基本信息
任培根 男 博导 深圳先进技术研究院
电子邮件:pg.ren@siat.ac.cn
通信地址:深圳市南山区学苑大道1068号
邮政编码:518055
部门/实验室:医药所

研究领域

目前研究领域:

1.针对细胞及信号通路的骨科基础性研究,包括骨组织来源多肽激素在糖代谢中的作用,对骨及其他组织生长代谢的调控,趋化因子、生长因子等对巨噬细胞、间充质干细胞的体内、体外调控研究等。利用分子细胞生物学、分子医学影像学、小动物体内成像、实验动物模型等手段,研究在骨裂解及骨形成中起重要作用的细胞如成骨细胞、破骨细胞、巨噬细胞及间充质干细胞等在其中的作用;希望能够通过对某些分子细胞调控机制,控制相关细胞对骨组织重建的参与,优化骨组织的重建。

2. 多肽类激素是动物体内的重要调控因子,参与多种代谢与调节途径。G蛋白偶联受体(GPCR)拥有一大类多肽受体,在细胞膜表面信号传导中具有重要作用。本课题组发现的一个小分子多肽具有调节胰岛beta-细胞分泌胰岛素的作用,在机体能量代谢方面有作用,目前正在深入研究中。


招生信息

本人所在的中国科学院深圳先进技术研究院具有生物化学与分子生物学博士点。


1. 报考学生应具备相关学科的学习及研究基础,以医学、生物学、化学专业专业毕业生为主要招收目标;

2. 报考学生应具有流畅的交流和表达能力,英文听说读写能力好的优先;

3. 报考学生应具有团队工作、相互友好协作的意愿和能力,加入本实验室学习应以获得学位为目标,认真工作,努力学习。


招生专业
071010-生物化学与分子生物学
071020-生物技术与医药
085238-生物工程
招生方向
分子生物学
分子成像
干细胞、分子成像

教育背景

2000-09--2001-10 日本理化研究所 访问学者
1999-09--2004-08 中国科学院微生物研究所 博士
学历
   
学位
   

工作经历

   
工作简历
2010-12--2014-06 中国科学院深圳先进技术研究院 研究员
2010-09--2010-12 斯坦福大学 Research Associate
2004-08--2010-08 斯坦福大学 博士后
社会兼职
2013-09--2017-09 深圳市预防医学会第一届实验动物管理委员会委员,委员
2012-10--2016-10 深圳市南山区产业(产学研)联盟特聘专家,特聘专家
2012-08--2016-08 中国科学院深圳先进技术研究院伦理委员会委员,委员
2010-05--今 国际华人硬组织学会,会员
2009-07--今 Orthopaedic Research Society, USA,活跃会员
2005-06--今 The Endocrine Society, USA,会员
2002-01--今 中国微生物学会,永久会员

教授课程

   

