基本信息
程靓  男  博导  中国科学院化学研究所
电子邮件： chengl@iccas.ac.cn
通信地址： 海淀区中关村北一街2号
邮政编码： 100190

学习工作经历

  • 2000-2004年，北京师范大学，学士

  • 2004-2009年，中国科学院化学研究所，博士

  • 2011-2014年，美国哥伦比亚大学，博士后

  • 2015年-至今，中国科学院化学研究所，研究员

教授课程

高等有机合成

研究兴趣与方向

RNA修饰的化学生物学研究

1）RNA表观修饰的精准化学干预（Acc. Chem. Res. 2025, 58, 1727）

2）功能性RNA的化学改造与应用（Angew. Chem. Int. Ed. 2025, 64, e202511756）

研究论文

  1. Chen, W.-D.; Liu, L.; Cheng, L.* "Nitroreductase-Responsive Oligomeric crRNAs for Enzyme-Triggered Regulation of CRISPR Activity", J. Org. Chem. 2026, 91 (12), 4494–4501. https://doi.org/10.1021/acs.joc.5c02287
  2. Li, X.-H.; Wang, Y.-J.; Cheng, L.*; Liu, L.* "Construction of Quinazoline-Bridged Donor-Acceptor Covalent Organic Frameworks for Photocatalytic Sulfoxide Synthesis from Alkenes and Thiols", Adv. Mater. 2026, e23654. https://doi.org/10.1002/adma.202523654
  3. Ge, F.; Liu, L.; Cheng, L.* Selective RNA Labeling Using Tetrazine-Based IEDDA Reactions with Allyl Adenosine Modifications, ChemBioChem 2026, 27 (4), e70229 . https://doi.org/10.1002/cbic.70229
  4. Liu, X.-L.; Liu, L.; Cheng, L.* Sequence-Independent Optical Regulation of CRISPR/Cas Editing Using Star-Shaped crRNA Dendrimers, Chem. Commun. 2026, 62 (6), 1877-1881. https://doi.org/10.1039/D5CC06011G
  5. Mazinani, M.; Sarmast, M. K.; Ghasemnezhad, A.; Cheng, L. The Capability of Synthetic Cytokinin Mimics for in Vitro Regeneration of Plants. Advanced Agrochem 2026, 5 (1), 65-71. https://doi.org/10.1016/j.aac.2025.09.002
  6. Cheng, L.* Topology-Engineered Guide RNAs for Programmable Control of CRISPR/Cas Activity. Angew. Chem. Int. Ed. 2025, 64 (41), e202511756. https://doi.org/10.1002/anie.202511756.
  7. 武传硕，程靓* “5-甲基尿苷（m5U）RNA修饰的生物学功能研究进展“，化学学报，2025, 83, 1046-1054. https://doi.org/10.6023/A25050152. 
  8. Cheng, L. Harnessing Cytokinins with Chemistry: New Frontiers and Challenges for Precision Plant Growth Control. Front. Plant Sci. 2025, 16, 1602749. https://doi.org/10.3389/fpls.2025.1602749. 
  9. Chen, W.-D.; Liu, L.; Cheng, L.* Functionally Tunable Star-Shaped Multivalent crRNAs for Photocontrol CRISPR/Cas Editing. Angew. Chem. Int. Ed. 2025, 64 (25), e202506527. https://doi.org/10.1002/anie.202506527.
  10. Cheng, L.* Chemical Strategies to Modulate and Manipulate RNA Epigenetic Modifications. Acc. Chem. Res. 2025, 58 (11), 1727–1741. https://doi.org/10.1021/acs.accounts.4c00844. (Cover Article)
  11. Chen, W.; Liu, L.; Cheng, L.* Conditionally Activated Cross-Linked crRNAs for CRISPR/Cas12a Based Nucleic Acid Detection. ACS Synth. Biol. 2025, 14 (1), 94–100. https://doi.org/10.1021/acssynbio.4c00695. 
  12. He, Y.-M.; Burkard, A.; Wu, C.-S.; Jin, X.-Y.; Liu, L.; Helm, M.*; Cheng, L.* A Direct Chemical Repair of Etheno-Type RNA Damages. Angew. Chem. Int. Ed. 2025, 64 (3), e202415417. https://doi.org/10.1002/anie.202415417.
