Dr. Tan’s  research interest is mainly focused on developing mass spectrometry-based chemical proteomics technologies to characterize protein post-translational modifications (PTMs), investigate the roles of PTMs in diseases, and identify new therapeutic opportunities and biomarkers.  

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09/1999-06/2003,  B.Sc. degree in Pharmacy, Fudan University
09/2003-07/2008,  Ph.D. degree in Medicinal Chemistry, Shanghai Institute of MateriaMedica, Chinese Academy of Sciences

1.        Guo A, Yan K, Hu, H, Zhai L, Hu T, Su,H, Chi Y, Zha,J, Xu Y, Zhao,Y Lu X, Xu Y, Zhang J, Tan M*, Chen X*.  (2023) Spatiotemporal and global profiling of DNA-protein interactions enables discovery of low-affinity transcription factors. Nat Chem (in press)

2.        Zhao WS, Chen KF, Liu M, Jia XL, Huang YQ, Hao BB, Hu H, Shen XY, Yu Q, Tan M*. (2023) Investigation of targets and anticancer mechanisms of covalently acting natural products by functional proteomics. Acta Pharmacol Sin Online ahead of print

3.        Zhang M, Liu T, Wang L, Huang Y, Fan R, Ma K, Kan Y, Tan M*, Xu JY*.  (2023) Global landscape of lysine acylomes in Bacillus subtilis. J Proteomics. 271:104767.

4.        Dong Y, Hu H, Zhang X, Zhang Y, Sun X, Wang H, Kan W, Tan M, Shi H, Zang Y, Li J. (2023) Phosphorylation of PHF2 by AMPK releases the repressive H3K9me2 and inhibits cancer metastasis. Signal Transduct Target Ther 8(1):95

5.        Zhou Q, Hao B, Cao X, Gao L, Yu Z, Zhao Y, Zhu M, Zhong G, Chi F, Dai X, Mao J, Zhu Y, Rong P, Chen L, Bai X, Ye C, Chen S, Liang T, Li L, Feng XH*, Tan M*, Zhao B*.  (2022) Energy sensor AMPK gamma regulates translation via phosphatase PPP6C independent of AMPK alpha. Mol Cell.  82(24):4700-4711

6.        Zhai LH, Chen KF, Hao BB, Tan M*. Proteomic characterization of post-translational modifications in drug discovery. Acta Pharmacol Sin. 2022, 43:3112-3129. (invited review)

7.        Zhai L, Wang L, Hu H, Liu Q, Lee S, Tan M*, Zhang Y.* (2022)  PBC, an easy and efficient strategy for high-throughput protein C-terminome profiling. Front Cell Dev Biol. 10:995590.

8.        Liu P, Cong X, Liao S, Jia X, Wang X, Dai W, Zhai L, Zhao L, Ji J, Ni D, Liu Z, Chen Y, Pan L, Liu W, Zhang J, Huang M, Liu B*, Tan M*. (2022) Global identification of phospho-dependent SCF substrates reveals a FBXO22 phosphodegron and an ERK-FBXO22-BAG3 axis in tumorigenesis. Cell Death Differ 2022 29(1):1-13. 

9.        Liu Q, Hao B, Zhang M, Liu Z, Huang Y, Zhao X, Hu H, Tan M*, Xu JY*. An Integrative Proteome-Based Pharmacologic Characterization and Therapeutic Strategy Exploration of SAHA in Solid Malignancies. J Proteome Res. 21(4):953-964. 

10.    Li N, Liu Q, Han Y, Pei S, Cheng B, Xu J, Miao X, Pan Q, Wang H, Guo J, Wang X, Zhang G, Lian Y, Zhang W, Zang Y, Tan M, Li Q, Wang X, Xiao Y, Hu G, Jiang J, Huang H, Qin J. (2022) ARID1A loss induces polymorphonuclear myeloid-derived suppressor cell chemotaxis and promotes prostate cancer progression. Nat Commun. 13:7281.

11.    Lao L, Bourdeau I, Gagliardi L, He X, Shi W, Hao B, Tan M, Hu Y, Peng J, Coulombe B, Torpy DJ, Scott HS, Lacroix A, Luo H, Wu J. (2022) ARMC5 is part of an RPB1-specific ubiquitin ligase implicated in adrenal hyperplasia. Nucleic Acids Res. 50(11):6343-6367.

12.    Wang X, Chen Z, Xu J, Tang S, An N, Jiang L, Zhang Y, Zhang S, Zhang Q, Shen Y, Chen S, Lan X, Wang T, Zhai L, Cao S, Guo S, Liu Y, Bi A, Chen Y, Gai X, Duan Y, Zheng Y, Fu Y, Li Y, Yuan L, Tong L, Mo K, Wang M, Lin SH, Tan M, Luo C, Chen Y, Liu J, Zhang Q, Li L, Huang M. (2022) SLC1A1-mediated cellular and mitochondrial influx of R-2-hydroxyglutarate in vascular endothelial cells promotes tumor angiogenesis in IDH1-mutant solid tumors. Cell Res. 2022 Jul;32(7):638-658.