专利与奖励

   
奖励信息
(1) STAR Award of SFB, USA,一等奖,其他级,2011
专利成果
   

出版信息

   
发表论文
(1) Expression of chemerin and its receptors in rat testes and its action on testosterone secretion,Journal of Endocrinology,2014,第5作者
(2) Novel biological strategies for treatment of wear particle-induced periprosthetic osteolysis of orthopaedic implants for joint replacement,J R Soc Interface,2014,第5作者
(3) Effects of Sclerostin abtibody on healing of a non-critical size femoral bone defect,J Orthop Res,2013,第3作者
(4) Exogenous MC3T3 pre-osteoblasts migrate systemically and mitigate the adverse effects of wear particles,Tissue Engineering,2012,第1作者
(5) Selective inhibition of the MCP-1-CCR2 ligand-receptor axis decreases systemic trafficking of macrophages in the presence of UHMWPE particles,J Orthop Res,2012,第3作者
(6) Continuous Infusion of UHMWPE Particles Induces Systemic Macrophage Trafficking and Osteolysis,Clin Orthop Relat Res.,2011,第1作者
(7) Noninvasive Monitoring of Placenta-Specific Transgene Expression by Bioluminescence Imaging,PlosOne,2011,第2作者
(8) An evaluation of the learning curve for a complex surgical technique: the full endoscopic interlaminar approach for lumbar disc herniations,Spine J,2011,第4作者
(9) Modulating osteogenesis of mesenchymal stem cells by modifying growth factor availability,Cytokine,2010,第2作者
(10) Effects of orthopaedic polymer particles on chemotaxis of macrophages and mesenchymal stem cells.,J Biomed Mater Res A.,2010,第3作者
(11) Surveillance of systemic trafficking of macrophages induced by UHMWPE particles in nude mice by non-invasive imaging,J Biomed Mater Res A.,2010,第1作者
(12) Efficacy of a p38 mitogen activated protein kinase inhibitor in mitigating an established inflammatory reaction to polyethylene particles in vivo,J Biomed Mater Res A,2009,第2作者
(13) In vivo murine model of continuous intramedullary infusion of particles--a preliminary study,J Biomed Mater Res B,2009,第4作者
(14) An In Vivo Murine Model of Continuous Intramedullary Infusion of Polyethylene Particles,Biomaterials,2008,第3作者
(15) Quantitation of bone area in undecalcified frozen sections with fluorescent microscopy.,J Histotechnology,2008,第1作者
(16) Controlled Release of Growth Factors on Allograft Bone in Vitro. ,Clin Orthop Relat Res,2008,第3作者
(17) Systemic trafficking of macrophages induced by bone cement particles in nude mice,Biomaterials,2008,第1作者
(18) Bacillus aidingensis sp. nov., a moderately halophilic bacterium isolated from Ai-Ding salt lake in China,Int J Syst Evol Microbiol,2008,第4作者
(19) Response to Comment on Obestatin, a Peptide Encoded by the Ghrelin Gene, Opposes Ghrelin‘s Effects on Food Intake,Science,2007,第3作者
(20) Lentibacillus halodurans sp. nov., a moderately halophilic bacterium isolated from a salt lake in Xin-Jiang, China. ,Int J Syst Evol Microbiol,2007,第2作者
(21) Salinibacillus aidingensis gen. nov., sp. nov. and Salinibacillus kushneri sp. nov., moderately halophilic bacteria isolated from a neutral saline lake in Xin-Jiang, China. ,Int J Syst Evol Microbiol.,2005,第1作者
(22) Natrinema altunense sp. nov., an extremely halophilic archaeon isolated from a salt lake in Altun Mountain in Xinjiang, China. ,Int J Syst Evol Microbiol.,2005,第2作者
(23) Obestatin, a peptide encoded by the Ghrelin gene, opposes ghrein’s effects on food intake,Science,2005,第2作者
(24) Tenuibacillus multivorans gen. nov., sp. nov., a moderately halophilic bacterium isolated from saline soil in Xin-Jiang, China. ,Int J Syst Evol Microbiol.,2005,第1作者
发表著作
(1) 分子生物学与转化科学进展,Progress in molecular biology and translational science,Academic Press,2013-03,第5作者
(2) 转化医学:理念、策略与实践,Translational medicine: concept, strategy, and practice,第四军医大学出版社,2013-02,第5作者
(3) 上皮细胞培养指南,Epithelial cell culture guide,科学出版社,2005-11,第5作者