  13. 柳鹏程，程靓，孟庆峰，熊莉君，田德录，"国家自然科学基金资助管理相关文献综述研究——基于2018—2023年中文文献的考察"，中国科学基金，2024, 38, 1075-1083. https://www.nsfc.gov.cn/csc/20345/20348/pdf/2024//202406-1075-1083.pdf
  14. Wu, C.-S.; Sun, X.; Liu, L.; Cheng, L. A Live-Cell Epigenome Manipulation by Photo-Stimuli-Responsive Histone Methyltransferase Inhibitor. Adv. Sci. 2024, 11 (41), e2404608. https://doi.org/10.1002/advs.202404608. 
  15. Liu, S.; Liu, Q.; Cheng, L.; Liu, L. Construction of 2-Substituted-3-Aryl Benzofurans and Indoles through an Acid-Catalyzed Cascade Intramolecular Friedel-Crafts Reaction/Rearrangement/Aromatization Process. J. Org. Chem. 2024, 89 (16), 11716–11726. https://doi.org/10.1021/acs.joc.4c01494.
  16. Lin, X.-N.; Gai, B.-X.; Liu, L.; Cheng, L. Advances in the Investigation of N6-Isopentenyl Adenosine i6A RNA Modification. Bioorg. Med. Chem. 2024, 110 (117838), 117838. https://doi.org/10.1016/j.bmc.2024.117838. (invited review)
  17. Yu, S.-C.; Li, X.; Cheng, L.; Liu, L. Constrution of Quinazoline-Linked Covalent Organic Frameworks via a Multicomponent Reaction for Photocatalysis. Chem.-Eur. J. 2024, 30 (42), e202400668. https://doi.org/10.1002/chem.202400668.
  18. Sun, X.; Hui, T.-H.; Liu, L.; Cheng, L. Discovery of Photoexcited 2-Chloro-3,5-Dinitrobenzoic Acid as a Chemical Deprenylase of i6A RNA. Chembiochem 2024, 25 (14), e202400361. https://doi.org/10.1002/cbic.202400361. (VIP article).
  19. Wang, Z.-L.; Xu, J.-X.; Liu, G.; He, Y.-M.; Nafie, J.; Wu, C.-S.; Wei, J.-C.; Liu, L.; Tang, H.-R.; Huang, K.-Y.; Xu, G.-L.; Cheng, L. Total Synthesis of All Stereoisomers of C5-Glyceryl-Methyl-2′-Deoxycytidine 5gmC and Their Occurrence in Chlamydomonas Reinhardtii. Cell Rep. Phys. Sci. 2024, 5 (7), 102041. https://doi.org/10.1016/j.xcrp.2024.102041.
  20. Wang, X.; Liu, L.; Cheng, L. A Direct Synthesis of 5-Azidomethyl Pyrimidine Nucleosides via Dehydroxyazidation. Tetrahedron Lett. 2024, 142, 155097. https://doi.org/10.1016/j.tetlet.2024.155097.
  21. Lin, C.-L.; Chen, W.-D.; Liu, L.; Cheng, L. Chemical Control of CRISPR/Cpf1 Editing via Orthogonal Activation and Deactivation of Crosslinked crRNA. Chem. Commun. 2024, 60 (39), 5197–5200. https://doi.org/10.1039/d4cc01106f.  
  22. Liu, Q.; Li, X.-D.; Cheng, L.; Liu, L. An Unprecedented Synthesis of Axially Chiral Biaryls by Rearrangement and Aromatization of Carbocations with Central-to-Axial Conversion of Chirality. Sci. China Chem. 2024, 67 (9), 2998–3003. https://doi.org/10.1007/s11426-024-2035-7.
  23. He, Y.-M.; Cheng, L. More than Just Alkene Construction -- Re-using Wittig Reactions/Reagents in Biomacromolecular Labeling, Imaging, Sequencing and Modification. Anal. Sens. 2024, 4 (4). https://doi.org/10.1002/anse.202300098. (Invited review)
  24. Liu, S.; Cheng, L.; Liu, L. Synthesis of Biaryl Carboxylic Acids through a Cascade Suzuki-Miyaura Coupling/Friedel-Crafts Alkylation/Lewis-Acid-Catalyzed Rearrangement/Aromatization Process. Org. Lett. 2024, 26 (9), 1902–1907. https://doi.org/10.1021/acs.orglett.4c00204.
