General
杨凌 男 汉族 博导 大连化学物理研究所
Email: yling@dicp.ac.cn
Telephone: 041184379317
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Email: yling@dicp.ac.cn
Telephone: 041184379317
Mobile phone:
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Research Areas
drug metabolism
biotransformation
Education
B.S. Medical Sciences, Zunyi Medical College (currently Dalian Medical University), 1983, P. R.China
M.S. Pharmaceutical Sciences, The graduate school of Toyama Medical and Pharmaceutical University (currently Toyama University), 1993, Japan
Ph.D. Pharmaceutical Sciences, The graduate school of Toyama Medical and Pharmaceutical University (currently Toyama University), 1996, Japan
M.S. Pharmaceutical Sciences, The graduate school of Toyama Medical and Pharmaceutical University (currently Toyama University), 1993, Japan
Ph.D. Pharmaceutical Sciences, The graduate school of Toyama Medical and Pharmaceutical University (currently Toyama University), 1996, Japan
Experience
EMPLOYMENT HISTORY
1983-1990, Dalian Institute of Medical & Pharmaceutical Sciences
1996-1997, Senior Scientist, Toyama Medical and Pharmaceutical University (currently Toyama University)
1997-1998, Senior Scientist, Showa Pharmaceutical University
1998-1999, Post-doctor, Dalian Institute of Chemical Physics, the Chinese Academy of Sciences
2000-present, Professor, Dalian Institute of Chemical Physics, the Chinese Academy of Sciences
1983-1990, Dalian Institute of Medical & Pharmaceutical Sciences
1996-1997, Senior Scientist, Toyama Medical and Pharmaceutical University (currently Toyama University)
1997-1998, Senior Scientist, Showa Pharmaceutical University
1998-1999, Post-doctor, Dalian Institute of Chemical Physics, the Chinese Academy of Sciences
2000-present, Professor, Dalian Institute of Chemical Physics, the Chinese Academy of Sciences
Honors & Distinctions
1990-1996, Japanese Government Scholarship (Monbushu Scholarship)
2000, Outstanding Overseas Chinese Scientist Award from the Chinese Academy of Sciences
2001, Top hundred of Liaoning BaiQianWan Talents Program
2005, Excellent Postdoctoral Award from the Chinese Academy of Sciences
2009, Technology Innovation Award from Dalian Institute of Chemical Physics, the Chinese Academy of Sciences
2010, Excellent Expert of Dalian City
2010, Prominent supervisor of Dalian Institute of Chemical Physics, the Chinese Academy of Sciences
2000, Outstanding Overseas Chinese Scientist Award from the Chinese Academy of Sciences
2001, Top hundred of Liaoning BaiQianWan Talents Program
2005, Excellent Postdoctoral Award from the Chinese Academy of Sciences
2009, Technology Innovation Award from Dalian Institute of Chemical Physics, the Chinese Academy of Sciences
2010, Excellent Expert of Dalian City
2010, Prominent supervisor of Dalian Institute of Chemical Physics, the Chinese Academy of Sciences
Publications
Papers
PUBLICATION
(1) Wang AX, Hu Y, Liu HX, Qi XY, Liu Y, Tu CX, Yang L. C5-Hydroxylation of liquiritigenin is catalyzed selectively by CYP1A2. Xenobiotica, 2011; accepted.
(2) Ma XC, Ning J, GE GB, Liang SC, Wang XL, Zhang BJ, Huang SS, Li JK, Yang L*. Comparative Metabolism of Cinobufagin in Liver Microsomes from Mouse, Rat, Dog, Minipig, Monkey and Human. Drug Metabolism and Disposition, 2011; 2011; 39(4):675-82.
(3) Dong PP, Fang ZZ, Zhang YY, GE GB, Mao YX, Zhu LL, Qu YQ, Li W, Wang LM, Liu CX, Yang L*. Substrate-dependent modulation of CYP3A catalytic activity by erlotinib. Acta Pharmacologica Sinica, 2011; accepted.
(4) Fang ZZ, Zhang YY, Ge GB, Liang SC, Sun DX, Zhu LL, Dong PP, Cao YF, Yang L*. Identification of cytochrome P450 (CYP) isoforms involved in metabolism of corynoline and assessment of its herb-drug interaction. Phytotherapy research, 2011; accepted.
(5) Hao DC, Yang L*, Xiao PG. The first insight into the Taxus genome via fosmid library construction and end sequencing. Mol Genet Genomics, 2011; accepted.
(6) Li W, Liu Y, Li XX, Yu Y, Wu JJ, Wang Q, Huo H, Yang L*, Wang LM. Triptolide induced apoptosis and growth inhibition in prostate cancer cell-lines with different p53 conditions is irrespective of MAPKs. Planta medica, 2011; 77: 27–31.
(7) Liang SC, Ge GB, Liu HX, Shang HT, Wei H, Fang ZZ, Zhu LL, Mao YX, Yang L*. Determination of propofol UDP-glucuronosyltransferase (UGT) activities in hepatic microsomes from different species by UFLC-ESI-MS. Journal of Pharmaceutical and Biomedical Analysis, 2011; 54(1):236-41.
(8) Fang ZZ, Nian Y, Li W, Wu JJ, Ge GB, Dong PP , Zhang YY , Qiu MH , Liu L, Yang L. Cycloartane Triterpenoids from Cimicifuga yunnanensis induce apoptosis of breast cancer cells (MCF7) via p53-dependent mitochondrial signaling pathway. Phytotherapy research, 2011; 25(1): 17-24.
(9) Ma JF, Hou CY, Sun LL, Tao DY, Zhang YY, Shan YC, Liang Z, Zhang LH, Yang L, Zhang YK. Coupling Formic Acid Assisted Solubilization and online Immobilized Pepsin Digestion with SCX-µRPLC-ESI-MS/MS for Integral Membrane Proteome Analysis. Analytical Chemistry, 2010; 82(23):9622-5.
(10) Huang T, Fang ZZ, Yang L*. Strong inhibitory effect of medroxyprogesterone acetate (MPA) on UDP-Glucuronosyltransferase (UGT) 2B7 might induce drug-drug interactions (DDIs). Pharmazie, 2010; 12(65): 919-921.
(11) Sun DX, Lu CJ, Fang ZZ, Zhang YY, Cao YF, Mao YX, Zhu LL, Yin J, Yang L*. Reversible inhibition of three important human liver cytochrome P450 enzymes by tiliroside. Phytotherapy research, 2010; 24:1670-1675.
(12) Ge GB, Liang SC, Liu XB, Hu Y, Mao YX, Zhang YY, Luan HW, Qiu MH, Yang L*. Rapid Qualitative and Quantitative Determination of Seven Valuable Taxanes from Various Taxus Species by UFLC-ESI-MS and UFLC-DAD. Planta Medica, 2010; 76(15):1773-7.
(13) Wang AX, Ge GB, Qi XY, Hu Y, Liang SC, Yang L, Tu CX. Rapid Profiling and Target Analysis of Principal Components in Fuling Decoctions by UFLC-DAD-ESI-MS. Fitoterapia, 2010; 81: 662-667.
(14) Liang SC, Ge GB, Liu HX, Zhang YY, Zhang JW, Yin L, Li W, Fang ZZ, Wang LM, Yang L*. Identification and Characterization of Human UDP- Glucuronosyltransferases responsible for the in vitro Glucuronidation of Daphnetin. Drug Metabolism and Disposition, 2010; 38: 973-980.
(15) Yan J, Sun LR, Li W, Zhou L, Li ZR, Zhang XM, Yang L, Qiu MH. Cytotoxic Serratane Triterpenes from Diphasiastrum complanatum with a Hydroxy Group at C-27. Planta Medica. 2010; 76(4): 353-357.
(16) Sun DX, Fang ZZ, Zhang YY, Cao YF, Yang L, Yin J. Inhibitory effect of curcumenol on human liver cytochrome P450 enzymes. Phytotherapy Research, 2010; 24(8):1213-1216.
