Ji-Bao was born in 1983 and raised in Linyi, Shandong, China. He completed his undergraduate studies at Shandong Normal University in 2005. Then he moved to Shanghai Institute of Organic Chemistry for graduate study and earned his Ph.D. in 2010 with Professor Shu-Li You. After postdoctoral training at UT Southwestern Medical Center in Professor Chuo Chen's lab, he began his independent academic career at Lanzhou Institute of Chemical Physics (LICP), Suzhou Research Institute of LICP, Chinese Academy of Sciences in 2015. His research group focuses on synthetic methodology development and small molecular synthesis, particularly in the activation of small C1 molecules (CO and CO₂) and inert chemical bonds (C–H and C–N) and their catalytic transformations.

2005.9 – 2010.7     Shanghai Institute of Organic Chemistry, CAS　PhD.　Organic Chemistry

2001.9 – 2005.7     Shandong Normal University　B.S.　Applied Chemistry

2015.3 – present    Professor, Lanzhou Institute of Chemical Physics (LICP), Chinese Academy of Sciences

2010.9 – 2015.4     Postdoct, University of Texas Southwestern Medical Center, USA

Homogeneous Catalysis，Catalytic Oxo Synthesis and Transformations

l  Activation of small C1 molecules (CO and CO₂) and inert chemical bonds (C–H and C–N) and their catalytic transformations

l  Discovery of new synthetic methodologies and their applications in the synthesis of biologically active small molecules

43.       Li, W.-D.; Wu, Y.; Li, S.-J.; Jiang, Y.-Q.; Li, Y.-L.; Lan, Y.; Xia, J.-B. Boryl Radical Activation of Aliphatic C−OH Bond: Cross-Electrophile Coupling of Free Alcohols and CO2 via Photoredox Catalysis. J. Am. Chem. Soc. 2022, 144, 8551-8559.

l    Front Cover.

42.       Li, W.-D.; Jiang, Y.-Q.; Li, Y.-L.; Xia, J.-B. Photoredox Ni-Catalyzed Selective Couping of Organic Halides and Oxalates to Esters via Alkoxycarbonyl Radical Intermediates. CCS Chem. 2022, 4, 1326-1336.

41.       Gu, Z.-Y.; Xia, J.-B. [3+1+1] Cyclization of Vinyl Oxiranes with Azides and CO by Tandem Palladium Catalysis: Efficient Synthesis of Oxazolidinones. Org. Chem. Front. 2021, 8, 4112-4117.

40.       Jiang, Y.-Q.; Gu, Z.-Y.; Chen, Y.; Xia, J.-B. Pd-Catalyzed Amidation of Silyl Enol Ethers with CO and Azides via an Isocyanate Intermediate. Asian. J. Org. Chem. 2021, 10, 1704-1707.

39.       Li, Y.-L.; Zhang, S.-Q.; Chen, J.; Xia, J.-B. Highly Regio- and Enantioselective Reductive Coupling of Alkynes and Aldehydes via Photoredox Cobalt Dual Catalysis. J. Am. Chem. Soc. 2021, 143, 7306-7313.

l  Highlighted in Chin. J. Org. Chem. 2021, 41, 3342-3343.

l  Highlighted in Org. Chem. Highlights.

l  Highlighted in Org. Chem. Portal.

38.       Gu, Z.-Y.; Wu, Y.; Jin, F.; Bao, X.; Xia, J.-B. Palladium-Catalyzed Selective Intermolecular C–H Amidation of Alkenes with Carbon Monoxide and Azides. Synthesis 2021, 53, 3361-3371.

l    Invited article for the special issue of ‘‘Bond Activation in Honor of Prof. Shinji Murai’’.

37.       Gu, Z.-Y.; Han, H; Li, Z.; Ji, S.-J.; Xia, J.-B. Catalytic Synthesis of Functionalized Amidines via Cobalt-Carbene Radical Coupling with Isocyanides and Amines. Org. Chem. Front. 2021, 8, 1544-1550.