  25. Sun, X.; Zhao, J.-Z.; Wu, C.-S.; Zhang, K.-W.; Cheng, L. Flavin Mononucleotide Regulated Photochemical Isomerization and Degradation of Zeatin. Org. Biomol. Chem. 2024, 22 (10), 2021–2026. https://doi.org/10.1039/d4ob00028e.
  26. Xie, L.-J.; Cheng, H.-P.; Chen, M.-Y.; Wang, X.; Liu, L.; Yuan, B.-F.; Cheng, L. A Bioorthogonal Post-Modification of N6-Isopentenyl Adenosine i6A RNA in Live Cells. CCS Chem 2024, 6 (9), 2241–2253. https://doi.org/10.31635/ccschem.024.202303752.  
  27. Jin, X.-Y.; He, Y.-M.; Hui, T.-H.; Liu, L.; Cheng, L. Selective Methylation of Nucleosides via an in Situ Generated Methyl Oxonium. J. Org. Chem. 2024, 89 (5), 3597–3604. https://doi.org/10.1021/acs.joc.3c02578.
  28. Wang, X.; Jin, X.-Y.; Cheng, L. Recent Advance in the Study on 5‐formylcytosine (f5C) RNA Modification. Isr. J. Chem. 2024, 64 (3–4), e202300178. https://doi.org/10.1002/ijch.202300178. (Invited review for Special Issue: Chemical Biology of Nucleic Acid Modifications).
  29. Yu, S.-C.; Cheng, L.; Liu, L. N‐heterocyclic Carbene Promoted Construction of Amide-linked COFs via the Oxidation of Imine-linked COFs with Molecular Oxygen. ChemistrySelect 2024, 9 (1), e202304668. https://doi.org/10.1002/slct.202304668.
  30. Cheng, L.; Wang, Z.-L.; Liu, A.-D.; Liu, L. Recent Advances in the Synthesis of 5-(Hetero)Aryl Uracil Derivatives. Synlett 2024, 35 (6), 603–615. https://doi.org/10.1055/a-2091-1071. (Special Issue to Celebrate the Centenary Year of Prof. Har Gobind Khorana).
  31. Chen, W.-D.; Cheng, L. Synthesis and Application of Stimulus-Triggered Cyclic Caged Oligonucleotides for Gene Expression Regulation. Tetrahedron Chem 2023, 8, 100051. https://doi.org/10.1016/j.tchem.2023.100051.
  32. Cheng, L. Chemical Modulation of RNA Epigenetic Modifications. Pak. J. Chem. 2023, 13 (3–4), 57–66. https://doi.org/10.15228/2023.v13.i03-4.p01.
  33. 贺胤铭, 孔素东, 林建国, 谢敏浩, 程靓 "N4-乙酰胞苷ac4C RNA检测技术的研究进展", 高等学校化学学报, 2023, 44, 20220319. http://www.cjcu.jlu.edu.cn/CN/10.7503/cjcu20220319
  34. Wang, Y.-Z.; Liu, S.-D.; Cheng, L.; Liu, L.; Li, C.-J. Asymmetric Addition of Hydrazones as Alkyl Carbanion Equivalents with Aryl Imines in Water. Org. Chem. Front. 2023, 10 (12), 3021–3026. https://doi.org/10.1039/d3qo00475a.
  35. He, Y.; Liu, L.; Cheng, L. A Short Review of Research Progress on the Synthesis Approaches of Aza-Dibenzocyclooctyne Derivatives. Molecules 2023, 28 (9), 3715. https://doi.org/10.3390/molecules28093715. (Special Issue in Bio-Orthogonal Chemistry in Bioimaging).
  36. Sun, X.; Liu, L.; Cheng, L. Photo- and Tetrazine-Responsive Modulation of Trans-Zeatin. J. Org. Chem. 2023, 88 (5), 2921–2930. https://doi.org/10.1021/acs.joc.2c02601.