(17) Ai CZ, Li Y, Wang YH, Li W, Dong PP, Ge GB, Yang L*. Investigation of binding features: Effects on the interaction between P450 2A6 and inhibitors. Journal of Computational Chemistry, 2010; 31(9):1822-1831.
(18) Li RB, Wu RA, Zhao L, Wu MH, Yang L, Zou HF. P-Glycoprotein Antibody Functionalized Carbon Nanotube Overcomes the Multidrug Resistance of Human Leukemia Cells. ACS Nano. 2010; 4 (3): 1399–1408.
(19) He YQ, Yang L, Liu HX, Zhang JW, Liu Y, Fong A, Xiong AZ, Lu YL, Yang L, Wang CH and Wang ZT. Glucuronidation, a new metabolic pathway of pyrrolizidine alkaloids. Chemical Research in Toxicology. 2010, 23 (3): 591–599.
(20) He YQ, Liu Y, Zhang BF, Liu HX, Lu YL, Yang L, Xiong AZ, Xu LL, Wang CH, Yang L, and Wang ZT. Identification of the UDP-Glucuronosyltransferase Isozyme Involved in Senecionine Glucuronidation in Human Liver Microsomes. Drug Metabolism and Disposition, 2010; 38: 626-634.
(21) Fang ZZ, Zhang YY, Ge GB, Huo H, Liang SC, Yang L*. Time-dependent inhibition (TDI) of CYP3A4 and CYP2C9 by noscapine potentially explains clinical noscapine-warfarin interaction. British Journal of Clinical Pharmacology, 2010; 69(2):193-199.
(22) Cao YF, Zhang YY, Li J, Ge GB, Hu D, Liu HX, Huang T, Wang YC, Fang ZZ, Sun DX, Huo H, Yin J, Yang L. CYP3A Catalyzes Schizandrin Biotransformation in Human, Minipig and Rat Liver Microsomes. Xenobiotica, 2010; 40(1): 38–47.
(23) Zhang YY, Liu Y, Zhang JW, Ge GB, Liu HX, Wang LM, Sun J, Yang L. C-7 Configuration as One of Determinants in Taxanes Metabolism by Human Cytochrome P450 Enzymes. Xenobiotica, 2009; 39(12): 903–914.
(24) He Y, Yang L, Liu Y, Zhang J, Tang J, Su J, Li Y, Lu Y, Wang C, Yang L, Wang Z. Characterization of cardamonin metabolism by P450 in different species via HPLC-ESI-ion trap and UPLC-ESI-quadrupole mass spectrometry. Acta Pharmacologica Sinica, 2009; 30: 1462–70.
(25) Dong PP, Ge GB, Zhang YY, Ai CZ, Li GH, Zhu LL, Luan HW, Liu XB, Yang L. Quantitative structure-retention relationship studies for taxanes including epimers and isomeric metabolites in ultra fast liquid chromatography. Journal of Chromatography A, 2009; 1216: 7055–62.
(26) Liu HX, Hu Y, He YQ, Liu Y, Li W, Yang L. Ultra-performance liquid chromatographic–electrospray mass spectrometric determination (UPLC-ESI-MS) of O-demethylated metabolite of paeonol in vitro: Assay development, human liver microsome activities and species differences. Talanta, 2009; 79(5):1433-40.
(27) Li RB, Wu RA, Wu MH, Zou HF, Ma H, Yang L, Le XC. MEKC-LIF analysis of rhodamine123 delivered by carbon nanotubes in K562 cells. Electrophoresis, 2009; 30(11):1906-12.
(28) Liu HX, Hu Y, Liu Y, He YQ, Li W, Yang L. CYP1A2 is the major isoform responsible for paeonol O-demethylation in human liver microsomes. Xenobiotica, 2009; 39 (9): 672-9.
(29) Zhang YY, Yang L. Interactions between human cytochrome P450 enzymes and steroids: physiological and pharmacological implications. Expert Opinion on Drug Metabolism and Toxicology ((Invited review), 2009; 5(6):621-9.
(30) Chen JJ, Zhang JW, Yang L, Li W. Structure elucidation of major metabolites from medroxyprogesterone acetate by P450. Chemical & Pharmaceutical Bulletin, 2009; 57 (8): 1-16.
(31) Liu HX, Hu Y, Liu Y, He YQ, Li W, Yang L. Hydroxylation of tanshinone IIa in human liver microsomes is specifically catalysed by cytochrome P4502A6. Xenobiotica, 2009; 39(5):382-90.
(32) Hu Y, Luan HW, Liu HX, Ge GB, Zhou K, Liu Y, Yang L. The acceptor specificity and transfer efficiency of a β-glycosidase from the China white jade snail. Bioscience Biotechnology and Biochemistry, 2009; 73(3):671-6.
(33) Zhang YY, Liu, Y, Zhang JW, Ge GB; Wang LM, Sun J, Yang L. Characterization of human cytochrome P450 isoforms involved in the metabolism of 7-epi-paclitaxel. Xenobiotica, 2009; 39(4): 283–292.
(34) Lei XY, Kong L, Zou HF, Ma H and Yang L. Evaluation of the interaction of bioactive compounds in Cortex Pseudolarix and Radix Stephaniae by the microdialysis probe coupled with high performance liquid chromatography–mass spectrometry. Journal of Chromatography A, 2009; 1216(11):2179-84.
(35) Ai CZ, Li Y，Wang YH， Chen Y, Yang L. Insight into the effects of chiral isomers quinidine and quinine on CYP2D6 inhibition. Bioorganic & Medicinal Chemistry Letters, 2009; 19(3): 803-6.
(36) Li W, Liu Y, Zhang JW, Ai CZ, Xiang N, Liu HX, Yang L. Structure-activity relationship of anti-prostate cancer effects of ginsenosides in vitro. Archives of Pharmacal Research, 2009; 32(1) 49-57.
(37) Ge GB, Zhang R, Ai CZ, Zhang YY, He YQ, Liu XB, Yang L, Wang ZT, Yang L. Stereochemical differentiation of C-7 hydroxyl taxane isomers by electrospray ionization mass spectrometry. Rapid Communications in Mass Spectrometry, 2009; 23(3): 425-32.
(38) Hu Y, Luan HW, Ge GB, Liu HX, Zhou K, Liu Y, Yang L. Deoxynojirimycin enhanced the transglycosylation activity of a glycosidase from the China White Jade Snail. Journal of biotechnology, 2009; 139: 229-35.
(39) Hao DC, Huang B, Yang L. Molecular evolution of paclitaxel biosynthetic genes TS and DBAT of Taxus species. Genetica, 2009; 135(2): 123-135.
(40) Li W, Liu Y, He YQ, Zhang JW, Gao Y, Ge GB, Liu HX, Liu HT, Wang LM, Sun J, Wang Q, Yang L. Characterization of triptolide hydroxylation by cytochrome P450 in human and rat liver microsomes. Xenobiotica, 2008; 38(12): 1551–65.
(41) Yang L, Xiong AZ, He YQ, Wang ZY, Wang CH, Wang ZT, Li W, Yang L and ZB Hu. Bile Acids Metabonomic Study on the CCl4- and α-Naphthylisothiocyanate-Induced Animal Models: Quantitative Analysis of 22 Bile Acids by Ultraperformance Liquid Chromatography−Mass Spectrometry. Chemical Research in Toxicology, 2008, 21 (12), 2280–8.
(42) Hao DC, Ge GB, Yang L. Bacterial diversity of Taxus Rhizosphere: culture-independent and culture-dependent approaches. FEMS Microbiology Letters, 2008; 284(2): 204–12.
(43) Hao DC, Huang B, Xiao PG, Ge GB, Yang L. Interspecific relationships and origins of Taxaceae and Cephalotaxaceae revealed by chloroplast and nuclear DNA sequences. Plant Systematics and Evolution, 2008; 276: 89-104.