36.       Li, W.-D.; Chen, J.; Zhu, D.-Y.; Xia, J.-B. Fe-Catalyzed Pictet-Spengler-type Cyclization via Selective Four-electron Reductive Functionalization of CO2. Chin. J. Chem. 2021, 39, 614-620.

35.       Li, Y.-L.; Gu, Z.-Y.; Xia, J.-B. Transition-Metal-Catalyzed Intermolecular C–H Carbonylation toward Amides. Synlett 2021, 32, 7-13.

l    Invited Synpacts Article.

34.       Li, W.-D.; Xia, J.-B. 1,5-Hydrogen Atom Transfer Promoted Remote C–H Carboxylation. Chin. J. Org. Chem. 2020, 40, 4375-4376. 

33.       Zhang, Z.-B.; Xia, J.-B.  Recent Advance in Transition-Metal-Catalyzed Transformations of Aromatic Amines via Neutral C–N Bond Cleavage. J. Mol. Catal. (China) 2020, 34, 569-578.

l  Invited review on homogeneous catalysis.

32.       Zhang, Z.-B.; Xia, J.-B. NHC-Nickel Catalyzed C−N Bond Cleavage of Mono-Protected Anilines for C−C Cross-Coupling. Org. Lett. 2020, 22, 9609-9613. 

31.       Guo, X.; Wu, Y.; Li, G.-Q.; Xia, J.-B. Redox-Triggered Ruthenium-Catalyzed Remote C–H Acylation with Primary Alcohols. ACS Catal. 2020, 10, 12987–12995.

30.       Gu, Z.-Y.; Chen, J.; Xia, J.-B. Pd-Catalyzed Amidation of 1,3-Diketones with CO and Azides via a Nitrene Intermediate. Chem. Commun. 2020, 56, 11437-11440.

29.       Guo, X.; Wang, Y.-Z.; Chen, J.; Li, G.-Q.; Xia, J.-B. Recent Advances of CO2 Fixation via Asymmetric Catalysis for the Direct Synthesis of Optically Active Small Molecules. Chin. J. Org. Chem. 2020, 40, 2208-2220. 

l   Invited review on C1 feedstock transformation.

28.      Zhang, Z.-B.; Yang Y.; Yu, Z.-X.; Xia, J.-B. Lewis Base-Catalyzed Amino-Acylation of Arylallenes via C–N Bond Cleavage: Reaction Development and Mechanistic Studies. ACS Catal. 2020, 10, 5419-5429.

27.       Li, Y.-L.; Li W.-D.; Gu, Z.-Y.; Chen, J.; Xia, J.-B. Photoredox Ni-catalyzed Branch-Selective Reductive Coupling of Aldehydes with 1,3-Dienes. ACS Catal. 2020, 10, 1528-1534.      

26.       Li, W.-D.; Zhu, D.-Y.; Li, G.; Chen, J.; Xia, J.-B. Iron-Catalyzed Selective N-Methylation and N-Formylation of Amines with CO2. Adv. Synth. Catal. 2019, 361, 5098-5104.

l    VIP Paper;  Front Cover

25.       Yuan, S.-W.; Han, H.; Li, Y.-L.; Wu, X.; Bao, X.; Gu, Z.-Y.; Xia, J.-B. Intermolecular C–H Amidation of (Hetero)arenes to Produce Amides through Rhodium-Catalyzed Carbonylation of Nitrene Intermediate. Angew. Chem. Int. Ed. 2019, 58, 8887-8892.

l    Highlighted in Chin. J. Org. Chem. 2019, 39, 2681.

24.      Han, H.; Fang, L.; Chen, J.; Yang, S.-D.; Xia, J.-B. Tetramethylguanidine (TMG)-Catalyzed Reductive Spirocyclization of Tryptamine Derivatives with Formic Acid as a C1 Synthon. Tetrahedron Lett. 2019, 60, 1487-1489.

