Research interests：

1. Mechanism studies about bone regeneration, bone resorption and their regulations

2. Adult stem cell and tissue engineering, especially the combination of stem cell and 3D printing scafold application in muscleskeletal system tissue engineering

3. Peptide hormones searching, screening and biofunction determination; peptide ligands and their G protein-coupled receptor in metabolism diseases and aging

2000.8–2001.10   Microbe Division (JCM), RIKEN, Wako, Saitama Prefecture, Japan. Visiting scholar/Ph.D candidate. On: Microbiota ecology of human GI tract. Supervisor: Dr. Benno Y.

1999.9–2004.7   Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, China. Ph.D awarded. on Microbiology. Supervisor: Professor PG Zhou.

1996.9–1999.7   Institute of Veterinary Medicine, Chinese Academy of Agriculture Sciences (CAAS), Beijing, China. Master of Science awarded on Veterinary Medicine/Molecular Viral Epidemiology. Supervisor: Professor QG Xie.

1991.9–1996.7  Department of Veterinary Medicine, Inner Mongolia Agriculture University, Huhehot, China - B.Sc. awarded on Veterinary Medicine

2012.9-Present    Professor. Translational Medicine R & D Center, Institute of Biomedical and Health Engineering, Shenzhen Institute of Advanced Techonology, CAS. 

2010.12-2012.9  Associate professor. Translational Medicine R & D Center, Institute of Biomedical and Health Engineering, Shenzhen Institute of Advanced Techonology, CAS. 

2009.9–2010.12  Research associate. Orthopaedics Surgery Dept., Medical Center, Stanford University, Stanford, California. 

2004.8–2009.9   Postdoctoral scholar. OB/GYN and Orthopaedics Surgery Dept., Medical Center, Stanford University, Stanford, California. 

1.     Xiang L, Jiang XT, Huang C, Li J, Chen J, Yan DW, Ren P-G*, Zhang J*. CMKLR1 deficiency leads to bone loss in male mice. J Endocrinol. 2017. (Submitted)

2.     Xue L, Yu Y, Tang HR, Xiang L, Chen J, Xiao TX, Ren P-G*, Zhang J*. Alleviation of high-fat-diet-induced fat accumulation and fatty liver damage by a small molecule CMKLR1 antagonist in mice. J Endocrinol Invest. 2017. (Submitted)

3.     Li J^#, Xiang L^#, Jiang XT, Teng B, Sun YT, Chen GL, Chen J, Zhang JV*, Ren P-G*. Investigation of bioeffects of GPR1 on bone turnover in male mice. J Orthop. Translat. 2017. (Invited article, under review)

4.     Li J, She C, Yao Z-Y, Li J, Teng B, Lin S-B, Dong Q-R*, Ren P-G*. Effects of low-dose X-ray irradiation on activated macrophages and their possible signal pathways. PlosOne. 2017. (Submitted, under review)

5.     Li J, Jahr H, Zheng W, Ren P-G*. Visualizing Angiogenesis by Multiphoton Microscopy in vivo in Genetically Modified 3D-PLGA/nHAp Scaffold for Calvarial Critical Bone Defect Repaired. JoVE. 2016. (Accepted) 

6.     Li J^#, Xu Q^#, Teng B, Yu C, Li J, Song L, Lai YX, Zhang J, Zheng W^*, Ren P-G^*. Investigation of Angiogenesis by in vivo Multiphoton Microscopy during Bone-formation in Murine Calvarial Critical Bone Defect Repaired by Genetically Modificated 3D-LGA/nHAp Scaffold. Acta Biomaterialia. 2016. 42: 389-99. 

7.     Yang Y-L*, Ren L-R*, Sun L-F*, Huang C, Xiao T-X, Wang B-B, Chen J, Zabel BA, Ren P-G^# and Zhang JV^#. The role of GPR1 signaling in mice corpus luteum. J Endocrinol. 2016. 230(1): 55-65. 