(44) Zhang JW, Liu Y, Zhao JY, Wang LM, Ge GB, Gao Y, Li W, Liu HT, Liu HX, Zhang YY, Sun J, and Yang L. Metabolic profiling and P450 reaction phenotyping of medroxyprogesterone acetate. Drug metabolism and disposition, 2008; 36(11): 2292-8.
(45) Ai CZ, Li Y, Wang YH, Li YH, Yang L. A 3D-QSAR Study of Catechol-O-methyltransferase Inhibitors using CoMFA and CoMSIA. QSAR & Combinatorial Science, 2008; 27 (10): 1183-92.
(46) Ai CZ, Sun RA, Wang CS, Ma L, Yang L. Theoretical studies on hydrogen overfall mechanism for catalyzed hydroisomerization of n-hexane. Chemical Journal of Chinese University-CHINESE, 2008; 29(1): 182-86. (in Chinese)
(47) Liu HX, Liu Y, Zhang JW, Li W, Liu HT, Yang L. UDP-glucuronosyltransferase 1A6 is the major isozyme responsible for protocatechuic aldehyde glucuronidation in human liver microsomes. Drug Metabolism and Disposition, 2008; 36(8): 1562-9.
(48) Ge GB, Luan HW, Zhang YY, He YQ, Liu XB, Yang L, Wang ZT, Yang L. Profiling of yew hair roots from various species using ultra-performance liquid chromatography-electrospray ionization mass spectrometry. Rapid Communications in Mass Spectrometry, 2008; 22(15): 2315-23.
(49) Liu HX, He YQ, Hu Y, Liu Y, Zhang JW, Li W, Wang ZT, Yang L. Determination of UDP-glucuronosyltransferase UGT2B7 activity in human liver microsomes by ultra-performance liquid chromatography with MS detection. Journal of Chromatography B, 2008; 870(1): 84-90.
(50) Ge GB, Zhang YY, Hao DC, Hu Y, Luan HW, Liu XB, He YQ, Wang ZT, Yang L. Chemotaxonomic study of medicinal Taxus species with fingerprint and multivariate analysis. Planta Medica., 2008; 74: 773-9.
(51) Hu Y, Luan HW, Zhou K, Ge GB, Yang SL, Yang L. Purification and characterization of a novel glycosidase from China White Jade Snail (Achatina fulica) showing transglycosylation activity. Enzyme and Microbial Technology, 2008; 43(1): 35-42.
(52) Zhang JW, Ge GB, Liu Y, Wang LM, Liu XB, Zhang YY, Li W, He YQ, Wang ZT, Sun J, Xiao HB, Yang L. Taxane's substituents at C3' affect its regioselective metabolism- Different in vitro metabolism of cephalomannine and paclitaxel. Drug Metabolism and Disposition, 2008; 36(2): 418-26.
(53) Hao DC, Huang B, Yang L. Phylogenetic relationships of the genus Taxus inferred from chloroplast intergenic spacer and nuclear coding DNA. Biological and Pharmaceutical Bulletin, 2008; 31(2): 260-5.
(54) Dong PP, Zhang YY, Ge GG, Ai CZ, Liu Y, Yang L, Liu CX. Modeling resistance index of taxoids to MCF-7 cell lines using ANN together with electrotopological state descriptors. Acta Pharmacologica Sinica, 2008; 29(3): 385-96.
(55) Zhang JW, Liu Y, Cheng J, Li W, Ma H, Liu HT, Sun J, Wang LM, He YQ, Wang Y, Wang ZT, Yang L. Inhibition of human liver cytochrome P450 by star fruit juice. Journal of Pharmacy & Pharmaceutical Sciences, 2007; 10(4): 496-503.
(56) Hao DC, Sun J, Furnes B, Schlenk D, Li MX, Yang SL, Yang L. Allele and genotype frequencies of polymorphic FMO3 gene in two genetically distinct populations. Cell Biochemistry and Function, 2007; 25(4): 443-53.
(57) Hu Y, Luan HW, Hao DC, Xiao HB, Yang SL, Yang L. Purification and characterization of a novel Ginsenoside-hydrolyzing β-D-glucosidase from the China white jade snail (Achatina fulica). Enzyme and Microbial Technology, 2007; 40: 1358-66.
(58) Xiao H, Yang LS, Zou HF, Yang L, Le XC. Analysis of oxidized multi-walled carbon nanotubes in single K562 cells by capillary electrophoresis with laser-induced fluorescence. Analytical Bioanalytical Chemistry, 2007; 387: 119-126.
(59) Hao DC, Zhu PH, Yang SL, Yang L. Enhanced production of human CYP2C9 by Escherichia coli BL21(DE3)pLysS through the novel use of grey relational analysis and Plackett Burman design. World Journal of Microbiology and Biotechnology, 2007; 23: 71-8.
(60) Hao DC, Sun J, Furnes B, Schlenk D, Hou ZF, Zhang YP, Yang SL, Yang L. Haplotype frequency distribution and linkage disequilibrium analysis of single nucleotide polymorphisms at the human FMO3 gene locus. Biochemical Genetics, 2006, 44: 391-407.
(61) Li YH, Wang YH, Li Y, Yang L. Prediction of the deleterious nsSNPs in ABCB transporters. FEBS Letters, 2006; 580(30): 6800-906.
(62) Xiao H, Zou HF, Pan CS, Jiang XG, Le XC, Yang L. Quantitative determination of oxidized carbon nanotube probes in yeast by capillary electrophoresis with laser-induced fluorescence detection. Analytica Chimica Acta., 2006; 580: 194-9.
(63) Hao DC, Zhu PH, Yang SL, Yang L. Optimization of recombinant cytochrome P450 2C9 protein production in Escherichia coli DH5α by statistically-based experimental design. World Journal of Microbiology and Biotechnology, 2006; 22(11): 1169-76.
(64) Wang YL, Hao DC, Stein WD, Yang L. A kinetic study of Rhodamine123 pumping by P-glycoprotein. Biochimica et Biophysica Acta, 2006; 1758(10): 1671-6.
(65) Xiao H, Li X, Zou HF, Yang L, Wang YL, Wang HL, Le XC. Capillary electrophoresis/laser-induced fluorescence coupled with flow cytometry for high-throughput quantitation of fluorophores in single intact cells. Electrophoresis, 2006; 27: 3452-9.
(66) Luan HW, Li X, Qi XH, Hu Y, Hao DC, Cui Y, Yang L. Purification and characterization of a novel stable β-D-glucosidase hydrolyzing ginsenoside Rb1 into Rd from China white jade snail. Process Biochemistry, 2006; 41: 1974-80.
(67) Yang L, Liu Y, Liu CX. Metabolism and pharmacokinetics of ginsenosides. Asian Journal of Pharmacodynamics and Pharmacokinetics, 2006; 6: 103-20.
(68) Li J, Liu Y, Zhang JW, Wei H, Yang L. Characterization of hepatic drug-metabolizing activities of Bama miniature pigs (Sus scrofa domestica): Comparison with Human Enzyme Analogs. Comparative Medicine, 2006; 56(4): 286-90.
(69) Zhang JW, Liu Y, Li W, Hao DC, Yang L. Inhibitory effect of medroxyprogesterone acetate on human liver cytochrome P450 enzymes. European Journal of Clinical Pharmacology, 2006; 62: 497-502.
(70) Wang YH, Li Y, Li YH, Ma XH, Yang SL, Yang L. Investigations into the analysis and modeling of the cytochrome P450 cycle. Journal of Physical Chemistry B, 2006; 110: 10139-43.
(71) Liu Y, Zhang JW, Li W, Ma H, Sun J, Deng MC, Yang L. Ginsenoside metabolites, rather than naturally occurring ginsenosides, lead to inhibition of human cytochrome P450 enzymes. Toxicological Sciences, 2006; 91(2): 356-64.