23.       Han, H.; Zhang, T.; Yang, S.-D.; Lan, Y.; Xia, J.-B. Palladium-Catalyzed Enantioselective C–H Aminocarbonylation: Synthesis of Chiral Isoquinolinones. Org. Lett. 2019, 21, 1749-1754.

22.       Han, H.; Yang, S.-D.; Xia, J.-B. Pd/Cu Cocatalyzed Oxidative Tandem C–H Aminocarbonylation and Dehydrogenation of Tryptamines: Synthesis of Carbolinones. J. Org. Chem. 2019, 84, 3357-3369.

21.       Zhang, Z.-B.; Ji, C.-L.; Yang, C.; Chen, J.; Hong, X.; Xia, J.-B. Nickel-Catalyzed Kumada Coupling of Boc-Activated Aromatic Amines via Nondirected Selective Aryl C−N Bond Cleavage. Org. Lett. 2019, 21, 1226-1231.

l    Highlighted in Synfacts 2019, 15, 526.

20.      Li, G.; Chen, Y.; Xia, J.-B. Progress on Transition-Metal-Catalyzed Cross-coupling Reactions of Ammonium Salts via C–N Bond Cleavage. Chin. J. Org. Chem. 2018, 38, 1949-1962.

19.       Li, G.; Chen, J.; Zhu, D.-Y.; Chen, Y.; Xia, J.-B. DBU-Catalyzed Selective N-Methylation and N-Formylation of Amines with CO2 and Polymethylhydrosiloxane. Adv. Synth. Catal. 2018, 360, 2364-2369.

18.       Zhu, D.-Y.; Li, W.-D.; Yang, C.; Chen. J.; Xia, J.-B. Transition-Metal-Free Reductive Deoxygenative Olefination with CO2. Org. Lett. 2018, 20, 3282-3285.

17.       Zhu, D.-Y.; Fang, L.; Han, H.; Wang Y.; Xia, J.-B. Reductive CO2 Fixation via Tandem C–C and C–N Bond Formation: Synthesis of Spiro-indolepyrrolidines. Org. Lett. 2017, 19, 4259-4262.

16.      Zhu, D.-Y.; Chen, P.; Xia, J.-B. Synthesis of Planar Chiral Ferrocenes by Transition-Metal-Catalyzed Enantioselective C–H Activation. ChemCatChem, 2016, 8, 68-73.

Publications from Graduate and Postdoctoral Studies:

15.  Han, L.; Xia, J.-B.; You, L.; Chen, C. Ketone-catalyzed photochemical C(sp3)–H chlorination. Tetrahedron 2017, 73, 3696-3701.

14.  Xia, J.-B.; Zhu, C.; Chen, C. Visible Light-Promoted Metal-Free sp3-C–H Fluorination. Chem. Commun. 2014, 50, 11701-11704.

13.  Xia, J.-B.; Ma, Y.; Chen, C. Vanadium-Catalyzed C(sp3)–H Fluorination Reactions. Org. Chem. Front. 2014, 1, 468-472.

l  One of three hot articles in April, 2014.

l  One of top ten most-read articles from April to June, 2014.

12.  Zhu, C.; Xia, J.-B.; Chen, C. A Simple Method for the Electrophilic Cyanation of Secondary Amines. Org. Lett. 2014, 16, 247-250.

11.  Zhu, C.; Xia, J.-B.; Chen, C. Vanadium-Catalyzed Oxidative Strecker Reaction: α-C–H Cyanation of para-Methoxyphenyl (PMP)-Protected Primary Amines. Tetrahedron Lett. 2014, 55, 232-234.

10.  Xia, J.-B.; Zhu, C.; Chen, C. Visible Light-Promoted Metal-Free C–H Activation: Diarylketone-Catalyzed Selective Benzylic Mono- and Difluorination. J. Am. Chem. Soc. 2013, 135, 17494-17500.

l  Highlighted in Synfacts 2014, 10, 85.

l  Highlighted in Org. Chem. Front. 2014, 1, 434-438.