13.    Ren J, Li N, Pei S, Lian Y, Li L, Peng Y, Liu Q, Guo J, Wang X, Han Y, Zhang G, Wang H, Li Y, Jiang J, Li Q, Tan M, Peng J, Hu G, Xiao Y, Li X, Lin M, Qin J. (2022) Histone methyltransferase WHSC1 loss dampens MHC-I antigen presentation pathway to impair IFN-γ-stimulated antitumor immunity. J Clin Invest. 132(8):e153167

14.    Li Y, Xu J, Lu Y, Bian H, Yang L, Wu H, Zhang X, Zhang B, Xiong M, Chang Y, Tang J, Yang F, Zhao L, Li J, Gao X, Xia M*, Tan M*, Li J*. (2021) DRAK2 aggravates nonalcoholic fatty liver disease progression through SRSF6-associated RNA alternative splicing. Cell Metab 33: 2004-2020. 

15.    Liu Z, Liu Y, Qian L, Jiang S, Gai X, Ye S, Chen Y, Wang X, Zhai L, Xu J, Pu C, Li J, He F, Huang M*, and Tan M*. (2021) A proteomic and phosphoproteomic landscape of KRAS mutant cancers identifies combination therapies. Mol Cell, 2021, 81: 4076-4090  

16.    Liu Q, Zhai L, Han M, Shi D, Sun Z, Peng S, Wang M, Zhang C, Gao J, Yan W, Jiang Q, Chen D, Xu Q*, Tan M*, Sun Y*. (2021) SHP2 inhibition attenuates osteoarthritis by maintaining homeostasis of cartilage metabolism via the DOK1/UPP1/uridine cascade. Arthritis Rheumatol doi: 10.1002/art.41988. Online ahead of print. 

17.    Cheng X, Zhao W, Zhu M, Wang B, Wang X, Yang X, Huang Y, Tan M*, Li J*. (2021) Drug repurposing for cancer treatment through global propagation with a greedy algorithm in a multilayer network. Cancer Biol Med doi: 10.20892/j.issn.2095-3941.2020.0218. 

18.    Delaney K, Tan M, Zhu Z, Gao J, Dai L, Kim S, Ding J, He M, Halabelian L, Yang L, Nagarajan P, Parthun MR, Lee S, Khochbin S, Zheng YG, Zhao Y. (2021) Histone lysine methacrylation is a dynamic post-translational modification regulated by HAT1 and SIRT2. Cell Discov 7(1):122

19.    Fan S, Yue L, Wan W, Zhang Y, Zhang B, Otomo C, Li Q, Lin T, Hu J, Xu P, Zhu M, Tao H, Chen Z, Li L, Ding H, Yao Z, Lu J, Wen Y, Zhang N, Tan M, Chen K, Xie Y, Otomo T, Zhou B*, Jiang H*, Dang Y*, Luo C*. (2021) Inhibition of autophagy by a small molecule through covalent modification of LC3. Angew Chem Int Ed Engl 60(50):26105-26114.

20.    Wei D, Wang H, Zeng Q, Wang W, Hao B, Feng X, Wang P, Song N, Kan W, Huang G, Zhou X, Tan M, Zhou Y, Huang R*, Li J*, Chen X*. (2021) Discovery of Potent and Selective CDK9 Degraders for Targeting Transcription Regulation in Triple-Negative Breast Cancer. J Med Chem 64(19):14822-14847.

21.    Gao M, Wang J, Rousseaux S, Tan M, Pan L, Peng L, Wang S, Xu W, Ren J, Liu Y, Spinck M, Barral S, Wang T, Chuffart F, Bourova-Flin E, Puthier D, Curtet S, Bargier L, Cheng Z, Neumann H, Li J, Zhao Y, Mi JQ*, Khochbin S*. (2021) Metabolically controlled histone H4K5 acylation/acetylation ratio drives BRD4 genomic distribution. Cell Rep 36(4):109460.

22.    Xiao Y, Li W, Yang H, Pan L, Zhang L, Lu L, Chen J, Wei W, Ye J, Li J, Li G, Zhang Y, Tan M, Ding J*, Wong J*. (2021) HBO1 is a versatile histone acyltransferase critical for promoter histone acylations. Nucleic Acids Res 49(14):8037-8059.

23.    Jiang Y, Dong Y, Luo Y, Jiang S, Meng F, Tan M, Li J*, Zang Y*. (2021) AMPK-mediated phosphorylation on 53BP1 promotes c-NHEJ. Cell Rep 34 (7), 108713.

24.    Pan Q, Zhong S, Wang H, Wang X, Li N, Li Y, Zhang G, Yuan H, Lian Y, Chen Q, Han Y, Guo J, Liu Q, Qiu T, Jiang J, Li Q, Tan M, Yin H, Peng J*, Xiao Y*, Qin J*. (2021) The ZMYND8-regulated mevalonate pathway endows YAP-high intestinal cancer with metabolic vulnerability. Mol Cell 81(13):2736-2751.

25.    Jiang Y, Cong X, Jiang S, Dong Y, Zhao L, Zang Y*, Tan M*, Li J*. (2021) Phosphoproteomics Reveals AMPK Substrate Network in Response to DNA Damage and Histone Acetylation. Genomics Proteomics Bioinformatics. Genom Proteom Bioinf doi: 10.1016/j.gpb.2020.09.003. 

26.    Ye S, Zhai L, Hu H, Tan M, Du S*. (2021) BoxCar increases the depth and reproducibility of diabetic urinary proteome analysis. Proteomics Clin Appl doi: 10.1002/prca.202000092.

