMISTRY, 2015, 第 5 作者
(56) Cu(ii)-catalyzed coupling of aromatic c-h bonds with malonates, ORGANICLETTERS, 2015, 通讯作者
(57) 过渡金属催化的C-H 炔基化反应, Transition-Metal-Catalyzed C-H Alkynylation, CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2015, 第 4 作者
(58) Transition-Metal-Catalyzed C-H Alkynylation, CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2015, 第 4 作者
(59) Ligand-Controlled Para-Selective C-H Arylation of Monosubstituted Arenes, ORGANIC LETTERS, 2015, 通讯作者
(60) Cu(oac)(2)-catalyzed coupling of aromatic c-h bonds with arylboron reagents, ORGANIC LETTERS, 2014, 通讯作者
(61) Cu(II)-Mediated C-H Amidation and Amination of Arenes: Exceptional Compatibility with Heterocycles, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2014, 通讯作者
(62) Cu(ii)-mediated ortho c-h alkynylation of (hetero)arenes with terminal alkynes, JOURNALOFTHEAMERICANCHEMICALSOCIETY, 2014, 通讯作者
(63) Cu(OAc)(2)-Catalyzed Coupling of Aromatic C-H Bonds with Arylboron Reagents, ORG. LETT., 2014, 第 3 作者
(64) Cu(II)-Mediated C-H Amidation and Amination of Arenes: Exceptional Compatibility with Heterocycles, J. AM. CHEM. SOC., 2014, 第 3 作者
(65) Overcoming the limitations of directed C-H functionalizations of heterocycles, NATURE, 2014, 通讯作者
(66) Exceedingly Fast Copper(II)-Promoted ortho C-H Trifluoromethylation of Arenes using TMSCF3, ANGEW. CHEM.-INT. EDIT., 2014, 第 5 作者
(67) Exceedingly fast copper(ii)-promoted ortho c-h trifluoromethylation of arenes using tmscf3, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2014, 通讯作者
(68) Cu(II)-Mediated Ortho C-H Alkynylation of (Hetero)Arenes with Terminal Alkynes, J. AM. CHEM. SOC., 2014, 第 4 作者
(69) Ru(II)-Catalyzed ortho-C-H Amination of Arenes and Heteroarenes at Room Temperature, ORGANIC LETTERS, 2013, 通讯作者
(70) Pd(II)-Catalyzed Ortho - or Meta -C–H Olefination of Phenol Derivatives, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2013, 第 1 作者
(71) Pd-Catalyzed Oxidative ortho-C-H Borylation of Arenes, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2012, 第 1 作者
(72) Pd(II)-Catalyzed ortho- Trifluoromethylation of Arenes and Insights into Coordination Mode of Acidic Amide Directing Groups, J. Am. Chem. Soc, 2012, 第 1 作者
(73) Divergent C–H Functionalizations Directed by Sufonamide Pharmacophores: Late-Stage Diversification as a Tool for Drug Discovery, J. Am. Chem. Soc, 2011, 第 1 作者
(74) Pd(II)-Catalyzed Hydroxy-Directed C–H Activation/C–O Cyclization: Expedient Construction of Dihydrobenzofurans, J. Am. Chem. Soc, 2010, 第 1 作者
(75) Palladium(II)/2,2′-bipyridine-catalyzed addition of arylboronic acids to N-tosyl-arylaldimines, TETRAHEDRON LETTERS, 2009, 第 1 作者
(76) Palladimn(II)-catalyzed one-pot enantioselective synthesis of arylglycine derivatives from ethyl glyoxylate, p-toluenesulfonyl isocyanate and arylboronic acids, ADVANCED SYNTHESIS & CATALYSIS, 2008, 第 1 作者
(77) 二价鈀催化的芳基硼酸对亚胺的加成研究, 2007, 第 1 作者
(78) Diastereoselective synthesis of arylglycine derivatives by cationic Palladium(II)-Catalyzed addition of arylboronic acids to N-tert-Butanesulfinyl imino esters, ORGANIC LETTERS, 2007, 第 1 作者

科研活动

   
科研项目
( 1 ) 过渡金属催化的碳氢键活反应研究, 负责人, 中国科学院计划, 2014-01--2017-12
( 2 ) 金属铜催化的惰性碳氢键活化反应的研究, 负责人, 国家任务, 2015-01--2018-12
( 3 ) 化学键活化与可控性重组研究, 参与, 国家任务, 2015-01--2017-12
( 4 ) 金属铜促进的惰性C(sp3)-H键官能团化反应研究, 负责人, 国家任务, 2018-01--2021-12
( 5 ) 中科院青年创新促进会优秀会员, 负责人, 中国科学院计划, 2019-01--2021-12
( 6 ) 高效合成关键技术, 负责人, 国家任务, 2019-01--2021-12
( 7 ) 基于多元技术融合平台的结构新颖抗结核先导化合物的发现, 参与, 国家任务, 2020-01--2024-12
( 8 ) 上海市优秀青年学术带头人, 负责人, 地方任务, 2019-01--2021-12
( 9 ) 钯催化碳-碳键活化实现酮类化合物的转化, 负责人, 国家任务, 2022-01--2025-12
( 10 ) 配体促进的芳酮C-C键活化反应研究及应用, 负责人, 地方任务, 2023-04--2026-03
参与会议
(1)Development of Novel and Practical Catalytic Systems for C–H Activation   14届全国均相催化学术讨论会   2015-09-22
(2)Development of Novel and Practical Catalytic Systems for C–H Activation   2015-08-22