  37. Liu, A.-D.; Liu, L.; Cheng, L. DMSO/PhPOCl2 Mediated Direct Methanethiolation of Uracils. ChemistrySelect 2023, 8 (4), e202204483. https://doi.org/10.1002/slct.202204483.
  38. Sun, Y.-J.; Chen, W.-D.; Liu, J.; Li, J.-J.; Zhang, Y.; Cai, W.-Q.; Liu, L.; Tang, X.-J.; Hou, J.; Wang, M.; Cheng, L. A Conformational Restriction Strategy for the Control of CRISPR/Cas Gene Editing with Photoactivatable Guide RNAs. Angew. Chem. Int. Ed. 2023, 62 (5), e202212413. https://doi.org/10.1002/anie.202212413. 
  39. Wu, C.-S.; Cheng, L. Recent Advances towards the Reversible Chemical Modification of Proteins. ChemBioChem 2023, 24 (2), e202200468. https://doi.org/10.1002/cbic.202200468. (VIP Article)
  40. Jin, X.-Y.; Huang, Z.-R.; Xie, L.-J.; Liu, L.; Han, D.-L.; Cheng, L. Photo-Facilitated Detection and Sequencing of 5-Formylcytidine RNA. Angew. Chem. Int. Ed. 2022, 61 (49), e202210652. https://doi.org/10.1002/anie.202210652. (VIP Article)
  41. Liu, A.-D.; Wang, Z.-L.; Liu, L.; Cheng, L. A Visible-Light-Promoted C-H Arylation and Heteroarylation of Uracil Derivatives with Diazoniums in Aqueous Conditions. Curr. Protoc. 2022, 2 (6), e432. https://doi.org/10.1002/cpz1.432.
  42. Jin, X.-Y.; Wu, C.-S.; Liu, A.-D.; Liu, L.; Cheng, L. Synthesis of Rigid Rod, Trigonal, and Tetrahedral Nucleobase-Terminated Molecules. Synthesis 2022, 54 (6), 1643–1651. https://doi.org/10.1055/a-1695-0820.
  43. Xie, L.-J.; Lin, C.-L.; Liu, L.; Cheng, L. A Chemical Labeling of N6-Formyl Adenosine (f6A) RNA. Chin. Chem. Lett. 2022, 33 (3), 1563–1566. https://doi.org/10.1016/j.cclet.2021.09.028. 
  44. Sun, Y.-J.; Cheng, L. The Chemistry behind ThiC Rearrangement. ChemBioChem 2022, 23 (1), e202100385. https://doi.org/10.1002/cbic.202100385.
  45. Liu, A.-D.; Wang, Z.-L.; Liu, L.; Cheng, L. Aqueous and Visible-Light-Promoted C-H (Hetero)Arylation of Uracil Derivatives with Diazoniums. J. Org. Chem. 2021, 86 (23), 16434–16447. https://doi.org/10.1021/acs.joc.1c01799.
  46. Lan, L.; Sun, Y.-J.; Liu, L.; Cheng, L. A Photo-Responsive Chemical Modulation of m6A RNA Demethylase FTO. Chem. Commun. 2021, 57 (81), 10548–10551. https://doi.org/10.1039/d1cc04091j.
  47.  Lan, L.; Sun, Y.-J.; Jin, X.-Y.; Xie, L.-J.; Liu, L.; Cheng, L. A Light-Controllable Chemical Modulation of m6A RNA Methylation. Angew. Chem. Int. Ed. 2021, 60 (33), 18116–18121. https://doi.org/10.1002/anie.202103854.
  48. Gao, Y.-T.; Liu, S.-D.; Cheng, L.; Liu, L. A Fast and Direct Iodide-Catalyzed Oxidative 2-Selenylation of Tryptophan. Chem. Commun. 2021, 57 (28), 3504–3507. https://doi.org/10.1039/d1cc00700a.
  49. Yu, S.-C.; Cheng, L.; Liu, L. Asymmetric Organocatalysis with Chiral Covalent Organic Frameworks. Org. Mater. 2021, 03 (2), 245–253. https://doi.org/10.1055/a-1400-5581.
  50. Wang, Y.-Z.; Liu, Q.; Cheng, L.; Yu, S.-C.; Liu, L.; Li, C.-J. Addition Reactions of Organic Carbanion Equivalents via Hydrazones in Water. Tetrahedron 2021, 80, 131889. https://doi.org/10.1016/j.tet.2020.131889.