27.    Tan R, Du W, Liu Y, Cong X, Bai M, Jiang C, Li Z, Tan M, Ma DK, Huang Q *, Jiang W*, Dang Y*. (2020) Nucleolus localization of SpyCas9 affects its stability and interferes with host protein translation in mammalian cells. Genes & Diseases https://doi.org/10.1016/j.gendis.2020.09.003

28.    Guo A, Wei D, Nie H, Hu H, Peng C, Li ST, Yan K, Zhou B, Feng L, Fang C, Tan M, Huang R, Chen X*. (2020) Light-induced primary amines and o-nitrobenzyl alcohols cyclization as a versatile photoclick reaction for modular conjugation. Nat Commun 11(1):5472.

29.    Yuan H, Han Y, Wang X, Li N, Liu Q, Yin Y, Wang H, Pan L, Li L, Song K, Qiu T, Pan Q, Chen Q, Zhang G, Zang Y, Tan M, Zhang J, Li Q, Wang X*, Jiang J*, Qin J*. (2020) SETD2 Restricts Prostate Cancer Metastasis by Integrating EZH2 and AMPK Signaling Pathways. Cancer Cell 38(3):350-36.

30.    Zhao M, Li L, Zhai L, Yue Q, Liu H, Ren S, Jiang X, Gao F, Bai S, Li H, Zhang Y, Xu H, Zhang L, Liu P*, Tan M*, Yu Q*. (2020) Comparative Transcriptomic and Proteomic Analyses Prove that IFN-λ1 is a More Potent Inducer of ISGs than IFN-α against Porcine Epidemic Diarrhea Virus in Porcine Intestinal Epithelial Cells. J Proteome Res 19(9):3697-3707. 

31.    Xu JY, Zhang CC, Wang X, Zhai LH, Ma YM, Mao YS, Qian K, Sun CQ, Liu ZW, Jiang SW, Wang MH, Feng L, Zhao L, Liu P, Wang B, Zhao X, Xie H, Yang XY, Zhao LY, Chang YF, Jia JY, Wang XJ, Zhang YM, Wang YR, Yang YK, Wu ZX, Yang LH, Liu B, Zhao T, Ren SG, Sun AH, Zhao Y, Ying WT, Wang F, Wang GS, Zhang Y, Cheng SJ, Qin J, Qian XH, Wang Y*, Li J*, He FC*, Xiao T*, Tan M*. (2020) Integrative proteomic characterization of human lung adenocarcinoma. Cell 182(1):245-261,e17.

32.    Pan L, Wang X, Yang H, Zhao L, Zhai L, Xu J, Yang Y, Mao Y, Cheng S, Xiao T*, Tan M*. (2020) Proteomic and phosphoproteomic maps of lung squamous cell carcinoma from Chinese patients. Fron. Oncol 10:963. 

33.    Cheng X, Qian L, Wang B, Tan M*, Li J*. (2020) SPA: A Quantitation Strategy for MS Data in Patient-Derived Xenograft Models. Genom Proteom Bioinf doi: 10.1016/j.gpb.2019.11.016. 

34.    Xu JY, Zhao L, Xu Y, Li B, Zhai L, Tan M*, Ye BC*. (2020) Dynamic Characterization of Protein and Posttranslational Modification Levels in Mycobacterial Cholesterol Catabolism. mSystems 5(1): e00424-19. 

35.    Sun Z, Zhang H, Zhang Y, Liao L, Zhou W, Zhang F, Lian F, Huang J, Xu P, Zhang R, Lu W, Zhu M, Tao H, Yang F, Ding H, Chen S, Yue L, Zhou B, Zhang N, Tan M, Jiang H, Chen K, Liu B*, Liu C*, Dang Y*, Luo C*. (2020) Covalent Inhibitors Allosterically Block the Activation of Rho Family Proteins and Suppress Cancer Cell Invasion. Adv Sci 7:2000098.

36.     Cui Z, Liu Y, Wan W, Xu Y, Hu Y, Ding M, Dou X, Wang R, Li H, Meng Y, Li W, Jiang W, Li Z, Li Y, Tan M, Ma DK, Ding Y, Liu JO, Luo C*, Yu B*, Tang Q*, Dang Y*. (2020) Ethacrynic acid targets GSTM1 to ameliorate obesity by promoting browning of white adipocytes. Protein Cell 12(6):493-501.

37.    Xie S, Wei F, Sun Y, Gao Y, Pan L, Tan M, Wang S, Ding J*, Chen Y*. (2020) EZH2 inhibitors abrogate upregulation of trimethylation of H3K27 by CDK9 inhibitors and potentiate its activity against diffuse large B-cell lymphoma. Haematologica 105:1021-1031.

38.    Hao BB, Li XJ, Jia XL, Wang YX, Zhai LH, Li DZ, Liu J, Zhang D, Chen YL, Xu YH, Lee SK, Xu GF, Chen XH, Dang YJ, Liu B*, Tan MJ*. (2020) The novel cereblon modulator CC-885 inhibits mitophagy via selective degradation of BNIP3L. Acta Pharmacol Sin 41(9):1246-1254. 

39.    Zhao L, Cong X, Zhai L, Hu H, Xu JY, Zhao W, Zhu M, Tan M*, Ye BC*. (2020) Comparative evaluation of label-free quantification strategies. J Proteomics 215:103669. 

40.    Jia X, Pan L, Zhu M, Hu H, Zhai L, Liu J, Hu M, Liu B*, Tan M*. (2020) pSILAC method coupled with two complementary digestion approaches reveals PRPF39 as a new E7070-dependent DCAF15 substrate. J Proteomics 210:103545. 

