基本信息

戴辉雄 男 博导 中国科学院上海药物研究所
电子邮件: hxdai@simm.ac.cn
通信地址: 上海市浦东新区祖冲之路555号
邮政编码:
电子邮件: hxdai@simm.ac.cn
通信地址: 上海市浦东新区祖冲之路555号
邮政编码:
招生信息
招生专业
100701-药物化学070303-有机化学
招生方向
药物化学
教育背景
2004-09--2007-07 中国科学院上海有机化学研究所 博士2001-09--2004-07 南开大学 硕士1997-09--2001-07 南昌大学 学士
工作经历
工作简历
2016-03~现在, 中国科学院上海药物研究所, 研究员2012-07~2016-02,中国科学院上海有机化学研究所, 副研究员2009-12~2012-07,美国Scipps研究所, 研究助理2007-12~2009-12,美国德州大学, 博士后2004-09~2007-07,中国科学院上海有机化学研究所, 博士2001-09~2004-07,南开大学, 硕士1997-09~2001-07,南昌大学, 学士
教授课程
高等有机化学
专利与奖励
奖励信息
(1) 上海市优秀青年学术带头人, , 市地级, 2019(2) 上海市科技系统青年五四奖章, 市地级, 2019(3) 中国科学院卢嘉锡青年人才奖, 院级, 2015(4) Thieme Chemistry Journals Award, 其他, 2015(5) 中科院青年创新促进会会员, 院级, 2014
专利成果
( 1 ) 内酰胺类化合物及其制备方法, 2017, 第 2 作者, 专利号: CN106831522A( 2 ) 一种制备3-亚氨基异吲哚啉酮类化合物的方法, 2016, 第 2 作者, 专利号: CN105294536A
出版信息
发表论文
(1) Palladium-Catalyzed Directed Carbon���Carbon Bond Activation of Aryl Nitriles for Cyano Transfer, Org. Lett., 2024, (2) Palladium-Catalyzed Deuteration of Arylketone Oxime Ethers, Angew. Chem. Int. Ed., 2024, (3) Construction of thiolated methylene oxindoles via decarbonylative carbocyclization of thioester tethered alkyne, Tetrahedron Letters, 2024, (4) Total Synthesis of Syringin and Its Natural Analogues via C���C Bond Activation of Aryl Ketones, Chin. J. Chem., 2023, (5) Construction of Chalcogenated Methylene Chroman-3-ones via Palladium-Catalyzed Carbocyclization, J. Org. Chem., 2023, (6) Construction of Indole-Fused Seven- and Eight-Membered Azaheterocycles via a Tandem Pd/NBE-Catalyzed Decarbonylation and Dual C���H Activation Sequence, Org. Lett., 2023, (7) Dual ligands relay-promoted transformation of unstrained ketones to polyfluoroarenes and nitriles, Sci China Chem, 2023, (8) Construction of polysubstituted pentafulvenes via palladium-catalyzed deacetylation of enones, Chem. Commun., 2023, (9) Fused-ring ��-pyrones from intramolecular C���H activation and their lipids-lowering activity associated with LXR-IDOL-LDLR axis regulation, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 第 10 作者 通讯作者(10) 铑催化吲哚C(4)—H选择性活化构建氮杂-螺4,5吲哚骨架, Construction of Aza-spiro4,5indole Scaffolds via Rhodium-Catalyzed Regioselective C(4)���H Activation of Indole, 化学学报, 2022, 第 5 作者(11) Functionalized styrene synthesis via palladium-catalyzed C-C cleavage of aryl ketones, TETRAHEDRON LETTERS, 2022, 第 5 作者 通讯作者(12) Enones as Alkenyl Reagents via Ligand-Promoted C-C Bond Activation, ACS CATALYSIS, 2022, 第 6 作者 通讯作者(13) Rhodium-Catalyzed C-H Activation of Indoles for the Construction of Spiroindole Scaffolds, SYNTHESIS-STUTTGART, 2022, 第 4 作者 通讯作者(14) Homologation of aryl ketones to long-chain ketones and aldehydes via C���C bond cleavage, ISCIENCE, 2022, 第 5 作者(15) Palladium-Catalyzed Alkynylation of Enones with Alkynylsilanes via C-C Bond Activation, JOURNAL OF ORGANIC CHEMISTRY, 2022, 第 4 作者 通讯作者(16) Palladium-catalyzed diarylative dearomatization of indoles with aryl thioesters, Palladium-catalyzed diarylative dearomatization of indoles with aryl thioesters, CHINESE CHEMICAL LETTERS, 2021, 第 5 作者 通讯作者(17) Construction of 2-alkynyl aza-spiro4,5indole scaffolds via sequential C-H activations for modular click chemistry libraries, CHEMICAL COMMUNICATIONS, 2021, 第 9 作者 通讯作者(18) Copper-mediated ortho C-H primary amination of anilines, TETRAHEDRON LETTERS, 2021, 第 4 作者 