(72) Li YH, Wang YH, Sun J, Li Y, Yang L. Distribution of the functional MDR1 C3435T polymorphism in the Han population of China. Swiss Medical Weekly, 2006; 136: 377-82.
(73) Han QB, Yang L, Liu Y, Wang YL, Qiao CF, Song JZ, Xu LJ, Yang DJ, Chen SL, Xu HX. Gambogic acid and epigambogic acid, C-2 epimers with movel anticancer effects form Garcinia hanburyi. Planta Medica, 2006; 72(3): 281-4.
(74) Cheng J, Wan DF, Gu JR, Gong Y, Yang SL, Hao DC, Yang L. Establishment of a yeast system that stably expressed human cytochrome P450 reductase: application for the study of drug metabolism of cytochrome P450s in vitro. Protein Expression and Purification, 2006; 47: 467-76.
(75) Li Y, Wang YH, Yang L,Zhang SW, Liu CH. Impact of molecular hydrophobic field on passive diffusion, P-glycoprotein active efflux,and P-glycoprotein modulation of steroids. Internet Electronic Journal of Molecular Design, 2006; 5(2): 60-78.
(76) Wang Y, Wang HM, Wang YH, Yang CL, Yang L, Han KL. Theoretical study of the mechanism of acetaldehyde hydroxylation by compound I of CYP2E1. Journal of Physical Chemistry B, 2006; 110: 6154-9.
(77) Han QB, Wang YL, Yang L, Tso TF, Qiao CF, Song JZ, Xu LJ, Chen SL, Yang DJ, Xu HX. Cytotoxic xanthones from the resin of Garcinia hanburyi. Chemical & Pharmaceutical Bulletin, 2006; 54: 265-7.
(78) Han QB, Yang L, Wang YL, Qiao CF, Song JZ, Sun HD, and Xu HX. A pair of novel cytotoxic polyprenylated xanthone epimers from Gamboges. Chemistry & Biodiversity, 2006; 3: 101-5.
(79) Li Y, Wang YH, Yang L, Zhang SW, Liu CH. Structural determinants of flavones interacting with the C-terminal nucleotide-binding domain as P-glycoprotein inhibitors. Internet Electronic Journal of Molecular Design, 2006; 5: 1-12.
(80) Liu Y, Yang L. Early metabolism evaluation making traditional Chinese medicine effective and safe therapeutics. Journal of Zhejiang University SCIENCE B, 2006; 7(2): 99-106.
(81) Xiao H, Li X, Zou HF, Yang L, Yang YQ, Wang YL, Le XC. Immunoassay of P-glycoprotein on single cell by capillary electrophoresis with laser induced fluorescence detection. Analytica Chimica Acta, 2006; 556: 340-6.
(82) Li YH, Wang YH, Li Y, Yang L. MDR1 Gene Polymorphisms and clinical relevance. Acta Genetica Sinica, 2006; 33(2): 93-104.
(83) Liu Y, Ma H, Zhang JW, Deng MC, Yang L. Influence of ginsenoside Rh1 and F1 on human cytochrome P450 enzymes. Planta Medica, 2006; 72(2): 126-31.
(84) Wang C, Yang L,Yang SL. Three dimensional quantitative structure-activity relationship of 4,5,6,7- tetrahydrothieno- pyridines analogues as glucose-6-phosphatase inhibitors. Journal of Molecular Structure, 2006; 782: 49-54.
(85) D Jiang, YH Wang, Y Li, Yang L, SW Zhang, SL Yang. Prediction of saccharomyces cerevisiae growth phenotypes based on elementary flux mode analysis. Chemical Journal of Chinese University-CHINESE, 2006, 27(9): 1683-5.
(86) Yonghua Wang, Yan Li, Yanhong Li, Yang SL, Yang L. Modeling Km values using electrotopological state: substrates for cytochrome P450 3A4-mediated metabolism. Bioorganic and Medicinal Chemistry Letters, 2005, 15: 4076-84.
(87) Wang YH, Li Y, Yang SL, Yang L. Classification of substrates and inhibitors of P-glycoprotein using unsupervised machine learning approach. Journal of Chemical Information and Computer Sciences, 2005; 45(3): 750-7.
(88) Li Y, Wang YH, Yang L, Zhang SW, Liu CH，Yang SL. Comparison of steroid substrates and inhibitors of P-glycoprotein by 3D-QSAR analysis. Journal of Molecular Structure, 2005; 733: 111-8.
(89) Wang YH, Li Y, Yang SL, Yang L. An in silico approach for screening flavonoids as P-glycoprotein inhibitors based on bayesian-regularized neural network. Journal of Computer-Aided Molecular Design, 2005; 19(3): 137-47.
(90) He KJ, Liu Y, Yang Y, Li P, Yang L. A dammarane glycoside derived from ginsenoside Rb3. Chemical & Pharmaceutical Bulletin, 2005; 53(2): 177-9.
(91) Wang YH, Han KL, Yang SL, Yang L. Structural determinants of steroids for cytochrome P4503A4-mediated metabolism. Journal of Molecular Structure-THEOCHEM, 2004; 710: 215-21.
(92) Liu Y, Li W, Li P, Deng MC, Yang SL, Yang L. The inhibitory effect of intestinal bacterial metabolite of ginsenosides on CYP3A activity. Biological & Pharmaceutical Bulletin, 2004; 27(10): 1555-60.
(93) ZM Liu, ZR Zhang, GW Xu, Yang L et al. Catalytic materials evaluated by adsorption and inactivation of parainfluenza virus and cytotoxicity of mammalian cells. Chinese Journal of Catalysis, 2003, 24(5): 323-7.
(94) Yang L, Akao T, Kobashi K, Hattori M. Purification and characterization of a novel sennoside-hydrolyzing beta-glucosidase from Bifidobacterium sp. strain SEN, a human intestinal anaerobe. Biological & Pharmaceutical Bulletin, 1996; 19(5): 705-9.
(95) Yang L, Akao T, Kobashi K, Hattori M. A sennoside-hydrolyzing beta-glucosidase from Bifidobacterium sp. strain SEN is inducible. Biological & Pharmaceutical Bulletin, 1996; 19(5): 701-4.
(96) Yang L, Akao T, Kobashi K. Purification and characterization of a geniposide-Hydrolyzing beta-glucosidase from Eubacterium sp. A-44, a strict anaerobe from human feces. Biological & Pharmaceutical Bulletin, 1995; 18(9): 1175-8.
(97) Akao T, Che QM, Kobashi K, Yang L, Hattori M, Namba T. Isolation of a human intestinal anaerobe, Bifidobacterium sp. strain SEN, capable of hydrolyzing sennosides to sennidins. Applied & Environmental Microbiolog, 1994; 60(3): 1041-3.
(98) Tsui ZC, Hou WH, Yang L, Zhu ZM. Effect of a cell differentiation inducer, ganglioside GM3, on the neutral glycosphingolipid composition and cell membrane fluidity of a human promyelocytic leukemia cell line HL-60. In Vivo. 1990; 4(3): 205-8.
(1) Wang AX, Hu Y, Liu HX, Qi XY, Liu Y, Tu CX, Yang L. C5-Hydroxylation of liquiritigenin is catalyzed selectively by CYP1A2. Xenobiotica, 2011; accepted.
(2) Ma XC, Ning J, GE GB, Liang SC, Wang XL, Zhang BJ, Huang SS, Li JK, Yang L*. Comparative Metabolism of Cinobufagin in Liver Microsomes from Mouse, Rat, Dog, Minipig, Monkey and Human. Drug Metabolism and Disposition, 2011; 2011; 39(4):675-82.
(3) Dong PP, Fang ZZ, Zhang YY, GE GB, Mao YX, Zhu LL, Qu YQ, Li W, Wang LM, Liu CX, Yang L*. Substrate-dependent modulation of CYP3A catalytic activity by erlotinib. Acta Pharmacologica Sinica, 2011; accepted.
