基本信息
谭敏佳 男 博导 上海药物研究所
电子邮件:mjtan@simm.ac.cn
通信地址:上海祖冲之路555号
邮政编码:201203

研究领域

基于质谱技术的蛋白质组学和蛋白质翻译后修饰研究、生物标志物和个性化药物机理研究。

招生信息

   
招生专业
100706-药理学
070302-分析化学
071010-生物化学与分子生物学
招生方向
蛋白质组学,蛋白翻译后修饰,生物质谱
生物标志物研究
组蛋白表观遗传学

教育背景

2003-09--2008-07 中科院上海药物所 博士
1999-09--2003-07 复旦大学 学士

工作经历

   
工作简历
2012-09--今 中国科学院上海药物研究所 课题组长
2008-10--2012-08 芝加哥大学 博士后
2008-08--2008-09 德克萨斯大学达拉斯西南医学中心 博士后

专利与奖励

   

出版信息

   
发表论文
(1) Systematic Proteomic Analysis of Protein Methylation in Prokaryotes and Eukaryotes Revealed Distinct Substrate Specificity, Proteomics, 2018, 通讯作者
(2) Prolyl 4-Hydroxylase 2 Promotes B-cell Lymphoma Progression via Hydroxylation of Carabin, Blood, 2018, 其他(合作组作者)
(3) USP9X controls translation efficiency via deubiquitination of eukaryotic translation initiation factor 4A1, Nucleic Acids Res, 2018, 第 9 作者
(4) Switching off IMMP2L signaling drives senescence via simultaneous metabolic alteration and blockage of cell death., Cell Res, 2018, 其他(合作组作者)
(5) Characterization of the Lysine Acylomes and the Substrates Regulated by Protein Acyltransferase in Mycobacterium smegmatis., ACS Chem Biol, 2018, 通讯作者
(6) Species-Specific Involvement of Integrin αIIbβ3 in a Monoclonal Antibody CH12 Triggers Off-Target Thrombocytopenia in Cynomolgus Monkeys., Mol Ther, 2018, 第 3 作者
(7) Protein Acylation Affects the Artificial Biosynthetic Pathway for Pinosylvin Production in Engineered E. coli., ACS Chem Biol, 2018, 通讯作者
(8) Proteome-wide analysis of USP14 substrates revealed its role in hepatosteatosis via stabilization of FASN, Nat Commun, 2018, 通讯作者
(9) Targeting Epigenetic Crosstalk as a Therapeutic Strategy for EZH2-Aberrant Solid Tumors., Cell, 2018, 通讯作者
(10) Identification of a cellularly active SIRT6 allosteric activator, Nat Chem Biol., 2018, 其他(合作组作者)
(11) Nut Directs p300-Dependent, Genome-Wide H4 Hyperacetylation in Male Germ Cells, Cell Rep., 2018, 第 4 作者
(12) Tryptic Peptides Bearing C-Terminal Dimethyllysine Need to Be Considered during the Analysis of Lysine Dimethylation in Proteomic Study, J Proteome Res., 2017, 通讯作者
(13) SIRT7 deacetylates DDB1 and suppresses the activity of the CRL4 E3 ligase complexes, The FEBS journal., 2017, 第 4 作者
(14) Aspirin Inhibits Cancer Metastasis and Angiogenesis via Targeting Heparanase, Clinical cancer research, 2017, 其他(合作组作者)
(15) Epithelial EZH2 serves as an epigenetic determinant in experimental colitis by inhibiting TNFα-mediated inflammation and apoptosis, Proc Natl Acad Sci U S A., 2017, 其他(合作组作者)
(16) Phosphoglycerate mutase 1 promotes cancer cell migration independent of its metabolic activity, Oncogene, 2017, 其他(合作组作者)
(17) Biochemical features of the adhesion G protein-coupled receptor CD97 related to its auto-proteolysis and HeLa cell attachment activities, Acta Pharmacol Sin, 2017, 第 8 作者
(18) The Landscape of Histone Modifications in a High-Fat-Diet-Induced Obese (DIO) Mouse Model., Mol Cell Proteomics, 2017, 通讯作者
(19) Phosphorylation of Pkp1 by RIPK4 regulates epidermal differentiation and skin tumorigenesis, EMBO J., 2017, 第 9 作者
(20) Phosphoglycerate mutase 1 regulates dNTP pool and promotes homologous recombination repair in cancer cells, J Cell Biol., 2017, 第 9 作者
