1. Nucleoside analogs targeting respiratory viruses:The objective of the research is to design and synthesis novel and selective nucleoside analogs as inhibitors of polymerases of influenza, RSV, Human Rhinovirus, parainfluenza virus and other RNA viruses.

2. HSP90 inhibitors for cancer: HSP90s, as chaperon proteins are involved in many diseases associated pathways and inhibition of HSP90 found to be an important strategy for development of anticancer drugs. HSP90 inhibitors have been found particularly valuable in the treatment of ALK positive, KRAS positive lung cancer areas and other cancers. We are involved in the design, synthesis and conjugation of novel HSP90 inhibitor based cancer drug discovery.

3. COPD and Asthma exacerbation studies:HRV is often found among COPD and Asthma exacerbation patients and these exacerbations are important unmet medical needs in the world. We are designing potent HRV inhibitor for HRV and later investigate their effect in COPD and Asthma exacerbations.

4.IDO inhibitors for cancer:Indoleamine 2,3-dioxygenase 1 (IDO1),which catalyzes the initial and ratelimiting step of tryptophan along the kynurenine pathway, is expressed by tumorcells to escape a potentially effective immune response. We are involved in the design, synthesis and conjugation of novel IDO inhibitor based cancer drug discovery.

1.Ph. D., Organic Chemistry, August, 1990, University of Pittsburgh, Pittsburgh, PA 15260, Advisor, Dennis P. Curran

2.English Language Certificate, May, 1985, Guangzhou English Language Center, Zhongshan University, Guangzhou, China

3.B. S., Chemistry, June 1984, Fudan University, Shanghai, China

1.Principle Investigator and Director, synthetic and natural product drug center (www.gibh.ac.cn)Guangzhou Institute of Biomedicine and Health, 2005, 1 -present

2.Chief Scientific Officer Tsinghua Yuanxing Biopharmaceutical Inc. (www.thyx.com),Shenzhen, China, 2001.11-2004, 12

3.Professor of Chemistry, Shanghai Jiaotong University,2002-2004.12

4.Scientist, Senior Scientist and Project Leader, Gilead Sciences, Inc.(www.gilead.com), 344 Lakeside Dr., Foster City, CA  94404, September, 1992, 9-2001, 12

5.Postdoctoral Research Associate, Duke University, Durham, NC27706, September, 1990-August, 1992

6.Teaching Fellow, Research Assistant and Teaching Assistant, University of Pittsburgh, Pittsburgh, PA 15260, September1985-August, 1990.

（1）Cai Lin, Chenghai Sun, Xiao Liu, Yiqian Zhou, Muzammal Hussain, Junting Wan, Minke Li, Xue Li, Ruiliang Jin, Zhengchao Tu, Jiancun Zhang, Design, synthesis, and in vitro biological evaluation of novel 6-methyl-7-substituted-7-deaza purine nucleoside analogs as anti-influenza A agents, Antiviral Research, Volume 129, 2016, Pages 13-20
（2） Muzammal Hussain, Zahir Shah, Nasir Abbas, Aqeel Javeed,Muhammad Mahmood Mukhtar, Jiancun Zhang,Targeting tumor-associated immune suppression with selective protein kinase A type I (PKAI) inhibitors may enhance cancer immunotherapy, Medical Hypotheses 2016，86, 56-59

（3）Xiao Liu, Xueliang Xia, Chenghai Sun, Cai Lin, Yiqian Zhou,Muzammal Hussain, Fei Tang, Lu Liu, Xue Lia, and Jiancun Zhang ,Synthesis and Evaluation of 2'-Deoxy-2'-Spirodiflurocyclopropyl Nucleoside Analogs, Nucleosides, Nucleotides and Nucleic Acids, 2016,vol.35,479-494

（4） Muzammal Hussain , Fei Tang , Jinsong Liu , Jiancun Zhang , Aqeel Javeed Dichotomous role of protein kinase A type I (PKAI) in the tumor microenvironment: A potential target for ‘two-in-one’ cancer chemoimmunotherapeutics, Cancer Letters, 369 (2015) 9–19
（5）Jian Sun, Cai Lin, Xiaochu Qin, Xiaoping Dong, Zhengchao Tu, Fei Tang, Chaonan Chen, Jiancun Zhang, Synthesis and biological evaluation of 3,5-disubstituted-4-alkynylisoxozales as a novel class of HSP90 inhibitors., Bioorg Med Chem Lett,2015, Aug 15;25(16):3129-34
（6） Fei Tang, Yiqian Zhou, Cai Lin, Chaonan Chen, Jiancun Zhang, Syntheses of Indolizidine Alkaloids from Cascade Cross-Coupling of gem-Dibromoolefins, Advance RSC,2014, 4(93):51298-51301

1. Nucleoside analogs targeting respiratory viruses

2. HSP90 inhibitors for cancer

3. COPD and Asthma exacerbation studies

4. New synthetic method and process development for important molecules

    5.IDO inhibitors for cancer

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