基本信息
王晓雪  女  博导  中国科学院南海海洋研究所
email: xxwang@scsio.ac.cn
address: 广州市新港西路164号
postalCode: 510301

招生信息

   
招生专业
071005-微生物学
071007-遗传学
071010-生物化学与分子生物学
招生方向
生物膜,环境微生物,海洋微生物
原噬菌体,环境胁迫反应
毒素-抗毒素,耐药性

教育背景

2017-02--2017-05   哈佛医学院   访问学者
2002-05--2006-12   美国德克萨斯A&M大学   博士学位
1996-06--2000-06   中国海洋大学   学士学位

工作经历

   
工作简历
2017-02~2017-05,哈佛医学院, 访问学者
2011-12~现在, 中国科学院南海海洋研究所, 研究员
2008-04~2011-11,美国德克萨斯A&M大学, 助理研究员
2007-01~2008-01,新泽西州州立大学, 博士后
2002-05~2006-12,美国德克萨斯A&M大学, 博士学位
1996-06~2000-06,中国海洋大学, 学士学位
社会兼职
2022-12-01-2026-12-30,中国科学 地球科学 期刊编委, 编委

教授课程

生物有机化学

专利与奖励

   
奖励信息
(1) TomSlick Fellowship, 一等奖, 研究所(学校), 2005
(2) Pinnacle Award, 一等奖, 专项, 2005
专利成果
( 1 ) 一种高效热稳定的核糖核酸酶SiRe_0917及其编码基因和应用, 2023, 第 2 作者, 专利号: CN116445453A