  51. Cheng, H.-P.; Yang, X.-H.; Lan, L.; Xie, L.-J.; Chen, C.; Liu, C.; Chu, J.; Li, Z.-Y.; Liu, L.; Zhang, T.-Q.; Luo, D.-Q.; Cheng, L. Chemical Deprenylation of N6-Isopentenyladenosine (i6A) RNA. Angew. Chem. Int. Ed. 2020, 59 (26), 10645–10650. https://doi.org/10.1002/anie.202003360.
  52. Sun, Y.-J.; Liu, L.; Cheng, L. Regioselective Synthesis and Anticancer Evaluation of H2O2-Activable Nucleosides. Chem. Commun. 2020, 56 (48), 6484–6487. https://doi.org/10.1039/d0cc02245d. (Insider front cover article).
  53. Xie, L.-J.; Liu, L.; Cheng, L. Modifying Methionine on Proteins. ChemBioChem 2020, 21 (4), 461–463. https://doi.org/10.1002/cbic.201900533. (Invited review).  
  54. Xie, L.-J.; Liu, L.; Cheng, L. Selective Inhibitors of AlkB Family of Nucleic Acid Demethylases. Biochemistry 2020, 59 (3), 230–239. https://doi.org/10.1021/acs.biochem.9b00774. (Invited review, Future of Biochemistry: The Asia-Pacific Issue). 
  55. Wang, R.; Lan, L.; Liu, L.; Cheng, L. Asymmetric Polymerase Chain Reaction and Loop-Mediated Isothermal Amplification (AP-LAMP) for Ultrasensitive Detection of microRNAs. Chin. Chem. Lett. 2020, 31 (1), 159–162. https://doi.org/10.1016/j.cclet.2019.05.003.
  56. Wang, R.-L.; Jin, X.-Y.; Kong, D.-L.; Chen, Z.-G.; Liu, J.; Liu, L.; Cheng, L. Visible‐light Facilitated Fluorescence “Switch-on” Labelling of 5-formylpyrimidine RNA. Adv. Synth. Catal. 2019, 361 (23), 5406–5411. https://doi.org/10.1002/adsc.201901032. 
  57. Wang, C.; Zou, P.; Yang, C.; Liu, L.; Cheng, L.; He, X.; Zhang, L.; Zhang, Y.; Jiang, H.; Chen, P. R. Dynamic Modifications of Biomacromolecules: Mechanism and Chemical Interventions. Sci. China Life Sci. 2019, 62 (11), 1459–1471. https://doi.org/10.1007/s11427-019-9823-1.
  58. Li, X.-D.; Gao, Y.-T.; Sun, Y.-J.; Jin, X.-Y.; Wang, D.; Liu, L.; Cheng, L. A NaI/H2O2-Mediated Sulfenylation and Selenylation of Unprotected Uracil and Its Derivatives. Org. Lett. 2019, 21 (17), 6643–6647. https://doi.org/10.1021/acs.orglett.9b02183.
  59. Jin, X.-Y.; Wang, R.-L.; Xie, L.-J.; Kong, D.-L.; Liu, L.; Cheng, L. A Chemical Photo-oxidation of 5-methyl Cytidines. Adv. Synth. Catal. 2019, 361 (20), 4685–4690. https://doi.org/10.1002/adsc.201900811. (VIP Article) 
  60. Lan, L.; Wang, R.-L.; Liu, L.; Cheng, L. A Label-Free Colorimetric Detection of microRNA via G-Quadruplex-Based Signal Quenching Strategy. Anal. Chim. Acta 2019, 1079, 207–211. https://doi.org/10.1016/j.aca.2019.06.063.
  61. Liu, T.; Zhu, J.; Sun, X.; Cheng, L.; Wu, L. I2/TBHP Mediated Divergent C(Sp2)‐P Cleavage of Allenylphosphine Oxides: Substituent‐controlled Regioselectivity. Adv. Synth. Catal. 2019, 361 (15), 3532–3537. https://doi.org/10.1002/adsc.201900334.