通讯作者(19) C3-Arylation of indoles with aryl ketones via C-C/C-H activations, CHEMICAL COMMUNICATIONS, 2021, 第 6 作者 通讯作者(20) Palladium/Norbornene-Catalyzed Decarbonylative Difunctionalization of Thioesters, JACS AU, 2021, 第 10 作者(21) Pd-Catalyzed Asymmetric Dearomatization of Indoles via Decarbonylative Heck-Type Reaction of Thioesters, ORGANIC LETTERS, 2021, 第 7 作者 通讯作者(22) Mizoroki-Heck Reaction of Unstrained Aryl Ketones via Ligand-Promoted C-C Bond Olefination, ORGANIC LETTERS, 2021, 第 7 作者 通讯作者(23) Ligand-Promoted Alkynylation of Aryl Ketones: A Practical Tool for Structural Diversity in Drugs and Natural Products, ACS CATALYSIS, 2021, 第 10 作者 通讯作者(24) Copper-Mediated ortho-C-H Amination Using DMF as the Amine Source, ORGANIC LETTERS, 2021, 第 5 作者 通讯作者(25) Enones as Alkenyl Reagents via Ligand-Promoted C-C Bond Activation, ACS CATALYSIS, 2021, 第 6 作者(26) Arylketones as Aryl Donors in Palladium-Catalyzed Suzuki-Miyaura Couplings, ORGANIC LETTERS, 2021, 第 6 作者 通讯作者(27) Pd-Catalyzed Asymmetric Acyl-Carbamoylation of an Alkene to Construct an alpha-Quaternary Chiral Cycloketone, ORGANIC LETTERS, 2021, 第 7 作者 通讯作者(28) Copper-mediated CsbndH thiolation of (hetero)arenes using weakly coordinating directing group, TETRAHEDRON LETTERS, 2020, 第 5 作者 通讯作者(29) Palladium-catalyzed meta-C—H bond iodination of arenes with I2, Palladium-catalyzed meta-C-H bond iodination of arenes with I-2, CHINESE CHEMICAL LETTERS, 2020, 第 5 作者 通讯作者(30) Palladium-catalyzed fluoroacylation of (Hetero)arylboronic acid with fluorothioacetates at ambient temperature, TETRAHEDRON LETTERS, 2020, 第 6 作者 通讯作者(31) Copper-Catalyzed Oxalamide-Directed ortho-C-H Amination of Anilines with Alkylamines, ORGANIC LETTERS, 2020, 第 6 作者 通讯作者(32) 镍介导的苯酚衍生物碳氧键活化合成三氟甲基芳烃, Synthesis of Trifluoromethylarenes via Nickel-Mediated C-O Bond Activation of Phenol Derivatives, 有机化学, 2020, 第 2 作者(33) Copper-mediated C-H thiolation of (hetero)arenes using weakly coordinating directing group, TETRAHEDRON LETTERS, 2020, 第 5 作者 通讯作者(34) Copper mediated C(sp(2))-H amination and hydroxylation of phosphinamides, CHEMICAL COMMUNICATIONS, 2020, 第 6 作者 通讯作者(35) Palladium-catalyzed meta-CsbndH bond iodination of arenes with I2, CHINESE CHEMICAL LETTERS, 2020, 第 5 作者 通讯作者(36) Cu(II) Mediated beta-C-H Alkynylation of Acrylamides with Terminal Alkynes, CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2020, 第 5 作者 通讯作者(37) Palladium-Catalyzed, Copper(I)-Promoted Methoxycarbonylation of Arylboronic Acids with O-Methyl S-Aryl Thiocarbonates, JOURNAL OF ORGANIC CHEMISTRY, 2020, 第 5 作者 通讯作者(38) Synthesis of Trifluoromethylarenes via Nickel-Mediated C-O Bond Activation of Phenol Derivatives, CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2020, 第 2 作者 通讯作者(39) 铜参与的烯基酰胺β-碳氢键与端炔的炔基化反应, Cu(II)-Mediated ��-C���H Alkynylation of Acrylamides with Terminal Alkynes, 有机化学, 2020, 第 5 作者(40) 铜参与的烯基酰胺β-碳氢键与端炔的炔基化反应(英文), 有机化学, 2020, 第 5 作者(41) Transformations of Aryl Ketones via Ligand-Promoted C-C Bond Activation, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2020, 第 9 作者 通讯作者(42) Synthesis of Axially Chiral Olefin-Oxazoline Ligands via Pd-Catalyzed Multiple C-H Functionalization, ORGANIC LETTERS, 2020, 第 7 作者 通讯作者(43) Remote Para-C-H Acetoxylation of Electron-Deficient Arenes, ORGANICLETTERS, 2019, 第 5 作者 