9.    Xia, J.-B.; Cormier, K. W.; Chen, C. A Highly Selective Vanadium Catalyst for Benzylic C–H Oxidation. Chem. Sci. 2012, 3, 2240-2245.

l  One of top ten most accessed articles in April, 2012.

8.    Liu, W.-B.; Xia, J.-B.; You, S.-L. Iridium-Catalyzed Asymmetric Allylic Substitutions. Top. Organomet. Chem. 2012, 38, 155-208.

7.    Xia, J.-B.; Liu, W.-B.; Wang, T.-M.; You, S.-L. Enantioselective Synthesis of 3-Azabicyclo[4.1.0]heptanes and 3-Azabicyclo[3.2.0]heptanes via Ir-Catalyzed Asymmetric Allylic Amination of N-Tosyl Propynylamine and Pt-Catalyzed Cycloisomerization Reaction. Chem. Eur. J. 2010, 16, 6442-6446.

l  Highlighted in Synfacts 2010, 8, 909.

6.    Xia, J.-B.; Zhuo, C.-X.; You, S.-L. Synthesis of Cyclopropane-containing Building Blocks via Ir-Catalyzed Enantioselective Allylic Substitution Reaction. Chin. J. Chem. 2010, 28, 1525-1528.

l  Invited paper for celebrating the 60th Anniversary of SIOC.

5.    You, S.-L.; Xia, J.-B. Palladium-Catalyzed Aryl–Aryl Bond Formation through Double C–H Activation. Top. Curr. Chem. 2010, 292, 165-194.

4.    Xia, J.-B.; You, S.-L. Synthesis of 3-Haloindolizines by Copper(II) Halides Mediated Direct Functionalization of Indolizines. Org. Lett. 2009, 11, 1187-1190.

3.    Xia, J.-B.; Wang, X.-Q.; You, S.-L. Synthesis of Biindolizines through Highly Regioselective Palladium-Catalyzed C–H Functionalization. J. Org. Chem. 2009, 74, 456-458.

2.    Wang, X.-Q.; Xia, J.-B.; Dai, X.-Y.; You, S.-L. Preparation of Ferrocenyl Imidazolines using Bis(triphenyl)oxodiphosphonium Trifluoromethansulfonate. Sci. China Chem. 2009, 52, 1331-1336.

l  Invited paper for the 90th Anniversary of Nankai University.

1.    Xia, J.-B.; You, S.-L. Carbon–Carbon Bond Formation through Double sp2 C–H Activations: Synthesis of Ferrocenyl Oxazoline Derivatives. Organometallics 2007, 26, 4869-4871.

l  One of the most-accessed articles in July-September 2007.

Book Chapters                                                            

2.    Xia, J.-B.; You, S.-L. C–C Bond Formation via Double C–H Bond Activation. in Science of Synthesis, Yu, J.-Q., Ed, Thieme: Stuttgart, 2015 115-136.

1.    Xia, J.-B.; Jamison, T. F.; You, S.-L. Monodentate Chiral Ferrocenyl Ligands. in Chiral Ferrocenes in Asymmetric Catalysis, Dai, L.-X., Hou, X.-L., Eds, WILEY-VCH: Weinheim, 2010, pp. 55-71. 

• 2020     Thieme Chemistry Journals Award

• 2015     The Hundred Talents Program of the Chinese Academy of Sciences

• 2010     the GlaxoSmithKline scholarship, Shanghai Institute of Organic Chemistry

• 2005     the excellent graduate award, Shandong Normal University

已指导学生

韩慧  博士研究生  070304-物理化学  

张正兵  博士研究生  070303-有机化学  

李彦霖  博士研究生  070303-有机化学  

李文多  博士研究生  070303-有机化学  

现指导学生

张士启  博士研究生  070303-有机化学  

吴洋  博士研究生  070303-有机化学