41.    Zhao M, Hao B, Li H, Cai M, Xie J, Liu H, Tan M, Zhai L*, Yu Q^,*. (2020) Peptidyl-Lys metalloendopeptidase (Lys-N) purified from dry fruit of Grifola frondosa demonstrates "mirror" digestion property with lysyl endopeptidase (Lys-C). Rapid Commun Mass Spectrom 34:e8573

42.    Hao B, Sun M, Zhang M, Zhao X, Zhao L, Li B, Zhai L, Liu P, Hu H, Xu JY*, Tan M*. (2020) Global characterization of proteome and lysine methylome features in EZH2 wild-type and mutant lymphoma cell lines. J Proteomics 213:103614. 

43.    Li B, Guo F, Hu H, Liu P, Tan M, Pan J*, Zhai L*. (2020) The characterization of column heating effect in nanoflow liquid chromatography mass spectrometry (nanoLC-MS)-based proteomics. J Mass Spectrom 55:e4441.

44.    Hu W, Yuan Y, Wang CH, Tian HT, Guo AD, Nie HJ, Hu H, Tan M, Tang Z*, Chen XH*. (2019) Genetically Encoded Residue-Selective Photo-Crosslinker to Capture Protein-Protein Interactions in Living Cells. Chem 5(11):2955-2968.

45.    Hu H, Zhao W, Zhu M, Zhao L, Zhai L, Xu JY, Liu P, Tan M*. (2019). LysargiNase and Chemical Derivatization Based Strategy for Facilitating In-Depth Profiling of C-Terminome. Anal Chem 91(22):14522-14529.

46.    Liu B, Zhang Z, Hu Y, Lu Y, Li D, Liu J, Liao S, Hu M, Wang Y, Zhang D, Chen Y, Qian Q, Lv X, Wu D, Tan M, Hu C, Xiong X*, Li X*. (2019) Sustained ER stress promotes hyperglycemia by increasing glucagon action through the deubiquitinating enzyme USP14. Proc Natl Acad Sci U S A 116(43):21732-21738.

47.   Gao Y, Lee H, Kwon OK, Tan M, Kim KT*, Lee S*. (2019) Global Proteomic Analysis of Lysine Succinylation in Zebrafish (Danio rerio). J Proteome Res 18(10):3762-3769.

48.    Xu ZW, Zhang HN, Zhang XR, Jiang HW, Liu CX, Wu FL, Qian LL, Hao BB, Czajkowsky DM, Guo SJ, Xu ZJ, Bi LJ, Wang SH, Li HT, Tan M, Yan W, Feng L, Hou JL, Tao SC*. (2019) Interplay between the bacterial protein deacetylase CobB and the second messenger c-di-GMP. EMBO J 38(18): e100948|

49.    Jin N, Bi A, Lan X, Xu J, Wang X, Liu Y, Wang T, Tang S, Zeng H, Chen Z, Tan M, Ai J, Xie H, Zhang T, Liu D, Huang R, Song Y, Leung EL, Yao X, Ding J, Geng M*, Lin SH*, Huang M*. (2019) Identification of metabolic vulnerabilities of receptor tyrosine kinases-driven cancer. Nat Commun 10:2701.

50.    Jiang Y, Sun A, Zhao Y, Ying W, Sun H, Yang X, Xing B, Sun W, Ren L, Hu B, Li C, Zhang L, Qin G, Zhang M, Chen N, Zhang M, Huang Y, Zhou J, Zhao Y, Liu M, Zhu X, Qiu Y, Sun Y, Huang C, Yan M, Wang M, Liu W, Tian F, Xu H, Zhou J, Wu Z, Shi T, Zhu W, Qin J, Xie L, Fan J, Qian X, He F; Chinese Human Proteome Project (CNHPP) Consortium. (2019) Proteomics identifies new therapeutic targets of early-stage hepatocellular carcinoma. Nature 567(7747):257-261

51.    Wang YL, Dai Y, Wu XW, Li F, Liu B, Li CP, Liu QF, Zhou YY, Wang B, Zhu MR, Cui RR, Tan XQ, Xiong ZP, Liu J, Tan M, Xu YC, Geng MY, Jiang HL, Liu H*, Ai J*, Zheng MY*. (2019) Discovery and Development of a Series of Pyrazolo 3,4-d pyridazinone Compounds as the Novel Covalent Fibroblast Growth Factor Receptor Inhibitors by the Rational Drug Design. J Med Chem 62(16):7473-7488.

52.    Gao Y., Lee H., Kwon O. K., Cheng Z. Y., Tan M. J., Kim K. T.*, Lee S.* (2019) Profiling of Histidine Phosphoproteome in Danio rerio by TiO2 Enrichment. Proteomics 19(9): e1800471.

53.    Liu M , Xiao C , Sun M, Tan M, Hu L*, Yu Q*. (2019) Xanthatin inhibits STAT3 and NF-kappa B signalling by covalently binding to JAK and IKK kinases. J Cell Mol Med 23(6):4301-4312.

54.    Qiu W, Xu Z, Zhang M, Zhang D, Fan H, Li T, Wang Q, Liu P, Zhu Z, Du D, Tan M, Wen B, Liu Y*. (2019) Determination of local chromatin interactions using a combined CRISPR and peroxidase APEX2 system. Nucleic Acids Res 47(9):e52.