科研活动

   
科研项目
(1) 深圳市基础研究项目:体内细胞迁移修复临界性骨缺损:基因、细胞、生物可降解材料支架的低成本修复策略,主持,市地级,2013-08--2015-08
(2) 深圳市基础研究计划项目:新的多肽激素在胰岛细胞及血糖调节中的作用机制研究,参与,市地级,2013-01--2015-01
(3) 深圳市孔雀团队:骨与关节退行性疾病防治新技术创新团队,参与,市地级,2013-01--2016-01
(4) 科技部973重大疾病治疗药物创制的基础研究专项:促胰岛素beta-细胞分泌胰岛素的新多肽激素研究,主持,国家级,2012-08--2014-08
(5) 深圳市技术开发项目:虚拟化知觉学习系统的产业化研发及其临床应用,参与,市地级,2012-08--2014-08
(6) 创新药物技术平台,参与,市地级,2011-01--2013-12
参与会议
(1) 镁植入颗粒在骨组织再生中的影响及其机制,中国生物材料学会2013年大会,深圳,中国,2013-12,郭成志,李健等
(2) 快速成型可降解支架负载生长因子基因诱导修复临界性骨缺损研究,中国生物材料学会2013年大会,深圳,中国,2013-12,李健,郭成志等
(3) Aseptic loosening and two-way cell-therapy in vitro and in vivo,中国生物材料学会2013年大会,深圳,中国,2013-12,任培根
(4) 关节假体磨屑病及其细胞治疗研究,深圳市平乐骨伤科医院-中国科学院深圳先进院2013交流会,2013-11,任培根
(5) 关节假体磨屑病及其细胞治疗研究,广东省医学会康复医学分会2013年会,2013-08,任培根
(6) Critical bone defect repairing by recruited MSCs induced by growth factor expressed from lentivector in LRP scaffold,2013-08,Li J, Guo CZ, Guo XY, Zhou JW, Zhang M, Ren P-G
(7) Insulin resistance regulation through resistin induced by a putative peptide hormone derived from bone,2013-06,Guo XY, Zhou JW, Li J, Guo CZ, Li D, Ren P-G
(8) Insulin resistance regulation through resistin induced by a putative peptide hormone derived from bone,第一届国际华人骨科研究大会,2013-05,Guo XY, Zhou JW, Li J, Guo CZ, Ren P-G
(9) The role of a bone-derived bioactive peptide in T2D which induces insulin secretion in beta-TC-6 cell,第一届国际华人骨科研究大会 ,2013-05,Zhou JW, Guo XY, Li J, Guo CZ, Li D, Ren P-G
(10) 无菌性松动机理研究及骨组织再生,深圳市医学会创伤骨科分会2012年会,2012-12,任培根
(11) Balancing of wear resistance and fracture toughness in crosslinked UHMWPE as orthopedic bearing surface,第九次世界生物材料大会,2012-05,Fritton K, Ren P-G, Ma T, Gibon E, Biswal S, Gambhir S, Goodman SB
(12) Inhibition of the MCP-1-CCR2 ligand-receptor axis decreases systemic macrophage trafficking to UHMWPE particles ,2012-04,Gibon E, Ma T, Ren P-G
(13) Selectinve inhibition of the MCP-1-CCR2 ligand-receptor axis decreases systemic trafficking of macrophages in the presence of UHMWPE particles,2011-06,Gibon E, Ma T, Ren P-G, Fritton K, Biswal S, Goodman SB
(14) Systemic migration of osteogenic cells mitigates particle-induced osteolysis,2011-06,Fritton K, Ren P-G, Ma T, Gibon E, Biswal S, Gambhir SS, Goodman SB
(15) Systemic Homing of Osteoprogenitor Cells to Continuously Infused UHMWPE Particles In Vivo,2011-05,Ren, P-G; Huang, ZN; Kate Fritton, Ma, T; Biswal, S; Smith, RL; Goodman, SB
(16) Monocyte Chemoattractant Protein-1 (MCP-1) Induced Macrophage Trafficking In Vivo.,2011-04,Ren, P-G; Huang, ZN; Ma, T; Biswal, S; Smith, RL; Goodman, SB
(17) A Novel Method of Monitoring Placenta-Specific Transgene Expression Throughout Pregnancy by Noninvasive Bioluminescence Imaging.,2010-07,1. Fan XJ, Ren P-G, Dhal S, Bejerano G, Goodman SB, Druzin ML, Gambhir SS, and Nayak NR
(18) Continuous Infusion of UHMWPE Particles Induces Systemic Macrophage Trafficking.,2010-05,Ren, Pei-Gen; Irani, Afraaz; Huang, Zhinong; Ma, Ting; Biswal, Sandip; Smith, Robert L.; Goodman, Stuart B
(19) Continuous Infusion of UHMWPE Particles Induces Systemic Macrophage Trafficking.,2010-04,Ren, Pei-Gen; Irani, Afraaz; Huang, Zhinong; Ma, Ting; Biswal, Sandip; Smith, Robert L, Goodman, Stuart B
(20) Surveillance of systemic trafficking of macrophages induced by UHMWPE particles in nude mice by non-invasive imaging.,2009-02,Ren, Pei-Gen; Lee, Sheen-Woo; Biswal, Sandip; Goodman, Stuart B
(21) Systemic Trafficking of Macrophages Induced by UHMWPE Particles,2008-12,Ren, Pei-Gen; Biswal, Sandip; Goodman, Stuart B
(22) Systemic trafficking of Macrophages induced by UHMWPE particles,2008-10,Ren P-G, Ma T, Huang ZN, Smith RL, Goodman SB
(23) Macrophages systemic trafficking induced by bone cement particles in nude mice,2008-05,Ren P-G, Ma T, Huang ZN, Smith RL, Goodman SB
(24) Surveillance of systemic trafficking of macrophages induced by PMMA cement particles in nude mice by IVIS.,2008-03,Pei-Gen Ren, Sheen-woo Lee, Sandip Biswal, Stuart B Goodman

合作情况

   
项目协作单位
   

指导学生

现指导学生

滕斌  硕士研究生  083100-生物医学工程