基本信息
王晓雪  女  博导  中国科学院南海海洋研究所
电子邮件: xxwang@scsio.ac.cn
通信地址: 广州市新港西路164号
邮政编码: 510301

招生信息

   
招生专业
071005-微生物学
071007-遗传学
071010-生物化学与分子生物学
招生方向
生物膜,环境微生物,海洋微生物
原噬菌体,环境胁迫反应
毒素-抗毒素,耐药性

教育背景

2017-02--2017-05   哈佛医学院   访问学者
2002-05--2006-12   美国德克萨斯A&M大学   博士学位
1996-06--2000-06   中国海洋大学   学士学位

工作经历

   
工作简历
2017-02~2017-05,哈佛医学院, 访问学者
2011-12~现在, 中国科学院南海海洋研究所, 研究员
2008-04~2011-11,美国德克萨斯A&M大学, 助理研究员
2007-01~2008-01,新泽西州州立大学, 博士后
2002-05~2006-12,美国德克萨斯A&M大学, 博士学位
1996-06~2000-06,中国海洋大学, 学士学位
社会兼职
2012-09-30-2020-12-01,中国科学 地球科学 期刊编委, 编委

教授课程

生物有机化学

专利与奖励

   
奖励信息
(1) TomSlick Fellowship, 一等奖, 研究所(学校), 2005
(2) Pinnacle Award, 一等奖, 专项, 2005

出版信息

   
发表论文
(1) Conjugative plasmid-encoded toxin-antitoxin system PrpT/PrpA directly controls plasmid copy number., Proc. Natl. Acad. Sci. USA., 2021, 通讯作者
(2) Xenogeneic silencing relies on temperature dependent phosphorylation of the host H-NS protein in Shewanella., Nucleic Acids Research, 2021, 通讯作者
(3) Prophage Tracer: precisely tracing prophages in prokaryotic genomes using overlapping split-read alignment, Nucleic Acids Research, 2021, 通讯作者
(4) Rapid detection of temperate bacteriophage using a simple motility assay, Environ Microbiol Rep., 2021, 第 3 作者
(5) Prophage encoding toxin/antitoxin system PfiT/PfiA inhibits Pf4 production in Pseudomonas aeruginosa, Microbial Biotechnology, 2020, 通讯作者
(6) Novel polyadenylylation-dependent neutralization mechanism of the HEPN/MNT toxin/antitoxin system, Nucleic Acids Research, 2020, 通讯作者
(7) Identification of bacteria-derived urease in the coral gastric cavity, SCIENCE CHINA Earth Sciences, 2020, 通讯作者
(8) Symbiosis of a P2-Family Phage and Deep-Sea Shewanella putrefaciens, Environmental Microbiology, 2019, 通讯作者
(9) Molybdenum-Mediated Chemotaxis of Pseudoalteromonas lipolytica Enhances Biofilm-Induced Mineralization on Low Alloy Steel Surface, Corrosion Science, 2019, 通讯作者
(10) Biofilm formation in Pseudoalteromonas lipolytica is related to IS5-like insertions in the capsular polysaccharide operon, FEMS Microbiology Ecology, 2019, 通讯作者
(11) Eliminating mcr-1-harbouring plasmids in clinical isolates using the CRISPR/Cas9 system, Journal of Antimicrobial Chemotherapy, 2019, 通讯作者
(12) Antitoxin HigA inhibits virulence gene mvfR expression in Pseudomonas aeruginosa, Environmental Microbiology, 2019, 通讯作者
(13) Phage Mediate Bacterial Self-Recognition, Cell Reports, 2019, 通讯作者
(14) Structure and allosteric coupling of type II antitoxin CopASO, Biochemical and Biophysical Research Communications, 2019, 通讯作者
(15) Characterization of Two Toxin-Antitoxin Systems in Deep-Sea Streptomyces sp. SCSIO 02999, Marine Drugs, 2019, 通讯作者
(16) Recent progress on signalling molecules of coral-associated microorganisms, Science China Earth Sciences, 2019, 通讯作者
(17) Excisionase in Pf Filamentous Prophage Controls Lytic-lysogeny Decision-making in Pseudomonas aeruginosa, Molecular Microbiology, 2019, 通讯作者
(18) Type II toxin/antitoxin system ParESO /CopASO stabilizes prophage CP4So in Shewanella oneidensis., Environmental Microbiology, 2018, 通讯作者
(19) Marine Bacteria Provide Lasting Anti-Corrosion Activity for Steel via Biofilm-induced Mineralization., ACS Applied Materials & Interfaces, 2018, 通讯作者
(20) Structure-function analyses reveal the molecular architecture and neutralization mechanism of a bacterial HEPN-MNT toxin-antitoxin, Journal of Biological Chemistry., 2018, 通讯作者
(21) Excisionase in Pf filamentous prophage controls lysis-lysogeny decision-making in Pseudomonas aeruginosa., Molecular Microbiology, 2018, 通讯作者
(22) Dissemination and loss of a biofilm-related genomic island in marine Pseudoalteromonas mediated by integrative and conjugative elements, Enviromental Microbiology, 2017, 通讯作者
(23) 细菌的毒素-抗毒素系统:定时炸弹还是免死金牌, 微生物学报, 2017, 通讯作者
(24) Biofilm Formation and Heat Stress Induce Pyomelanin Production in Deep-Sea Pseudoalteromonas sp. SM9913, Fronties in Microbiology, 2017, 通讯作者
(25) Pyomelanin from Pseudoalteromonas lipolytica reduces biofouling, Microbial Biotechnology, 2017, 通讯作者
(26) Interaction of Type IV Toxin/Antitoxin Systems in Cryptic Prophages of Escherichia coli K-12, Toxins, 2017, 通讯作者
(27) MqsR/MqsA Toxin/Antitoxin System Regulates Persistence and Biofilm Formation in Pseudomonas putida KT2440, Fronties in Microbiology, 2017, 通讯作者
(28) Tail-Anchored Inner Membrane Protein ElaB Increases Resistance to Stress While Reducing Persistence in Escherichia coli, Journal of Bacteriology, 2017, 通讯作者
(29) Interaction of Type IV Toxin/Antitoxin Systems in Cryptic Prophages of Escherichia coli K-12, Toxins, 2017, 通讯作者
(30) Cryptic Prophages as Targets For Drug Development., Drug Resistance Updates, 2016, 通讯作者
(31) Cold adaptation regulated by cryptic prophage excision in Shewanella oneidensis., The ISME Journal, 2016, 通讯作者
(32) Characterization of the Deep-Sea Streptomyces sp. SCSIO 02999 Derived VapC/VapB Toxin-Antitoxin System in Escherichia coli., Toxins, 2016, 通讯作者
(33) Development of an efficient conjugation-based genetic manipulation system for Pseudoalteromonas , Microbial Cell Factories, 2015, 通讯作者
(34) Characterization of self-generated variants in Pseudoalteromonas lipolytica biofilm with increased antifouling activities., Applied Microbiology and Biotechnology, 2015, 通讯作者
(35) RalR (a DNase) and RalA (a small RNA) form a type I toxin–antitoxin system in Escherichia coli, Nucleic Acids Research, 2014, 通讯作者
(36) Type II Toxin/Antitoxin MqsR/MqsA Controls Type V Toxin/Antitoxin GhoT/GhoS, Environmental Microbiology, 2013, 通讯作者
(37)  海洋微型生物碳泵储碳机制及气候效应, 中国科学, 2013, 第 4 作者
(38) Bacterial persistence increases as environmental fitness decreases, Microbial Biotechnology, 2012, 第 2 作者
(39) Synthetic Quorum Sensing circuit to control consortial biofilm formation and dispersal in a microfluidic device, Nature Communications, 2012, 第 4 作者
(40) A new type V toxin-antitoxin system where mRNA for toxin GhoT is cleaved by antitoxin GhoS, Nature Chemical Biology , 2012, 第 1 作者
(41)  Antitoxin MqsA helps mediate the bacterial general stress response , Nature Chemical Biology, 2011, 第 1 作者
(42) Toxin/antitoxin systems influence biofilm and persister cell formation and the general stress response., Applied and Environmental Microbiology , 2011, 第 1 作者
(43) IS5 inserts upstream of flhDCin a quasi-Lamarckian way , The ISME Journal , 2011, 第 1 作者
(44) Cryptic prophages help bacteria cope with adverse environments, Nature Communications, 2010, 第 1 作者
(45) Escherichia coli toxin/antitoxin pairMqsR/MqsAregulate toxin CspD., Environmental Microbiology , 2010, 第 2 作者
(46) Controlling biofilm formation, prophage Excision, and cell death rewiring global regulator H-NS of Escherichia coli, Microbial Biotechnology , 2010, 第 2 作者
(47) Control and benefits of CP4-57 prophage excision in Escherichia coli biofilms, The ISME Journal, 2009, 第 1 作者
(48) Toxin-antitoxin systems in Escherichia coli influence biofilm formations through YjgK (TabA) and fimbriae., Journal of Bacteriology, 2009, 第 2 作者
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科研活动