8.     Li J, Teng B, Lin RQ, She C, Yao ZY, Zhang J, Song L*, Ren P-G*. Neovasculature in 3D-PLGA/nHAp Scaffolds for Murine Critical sized Bone Defect Regeneration by Photoacoustic Imaging: A Preliminary Study. International Advanced Research Journal in Science, Engineering and Technology (IARJSET). 2016. 3(4):162-70. 

9.     Huang C, Wang MM, Ren LR, Xiang L, Chen J, Li MX, Xiao TX, Ren P-G, Xiong LK, Zhang JV. CMKLR1 deficiency influences glucose tolerance and thermogenesis in mice on high fat diet. Biochemical and Biophysical Research Communications (BBRC). 2016. 473(2): 435-41. 

10.  She C, Shi GL, Xu W, Zhou XZ, Li J, Tian Y, Li J, Li WH, Dong QR*, Ren P-G*. Effect of low-dose X-ray irradiation and Ti particles on the osseointegration of prosthetic. J Orthop Res. 2016. 34(4):725-8. 

11.  Tang M, Huang C, Wang Y-F, Ren P-G, Chen L, Xiao T-X, Wang B-B, Pan Y-F, Tsang BK, Zabel BA, Ma B-H, Zhao H-Y, Zhang JV. CMKLR1 deficiency maintains ovarian steroid production in mice treated chronically with dihydrotestosterone. Scientific Reports. 2016. (Epub Ahead). 

12.  Guo CZ, Li J, She C, Shao XZ, Teng B, Feng J, Zhang JV, Ren P-G. Bioeffects of Micron-Size Magnesium Particles on Inflammatory Cells and Bone Turnover In vivo and In vitro. J Biomed Mater Res B. 2016.104(5):923-31. 

13.  She C, Xu W, Shi GL, Zhou XZ, Li J, Guo CZ, Chen M, Keng Y-K, Ren P-G*, Dong QR*. The effect of low dose-X-ray radiation on the bone ingrowth onto prosthesis interface. J Orthop Translat. 2015. 2(4): 231-232.

14.  Goodman SB, Gibon E, Pajarinen J, Lin TH, Keeney M, Ren P-G, Nich C, Yao Z, Egashira K, Yang F, Konttinen YT. Novel biological strategies for treatment of wear particle-induced periprosthetic osteolysis of orthopaedic implants for joint replacement. J R Soc Interface. 2014. 11(93). 

15.  Li L, Ma P, Huang C, Liu Y, Zhang Y, Gao C, Xiao T, Ren P-G, Zabel BA, Zhang JV. Expression of chemerin and its receptors in rat testes and its action on testosterone secretion. J Endocrinol. 2014. 220(2):155-63. 

16.  Zhang JV, Li L, Huang QS, Ren P-G, Obestatin receptor in energy homeostasis and obesity pathogenesis. 2013. Prog Mol Biol Transl Sci. 114:89-107. 

17.  Jawad U, Fritton K, Ren P-G, Ma T, Gambhir S, Goodman SB. Effects of Sclerostin Antibody on Healing of a Non-critical Size Femoral Bone Defect. 2013. J Orthop Res. 31(1): 155-63.

18.  Fritton K, Ren P-G*, Gibon E, Rao A, Ma T, Biswal S, Gambhir S, Goodman SB. Exogenous MC3T3 Pre-osteoblasts Migrate Systemically and Mitigate the Adverse Effects of Wear Particles. 2012. Tissue Engineering. 18(23-24): 2559-67. (*:Co-first author.) 

19.  Gibon E, Ma T, Ren P-G, Fritton K, Biswal S, Yao Z, Smith L, Goodman SB. Selective inhibition of the MCP-1-CCR2 ligand-receptor axis decreases systemic trafficking of macrophages in the presence of UHMWPE particles. 2012. J Orthop Res. 30(4):547-53.

20. Fan XJ, Ren P-G, Dhal S, Bejerano G, Goodman SB, Druzin ML, Gambhir SS, and Nayak NR. Noninvasive Monitoring of Placenta-Specific Transgene Expression by Bioluminescence Imaging. 2011. PlosOne. 6(1):e16348. 