(4) Fang ZZ, Zhang YY, Ge GB, Liang SC, Sun DX, Zhu LL, Dong PP, Cao YF, Yang L*. Identification of cytochrome P450 (CYP) isoforms involved in metabolism of corynoline and assessment of its herb-drug interaction. Phytotherapy research, 2011; accepted.
(5) Hao DC, Yang L*, Xiao PG. The first insight into the Taxus genome via fosmid library construction and end sequencing. Mol Genet Genomics, 2011; accepted.
(6) Li W, Liu Y, Li XX, Yu Y, Wu JJ, Wang Q, Huo H, Yang L*, Wang LM. Triptolide induced apoptosis and growth inhibition in prostate cancer cell-lines with different p53 conditions is irrespective of MAPKs. Planta medica, 2011; 77: 27–31.
(7) Liang SC, Ge GB, Liu HX, Shang HT, Wei H, Fang ZZ, Zhu LL, Mao YX, Yang L*. Determination of propofol UDP-glucuronosyltransferase (UGT) activities in hepatic microsomes from different species by UFLC-ESI-MS. Journal of Pharmaceutical and Biomedical Analysis, 2011; 54(1):236-41.
(8) Fang ZZ, Nian Y, Li W, Wu JJ, Ge GB, Dong PP , Zhang YY , Qiu MH , Liu L, Yang L. Cycloartane Triterpenoids from Cimicifuga yunnanensis induce apoptosis of breast cancer cells (MCF7) via p53-dependent mitochondrial signaling pathway. Phytotherapy research, 2011; 25(1): 17-24.
(9) Ma JF, Hou CY, Sun LL, Tao DY, Zhang YY, Shan YC, Liang Z, Zhang LH, Yang L, Zhang YK. Coupling Formic Acid Assisted Solubilization and online Immobilized Pepsin Digestion with SCX-µRPLC-ESI-MS/MS for Integral Membrane Proteome Analysis. Analytical Chemistry, 2010; 82(23):9622-5.
(10) Huang T, Fang ZZ, Yang L*. Strong inhibitory effect of medroxyprogesterone acetate (MPA) on UDP-Glucuronosyltransferase (UGT) 2B7 might induce drug-drug interactions (DDIs). Pharmazie, 2010; 12(65): 919-921.
(11) Sun DX, Lu CJ, Fang ZZ, Zhang YY, Cao YF, Mao YX, Zhu LL, Yin J, Yang L*. Reversible inhibition of three important human liver cytochrome P450 enzymes by tiliroside. Phytotherapy research, 2010; 24:1670-1675.
(12) Ge GB, Liang SC, Liu XB, Hu Y, Mao YX, Zhang YY, Luan HW, Qiu MH, Yang L*. Rapid Qualitative and Quantitative Determination of Seven Valuable Taxanes from Various Taxus Species by UFLC-ESI-MS and UFLC-DAD. Planta Medica, 2010; 76(15):1773-7.
(13) Wang AX, Ge GB, Qi XY, Hu Y, Liang SC, Yang L, Tu CX. Rapid Profiling and Target Analysis of Principal Components in Fuling Decoctions by UFLC-DAD-ESI-MS. Fitoterapia, 2010; 81: 662-667.
(14) Liang SC, Ge GB, Liu HX, Zhang YY, Zhang JW, Yin L, Li W, Fang ZZ, Wang LM, Yang L*. Identification and Characterization of Human UDP- Glucuronosyltransferases responsible for the in vitro Glucuronidation of Daphnetin. Drug Metabolism and Disposition, 2010; 38: 973-980.
(15) Yan J, Sun LR, Li W, Zhou L, Li ZR, Zhang XM, Yang L, Qiu MH. Cytotoxic Serratane Triterpenes from Diphasiastrum complanatum with a Hydroxy Group at C-27. Planta Medica. 2010; 76(4): 353-357.
(16) Sun DX, Fang ZZ, Zhang YY, Cao YF, Yang L, Yin J. Inhibitory effect of curcumenol on human liver cytochrome P450 enzymes. Phytotherapy Research, 2010; 24(8):1213-1216.
(17) Ai CZ, Li Y, Wang YH, Li W, Dong PP, Ge GB, Yang L*. Investigation of binding features: Effects on the interaction between P450 2A6 and inhibitors. Journal of Computational Chemistry, 2010; 31(9):1822-1831.
(18) Li RB, Wu RA, Zhao L, Wu MH, Yang L, Zou HF. P-Glycoprotein Antibody Functionalized Carbon Nanotube Overcomes the Multidrug Resistance of Human Leukemia Cells. ACS Nano. 2010; 4 (3): 1399–1408.
(19) He YQ, Yang L, Liu HX, Zhang JW, Liu Y, Fong A, Xiong AZ, Lu YL, Yang L, Wang CH and Wang ZT. Glucuronidation, a new metabolic pathway of pyrrolizidine alkaloids. Chemical Research in Toxicology. 2010, 23 (3): 591–599.
(20) He YQ, Liu Y, Zhang BF, Liu HX, Lu YL, Yang L, Xiong AZ, Xu LL, Wang CH, Yang L, and Wang ZT. Identification of the UDP-Glucuronosyltransferase Isozyme Involved in Senecionine Glucuronidation in Human Liver Microsomes. Drug Metabolism and Disposition, 2010; 38: 626-634.
(21) Fang ZZ, Zhang YY, Ge GB, Huo H, Liang SC, Yang L*. Time-dependent inhibition (TDI) of CYP3A4 and CYP2C9 by noscapine potentially explains clinical noscapine-warfarin interaction. British Journal of Clinical Pharmacology, 2010; 69(2):193-199.
(22) Cao YF, Zhang YY, Li J, Ge GB, Hu D, Liu HX, Huang T, Wang YC, Fang ZZ, Sun DX, Huo H, Yin J, Yang L. CYP3A Catalyzes Schizandrin Biotransformation in Human, Minipig and Rat Liver Microsomes. Xenobiotica, 2010; 40(1): 38–47.
(23) Zhang YY, Liu Y, Zhang JW, Ge GB, Liu HX, Wang LM, Sun J, Yang L. C-7 Configuration as One of Determinants in Taxanes Metabolism by Human Cytochrome P450 Enzymes. Xenobiotica, 2009; 39(12): 903–914.
(24) He Y, Yang L, Liu Y, Zhang J, Tang J, Su J, Li Y, Lu Y, Wang C, Yang L, Wang Z. Characterization of cardamonin metabolism by P450 in different species via HPLC-ESI-ion trap and UPLC-ESI-quadrupole mass spectrometry. Acta Pharmacologica Sinica, 2009; 30: 1462–70.
(25) Dong PP, Ge GB, Zhang YY, Ai CZ, Li GH, Zhu LL, Luan HW, Liu XB, Yang L. Quantitative structure-retention relationship studies for taxanes including epimers and isomeric metabolites in ultra fast liquid chromatography. Journal of Chromatography A, 2009; 1216: 7055–62.
(26) Liu HX, Hu Y, He YQ, Liu Y, Li W, Yang L. Ultra-performance liquid chromatographic–electrospray mass spectrometric determination (UPLC-ESI-MS) of O-demethylated metabolite of paeonol in vitro: Assay development, human liver microsome activities and species differences. Talanta, 2009; 79(5):1433-40.
(27) Li RB, Wu RA, Wu MH, Zou HF, Ma H, Yang L, Le XC. MEKC-LIF analysis of rhodamine123 delivered by carbon nanotubes in K562 cells. Electrophoresis, 2009; 30(11):1906-12.
(28) Liu HX, Hu Y, Liu Y, He YQ, Li W, Yang L. CYP1A2 is the major isoform responsible for paeonol O-demethylation in human liver microsomes. Xenobiotica, 2009; 39 (9): 672-9.
(29) Zhang YY, Yang L. Interactions between human cytochrome P450 enzymes and steroids: physiological and pharmacological implications. Expert Opinion on Drug Metabolism and Toxicology ((Invited review), 2009; 5(6):621-9.