55.    An Z, Zhai L, Ying W, Qian X, Gong F*, Tan M*, Fu Y*. (2019) PTMiner: Localization and Quality Control of Protein Modifications Detected in an Open Search and Its Application to Comprehensive Post-translational Modification Characterization in Human Proteome. Mol Cell Proteomics 18(2):391-405. 

56.    Huang X, Yan J, Zhang M, Wang Y, Chen Y, Fu X, Wei R, Zheng XL, Liu Z, Zhang X, Yang H, Hao B, Shen YY, Su Y, Cong X, Huang M, Tan M*, Ding J*, Geng M*. (2018) Targeting Epigenetic Crosstalk as a Therapeutic Strategy for EZH2-Aberrant Solid Tumors. Cell 175(1):186-199. 

57.    Liu B, Jiang S, Li M, Xiong X, Zhu M, Li D, Zhao L, Qian L, Zhai L, Li J, Lu H, Sun S, Lin J, Lu Y *, Li X*, Tan M*. (2018) Proteome-wide analysis of USP14 substrates revealed its role in hepatosteatosis via stabilization of FASN. Nat Commun 9: 4770. 

58.    Xu JY, Xu Y, Xu Z, Zhai LH, Ye Y, Zhao Y, Chu X, Tan M*, Ye BC* (2018) Protein Acylation is a General Regulatory Mechanism in Biosynthetic Pathway of Acyl-CoA-Derived Natural Products. Cell Chem Biol 25(8):984-995. 

59.    Xu JY, Xu Y, Chu X, Tan M*, Ye BC*. (2018) Protein Acylation Affects the Artificial Biosynthetic Pathway for Pinosylvin Production in Engineered E. coli. ACS Chem Biol 13(5):1200-1208. 

60.    Xu JY, Zhao L, Liu X, Hu H, Liu P, Tan M*, Ye BC*. (2018) Characterization of the Lysine Acylomes and the Substrates Regulated by Protein Acyltransferase in Mycobacterium smegmatis. ACS Chem Biol 13(6), 1588-1597. 

61.    Huang Z, Zhao J, Deng W, Chen Y, Shang J, Song K, Zhang L, Wang C, Lu S, Yang X, He B, Min J, Hu H, Tan M, Xu J, Zhang Q, Zhong J, Sun X, Mao Z, Lin H, Xiao M, Chin YE, Jiang H, Xu Y*, Chen G*, Zhang J*. (2018) Identification of a cellularly active SIRT6 allosteric activator. Nat Chem Biol 14: 1118–1126.

62.    Yuan L, Zhai L, Qian L, Huang, Ding Y, Xiang H, Liu X, Thompson JW, Liu J, He YH, Chen XQ, Hu J, Kong QP, Tan M, Wang XF*. (2018) Switching off IMMP2L signaling drives senescence via simultaneous metabolic alteration and blockage of cell death. Cell Res 28(6):625-643.

63.    Jiang W, Zhou X, Li Z, Liu K, Wang W, Tan R, Cong X, Shan J, Zhan Y, Cui Z, Jiang L, Li Q, Shen S, Bai M, Cheng Y, Li B, Tan M, Ma DK, Liu JO, Dang Y*. (2018) Prolyl 4-Hydroxylase 2 Promotes B-cell Lymphoma Progression via Hydroxylation of Carabin. Blood 131(12):1325-1336.

64.    Shiota H, Barral S, Buchou T, Tan M, Couté Y, Charbonnier G, Reynoird N, Boussouar F, Gérard M, Zhu M, Bargier L, Puthier D, Chuffart F, Bourova-Flin E, Picaud S, Filippakopoulos P, Goudarzi A, Ibrahim Z, Panne D, Rousseaux S, Zhao Y, Khochbin S*. (2018) Nut Directs p300-Dependent, Genome-Wide H4 Hyperacetylation in Male Germ Cells. Cell Rep 24(13):3477-3487.e6.

65.    Liu M, Xiao C, Sun M, Tan M, Hu L, Yu Q*. (2018) Parthenolide Inhibits STAT3 Signaling by Covalently Targeting Janus Kinases. Molecules 23(6): E1478.

66.    Xu JY, Xu Z, Liu X, Tan M, Ye BC* (2018) Protein Acetylation and Butyrylation Regulate the Phenotype and Metabolic Shifts of the Endospore-forming Clostridium acetobutylicum. Mol Cell Proteomics 17(6):1156-1169.

67.    Zhang Y, Sun J, Tan M, Liu Y, Li Q, Jiang H, Wang H, Li Z, Wan W, Jiang H, Lu H, Wang B, Ren J*, Gong L*. (2018) Species-Specific Involvement of Integrin αIIbβ3 in a Monoclonal Antibody CH12 Triggers Off-Target Thrombocytopenia in Cynomolgus Monkeys. Mol Ther 26(6):1457-1470.

68.    Li Z, Cheng Z, Raghothama C, Cui Z, Liu K, Li X, Jiang C, Jiang W, Tan M, Ni X, Pandey A, Liu JO, Dang Y*. (2018) USP9X controls translation efficiency via deubiquitination of eukaryotic translation initiation factor 4A1. Nucleic Acids Res 46(2):823-839

69.    Zhang M, Xu JY, Hu H, Ye BC*, Tan M*. (2018) Systematic Proteomic Analysis of Protein Methylation in Prokaryotes and Eukaryotes Revealed Distinct Substrate Specificity. Proteomics 18, 1700300. 

