071011-生物物理学

单分子生物物理学

2005-09--2011-01   北京大学   博士
2001-09--2005-07   南开大学   学士

   

2023-01~现在, 中国科学院生物物理研究所, 研究员
2014-01~2022-12,中国科学院生物物理研究所, 副研究员
2011-03~2013-12,中国科学院生物物理研究所, 助理研究员
2005-09~2011-01,北京大学, 博士
2001-09~2005-07,南开大学, 学士

生物物理学实验-01
生物物理学实验-02
生物物理学实验
生物物理学实验-01班
生物物理学实验-02班

   

（1） Reversible Redox-Dependent Conformational Switch of the C-Terminal alpha-Helical Lid of Human Hsp70 Observed by In-Cell NMR, ACS CHEMICAL BIOLOGY, 2023, 第 4 作者
（2） Effect of evolution of the C-terminal region on chaperone activity of Hsp70, PROTEIN SCIENCE, 2023, 第 3 作者
（3） Methylene blue accelerates liquid-to-gel transition of Tau condensates: impacts on functional and pathological roles of Tau, Nature Communications, 2023, 第 16 作者
（4） Interaction between Huntingtin exon 1 and HEAT repeat structure probed by chimeric model proteins, Protein Science, 2023, 第 3 作者
（5） 蛋白质错误折叠相关疾病的多肽药物研究进展, 生物化学与生物物理进展, 2022, 通讯作者
（6） Peptide-based Strategies for Treatment of Protein Misfolding Diseases, PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2022, 通讯作者
（7） Unravelling the microscopic characteristics of intrinsically disordered proteins upon liquid-liquid phase separation, ESSAYS IN BIOCHEMISTRY, 2022, 通讯作者
（8） Hsp70 in Redox Homeostasis, CELLS, 2022, 第 3 作者
（9） Distinct lipid membrane-mediated pathways of Tau assembly revealed by single-molecule analysis, Nanoscale, 2022, 通讯作者
（10） Single Molecule Characterization of Amyloid Oligomers, MOLECULES, 2021, 通讯作者
（11） PES inhibits human-inducible Hsp70 by covalent targeting of cysteine residues in the substrate-binding domain, JOURNAL OF BIOLOGICAL CHEMISTRY, 2021, 第 3 作者
（12） Conformational Expansion of Tau in Condensates Promotes Irreversible Aggregation, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2021, 通讯作者
（13） Studying protein folding in health and disease using biophysical approaches, Emerg. Top. Life Sci., 2021, 
（14） S -Glutathionylation of human inducible Hsp70 reveals a regulatory mechanism involving the C-terminal α-helical lid, JOURNAL OF BIOLOGICAL CHEMISTRY, 2020, 第 9 作者
（15） Distinct microscopic mechanisms for the accelerated aggregation of pathogenic Tau mutants revealed by kinetic analysis, PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2020, 通讯作者
（16） Kinetic diversity of amyloid oligomers, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 第 5 作者
（17） Kinetics of the conformational cycle of Hsp70 reveals the importance of the dynamic and heterogeneous nature of Hsp70 for its function, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 第 1 作者
（18） Amelioration of aggregate cytotoxicity by catalytic conversion of protein oligomers into amyloid fibrils, NANOSCALE, 2020, 通讯作者
（19） Protein Microgels from Amyloid Fibril Networks, BIOLOGICAL AND BIO-INSPIRED NANOMATERIALS: PROPERTIES AND ASSEMBLY MECHANISMS, 2019, 第 3 作者
（20） DirectObservation of Oligomerization by Single MoleculeFluorescence Reveals a Multistep Aggregation Mechanism for the YeastPrion Protein Ure2, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2018, 通讯作者
（21） The C-terminal GGAP motif of Hsp70 mediates substrate recognition and stress response in yeast, JOURNAL OF BIOLOGICAL CHEMISTRY, 2018, 第 5 作者
（22） Revealing the Mechanism of Amyloid Fibril Formation by Combined Single Molecule FRET and Kinetic Modeling, BIOPHYSICAL JOURNAL, 2018, 第 7 作者
（23） A co-expression strategy to achieve labeling of individual subunits within a dimeric protein for single molecule analysis, CHEMICAL COMMUNICATIONS, 2017, 通讯作者
（24） Glutathionylation of the Bacterial Hsp70 Chaperone DnaK Provides a Link between Oxidative Stress and the Heat Shock Response, JOURNAL OF BIOLOGICAL CHEMISTRY, 2016, 第 3 作者
（25） Enzymatically Active Microgels from Self-Assembling Protein Nanofibrils for Microflow Chemistry, ACS NANO, 2015, 第 4 作者
（26） Influence of specific HSP70 domains on fibril formation of the yeast prion protein Ure2, PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2013, 第 2 作者

Protein microgels from amyloid fibril networks, In book: Biological and Bio-inspired Nanomaterials, Nature-Springer, 2019-12, 第 3 作者

   

（ 1 ） 酵母prion蛋白Ure2的寡聚及构象变化的单分子水平研究, 负责人, 国家任务, 2017-01--2020-12
（ 2 ） 单分子荧光技术结合动力学分析手段研究淀粉样纤维化及其加速和抑制机制, 参与, 国家任务, 2020-01--2024-12
（ 3 ） 人源组成型与应激型Hsp70差异机制的单分子研究, 负责人, 国家任务, 2022-01--2025-12

（1）A mechanistic view of the liquid phase separation of Tau at single-molecule level   第十九次中国暨国际生物物理大会   2021-07-23
（2）Conformational expansion of Tau during liquid phase separation facilitates intermolecular interactions and self-aggregation   2021-06-23
（3）Revealing the mechanism of amyloid fibril formation by combined single molecule FRET and kinetic modeling   第六届全国生物物理化学会议   2018-07-22
（4）Revealing the mechanism of amyloid fibril formation by combined single molecule FRET and kinetic modeling   第十五次中国暨国际生物物理大会   2017-10-24
（5）A two-step mechanism of amyloid formation revealed by direct observation of oligomerization of the yeast prion protein Ure2   第十四次中国暨国际生物物理大会   2015-11-17