21.  Ren P-G, Irani A, Huang ZN, Ma T, Biswal S, Smith RL, Goodman SB. Continuous Infusion of UHMWPE Particles Induces Systemic Macrophage Trafficking and Osteolysis. Clin Orthop Relat Res. 2011. 469(1):113-22.

22.  Wang B, Lü GH, Patel AA, Ren P-G, Cheng I. An evaluation of the learning curve for a complex surgical technique: the full endoscopic interlaminar approach for lumbar disc herniations. 2011. Spine J. 11(2): 122-130. 

23.  Huang ZN, Ren P-G, Ma T, Smith RL, Goodman SB. Modulating osteogenesis of mesenchymal stem cells by modifying growth factor availability. Cytokine. 2010. 51(3):305-10. 

24.  Huang ZN, Ma T, Ren P-G, Smith RL, Goodman SB. Effects of orthopaedic polymer particles on chemotaxis of macrophages and mesenchymal stem cells. J Biomed Mater Res A. 2010, 94(4):1264-9. 

25.  Ren P-G, Huang ZN, Ma T, Biswal S, Smith RL, Goodman SB. Surveillance of systemic trafficking of macrophages induced by UHMWPE particles in nude mice by non-invasive imaging. J Biomed Mater Res A. 2010. 94(3):706-11. 

26.  Ma T, Ortiz SG, Huang Z, Ren P-G, Smith RL, Goodman SB. In vivo murine model of continuous intramedullary infusion of particles--a preliminary study. J Biomed Mater Res B., 2009. 88B(1): 250-253. 

27.  Ma T, Ren P-G, Larsen DM, Suenaga E, Zilber S, Genovese M, Smith RL, Goodman SB. Efficacy of a p38 mitogen activated protein kinase inhibitor in mitigating an established inflammatory reaction to polyethylene particles in vivo. J Biomed Mater Res A., 2008. 89(1):117-23. 

28.  Ren P-G, Lee S-W, Biswal S, Goodman SB. Systemic trafficking of macrophages induced by bone cement particles in nude mice. Biomaterials, 2008. 29: 4760-4765. 

29.  Xue Y, Ventosa A, Wang X, Ren P-G, Zhou P, Ma Y. Bacillus aidingensis sp. nov., a moderately halophilic bacterium isolated from Ai-Ding salt lake in China. Int J Syst Evol Microbiol., 2008. 58(12): 2828-32. 

30.  Ma T, Huang ZN, Ren P-G, Smith RL, Goodman SB. An In Vivo Murine Model of Continuous Intramedullarly Infusion of Polyethylene Particles. Biomaterials, 2008. 29(27): 3738-42. 

31.  Ren P-G, Ma T, Huang ZN, Smith RL, Goodman SB. Quantitation of bone area in undecalcified frozen sections with fluorescent microscopy. J Histotechnology, 2008. 31(1): 15-18. 

32.  Huang Z, Ryu W, Ren P-G, Fasching R, Goodman SB. Controlled Release of Growth Factors on Allograft Bone in Vitro. Clin Orthop Relat Res., 2008. 466(8): 1905-11. 

33.  Zhang JV, Klein C, Ren P-G, Kass S, Ver Donck L, Moechars D, Hsueh AJW. Response to Comment on “Obestatin, a Peptide Encoded by the Ghrelin Gene, Opposes Ghrelin's Effects on Food Intake”. Science, 2007. 315: 766d. 

34.  Yuan S., Ren P-G, Liu J., Xue Y., Ma Y., and Zhou P.  Lentibacillus halodurans sp. nov., a moderately halophilic bacterium isolated from a salt lake in Xin-Jiang,China. Int J Syst Evol Microbiol., 2007. 57(3): 485 - 488. 

35.  Zhang JV, Ren P-G, Avsian-Kretchmer O, Luo CW, Rauch R, Klein C, Hsueh AJ. Obestatin, a peptide encoded by the Ghrelin gene, opposes ghrein’s effects on food intake. Science, 2005. 310: 996-9. 