70.    Nie L, Shuai L, Zhu M, Liu P, Xie ZF, Jiang S, Jiang HW, Li J, Zhao Y, Li JY*, Tan M*. (2017) The Landscape of Histone Modifications in a High-Fat-Diet-Induced Obese (DIO) Mouse Model. Mol Cell Proteomics 16(7), 1324-1334. 

71.    Chen M, Zhang M, Zhai L, Hu H, Liu P, Tan M*. (2017) Tryptic Peptides Bearing C-Terminal Dimethyllysine Need to Be Considered during the Analysis of Lysine Dimethylation in Proteomic Study. J Proteome Res 16(9), 3460-3469. 

72.    Mo Y, Lin R, Liu P, Tan M, Xiong Y, Guan KL, Yuan HX*. (2017) SIRT7 deacetylates DDB1 and suppresses the activity of the CRL4 E3 ligase complexes. The FEBS J 284, 3619-3636.

73.    Dai XY, Yan J, Fu X, Pan Q, Sun D, Xu Y, Wang J, Nie L, Tong LJ, Shen A, Zheng M, Huang M, Tan M, Liu H, Huang X*, Ding J*, Geng M*.(2017) Aspirin inhibits cancer metastasis and angiogenesis via targeting heparanase. Clin Cancer Res 23(20):6267-6278.

74.    Li Q, Feng Y, Tan M, Zhai L*. (2017) Evaluation of Endoproteinase Lys- C/Trypsin Sequential Digestion Used in Proteomics Sample Preparation. Chinese J Anal Chem 45, 316-321.

75.    Liu Y, Peng J, Sun T, Li N, Zhang L, Ren J, Yuan H, Kan S, Pan Q, Li X, Ding Y, Jiang M, Cong X, Tan M, Ma Y, Fu D, Cai S, Xiao Y, Wang X, Qin J*. (2017) Epithelial EZH2 serves as an epigenetic determinant in experimental colitis by inhibiting TNFα-mediated inflammation and apoptosis. Proc Natl Acad Sci U S A 114, E3796-E3805.

76.    Lee P, Jiang S, Li Y, Yue J, Gou X, Chen SY, Zhao Y, Schober M, Tan M, Wu X*. (2017) Phosphorylation of Pkp1 by RIPK4 regulates epidermal differentiation and skin tumorigenesis. EMBO J 36,1963-1980

77.    Zhang D, Jin N, Sun W, Li X, Liu B, Xie Z, Qu J, Xu J, Yang X, Su Y, Tang S, Han H, Chen D, Ding J, Tan M, Huang M*, Geng M*. (2017) Phosphoglycerate mutase 1 promotes cancer cell migration independent of its metabolic activity. Oncogene 36(20):2900-2909.

78.    Qu J, Sun W, Zhong J, Lv H, Zhu M, Xu J, Jin N, Xie Z, Tan M, Lin SH, Geng M, Ding J*, Huang M*. (2017) Phosphoglycerate mutase 1 regulates dNTP pool and promotes homologous recombination repair in cancer cells. J Cell Biol 216(2), 409-424.

79.    Yang LY, Liu XF, Yang Y, Yang LL, Liu KW, Tang YB, Zhang M, Tan M, Cheng SM, Xu YC, Yang HY, Liu ZJ, Song GJ*, Huang W*. (2017) Biochemical features of the adhesion G protein-coupled receptor CD97 related to its auto-proteolysis and HeLa cell attachment activities. Acta Pharmacol Sin 38:56-68.

80.    Buchou T, Tan M, Barral S, Vitte AL, Rousseaux S, Arechaga J, Khochbin S. (2017) Purification and Analysis of Male Germ Cells from Adult Mouse Testis. Methods Mol Biol 1510:159-168.

81.    Sun M, Xu JY, Wu Z, Zhai L, Liu C, Cheng Z, Xu G, Tao S, Ye BC, Zhao Y, Tan M*. (2016) Characterization of Protein Lysine Propionylation in Escherichia coli: Global Profiling, Dynamic Change and Enzymatic Regulation. J Proteome Res 15(12), 4696-4708. 

82.    Xie Z, Zhang D, Chung D, Tang Z, Huang H, Dai L, Qi S, Li J, Colak G, Chen Y, Xia C, Peng C, Ruan H, Kirkey M, Wang D, Jensen LM, Kwon OK, Lee S, Pletcher SD, Tan M, Lombard DB, White KP, Zhao H, Li J, Roeder RG, Yang X*, Zhao Y*. (2016) Metabolic Regulation of Gene Expression by Histone Lysine β-Hydroxybutyrylation. Mol Cell 62(2):194-206.

83.    Qian L, Nie L, Chen M, Liu P, Zhu J, Zhai L, Tao SC, Cheng Z, Zhao Y, Tan M*. (2016) Global Profiling of Protein Lysine Malonylation in Escherichia coli Reveals Its Role in Energy Metabolism. J Proteome Res 15(6), 2060-2071. 

84.    Respuela P, Nikolić M, Tan M, Frommolt P, Zhao Y, Wysocka J, Rada-Iglesias A*. (2016) Foxd3 Promotes Exit from Naive Pluripotency through Enhancer Decommissioning and Inhibits Germline Specification. Cell Stem Cell 18(1), 118-133.

85.    Nie L, Zhu M, Sun S, Zhai L, Wu Z, Qian L, Tan M*. (2016) An optimization of the LC-MS/MS workflow for deep proteome profiling on an Orbitrap Fusion Anal Methods 8(2), 425-434. 