( 2 ) 一种快速定量ssDNA丝状噬菌体的方法及其应用, 2022, 第 1 作者, 专利号: CN114438177A

( 3 ) 一种快速定量ssDNA丝状噬菌体的方法及其应用, 2022, 第 1 作者, 专利号: CN114438177A

( 4 ) 一种海洋真菌-细菌共生体及其代谢产物和在制备抗菌药物中的应用, 2021, 第 5 作者, 专利号: CN112694983A

( 5 ) 一种调控珊瑚菌群的温和噬菌体VneM1及其应用, 2021, 第 1 作者, 专利号: CN112011520B

( 6 ) 一种生物膜基因岛GIVal43097及其切除方法, 2020, 第 1 作者, 专利号: CN112143741A

( 7 ) 一种毒素蛋白的纯化方法, 2017, 第 1 作者, 专利号: CN106978364A

( 8 ) 抗毒素SO_1445或其编码基因在提高质粒在宿主细胞中的稳定性中的应用, 2017, 第 1 作者, 专利号: CN106834322A

出版信息

   
发表论文
(1) Genomic Island-Encoded Diguanylate Cyclase from Vibrio alginolyticus Regulates Biofilm Formation and Motility in Pseudoalteromonas, Microorganisms, 2023, 通讯作者
(2) Comparative genomic insights into habitat adaptation of coral-associated Prosthecochloris, FRONTIERS IN MICROBIOLOGY, 2023, 通讯作者
(3) 海洋储碳机制及相关生物地球化学过程研究策略, Research strategies for ocean carbon storage mechanisms and effects, 科学通报, 2022, 第 4 作者
(4) Mobile genetic elements used by competing coral microbial populations increase genomic plasticity, ISME JOURNAL, 2022, 通讯作者
(5) The coral pathogen Vibrio coralliilyticus kills non-pathogenic holobiont competitors by triggering prophage induction, NATURE ECOLOGY & EVOLUTION, 2022, 通讯作者
(6) 两种蓝细菌中7对毒素-抗毒素系统的分析和鉴定, Analysis and identification of seven toxin-antitoxin systems in two cyanobacteria, 热带海洋学报, 2022, 第 2 作者
(7) 海洋假交替单胞菌SM9913中基因岛GIPspSM9913的鉴定和功能研究, Identification and functional study of the genomic island GIPspSM9913 in Pseudoalteromonas sp.SM9913, 热带海洋学报, 2022, 通讯作者
(8) Xenogeneic silencing relies on temperature-dependent phosphorylation of the host H-NS protein in Shewanella, NUCLEIC ACIDS RESEARCH, 2021, 通讯作者
(9) Prophage Tracer: precisely tracing prophages in prokaryotic genomes using overlapping split-read alignment, NUCLEIC ACIDS RESEARCH, 2021, 通讯作者
(10) Conjugative plasmid-encoded toxin-antitoxin system PrpT/PrpA directly controls plasmid copy number, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 通讯作者
(11) Type VII Toxin/Antitoxin Classification System for Antitoxins that Enzymatically Neutralize Toxins, TRENDS IN MICROBIOLOGY, 2021, 通讯作者
(12) Rapid detection of temperate bacteriophage using a simple motility assay, ENVIRONMENTAL MICROBIOLOGY REPORTS, 2021, 第 3 作者
(13) Prophage encoding toxin/antitoxin system PfiT/PfiA inhibits Pf4 production in Pseudomonas aeruginosa, MICROBIAL BIOTECHNOLOGY, 2020, 第 6 作者
(14) Identification of bacteria-derived urease in the coral gastric cavity, Identification of bacteria-derived urease in the coral gastric cavity, SCIENCE CHINA-EARTH SCIENCES, 2020, 通讯作者
(15) Upregulation of a marine fungal biosynthetic gene cluster by an endobacterial symbiont, COMMUNICATIONS BIOLOGY, 2020, 第 4 作者
(16) Antagonism between coral pathogen Vibrio coralliilyticus and other bacteria in the gastric cavity of scleractinian coral Galaxea fascicularis, Antagonism between coral pathogen Vibrio coralliilyticus and other bacteria in the gastric cavity of scleractinian coral Galaxea fascicularis, SCIENCE CHINA-EARTH SCIENCES, 2020, 通讯作者
(17) Novel polyadenylylation-dependent neutralization mechanism of the HEPN/MNT toxin/antitoxin system, NUCLEIC ACIDS RESEARCH, 2020, 通讯作者
(18) Molybdenum-mediated chemotaxis of Pseudoalteromonas lipolytica enhances biofilm-induced mineralization on low alloy steel surface, CORROSION SCIENCE, 2019, 通讯作者
(19) Recent progress on signalling molecules of coral-associated microorganisms, Recent progress on signalling molecules of coral-associated microorganisms, 中国科学:地球科学英文版, 2019, 第 3 作者
(20) 造礁珊瑚共附生微生物信号分子的研究进展, Recent progress on signalling molecules of coral-associated microorganisms, 中国科学:地球科学, 2019, 第 3 作者
(21) Structure and allosteric coupling of type II antitoxin CopA(SO), BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2019, 通讯作者
(22) Resistance to oxidative stress by inner membrane protein ElaB is regulated by OxyR and RpoS, MICROBIAL BIOTECHNOLOGY, 2019, 第 5 作者
(23) Biofilm formation in Pseudoalteromonas lipolytica is related to IS5-like insertions in the capsular polysaccharide operon, FEMS MICROBIOLOGY ECOLOGY, 2019, 通讯作者
(24) Eliminating mcr-1-harbouring plasmids in clinical isolates using the CRISPR/Cas9 system, JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2019, 通讯作者
(25) Symbiosis of a P2-family phage and deep-sea Shewanella putrefaciens, ENVIRONMENTAL MICROBIOLOGY, 2019, 通讯作者
(26) Recent progress on signalling molecules of coral-associated microorganisms, SCIENCECHINAEARTHSCIENCES, 2019, 通讯作者
(27) Characterization of Two Toxin-Antitoxin Systems in Deep-Sea Streptomyces sp. SCSIO 02999, MARINE DRUGS, 2019, 第 6 作者
(28) Phage Mediate Bacterial Self-Recognition, CELLREPORTS, 2019, 通讯作者
(29) Excisionase in Pf Filamentous Prophage Controls Lytic-lysogeny Decision-making in Pseudomonas aeruginosa, Molecular Microbiology, 2019, 通讯作者
(30) Phages Mediate Bacterial Self-Recognition, CELL REPORTS, 2019, 通讯作者
(31) Antitoxin HigA inhibits virulence gene mvfR expression in Pseudomonas aeruginosa, ENVIRONMENTAL MICROBIOLOGY, 2019, 通讯作者
(32) Transposon-insertion sequencing screens unveil requirements for EHEC growth and intestinal colonization, PLOS PATHOGENS, 2019, 第 7 作者
(33) Excisionase in Pf filamentous prophage controls lysis-lysogeny decision-making in Pseudomonas aeruginosa., Molecular Microbiology, 2018, 通讯作者
(34) Type II toxin/antitoxin system ParE(SO)/CopA(SO) stabilizes prophage CP4So in Shewanella oneidensis, ENVIRONMENTAL MICROBIOLOGY, 2018, 通讯作者