36.  Xu X.-W., Ren P-G, Liu S.-J., Wu M, Zhou P.-J. Natrinema altunense sp. nov., an extremely halophilic archaeon isolated from a salt lake in Altun Mountain in Xinjiang,China. Int J Syst Evol Microbiol., 2005. 55: 1311-4. 

37.  Ren, P-G & Zhou, P.-J. Salinibacillus aidingensis gen. nov., sp. nov. and Salinibacillus kushneri sp. nov., moderately halophilic bacteria isolated from a neutral saline lake in Xin-Jiang,China. Int J Syst Evol Microbiol., 2005. 55: 949-53. 

38.  Ren, P-G & Zhou, P.-J. Tenuibacillus multivorans gen. nov., sp. nov., a moderately halophilic bacterium isolated from saline soil in Xin-Jiang,China. Int J Syst Evol Microbiol., 2005. 55: 95-9. 

1. 中国发明专利，201210575057.5，动物模拟失重训练仪，任培根，张键，周洁文，李丹，郭小勇，李健。授权日期：2016.02.24

2. 中国发明专利，201410647550.2，一种基于基因修饰的复合多孔骨支架及其制备方法和应用，任培根，李健，滕斌。授权日期：2016.2.17

  申请中专利：

1.     PCT专利申请号：GAI15CN3823P . 雌性生殖疾病靶点CMKLR1及其拮抗剂与相关应用.发明人：张键，任培根，黄晨，王苗苗。

2.     PCT专利申请号：PCT/CN2017/076882. 调节糖代谢的多肽及其用途。发明人：任培根，张键，滕斌，李健，姚振宇

3.     中国专利申请号：201710156024.X. 调节糖代谢的多肽及其用途。发明人：任培根，张键，滕斌，李健，姚振宇

4.     PCT专利申请号：PCT/CN2017/076886. 调节能量代谢的多肽及其用途。发明人：任培根等，张键，滕斌，李健，姚振宇

5.     中国专利申请号：201710156032.4. 调节能量代谢的多肽及其用途。发明人：任培根等，张键，滕斌，李健，姚振宇

Some of the conferences abstracts and presentations:

1.     High quality oral presentation: Investigation of Angiogenesis in Bioactive 3D PLGA/nHAP scaffolds by in vivo Multiphoton Microscopy in Murine Calvarial Critical Bone Defect. BioNanoMed 2016 - Nanotechnology enables Personalized Medicine. 7th International Congress.  6-8 April 2016, Krems/Austria.

2.     基于多模态分子成像监测3D打印骨组织支架中血管生成的研究. 2014中华医学会第十六届骨科学术会议暨第九届国际COA学术大会，2014.11.20-23.北京。

3.     The effect of low dose X-ray radiation on the bone ingrowth onto prosthesis interface 2014 The 20^th International Bone Densitometry Workshop.

4.     Keynote report: Aseptic loosening and two-way cell-therapy in vitro and in vivo. 2013 中国生物材料学会2013年大会，深圳，中国。

5.     Oral presentation：镁植入颗粒在骨组织在再生中的影响极其机制 2013      中国生物材料学会2013年大会，深圳，中国。(Corresponding author)

6.     Poster：快速成型可降解支架负载生长因子基因诱导修复临界性骨缺损研究    2013 中国生物材料学会2013年大会，深圳，中国。(Corresponding author)

7.     Keynote report. 深圳市平乐骨伤科医院2013年专题报告。关节假体磨屑病及其细胞治疗研究。2013-11，深圳。

8.     Keynote report. 广东省医学会康复医学分会2013年会专题报告。关节假体磨屑病及其细胞治疗研究。2013-08-17，广州。

9.     Poster in ENDO 2013 San   Francisco, CA. Insulin resistance regulation through resistin induced by a putative peptide hormone derived from bone. (2013-06-15) (Corresponding Author)

10.  Oral presentation in Inaugural ICMRS-ASBMR International Chinese Musculoskeletal Research Conference (ICMRC2013) Suzhou,China. Insulin resistance regulation through resistin induced by a putative peptide hormone derived from bone. (Corresponding Author) 2013.5.21-23. Suzhou, China.