(30) Chen JJ, Zhang JW, Yang L, Li W. Structure elucidation of major metabolites from medroxyprogesterone acetate by P450. Chemical & Pharmaceutical Bulletin, 2009; 57 (8): 1-16.
(31) Liu HX, Hu Y, Liu Y, He YQ, Li W, Yang L. Hydroxylation of tanshinone IIa in human liver microsomes is specifically catalysed by cytochrome P4502A6. Xenobiotica, 2009; 39(5):382-90.
(32) Hu Y, Luan HW, Liu HX, Ge GB, Zhou K, Liu Y, Yang L. The acceptor specificity and transfer efficiency of a β-glycosidase from the China white jade snail. Bioscience Biotechnology and Biochemistry, 2009; 73(3):671-6.
(33) Zhang YY, Liu, Y, Zhang JW, Ge GB; Wang LM, Sun J, Yang L. Characterization of human cytochrome P450 isoforms involved in the metabolism of 7-epi-paclitaxel. Xenobiotica, 2009; 39(4): 283–292.
(34) Lei XY, Kong L, Zou HF, Ma H and Yang L. Evaluation of the interaction of bioactive compounds in Cortex Pseudolarix and Radix Stephaniae by the microdialysis probe coupled with high performance liquid chromatography–mass spectrometry. Journal of Chromatography A, 2009; 1216(11):2179-84.
(35) Ai CZ, Li Y，Wang YH， Chen Y, Yang L. Insight into the effects of chiral isomers quinidine and quinine on CYP2D6 inhibition. Bioorganic & Medicinal Chemistry Letters, 2009; 19(3): 803-6.
(36) Li W, Liu Y, Zhang JW, Ai CZ, Xiang N, Liu HX, Yang L. Structure-activity relationship of anti-prostate cancer effects of ginsenosides in vitro. Archives of Pharmacal Research, 2009; 32(1) 49-57.
(37) Ge GB, Zhang R, Ai CZ, Zhang YY, He YQ, Liu XB, Yang L, Wang ZT, Yang L. Stereochemical differentiation of C-7 hydroxyl taxane isomers by electrospray ionization mass spectrometry. Rapid Communications in Mass Spectrometry, 2009; 23(3): 425-32.
(38) Hu Y, Luan HW, Ge GB, Liu HX, Zhou K, Liu Y, Yang L. Deoxynojirimycin enhanced the transglycosylation activity of a glycosidase from the China White Jade Snail. Journal of biotechnology, 2009; 139: 229-35.
(39) Hao DC, Huang B, Yang L. Molecular evolution of paclitaxel biosynthetic genes TS and DBAT of Taxus species. Genetica, 2009; 135(2): 123-135.
(40) Li W, Liu Y, He YQ, Zhang JW, Gao Y, Ge GB, Liu HX, Liu HT, Wang LM, Sun J, Wang Q, Yang L. Characterization of triptolide hydroxylation by cytochrome P450 in human and rat liver microsomes. Xenobiotica, 2008; 38(12): 1551–65.
(41) Yang L, Xiong AZ, He YQ, Wang ZY, Wang CH, Wang ZT, Li W, Yang L and ZB Hu. Bile Acids Metabonomic Study on the CCl4- and α-Naphthylisothiocyanate-Induced Animal Models: Quantitative Analysis of 22 Bile Acids by Ultraperformance Liquid Chromatography−Mass Spectrometry. Chemical Research in Toxicology, 2008, 21 (12), 2280–8.
(42) Hao DC, Ge GB, Yang L. Bacterial diversity of Taxus Rhizosphere: culture-independent and culture-dependent approaches. FEMS Microbiology Letters, 2008; 284(2): 204–12.
(43) Hao DC, Huang B, Xiao PG, Ge GB, Yang L. Interspecific relationships and origins of Taxaceae and Cephalotaxaceae revealed by chloroplast and nuclear DNA sequences. Plant Systematics and Evolution, 2008; 276: 89-104.
(44) Zhang JW, Liu Y, Zhao JY, Wang LM, Ge GB, Gao Y, Li W, Liu HT, Liu HX, Zhang YY, Sun J, and Yang L. Metabolic profiling and P450 reaction phenotyping of medroxyprogesterone acetate. Drug metabolism and disposition, 2008; 36(11): 2292-8.
(45) Ai CZ, Li Y, Wang YH, Li YH, Yang L. A 3D-QSAR Study of Catechol-O-methyltransferase Inhibitors using CoMFA and CoMSIA. QSAR & Combinatorial Science, 2008; 27 (10): 1183-92.
(46) Ai CZ, Sun RA, Wang CS, Ma L, Yang L. Theoretical studies on hydrogen overfall mechanism for catalyzed hydroisomerization of n-hexane. Chemical Journal of Chinese University-CHINESE, 2008; 29(1): 182-86. (in Chinese)
(47) Liu HX, Liu Y, Zhang JW, Li W, Liu HT, Yang L. UDP-glucuronosyltransferase 1A6 is the major isozyme responsible for protocatechuic aldehyde glucuronidation in human liver microsomes. Drug Metabolism and Disposition, 2008; 36(8): 1562-9.
(48) Ge GB, Luan HW, Zhang YY, He YQ, Liu XB, Yang L, Wang ZT, Yang L. Profiling of yew hair roots from various species using ultra-performance liquid chromatography-electrospray ionization mass spectrometry. Rapid Communications in Mass Spectrometry, 2008; 22(15): 2315-23.
(49) Liu HX, He YQ, Hu Y, Liu Y, Zhang JW, Li W, Wang ZT, Yang L. Determination of UDP-glucuronosyltransferase UGT2B7 activity in human liver microsomes by ultra-performance liquid chromatography with MS detection. Journal of Chromatography B, 2008; 870(1): 84-90.
(50) Ge GB, Zhang YY, Hao DC, Hu Y, Luan HW, Liu XB, He YQ, Wang ZT, Yang L. Chemotaxonomic study of medicinal Taxus species with fingerprint and multivariate analysis. Planta Medica., 2008; 74: 773-9.
(51) Hu Y, Luan HW, Zhou K, Ge GB, Yang SL, Yang L. Purification and characterization of a novel glycosidase from China White Jade Snail (Achatina fulica) showing transglycosylation activity. Enzyme and Microbial Technology, 2008; 43(1): 35-42.
(52) Zhang JW, Ge GB, Liu Y, Wang LM, Liu XB, Zhang YY, Li W, He YQ, Wang ZT, Sun J, Xiao HB, Yang L. Taxane's substituents at C3' affect its regioselective metabolism- Different in vitro metabolism of cephalomannine and paclitaxel. Drug Metabolism and Disposition, 2008; 36(2): 418-26.
(53) Hao DC, Huang B, Yang L. Phylogenetic relationships of the genus Taxus inferred from chloroplast intergenic spacer and nuclear coding DNA. Biological and Pharmaceutical Bulletin, 2008; 31(2): 260-5.
(54) Dong PP, Zhang YY, Ge GG, Ai CZ, Liu Y, Yang L, Liu CX. Modeling resistance index of taxoids to MCF-7 cell lines using ANN together with electrotopological state descriptors. Acta Pharmacologica Sinica, 2008; 29(3): 385-96.
(55) Zhang JW, Liu Y, Cheng J, Li W, Ma H, Liu HT, Sun J, Wang LM, He YQ, Wang Y, Wang ZT, Yang L. Inhibition of human liver cytochrome P450 by star fruit juice. Journal of Pharmacy & Pharmaceutical Sciences, 2007; 10(4): 496-503.
(56) Hao DC, Sun J, Furnes B, Schlenk D, Li MX, Yang SL, Yang L. Allele and genotype frequencies of polymorphic FMO3 gene in two genetically distinct populations. Cell Biochemistry and Function, 2007; 25(4): 443-53.