通讯作者(44) Palladium-catalyzed intramolecular CsbndH acylation of indoles with thioester, TETRAHEDRON LETTERS, 2019, 第 4 作者 通讯作者(45) Copper-catalyzedα-selective C–H trifluoromethylation of acrylamides with TMSCF3, Copper-catalyzed ��-selective C���H trifluoromethylation of acrylamides with TMSCF3, 中国化学快报:英文版, 2019, 第 3 作者 通讯作者(46) Copper-catalyzed alpha-selective C-H trifluoromethylation of acrylamides with TMSCF3, CHINESE CHEMICAL LETTERS, 2019, 第 3 作者 通讯作者(47) coppercatalyzedselectivechtrifluoromethylationofacrylamideswithtmscf3, CHINESECHEMICALLETTERS, 2019, 第 3 作者 通讯作者(48) Palladium-Catalyzed Remote meta-C-H Bond Deuteration of Arenes Using a Pyridine Template, ORGANIC LETTERS, 2019, 第 6 作者 通讯作者(49) Efficient Synthesis of Spirooxindole Pyrrolones by a Rhodium(III)-Catalyzed C-H Activation/Carbene Insertion/Lossen Rearrangement Sequence, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2019, 第 6 作者 通讯作者(50) Cu-Mediated C-H Thioetherification of Arenes at Room Temperature, ORGANIC LETTERS, 2019, 第 4 作者 通讯作者(51) Palladium-catalyzed intramolecular C-H acylation of indoles with thioester, TETRAHEDRON LETTERS, 2019, 第 4 作者 通讯作者(52) Copper-Mediated Diastereoselective C-H Thiolation of Ferrocenes, ORGANOMETALLICS, 2018, 第 6 作者 通讯作者(53) 基于C-H键官能团化合成芳香伯胺的研究进展, Progress in the Synthesis of Primary Anilines via C-H Bond Functionalization, 有机化学, 2018, 第 4 作者(54) Progress in the Synthesis of Primary Anilines via C-H Bond Functionalization, CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2018, 第 4 作者 通讯作者(55) Ligand-enabled ortho-C-H olefination of phenylacetic amides with unactivated alkenes, CHEMICAL SCIENCE, 2018, 第 4 作者 通讯作者(56) Rapid Syntheses of Heteroaryl-Substituted Imidazo1,5-aindole and Pyrrolo1,2-cimidazole via Aerobic C2-H Functionalizations, ORGANIC LETTERS, 2018, 第 4 作者 通讯作者(57) Copper mediated c-h amination with oximes: en route to primary anilines, CHEMICAL SCIENCE, 2018, 第 6 作者 通讯作者(58) Identification of monodentate oxazoline as a ligand for copper-promoted ortho-c-h hydroxylation and amination, CHEMICAL SCIENCE, 2017, 第 6 作者 通讯作者(59) Copper-Mediated Late-Stage Functionalization of Heterocycle-Containing Molecules, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2017, 第 5 作者 通讯作者(60) Pd-Catalyzed alpha-Selective C-H Functionalization of Olefins: En Route to 4-Imino-beta-Lactams, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2016, 第 5 作者 通讯作者(61) Recent progress on copper-mediated directing-group-assisted c(sp(2))-h activation, SYNTHESIS-STUTTGART, 2016, 第 5 作者 通讯作者(62) Pd-Catalyzed ��-Selective C-H Functionalization of Olefins: En Route to 4-Imino-��-Lactams, J. Am. Chem. Soc, 2016, 第 1 作者 通讯作者(63) Cu(ii)-mediated c(sp(2))-h hydroxylation, JOURNAL OF ORGANIC CHEMISTRY, 2015, 第 5 作者(64) Cu(ii)-catalyzed coupling of aromatic c-h bonds with malonates, ORGANICLETTERS, 2015, 第 6 作者 通讯作者(65) 过渡金属催化的C-H 炔基化反应, Transition-Metal-Catalyzed C-H Alkynylation, CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2015, 第 4 作者(66) Transition-Metal-Catalyzed C-H Alkynylation, CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2015, 第 4 作者(67) Ligand-Controlled Para-Selective C-H Arylation of Monosubstituted Arenes, ORGANIC LETTERS, 2015, 第 3 作者 通讯作者(68) Cu(oac)(2)-catalyzed coupling of aromatic c-h bonds with arylboron