11.  Poster in Inaugural ICMRS-ASBMR International Chinese Musculoskeletal Research Conference (ICMRC2013) Suzhou,China. The role of a bone-derived bioactive peptide in type 2 diabetes which induces insulin secretion in beta-TC-6 cell. (Corresponding Author)

12.  Poster in WACBE World Congress 2013, Beijing. Critical bone defect repairing by recruited MSCs induced by growth factor expressed from lentivector in LRP scaffold. (Corresponding author)

13.  Keynote report. 深圳市医学会创伤骨科分会2012年会专题报告。无菌性松动机理研究及骨组织再生。2012，深圳。

14.  Symposium in WBC, Chengdu,China. 2012. S070 - 47.1. Balancing of wear resistance and fracture toughness in crosslinked UHMWPE as orthopedic bearing surfaces. 2^nd author.

15.  Poster in AAOS 2012, San Francisco, CA. Inhibition of the MCP-1-CCR2 Ligand-receptor Axis Decreases Systemic Macrophage Trafficking to UHMWPE Particles.

16.  Poster in: Transactions of the Hip Society Summer Meeting, 16, 2011. Gibon E, Ma T, Ren P-G, Fritton K, Biswal S, Goodman SB: Selective inhibition of the MCP-1-CCR2 ligand-receptor axis decreases systemic trafficking of macrophages in the presence of UHMWPE particles.  

17.  Poster in: Transactions of the Knee Society Summer Meeting, 56, 2011. Fritton K, Ren P-G, Ma T, Gibon E, Biswal S, Gambhir SS, Goodman SB: Systemic migration of osteogenic cells mitigates particle-induced osteolysis. Co-1^st author.

18.  Poster in Society for Biomaterials 2011 Annual Meeting, Orlando, FL. Systemic Homing of Osteoprogenitor Cells to Continuously Infused UHMWPE Particles In Vivo.

19.  Poster in Orthopaedic Research Society (ORS) 2011, Long Beach, CA. Monocyte Chemoattractant Protein-1 (MCP-1) Induced Macrophage Trafficking In Vivo. 1^st author.

20.  Poster in 43rd SSR Annual Meeting, 2010, Milwaukee, WI. A Novel Method of Monitoring Placenta-Specific Transgene Expression Throughout Pregnancy by Noninvasive Bioluminescence Imaging. (2^nd author)

21.  Poster in Orthopaedic Research Society (ORS) 2010, New   Orleans, LA. AND in Society For Biomaterials 2010 Annual Meeting, Seattle, WA.  Continuous Infusion of UHMWPE Particles Induces Systemic Macrophage Trafficking. First author.

22.  Poster in Orthopaedic Research Society (ORS) 2009, Las Vegas. Surveillance of systemic trafficking of macrophages induced by UHMWPE particles in nude mice by non-invasive imaging. February, 2009. First author.

23.  Podium presentation in TERMIS-NA2008, San Diego. Systemic Trafficking of Macrophages Induced by UHMWPE Particles. December, 2008. First author.

24.  Presentation for course BioE393 of Department of Bioengineering, Stanford University, Stanford, California. Systemic Trafficking of Macrophages Induced by UHMWPE Particles. October, 2008.

25.  Poster in Orthopaedic Research Society (ORS) 2008, San Francisco. Surveillance of systemic trafficking of macrophages induced by PMMA cement particles in nude mice by IVIS. March, 2008. First author.

26.  Poster in  8^th World Biomaterials Congress. Amsterdam,Netherlands. Macrophages Systemic Trafficking induced by Bone Cement Particles in Nude Mice. 28 May – 1 June 2008. First author.

27.  Poster in 10th Annual Reproductive Research Day. 2006. Stanford. Ovarian expression of obestatin and its receptor, GPR39. （2^nd author）

28.  Presentation in Johnson & Johnson Company, San Diego. Tachykinin-Associated Peptide (TKAP) Derived from Prepro-TAC1 Gene Activates TACR2 and TACR3 Receptors and Regulates Nociception. February, 2004.

现指导学生

滕斌  硕士研究生  083100-生物医学工程