  62. Xie, L.-J.; Yang, X.-T.; Wang, R.-L.; Cheng, H.-P.; Li, Z.-Y.; Liu, L.; Mao, L.; Wang, M.; Cheng, L. Identification of Flavin Mononucleotide as a Cell-Active Artificial N6-Methyladenosine RNA Demethylase. Angew. Chem. Int. Ed. 2019, 58 (15), 5028–5032. https://doi.org/10.1002/anie.201900901.
  63. Liu, J.-J.; Lan, L.; Gao, Y.-T.; Liu, Q.; Cheng, L.; Wang, D.; Liu, L. Visible‐light‐mediated Stereoselective 1,2-iodoalkylation of Alkynes. Adv. Synth. Catal. 2019, 361 (6), 1283–1288. https://doi.org/10.1002/adsc.201801636. 
  64. Li, X.-D.; Liu, L.; Cheng, L. Identification of Thienopyridine Carboxamides as Selective Binders of HIV-1 Trans Activation Response (TAR) and Rev Response Element (RRE) RNAs. Org. Biomol. Chem. 2018, 16 (47), 9191–9196. https://doi.org/10.1039/c8ob02753f.
  65. Li, X.; Chen, B.; Lan, L.; Wang, R.; Luo, D.; Liu, L.; Cheng, L. Selective Recognition of HIV RNA by Dinuclear Metallic Ligands. Chin. Chem. Lett. 2018, 29 (11), 1637–1640. https://doi.org/10.1016/j.cclet.2018.06.003.
  66. Gao, Y.-T.; Jin, X.-Y.; Liu, Q.; Liu, A.-D.; Cheng, L.; Wang, D.; Liu, L. Iodide/H2O2 Catalyzed Intramolecular Oxidative Amination for the Synthesis of 3,2’-Pyrrolidinyl Spirooxindoles. Molecules 2018, 23 (9), 2265. https://doi.org/10.3390/molecules23092265.
  67. Liu, Q.; Liu, J.-J.; Cheng, L.; Wang, D.; Liu, L. TEMPO Promoted Direct Multi-Functionalization of Terminal Alkynes with 2-Oxindoles/Benzofuran-2(3H)-One. Org. Biomol. Chem. 2018, 16 (29), 5228–5231. https://doi.org/10.1039/c8ob01380b.
  68. Zhong, N.-J.; Wang, Y.-Z.; Cheng, L.; Wang, D.; Liu, L. Recent Advances in the Annulation of Morita-Baylis-Hillman Adducts. Org. Biomol. Chem. 2018, 16 (29), 5214–5227. https://doi.org/10.1039/c8ob00929e.
  69. Jin, X.-Y.; Xie, L.-J.; Cheng, H.-P.; Liu, A.-D.; Li, X.-D.; Wang, D.; Cheng, L.; Liu, L. Ruthenium-Catalyzed Decarboxylative C-H Alkenylation in Aqueous Media: Synthesis of Tetrahydropyridoindoles. J. Org. Chem. 2018, 83 (14), 7514–7522. https://doi.org/10.1021/acs.joc.8b00229.
  70. Liu, J.-J.; Huang, H.-Y.; Cheng, L.; Liu, Q.; Wang, D.; Liu, L. A Catalyst-Free Intermolecular Trans-Iodoalkylation of Alkynes. Org. Biomol. Chem. 2018, 16 (6), 899–903. https://doi.org/10.1039/c7ob03159a.
  71. Gu, C.; Li, Y.; Xiao, L.; Fu, H.; Wang, D.; Cheng, L.; Liu, L. Tunable Heck-Mizoroki Reaction of Dibromonaphthalene Diimide with Aryl Ethylenes: Design, Synthesis, and Characterization of Coplanar NDI-Based Conjugated Molecules. J. Org. Chem. 2017, 82 (23), 12806–12812. https://doi.org/10.1021/acs.joc.7b02140.
  72. Xie, L.-J.; Wang, R.-L.; Wang, D.; Liu, L.; Cheng, L. Visible-Light-Mediated Oxidative Demethylation of N6-Methyl Adenines. Chem. Commun. 2017, 53 (77), 10734–10737. https://doi.org/10.1039/c7cc05544g.