86.    Morozumi Y, Boussouar F, Tan M, Chaikuad A, Jamshidikia M, Colak G, He H, Nie L, Petosa C, de Dieuleveult M, Curtet S, Vitte AL, Rabatel C, Debernardi A, Cosset FL, Verhoeyen E, Emadali A, Schweifer N, Gianni D, Gut M, Guardiola P, Rousseaux S, Gérard M, Knapp S, Zhao Y, Khochbin S*. (2016) Atad2 is a generalist facilitator of chromatin dynamics in embryonic stem cells. J Mol Cell Biol 8(4):349-362

87.    Wu, Z., Cheng, Z., Sun, M., Wan, X., Liu, P., He, T., Tan, M*, and Zhao, Y.*. (2015) A Chemical Proteomics Approach for Global Analysis of Lysine Mono-Methylation. Mol Cell Proteomics 14(2), 329-339. 

88.    Sun W, Xie Z, Liu Y, Zhao D, Wu Z, Zhang D, Lv H, Tang S, Jin N, Jiang H, Tan M, Ding J, Luo C*, Li J*, Huang M*, Geng M*. (2015) JX06 Selectively Inhibits Pyruvate Dehydrogenase Kinase PDK1 by a Covalent Cysteine Modification. Cancer Res 75(22), 4923-4936.

89.    Colak G, Pougovkina O, Dai L, Tan M, Brinke HT, Huang H, Cheng Z, Park J, Wan W, Liu W, Yue WW, Wanders RJA, Locasale JW, Lombard DB, de Boer VCJ*,  Zhao Y*. (2015) Proteomic and biochemical studies of lysine malonylation suggests its malonic aciduria-associated regulatory role in mitochondrial function and fatty acid oxidation. Mol Cell Proteomics 14(11), 3056-3071

90.    Kang Y, Zhou XE, Gao X, He Y, Liu W, Ishchenko A, Barty A, White TA, Yefanov O, Han GW, Xu Q, de Waal PW, Ke J, Tan MH, Zhang C, Moeller A, West GM, Pascal BD, Van Eps N, Caro LN, Vishnivetskiy SA, Lee RJ, Suino-Powell KM, Gu X, Pal K, Ma J, Zhi X, Boutet S, Williams GJ, Messerschmidt M, Gati C, Zatsepin NA, Wang D, James D, Basu S, Roy-Chowdhury S, Conrad CE, Coe J, Liu H, Lisova S, Kupitz C, Grotjohann I, Fromme R, Jiang Y, Tan M, Yang H, Li J, Wang M, Zheng Z, Li D, Howe N, Zhao Y, Standfuss J, Diederichs K, Dong Y, Potter CS, Carragher B, Caffrey M, Jiang H, Chapman HN, Spence JC, Fromme P, Weierstall U, Ernst OP, Katritch V, Gurevich VV, Griffin PR, Hubbell WL, Stevens RC, Cherezov V, Melcher K, Xu HE*. (2015) Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser. Nature 523, 561-567.

91.    Deng SS, Wu LY, Wang YC, Cao PR, Xu L, Li QR, Liu M, Zhang L, Jiang YJ, Yang XY, Sun SN, Tan, M., Qian M, Zang Y*, Feng L*, Li J*. (2015) Protein Kinase A Rescues Microtubule Affinity-regulating Kinase 2-induced Microtubule Instability and Neurite Disruption by Phosphorylating Serine 409. J Biol Chem 290(5), 3149-3160.

92.    He, Q. L., Titov, D. V., Li, J., Tan, M., Ye, Z., Zhao, Y., Romo, D., and Liu, J. O*. (2015) Covalent Modification of a Cysteine Residue in the XPB Subunit of the General Transcription Factor TFIIH through Single Epoxide Cleavage of the Transcription Inhibitor Triptolide. Angew Chem Int Ed 54, 1859-1863

93.    Tan, M., Peng, C., Anderson, K.A., Chhoy, P., Xie, Z., Dai, L., Park, J.S., Chen, Y., Huang, H., Zhang, Y., Ro, J., Wagner, G.R., Green, M.F., Madsen, A.S., Schmiesing, J., Peterson, B.S., Xu, G., Ilkayeva, O.R., Muehlbauer, M.J., Braulke, T., Mühlhausen, C., Backos, D.S., Olsen, C.A., McGuire, P.J., Pletcher, S.D., Lombard, D.B., Hirschey, M.D.*, Zhao, Y*. (2014) Lysine Glutarylation Is a Protein Post-Translational Modification Regulated by SIRT5. Cell Metab 19(4), 605-617

94.    Zhang, Y. Wu, Z. Wan, X., Liu, P., Zhang, J., Ye, Y., Zhao, Y., Tan, M.* (2014) Comprehensive Profiling of Lysine Acetylome in Staphylococcus aureus. Sci China Chem 57(5), 732-738. 

95.    Buecker, C., Srinivasan, R., Wu, Z., Calo, E., Acampora, D., Faial, T., Simeone, A., Tan, M., Swigut,T.*, Wysocka, J*. (2014) Reorganization of Enhancer Patterns in Transition from Naive to Primed Pluripotency. Cell Stem Cell 14(6), 838–853.

96.    Lu, C., Zhang, K.*, Zhang, Y., Tan, M., Li, Y., He, X., and Zhang, Y. (2014) Preparation and characterization of vorinostat-coated beads for profiling of novel target proteins. J Chromatogr A 1372, 34-41.

