General

Wang Xueying,  Female, 

Dalian Institute of Chemical Physics, Chinese Academy of Sciences

Email: wangxueying@dicp.ac.cn

Address: Dalian Institute of Chemical Physics, CAS, 457 Zhongshan Road, Dalian, Chine 116023

Research Areas

1. Creating non-natural coenzyme-preferred oxidoreductases.

2. Constructing reaction systems mediated by non-natural coenzymes.

3. Constructing microbial cell factories driven by non-natural coenzyme-mediated selective regulation.  

Education


Publications

   
Papers

  1. Wan L, Wang XY*, Hu YH, Li Q, Zhao ZK. “Gram-scale biocatalytic  preparation of the non-natural cofactor nicotinamide cytosine dinucleotide” Tetrahedron Lett. 2022,  88, 153368.

  2. Wang XY, Feng YB, Guo XJ, Wang Q, Ning SY, Li Q, Wang JT, Wang L, Zhao ZK*. “Creating enzymes and self-sufficient cells for biosynthesis of the non-natural cofactor nicotinamide cytosine dinucleotide” Nat. Commun. 2021, 12(1), 2116.

  3. Guo XJ, Liu YX, Wang Q, Wang XY, Li Q, Liu WJ, Zhao ZK*. “Non-natural cofactor and formate-driven reductive carboxylation of pyruvate” Angew. Chem. Int. Ed. 2020, 59(8), 3143–3146.

  4. Guo XJ, Wang XY, Liu YX, Li Q, Wang JT, Liu WJ*, Zhao ZK*. “Structure-guided design of formate dehydrogenase for regeneration of a non-natural redox cofactor” Chem. Eur. J. 2020, 26(70), 16611–16615.

  5. Guo XJ, Feng YB, Wang XY, Liu YX, Liu WJ, Li Q, Wang JT, Xue S, Zhao ZK*. “Characterization of the substrate scope of an alcohol dehydrogenase commonly used as methanol dehydrogenase” Bioorg. Med. Chem. Lett. 2019, 29(12), 1446–1449.

  6. Liu YX, Feng YB, Wang L, Guo XJ, Liu WJ, Li Q, Wang XY, Xue S*, Zhao ZK*. “Structural insights into phosphite dehydrogenase variants favoring a non-natural redox cofactor” ACS Catal. 2019, 9, 1883–1887.

  7. Guo XJ, Shen HW, Liu YX, Wang Q, Wang XY, Peng C, Liu WJ, Zhao ZK*. “Enabling heterologous synthesis of lupulones in the yeast Saccharomyces cerevisiae” Appl. Biochem. Biotechnol. 2019, 188, 787–797.

  8. Wang XY, Wang L, Lin XP, Yang XB, Liu WJ, Zhao ZK*. “Visualizing soluble protein mutants by using monomeric red fluorescent protein as a reporter for directed evolution.”Appl Biochem Biotechnol. 2018, 185(1), 81-90.

  9. Sun WY, Yang XB, Wang XY, Jiao X, Zhang SF, Luan YS, Zhao ZK*. “Developing a flippase-mediated maker recycling protocol for the oleaginous yeastRhodosporidium toruloides.” Biotechnol. Lett. 2018, 40(6), 993-940.

  10. Wang XY, Zhou YJ, Wang L, Liu WJ, Peng C, Zhao ZK*. “EngineeringEscherichia colinicotinic acid mononucleotide adenylyltransferase for fully active amidated NAD biosynthesis.” Appl Environ Microbiol. 2017, 81(13), e00692-17.

  11. Sun WY, Yang XB, Wang XY, Lin XP, Wang YN, Zhang SF, Luan YS, Zhao ZK*. “Homologous gene targeting of a carotenoids biosynthetic gene inRhodosporidium toruloidesby Agrobacterium mediated transformation” Biotechnol. Lett. 2017, 39(7), 1001-1007.

  12. Wang L, Ji DB, Liu YX, Wang Q, Wang XY, Zhou YJ, Zhang YX, Liu WJ*, Zhao ZK*. “Synthetic cofactor-linked metabolic circuits for selective energy transfer” ACS Catal. 2017, 7(3), 1977–1983.

  13. Zhang YX, Liu WJ, Sohail M, Wang XY, Liu YX, Zhao ZK*. “Enzymatic allylation of catechols” Chem. Lett. 2015, 44(7), 949–951.

  14. 王磊，刘武军，刘玉雪，王雪颖，赵宗保*. “正交氧化还原体系及其应用” 中国科学：生命科学 2015, 45(10), 969–975.

  15. Lin XP, Wang YN, Zhang SF, Zhu ZW, Zhou YJ, Yang F, Sun WY, Wang XY, Zhao ZK*. “Functional integration of multiple genes into the genome of the oleaginous yeastRhodosporidium toruloides” FEMS Yeast Res. 2014, 14(6), 547–555.