  73. Liu, J.-J.; Cheng, L.; Huang, H.-Y.; Wei, F.; Wang, D.; Liu, L. Unprecedented Formation of 3-(Tetrahydrofuran-2-yl)-4H-Chromen-4-One in a Reaction between 3,3a-Dihydro-9H-Furo[3,4-b]Chromen-9-One and Malononitrile. Org. Biomol. Chem. 2017, 15 (23), 5078–5088. https://doi.org/10.1039/c7ob00904f.
  74. Huang, H.-Y.; Cheng, L.; Liu, J.-J.; Wang, D.; Liu, L.; Li, C.-J. Transition-Metal-Free Alkynylation of 2-Oxindoles through Radical-Radical Coupling. J. Org. Chem. 2017, 82 (5), 2656–2663. https://doi.org/10.1021/acs.joc.6b03057.
  75. Wei, F.; Cheng, L.; Huang, H.; Liu, J.; Wang, D.; Liu, L. Intermolecular Dearomative Oxidative Coupling of Indoles with Ketones and Sulfonylhydrazines Catalyzed by I2: Synthesis of [2,3]-Fused Indoline Tetrahydropyridazines. Sci. China Chem. 2016, 59 (10), 1311–1316. https://doi.org/10.1007/s11426-016-0170-8.
  76. Kong, D.-L.; Cheng, L.; Yue, T.; Wu, H.-R.; Feng, W.-C.; Wang, D.; Liu, L. Cobalt-Catalyzed Peroxidation of 2-Oxindoles with Hydroperoxides. J. Org. Chem. 2016, 81 (13), 5337–5344. https://doi.org/10.1021/acs.joc.6b00622.
  77. Wu, H.-R.; Cheng, L.; Kong, D.-L.; Huang, H.-Y.; Gu, C.-L.; Liu, L.; Wang, D.; Li, C.-J. FeCl3-Mediated Radical Tandem Reactions of 3-Benzyl-2-Oxindoles with Styrene Derivatives for the Stereoselective Synthesis of Spirocyclohexene Oxindoles. Org. Lett. 2016, 18 (6), 1382–1385. https://doi.org/10.1021/acs.orglett.6b00234.
  78. Li, X.-D.; Xie, L.-J.; Kong, D.-L.; Liu, L.; Cheng, L. Metal-Free Allylation of Electron-Rich Heteroaryl Boronic Acids with Allylic Alcohols. Tetrahedron 2016, 72 (15), 1873–1880. https://doi.org/10.1016/j.tet.2016.02.047.
  79. Kong, D.-L.; Cheng, L.; Wu, H.-R.; Li, Y.-X.; Wang, D.; Liu, L. A Metal-Free Yne-Addition/1,4-Aryl Migration/Decarboxylation Cascade Reaction of Alkynoates with Csp(3)-H Centers. Org. Biomol. Chem. 2016, 14 (7), 2210–2217. https://doi.org/10.1039/c5ob02478a.
  80. Cheng, L.; Doubleday, C.; Breslow, R. Evidence for Tunneling in Base-Catalyzed Isomerization of Glyceraldehyde to Dihydroxyacetone by Hydride Shift under Formose Conditions. Proc. Natl. Acad. Sci. U. S. A. 2015, 112 (14), 4218–4220. https://doi.org/10.1073/pnas.1503739112.
  81. Cheng, L.; Mahendran, A.; Gonzalez, R. L., Jr; Breslow, R. Deoxypolypeptides Bind and Cleave RNA. Proc. Natl. Acad. Sci. U. S. A. 2014, 111 (22), 7920–7924. https://doi.org/10.1073/pnas.1407295111.
  82. Cheng, L.; Abhilash, K. G.; Breslow, R. Binding and Biomimetic Cleavage of the RNA Poly(U) by Synthetic Polyimidazoles. Proc. Natl. Acad. Sci. U. S. A. 2012, 109 (32), 12884–12887. https://doi.org/10.1073/pnas.1210846109.
  83. Cheng, L.; Liu, L.; Li, C.; Jia, H.; Wang, D.; Chen, Y.-J. Nucleophilic Addition of Regioselectively Lithiated Indoline with Aldimines for the Syntheses of 2- and 7-Indolinyl Methanamine Derivatives. Tetrahedron Lett. 2012, 53 (31), 4004–4007. https://doi.org/10.1016/j.tetlet.2012.05.119.
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