(57) Hu Y, Luan HW, Hao DC, Xiao HB, Yang SL, Yang L. Purification and characterization of a novel Ginsenoside-hydrolyzing β-D-glucosidase from the China white jade snail (Achatina fulica). Enzyme and Microbial Technology, 2007; 40: 1358-66.
(58) Xiao H, Yang LS, Zou HF, Yang L, Le XC. Analysis of oxidized multi-walled carbon nanotubes in single K562 cells by capillary electrophoresis with laser-induced fluorescence. Analytical Bioanalytical Chemistry, 2007; 387: 119-126.
(59) Hao DC, Zhu PH, Yang SL, Yang L. Enhanced production of human CYP2C9 by Escherichia coli BL21(DE3)pLysS through the novel use of grey relational analysis and Plackett Burman design. World Journal of Microbiology and Biotechnology, 2007; 23: 71-8.
(60) Hao DC, Sun J, Furnes B, Schlenk D, Hou ZF, Zhang YP, Yang SL, Yang L. Haplotype frequency distribution and linkage disequilibrium analysis of single nucleotide polymorphisms at the human FMO3 gene locus. Biochemical Genetics, 2006, 44: 391-407.
(61) Li YH, Wang YH, Li Y, Yang L. Prediction of the deleterious nsSNPs in ABCB transporters. FEBS Letters, 2006; 580(30): 6800-906.
(62) Xiao H, Zou HF, Pan CS, Jiang XG, Le XC, Yang L. Quantitative determination of oxidized carbon nanotube probes in yeast by capillary electrophoresis with laser-induced fluorescence detection. Analytica Chimica Acta., 2006; 580: 194-9.
(63) Hao DC, Zhu PH, Yang SL, Yang L. Optimization of recombinant cytochrome P450 2C9 protein production in Escherichia coli DH5α by statistically-based experimental design. World Journal of Microbiology and Biotechnology, 2006; 22(11): 1169-76.
(64) Wang YL, Hao DC, Stein WD, Yang L. A kinetic study of Rhodamine123 pumping by P-glycoprotein. Biochimica et Biophysica Acta, 2006; 1758(10): 1671-6.
(65) Xiao H, Li X, Zou HF, Yang L, Wang YL, Wang HL, Le XC. Capillary electrophoresis/laser-induced fluorescence coupled with flow cytometry for high-throughput quantitation of fluorophores in single intact cells. Electrophoresis, 2006; 27: 3452-9.
(66) Luan HW, Li X, Qi XH, Hu Y, Hao DC, Cui Y, Yang L. Purification and characterization of a novel stable β-D-glucosidase hydrolyzing ginsenoside Rb1 into Rd from China white jade snail. Process Biochemistry, 2006; 41: 1974-80.
(67) Yang L, Liu Y, Liu CX. Metabolism and pharmacokinetics of ginsenosides. Asian Journal of Pharmacodynamics and Pharmacokinetics, 2006; 6: 103-20.
(68) Li J, Liu Y, Zhang JW, Wei H, Yang L. Characterization of hepatic drug-metabolizing activities of Bama miniature pigs (Sus scrofa domestica): Comparison with Human Enzyme Analogs. Comparative Medicine, 2006; 56(4): 286-90.
(69) Zhang JW, Liu Y, Li W, Hao DC, Yang L. Inhibitory effect of medroxyprogesterone acetate on human liver cytochrome P450 enzymes. European Journal of Clinical Pharmacology, 2006; 62: 497-502.
(70) Wang YH, Li Y, Li YH, Ma XH, Yang SL, Yang L. Investigations into the analysis and modeling of the cytochrome P450 cycle. Journal of Physical Chemistry B, 2006; 110: 10139-43.
(71) Liu Y, Zhang JW, Li W, Ma H, Sun J, Deng MC, Yang L. Ginsenoside metabolites, rather than naturally occurring ginsenosides, lead to inhibition of human cytochrome P450 enzymes. Toxicological Sciences, 2006; 91(2): 356-64.
(72) Li YH, Wang YH, Sun J, Li Y, Yang L. Distribution of the functional MDR1 C3435T polymorphism in the Han population of China. Swiss Medical Weekly, 2006; 136: 377-82.
(73) Han QB, Yang L, Liu Y, Wang YL, Qiao CF, Song JZ, Xu LJ, Yang DJ, Chen SL, Xu HX. Gambogic acid and epigambogic acid, C-2 epimers with movel anticancer effects form Garcinia hanburyi. Planta Medica, 2006; 72(3): 281-4.
(74) Cheng J, Wan DF, Gu JR, Gong Y, Yang SL, Hao DC, Yang L. Establishment of a yeast system that stably expressed human cytochrome P450 reductase: application for the study of drug metabolism of cytochrome P450s in vitro. Protein Expression and Purification, 2006; 47: 467-76.
(75) Li Y, Wang YH, Yang L,Zhang SW, Liu CH. Impact of molecular hydrophobic field on passive diffusion, P-glycoprotein active efflux,and P-glycoprotein modulation of steroids. Internet Electronic Journal of Molecular Design, 2006; 5(2): 60-78.
(76) Wang Y, Wang HM, Wang YH, Yang CL, Yang L, Han KL. Theoretical study of the mechanism of acetaldehyde hydroxylation by compound I of CYP2E1. Journal of Physical Chemistry B, 2006; 110: 6154-9.
(77) Han QB, Wang YL, Yang L, Tso TF, Qiao CF, Song JZ, Xu LJ, Chen SL, Yang DJ, Xu HX. Cytotoxic xanthones from the resin of Garcinia hanburyi. Chemical & Pharmaceutical Bulletin, 2006; 54: 265-7.
(78) Han QB, Yang L, Wang YL, Qiao CF, Song JZ, Sun HD, and Xu HX. A pair of novel cytotoxic polyprenylated xanthone epimers from Gamboges. Chemistry & Biodiversity, 2006; 3: 101-5.
(79) Li Y, Wang YH, Yang L, Zhang SW, Liu CH. Structural determinants of flavones interacting with the C-terminal nucleotide-binding domain as P-glycoprotein inhibitors. Internet Electronic Journal of Molecular Design, 2006; 5: 1-12.
(80) Liu Y, Yang L. Early metabolism evaluation making traditional Chinese medicine effective and safe therapeutics. Journal of Zhejiang University SCIENCE B, 2006; 7(2): 99-106.
(81) Xiao H, Li X, Zou HF, Yang L, Yang YQ, Wang YL, Le XC. Immunoassay of P-glycoprotein on single cell by capillary electrophoresis with laser induced fluorescence detection. Analytica Chimica Acta, 2006; 556: 340-6.
(82) Li YH, Wang YH, Li Y, Yang L. MDR1 Gene Polymorphisms and clinical relevance. Acta Genetica Sinica, 2006; 33(2): 93-104.
(83) Liu Y, Ma H, Zhang JW, Deng MC, Yang L. Influence of ginsenoside Rh1 and F1 on human cytochrome P450 enzymes. Planta Medica, 2006; 72(2): 126-31.
(84) Wang C, Yang L,Yang SL. Three dimensional quantitative structure-activity relationship of 4,5,6,7- tetrahydrothieno- pyridines analogues as glucose-6-phosphatase inhibitors. Journal of Molecular Structure, 2006; 782: 49-54.
(85) D Jiang, YH Wang, Y Li, Yang L, SW Zhang, SL Yang. Prediction of saccharomyces cerevisiae growth phenotypes based on elementary flux mode analysis. Chemical Journal of Chinese University-CHINESE, 2006, 27(9): 1683-5.
(86) Yonghua Wang, Yan Li, Yanhong Li, Yang SL, Yang L. Modeling Km values using electrotopological state: substrates for cytochrome P450 3A4-mediated metabolism. Bioorganic and Medicinal Chemistry Letters, 2005, 15: 4076-84.
(87) Wang YH, Li Y, Yang SL, Yang L. Classification of substrates and inhibitors of P-glycoprotein using unsupervised machine learning approach. Journal of Chemical Information and Computer Sciences, 2005; 45(3): 750-7.