(35) Marine Bacteria Provide Lasting Anticorrosion Activity for Steel via Biofilm-Induced Mineralization, ACS APPLIED MATERIALS & INTERFACES, 2018, 通讯作者
(36) Structure–function analyses reveal the molecular architecture and neutralization mechanism of a bacterial hepn–mnt toxin–antitoxin system, THE JOURNAL OF BIOLOGICAL CHEMISTRY, 2018, 第 6 作者
(37) Shewanella oneidensis内源性大质粒上ParE-ParD家族毒素-抗毒素系统(SO_A0088-A0087)的鉴定, Characterization of a ParE-ParD toxin-antitoxin TA system(SO_A0087-A0088)on a megaplasmid of Shewanella oneidensis, 热带海洋学报, 2018, 第 3 作者
(38) Structure–function analyses reveal the molecular architecture and neutralization mechanism of a bacterial HEPN–MNT toxin–antitoxin system, JOURNAL OF BIOLOGICAL CHEMISTRY, 2018, 通讯作者
(39) MqsR/MqsA Toxin/Antitoxin System Regulates Persistence and Biofilm Formation in Pseudomonas putida KT2440, FRONTIERS IN MICROBIOLOGY, 2017, 通讯作者
(40) Biochemical basis for hydrolysis of organophosphorus by a marine bacterial prolidase, PROCESS BIOCHEMISTRY, 2017, 第 4 作者
(41) 细菌的毒素-抗毒素系统:定时炸弹还是免死金牌, Bacterial toxin-antitoxin systems: yin and yang of death and persistence, 微生物学报, 2017, 第 3 作者
(42) Dissemination and loss of a biofilm-related genomic island in marine Pseudoalteromonas mediated by integrative and conjugative elements, ENVIRONMENTAL MICROBIOLOGY, 2017, 通讯作者
(43) Biofilm Formation and Heat Stress Induce Pyomelanin Production in Deep-Sea Pseudoalteromonas sp. SM9913, FRONTIERS IN MICROBIOLOGY, 2017, 通讯作者
(44) 建立一种新型的评价大肠杆菌在宿主体内生长及对宿主防御反应差异的小鼠模型, 免疫学杂志, 2017, 第 13 作者
(45) Tail-Anchored Inner Membrane Protein ElaB Increases Resistance to Stress While Reducing Persistence in Escherichia coli, JOURNAL OF BACTERIOLOGY, 2017, 通讯作者
(46) Interaction of Type IV Toxin/Antitoxin Systems in Cryptic Prophages of Escherichia coli K-12, TOXINS, 2017, 通讯作者
(47) Pyomelanin from Pseudoalteromonas lipolytica reduces biofouling, MICROBIAL BIOTECHNOLOGY, 2017, 通讯作者
(48) High Efficiency Hydrodynamic DNA Fragmentation in a Bubbling System, SCIENTIFIC REPORTS, 2017, 第 4 作者
(49) Characterization of the Deep-Sea Streptomyces sp SCSIO 02999 Derived VapC/VapB Toxin-Antitoxin System in Escherichia coli, TOXINS, 2016, 通讯作者
(50) Cryptic prophages as targets for drug development, DRUG RESISTANCE UPDATES, 2016, 通讯作者
(51) Complete genome sequence of Vibrio alginolyticus ATCC 33787T isolated from seawater with three native megaplasmids, MARINE GENOMICS, 2016, 通讯作者
(52) 海洋碳汇对气候变化的响应与反馈, Response and Feedback of Marine Carbon Sink to Climate Change, 地球科学进展, 2016, 第 3 作者
(53) Cold adaptation regulated by cryptic prophage excision in Shewanella oneidensis, ISME JOURNAL, 2016, 通讯作者
(54) Cold adaptation regulated by cryptic prophage excision in Shewanella oneidensis, ISME JOURNAL, 2016, 通讯作者
(55) 铜绿假单胞菌分泌物对中性粒细胞趋化运动的抑制功能, The secretions from Pseudomonas aeruginosa inhibit the chemotactic migration of neutrophils, 免疫学杂志, 2016, 第 10 作者
(56) Physiological Function of Rac Prophage During Biofilm Formation and Regulation of Rac Excision in Escherichia coli K-12, SCIENTIFIC REPORTS, 2015, 通讯作者
(57) Development of an efficient conjugation-based genetic manipulation system for Pseudoalteromonas, MICROBIAL CELL FACTORIES, 2015, 通讯作者
(58) Characterization of self-generated variants in Pseudoalteromonas lipolytica biofilm with increased antifouling activities, APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2015, 第 9 作者
(59) RalR (a DNase) and RalA (a small RNA) form a type I toxin–antitoxin system in Escherichia coli, NUCLEIC ACIDS RESEARCH, 2014, 通讯作者
(60) 海洋微型生物碳泵储碳机制及气候效应, 中国科学. 地球科学, 2013, 第 4 作者
(61) Type II toxin/antitoxin MqsR/MqsA controls type V toxin/antitoxin GhoT/GhoS, ENVIRONMENTAL MICROBIOLOGY, 2013, 第 1 作者
(62) Synthetic quorum-sensing circuit to control consortial biofilm formation and dispersal in a microfluidic device, NATURE COMMUNICATIONS, 2012, 第 4 作者
(63) A new type V toxin-antitoxin system where mRNA for toxin GhoT is cleaved by antitoxin GhoS, NATURE CHEMICAL BIOLOGY, 2012, 第 1 作者
(64) Bacterial persistence increases as environmental fitness decreases, MICROBIAL BIOTECHNOLOGY, 2012, 第 2 作者
(65) IS5 inserts upstream of flhDCin a quasi-Lamarckian way, 2011, 第 1 作者
(66) Toxin-Antitoxin Systems Influence Biofilm and Persister Cell Formation and the General Stress Response ▿, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2011, 第 1 作者
(67) Antitoxin MqsA Helps Mediate the Bacterial General Stress Response, NATURE CHEMICAL BIOLOGY, 2011, 通讯作者
(68) Cryptic prophages help bacteria cope with adverse environments, NATURE COMMUNICATIONS, 2010, 第 1 作者
(69) Controlling biofilm formation, prophage excision and cell death by rewiring global regulator H‐NS of Escherichia coli, MICROBIAL BIOTECHNOLOGY, 2010, 第 2 作者
(70) Escherichia coli toxin/antitoxin pair MqsR/MqsA regulate toxin CspD, ENVIRONMENTAL MICROBIOLOGY, 2010, 第 2 作者
(71) Control and benefits of CP4-57 prophage excision in Escherichia coli biofilms, ISME JOURNAL, 2009, 第 1 作者
(72) Toxin-antitoxin systems in Escherichia coli influence biofilm formations through YjgK (TabA) and fimbriae., Journal of Bacteriology, 2009, 第 1 作者
(73) Structure and allosteric coupling of type Ⅱ antitoxin CopASO, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 第 8 作者
发表著作
( 1 ) 噬菌体学: 从理论到实践, 北京科学出版社, 2021-09, 第 其他 作者