97.    Xu G, Wang J, Wu Z, Qian L, Dai L, Wan X, Tan M, Zhao Y*, Wu Y*. (2014) SAHA Regulates Histone Acetylation, Butyrylation, and Protein Expression in Neuroblastoma. J Proteome Res 13(10), 4211-4219.

98.    Zhou X, Zeng XY, Wang H, Li S, Jo E, Xue CC, Tan M, Molero JC, Ye JM*. (2014) Hepatic FoxO1 acetylation is involved in oleanolic acid-induced memory of glycemic control: novel findings from Study 2. PLoS One 9,e107231

99.    Colak, G., Xie, Z., Zhu, A.Y., Dai, L., Lu, Z., Zhang, Y., Wan, X., Chen, Y., Cha, Y.H., Lin, H.,* Zhao, Y.,* Tan, M.* (2013) Identification of lysine succinylation substrates and the succinylation regulatory enzyme CobB in E. coli. Mol Cell Proteomics 12(12), 3509-3520. 

100.Montellier, E., Boussouar, F., Rousseaux, S., Zhang, K., Buchou, T., Fenaille, F., Shiota, H., Debernardi, A., Héry, P., Curtet, S., Jamshidikia, M., Barral, S., Holota, H., Bergon, A., Lopez, F., Guardiola, P., Pernet, K., Imbert, J., Petosa, C., Tan, M., Zhao, Y., Gérard, M., Khochbin, S*. (2013) Chromatin-to-nucleoprotamine transition is controlled by the histone H2B variant, TH2B. Genes Dev 27, 1680-1692.

101.Park, J. , Chen, Y. , Tishkoff, D.X., Peng, C., Tan, M., Dai, L., Xie, Z., Zhang, Y., Zwaans, B.M.M., Skinner, M.E., Lombard, D.B.*, Zhao, Y*. (2013) SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways. Mol Cell 50(6), 919-930.

102.Lee, S.*, Tan, M., Dai, L., Kwon, O.K., Yang, J., Zhao, Y., Chen Y*. (2013) MS/MS of synthetic peptide is not sufficient to confirm new types of protein modifications. J Proteome Res 12(2), 1007-1013.

103.Chen, Y. , Zhao, W. , Yang, J.S. , Cheng, Z. , Luo, H., Lu, Z., Tan, M., Gu, W.*, Zhao Y*. (2012) Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways. Mol Cell Proteomics 11(10), 1048-1062.

104.Li, N., Kon, N., JIang, L., Tan, M., Ludwig, T., Zhao, Y., Baer, R., W., G.*. (2012) Tumor suppression in the absence of p53-mediated cell cycle arrest, apoptosis, and senescence. Cell 149, 1269-1283. (Previewed by Cell, 2012, 1183)

105.Xie Z., Dai J., Dai L., Tan M., Cheng Z., Wu Y., Boeke J.D., Zhao Y*. (2012) Lysine succinylation and lysine malonylation in histones. Mol Cell Proteomics 11,100-107.

106.Tan M., Luo H., Lee S., Jin F., Yang J.S., Montellier E., Buchou T., Cheng Z., Rousseaux S., Rajagopal N., Lu Z., Ye Z., Zhu Q., Wysocka J., Ye Y., Khochbin S., Ren B., Zhao Y*. (2011) Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification. Cell 146, 1016-1028.

107.Zhang, Z., Tan, M., Xie, Z., Dai, L., Chen, Y., Zhao, Y.*. (2011) Identification of lysine succinylation as a new post-translational modification. Nat Chem Biol 7, 58-63.

108. Peng, C., Lu, Z., Xie, Z., Cheng, Z., Chen, Y., Tan, M., Luo, H., Zhang, Y., He, W., Yang, K., Zwaans, B.M., Tishkoff, D., Ho, L., Lombard, D., He, T.C., Dai, J., Verdin, E., Ye, Y., Zhao, Y*. (2011) The first identification of lysine malonylation substrates and its regulatory enzyme. Mol Cell Proteomics 10(12), M111.012658.

109.Tan, M., Yin, C., Tang, C.P., Ke, C.Q., Lin, G.*, Ye, Y*. (2011) Antitussive indole alkaloids from Kopsia hainanensis. Planta Med 77, 939-944.

110.Kuo, H.P., Lee, D.F., Chen, C.T., Liu, M., Chou, C.K., Lee, H.J., Du, Y., Xie, X.M., Wei, Y.K., Xia, W.Y., Weihua, Z., Yang J.Y., Yen, C.J., Huang, T.H., Tan, M., Xing, G., Zhao, Y., Lin, C.H., Tsai, S.F., Fidler, I.J., Hung, M.C.*. (2010) ARD1 stabilization of TSC2 suppresses tumorigenesis through the mTOR signaling pathway. Sci Signal 3, ra9.

111.Xu, Y.J., Tang, C.P., Tan, M., Ke, C.Q., Wu, T., Ye, Y.*. (2010) Sesquiterpenoids and Diterpenoids from Chloranthus anhuiensis. Chem Biodivers 7, 151-157.

112.Tan, M., Ye, J.M., Turner, N., Hohnen-Behrens, C., Ke, C.Q., Tang, C.P., Chen, T., Weiss, H.C., Gesing, E.R., Rowland, A., James, D.E., Ye, Y*. (2008) Antidiabetic activities of triterpenoids isolated from bitter melon associated with activation of the AMPK pathway. Chem Biol 15(5), 263-273.