(88) Li Y, Wang YH, Yang L, Zhang SW, Liu CH，Yang SL. Comparison of steroid substrates and inhibitors of P-glycoprotein by 3D-QSAR analysis. Journal of Molecular Structure, 2005; 733: 111-8.
(89) Wang YH, Li Y, Yang SL, Yang L. An in silico approach for screening flavonoids as P-glycoprotein inhibitors based on bayesian-regularized neural network. Journal of Computer-Aided Molecular Design, 2005; 19(3): 137-47.
(90) He KJ, Liu Y, Yang Y, Li P, Yang L. A dammarane glycoside derived from ginsenoside Rb3. Chemical & Pharmaceutical Bulletin, 2005; 53(2): 177-9.
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Patents
PATENTS
1. US60/752,961. Novel Compounds from Garcinia Hanburyi and Their Use in Treating Cancer and Enhancing Other Drug's Bioavailability.
2. WO2004 054590 A1. A novol anticancer ginsenoside.
3. WO2004 054595 A1. A heat treated method for preparing low-polar ginsenosides and their aglycone.
4. WO03 040383 A1. An enzymic hydrolysis method for preparing 20-β-Dglucoside- proginsediol from ginsenoside.
5. PCT/CN2008/000593. A novel method for preparation of paclitaxel and its derivatives.
6. PCT/CN2008/000594. A novel method for preparation of paclitaxel, baccatin III and their derivatives.
7. CN101608212 Methods of measuring the activity of cytochrome P4503A using deoxyschizandrin.
8. CN101613388 Coumarin glucuronides and its application
9. CN101307041 A series of novel taxane analogous with anticancer activities.
10. CN101307040 A method for isolation of paclitaxel.
11. CN101274924 A method for preparation of paclitaxel and its analogous.
12. CN101274923 A method for preparation of paclitaxel, baccatin III and their analogous.
13. CN101191144 A method for authentification and distinguishing of medicinal plant Taxus.
14. CN101143858 A method for selective acylation of C-10 and C-2’ hydroxyl groups of taxanes.
15. CN101143883 A method for preparation of mixture of taxane glycosides from natural yew resources.
16. CN01133410.X Preparation of ginsenoside 20-β-D-glucopyranosyl-protopanaxadiol by enzyme degradation.
17. CN101054561 A microorganism for hydrolysis of taxane glycosides.
18. CN101139376 A method for prepartion of 10-deacetyl-7-xylsoylbaccatin III and 7-xylsoylbaccatin III.
19. CN101139329 A method for selective acylation of C-10 hydroxyl group of taxanes.
20. CN03213378.2 A kind of fast liquid chromatography.
21. CN03/01056 A new type of anti-cancer ginsenoside
22. CN03/01055 A preparation method of less polar ginsenosides and saponins by heat-treatment
23. CN10021415.3 A preparation method of paclitaxel
24. CN10021414.9 A preparation method of Danshensu (Salvianic A)
25. CN03134091.1 A series of compounds of ginsenosides, less polar and anti-cancer agent
26. CN03134090.3 A preparation method of less polar individual ginsenosides and saponins by base hydrolysis
27. CN03133507.1 A kind of an axial compression chromatography column
28. CN03133506.3 A kind of assembled dry-column
29. CN02/00786 Preparation of ginsenoside 20-β-D-glucopyranosyl-protopanaxadiol by enzyme degradation.
30. CN02144781.0 anti-cancer agent of derivatives of ginsenoside saponins.
31. CN02144780.2 A preparation method of less polar ginsenosides and saponins by heat-treatment.
32. CN02144779.9 Preparation method of a new type anti-cancer ginsenoside.
33. CN02144778.0 A new type of anti-cancer ginsenoside.
34. CN02144776.4 anti-cancer agent of derivatives of ginsenoside saponins.
35. CN02144773.X Preparative method of saponins of ginsenosides.
36. CN02132403.4 A preparation method of less polar rare ginsenosides by Aspergillus niger.
37. CN 02109790.9 A preparation method of ginsenosides Rk1 and Rg5 by acid hydrolysis.
38. CN 01138817.X A purification method of ginsenoside with the combination of resins.
39. CN01133409.6 A preparation method of ginsenoside Rg3 with acid hydrolysis.
40. CN01133408.8 A preparation method of protopanaxadiol by acid hydrolysis.
1. US60/752,961. Novel Compounds from Garcinia Hanburyi and Their Use in Treating Cancer and Enhancing Other Drug's Bioavailability.
2. WO2004 054590 A1. A novol anticancer ginsenoside.
3. WO2004 054595 A1. A heat treated method for preparing low-polar ginsenosides and their aglycone.
4. WO03 040383 A1. An enzymic hydrolysis method for preparing 20-β-Dglucoside- proginsediol from ginsenoside.
5. PCT/CN2008/000593. A novel method for preparation of paclitaxel and its derivatives.
6. PCT/CN2008/000594. A novel method for preparation of paclitaxel, baccatin III and their derivatives.
7. CN101608212 Methods of measuring the activity of cytochrome P4503A using deoxyschizandrin.
8. CN101613388 Coumarin glucuronides and its application
9. CN101307041 A series of novel taxane analogous with anticancer activities.
10. CN101307040 A method for isolation of paclitaxel.
11. CN101274924 A method for preparation of paclitaxel and its analogous.
12. CN101274923 A method for preparation of paclitaxel, baccatin III and their analogous.
13. CN101191144 A method for authentification and distinguishing of medicinal plant Taxus.
14. CN101143858 A method for selective acylation of C-10 and C-2’ hydroxyl groups of taxanes.
15. CN101143883 A method for preparation of mixture of taxane glycosides from natural yew resources.
16. CN01133410.X Preparation of ginsenoside 20-β-D-glucopyranosyl-protopanaxadiol by enzyme degradation.
17. CN101054561 A microorganism for hydrolysis of taxane glycosides.
18. CN101139376 A method for prepartion of 10-deacetyl-7-xylsoylbaccatin III and 7-xylsoylbaccatin III.
19. CN101139329 A method for selective acylation of C-10 hydroxyl group of taxanes.
20. CN03213378.2 A kind of fast liquid chromatography.
21. CN03/01056 A new type of anti-cancer ginsenoside
22. CN03/01055 A preparation method of less polar ginsenosides and saponins by heat-treatment
23. CN10021415.3 A preparation method of paclitaxel
24. CN10021414.9 A preparation method of Danshensu (Salvianic A)
25. CN03134091.1 A series of compounds of ginsenosides, less polar and anti-cancer agent
26. CN03134090.3 A preparation method of less polar individual ginsenosides and saponins by base hydrolysis
27. CN03133507.1 A kind of an axial compression chromatography column
28. CN03133506.3 A kind of assembled dry-column
29. CN02/00786 Preparation of ginsenoside 20-β-D-glucopyranosyl-protopanaxadiol by enzyme degradation.
30. CN02144781.0 anti-cancer agent of derivatives of ginsenoside saponins.
31. CN02144780.2 A preparation method of less polar ginsenosides and saponins by heat-treatment.
32. CN02144779.9 Preparation method of a new type anti-cancer ginsenoside.
33. CN02144778.0 A new type of anti-cancer ginsenoside.
34. CN02144776.4 anti-cancer agent of derivatives of ginsenoside saponins.
35. CN02144773.X Preparative method of saponins of ginsenosides.
36. CN02132403.4 A preparation method of less polar rare ginsenosides by Aspergillus niger.
37. CN 02109790.9 A preparation method of ginsenosides Rk1 and Rg5 by acid hydrolysis.
38. CN 01138817.X A purification method of ginsenoside with the combination of resins.
39. CN01133409.6 A preparation method of ginsenoside Rg3 with acid hydrolysis.
40. CN01133408.8 A preparation method of protopanaxadiol by acid hydrolysis.
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