   
科研项目
( 1 ) 青年****, 负责人, 国家任务, 2012-08--2016-08
( 2 ) MCP的惰性有机碳(RDOC)生成过程与分子生物学机制, 负责人, 国家任务, 2013-01--2017-07
( 3 ) 深海细菌的特殊应激反应和次级代谢及其深海环境适应机制, 负责人, 国家任务, 2013-01--2017-12
( 4 ) 大肠杆菌原噬菌体e14、rac和CPS-53中毒素-抗毒素系统的功能性研究, 负责人, 国家任务, 2013-01--2016-12
( 5 ) 微生物生理与代谢, 负责人, 国家任务, 2017-01--2021-12
( 6 ) 南海重要岛礁及邻近海域生物资源评价与生态修复, 负责人, 国家任务, 2018-08--2021-12
( 7 ) 温和噬菌体与细菌宿主的互作对造礁珊瑚的健康与生物矿化的影响, 负责人, 国家任务, 2020-01--2023-12
参与会议
(1)接合型质粒上 毒素-抗毒素系统的新功能   2021年全国中青年微生物学者交叉论坛   2021-11-13
(2)Cost and Benefits of prophage excision in Shewanella    2017-06-29
(3)Characterization of toxin-antitoxin systems in marine bacteria   中美微生物年会   2016-06-15
(4)Antitoxin MqsA helps mediate the bacterial general stress response   Wang XX,Kim Y, Hong SH, Ma Q, Brown BL, Pu M, Tarone AM, Benedik MJ, Peti W, Page R,TK Wood   2011-04-21
(5)Impact of cryptic prophage on bacterial cell physiology   Wang XX, Kim Y,PokusaevaK, Sturino JM, Wood TK   2010-05-24
(6)Hha induces prophage excision causing programmed cell death in Escherichia coli biofilms   Wang XX,Kim Y,Wood TK   2009-05-27