reagents, ORGANIC LETTERS, 2014, 第 3 作者 通讯作者(69) Cu(II)-Mediated C-H Amidation and Amination of Arenes: Exceptional Compatibility with Heterocycles, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2014, 第 3 作者 通讯作者(70) Cu(ii)-mediated ortho c-h alkynylation of (hetero)arenes with terminal alkynes, JOURNALOFTHEAMERICANCHEMICALSOCIETY, 2014, 第 4 作者 通讯作者(71) Cu(OAc)(2)-Catalyzed Coupling of Aromatic C-H Bonds with Arylboron Reagents, ORG. LETT., 2014, 第 3 作者(72) Cu(II)-Mediated C-H Amidation and Amination of Arenes: Exceptional Compatibility with Heterocycles, J. AM. CHEM. SOC., 2014, 第 3 作者(73) Overcoming the limitations of directed C-H functionalizations of heterocycles, NATURE, 2014, 第 5 作者 通讯作者(74) Exceedingly Fast Copper(II)-Promoted ortho C-H Trifluoromethylation of Arenes using TMSCF3, ANGEW. CHEM.-INT. EDIT., 2014, 第 5 作者(75) Exceedingly fast copper(ii)-promoted ortho c-h trifluoromethylation of arenes using tmscf3, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2014, 第 5 作者 通讯作者(76) Cu(II)-Mediated Ortho C-H Alkynylation of (Hetero)Arenes with Terminal Alkynes, J. AM. CHEM. SOC., 2014, 第 4 作者(77) Ru(II)-Catalyzed ortho-C-H Amination of Arenes and Heteroarenes at Room Temperature, ORGANIC LETTERS, 2013, 第 4 作者 通讯作者(78) Pd(II)-Catalyzed Ortho - or Meta -C���H Olefination of Phenol Derivatives, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2013, 第 1 作者(79) Pd-Catalyzed Oxidative ortho-C-H Borylation of Arenes, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2012, 第 1 作者(80) Pd(II)-Catalyzed ortho- Trifluoromethylation of Arenes and Insights into Coordination Mode of Acidic Amide Directing Groups, J. Am. Chem. Soc, 2012, 第 1 作者(81) Divergent C���H Functionalizations Directed by Sufonamide Pharmacophores: Late-Stage Diversification as a Tool for Drug Discovery, J. Am. Chem. Soc, 2011, 第 1 作者(82) Pd(II)-Catalyzed Hydroxy-Directed C���H Activation/C���O Cyclization: Expedient Construction of Dihydrobenzofurans, J. Am. Chem. Soc, 2010, 第 1 作者(83) Palladium(II)/2,2���-bipyridine-catalyzed addition of arylboronic acids to N-tosyl-arylaldimines, TETRAHEDRON LETTERS, 2009, 第 1 作者(84) Palladimn(II)-catalyzed one-pot enantioselective synthesis of arylglycine derivatives from ethyl glyoxylate, p-toluenesulfonyl isocyanate and arylboronic acids, ADVANCED SYNTHESIS & CATALYSIS, 2008, 第 1 作者(85) 二价鈀催化的芳基硼酸对亚胺的加成研究, 2007, 第 1 作者(86) Diastereoselective synthesis of arylglycine derivatives by cationic Palladium(II)-Catalyzed addition of arylboronic acids to N-tert-Butanesulfinyl imino esters, ORGANIC LETTERS, 2007, 第 1 作者
科研活动
科研项目
( 1 ) 配体促进的芳酮C-C键活化反应研究及应用, 负责人, 地方任务, 2023-04--2026-03( 2 ) 钯催化碳-碳键活化实现酮类化合物的转化, 负责人, 国家任务, 2022-01--2025-12( 3 ) 基于多元技术融合平台的结构新颖抗结核先导化合物的发现, 参与, 国家任务, 2020-01--2024-12( 4 ) 中科院青年创新促进会优秀会员, 负责人, 中国科学院计划, 2019-01--2021-12( 5 ) 高效合成关键技术, 负责人, 国家任务, 2019-01--2021-12( 6 ) 上海市优秀青年学术带头人, 负责人, 地方任务, 2019-01--2021-12( 7 ) 金属铜促进的惰性C(sp3)-H键官能团化反应研究, 负责人, 国家任务, 2018-01--2021-12( 8 ) 金属铜催化的惰性碳氢键活化反应的研究, 负责人, 国家任务, 2015-01--2018-12( 9 ) 化学键活化与可控性重组研究, 参与, 国家任务, 2015-01--2017-12( 10 ) 过渡金属催化的碳氢键活反应研究, 负责人, 中国科学院计划, 2014-01--2017-12
参与会议
(1)Development of Novel and Practical Catalytic Systems for C–H Activation 14届全国均相催化学术讨论会 2015-09-22(2)Development of Novel and Practical Catalytic Systems for C–H Activation 2015-08-22