(21) Phosphoglycerate mutase 1 regulates dNTP pool and promotes homologous recombination repair in cancer cells, Methods Mol Biol., 2017, 第 2 作者
(22) Characterization of Protein Lysine Propionylation in Escherichia coli: Global Profiling, Dynamic Change, and Enzymatic Regulation., J Proteome Res., 2016, 通讯作者
(23) Global Profiling of Protein Lysine Malonylation in Escherichia coli Reveals Its Role in Energy Metabolism., J Proteome Res, 2016, 通讯作者
(24) Metabolic Regulation of Gene Expression by Histone Lysine β-Hydroxybutyrylation., Mol Cell, 2016, 第 4 作者
(25) Foxd3 Promotes Exit from Naive Pluripotency through Enhancer Decommissioning and Inhibits Germline Specification, Cell Stem Cell, 2016, 第 3 作者
(26) An optimization of the LC-MS/MS workflow for deep proteome profiling on an Orbitrap Fusion, ANALYTICAL METHODS, 2016, 通讯作者
(27) Covalent Modification of a Cysteine Residue in the XPB Subunit of the General Transcription Factor TFIIH Through Single Epoxide Cleavage of the Transcription Inhibitor Triptolide, Angew Chem Int Ed, 2015, 第 4 作者
(28) A Chemical Proteomics Approach for Global Analysis of Lysine Mono-Methylation, Mol Cell Proteomics, 2015, 通讯作者
(29) JX06 Selectively Inhibits Pyruvate Dehydrogenase Kinase PDK1 by a Covalent Cysteine Modification., Cancer Res, 2015, 第 4 作者
(30) Atad2 is a generalist facilitator of chromatin dynamics in embryonic stem cells., J Mol Cell Biol, 2015, 第 4 作者
(31) Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser., Nature, 2015, 第 4 作者
(32) Comprehensive Profiling of Lysine Acetylome in Staphylococcus aureus, Sci China Chem, 2014, 通讯作者
(33) Lysine Glutarylation Is a Protein Post-Translational Modification Regulated by SIRT5, Cell Metab, 2014, 第 1 作者
(34) Reorganization of Enhancer Patterns in Transition from Naive to Primed Pluripotency, Cell Stem Cell, 2014, 第 4 作者
(35) MS/MS of synthetic peptide is not sufficient to confirm new types of protein modifications, J Proteome Res, 2013, 第 2 作者
(36) Identification of lysine succinylation substrates and the succinylation regulatory enzyme CobB in E. coli, Mol Cell Proteomics, 2013, 通讯作者
(37) Chromatin-to-nucleoprotamine transition is controlled by the histone H2B variant, TH2B, Genes Dev, 2013, 第 4 作者
(38) SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways, Mol Cell, 2013, 第 4 作者
(39) Tumor suppression in the absence of p53-mediated cell cycle arrest, apoptosis, and senescence, cell, 2012, 第 4 作者
(40)  Lysine succinylation and lysine malonylation in histones, Mol Cell Proteomics, 2012, 第 4 作者
(41) The first identification of lysine malonylation substrates and its regulatory enzyme, Mol Cell Proteomics, 2011, 第 4 作者
(42)  Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification, Cell, 2011, 第 1 作者
(43) Identification of lysine succinylation as a new post-translational modification, Nature Chem Biol , 2011, 第 1 作者
(44) Antitussive indole alkaloids from Kopsia hainanensis, Planta Med, 2011, 第 1 作者
(45)  Sesquiterpenoids and Diterpenoids from Chloranthus anhuiensis, Chem Biodivers , 2010, 第 3 作者
(46) Antidiabetic activities of triterpenoids isolated from bitter melon associated with activation of the AMPK pathway., Chem Biol, 2008, 第 1 作者

科研活动