科研活动

   
科研项目
( 1 ) 青年****, 负责人, 国家任务, 2012-08--2016-08
( 2 ) MCP的惰性有机碳(RDOC)生成过程与分子生物学机制, 负责人, 国家任务, 2013-01--2017-07
( 3 ) 深海细菌的特殊应激反应和次级代谢及其深海环境适应机制, 负责人, 国家任务, 2013-01--2017-12
( 4 ) 大肠杆菌原噬菌体e14、rac和CPS-53中毒素-抗毒素系统的功能性研究, 负责人, 国家任务, 2013-01--2016-12
( 5 ) 微生物生理与代谢, 负责人, 国家任务, 2017-01--2021-12
( 6 ) 南海重要岛礁及邻近海域生物资源评价与生态修复, 负责人, 国家任务, 2018-08--2021-12
( 7 ) 温和噬菌体与细菌宿主的互作对造礁珊瑚的健康与生物矿化的影响, 负责人, 国家任务, 2020-01--2023-12
( 8 ) 西沙群岛深水珊瑚礁生物多样性及其特殊生境调查, 负责人, 国家任务, 2022-11--2026-10
参与会议
(1)新型毒素-抗毒素系统的发现与功能   首届微生物与药物前沿论坛   2022-11-27
(2)珊瑚共附生菌群互作机制研究   中国微生物学会第十届地质微生物学术研讨会   2022-07-31
(3)接合型质粒上 毒素-抗毒素系统的新功能   2021年全国中青年微生物学者交叉论坛   2021-11-13
(4)Cost and Benefits of prophage excision in Shewanella    2017-06-29
(5)Characterization of toxin-antitoxin systems in marine bacteria   中美微生物年会   2016-06-15
(6)Antitoxin MqsA helps mediate the bacterial general stress response   Wang XX,Kim Y, Hong SH, Ma Q, Brown BL, Pu M, Tarone AM, Benedik MJ, Peti W, Page R,TK Wood   2011-04-21
(7)Impact of cryptic prophage on bacterial cell physiology   Wang XX, Kim Y,PokusaevaK, Sturino JM, Wood TK   2010-05-24
(8)Hha induces prophage excision causing programmed cell death in Escherichia coli biofilms   Wang XX,Kim Y,Wood TK   2009-05-27