基本信息
夏纪宝  男  博导  中国科学院兰州化学物理研究所
电子邮件: jibaoxia@licp.cas.cn
通信地址: 苏州市苏州工业园区金鸡湖大道99号
邮政编码: 215123

研究领域

Homogeneous Catalysis,Catalytic Oxo Synthesis and Transformations:

l  Activation of small C1 molecules (CO and CO2) and inert chemical bonds (C–H and C–N) and their catalytic transformations

l  Discovery of new synthetic methodologies and their applications in the synthesis of biologically active small molecules

招生信息

欢迎热爱化学的硕士研究生报考我们课题组的博士研究生;招收对我们在研方向感兴趣的联合培养硕士生和博士生。课题组有固定职工职位:实习研究员(学士和硕士)和助理研究员(博士);课题组招收博士后;有意者请直接联系夏老师(jibaoxia@licp.cas.cn)。


招生专业
070303-有机化学
081701-化学工程
招生方向
金属有机化学
不对称催化

教育背景

2005-09--2010-07   中国科学院上海有机化学研究所   博士
2001-09--2005-07   山东师范大学   学士

工作经历

   
工作简历
2015-05~现在, 中国科学院兰州化学物理研究所苏州研究院, 研究员
2015-03~现在, 中国科学院兰州化学物理研究所, 研究员
2010-09~2015-03,University of Texas Southwestern Medical Center, 博士后

出版信息

39.  Li, Y.-L.; Zhang, S.-Q.; Chen, J.; Xia, J.-B. Highly Regio- and Enantioselective Reductive Coupling of Alkynes and Aldehydes via Photoredox Cobalt Dual Catalysis. J. Am. Chem. Soc. 2021, DOI: 10.1021/jacs.1c03527. [HTML]

38.  Gu, Z.-Y.; Wu, Y.; Jin, F.; Bao, X.; Xia, J.-B. Palladium-Catalyzed Selective Intermolecular CH Amidation of Alkenes with Carbon Monoxide and Azides. Synthesis 2021, DOI: 10.1055/a-1401-4486. [HTML]

l    Invited article for the special issue of ‘‘Bond Activation in Honor of Prof. Shinji Murai’’.

37.  Gu, Z.-Y.; Han, H; Li, Z.; Ji, S.-J.; Xia, J.-B. Catalytic Synthesis of Functionalized Amidines via Cobalt-Carbene Radical Coupling with Isocyanides and Amines. Org. Chem. Front. 2021, 8, 1544-1550. [HTML]

36.  Li, W.-D.; Chen, J.; Zhu, D.-Y.; Xia, J.-B. Fe-Catalyzed Pictet-Spengler-Type Cyclization via Selective Four-Electron Reductive Functionalization of CO2. Chin. J. Chem. 2021, 39, 614-620. [HTML]

35.  Li, Y.-L.; Gu, Z.-Y.; Xia, J.-B. Transition-Metal-Catalyzed Intermolecular CH Carbonylation toward Amides. Synlett 2021, 32, 7-13. [HTML]

l  Invited Synpacts article.

34. Li, W.-D.; Xia, J.-B. 1,5-Hydrogen Atom Transfer Promoted Remote CH Carboxylation. Chin. J. Org. Chem. 2020, 40, 4375-4376. [HTML]

l  Invited highlight.

33.  Zhang, Z.-B.; Xia, J.-B. Recent Advance in Transition-Metal-Catalyzed Transformations of Aromatic Amines via Neutral C–N Bond Cleavage. J. Mol. Catal. (China) 2020, 34, 569-578. [HTML]

l  Invited review on homogeneous catalysis.

32. Zhang, Z.-B.; Xia, J.-B. NHC-Nickel Catalyzed C−N Bond Cleavage of Mono-Protected Anilines for C−C Cross-Coupling. Org. Lett. 2020, 22, 9609-9613. [HTML]

31.  Guo, X.; Wu, Y.; Li, G.-Q.; Xia, J.-B. Redox-Triggered Ruthenium-Catalyzed Remote C–H Acylation with Primary Alcohols. ACS Catal. 2020, 10, 12987–12995. [HTML]

30.  Gu, Z.-Y.; Chen, J.; Xia, J.-B. Pd-Catalyzed Amidation of 1,3-Diketones with CO and Azides via a Nitrene Intermediate. Chem. Commun. 2020, 56, 11437-11440. [HTML]

29.  Guo, X.; Wang, Y.-Z.; Chen, J.; Li, G.-Q.; Xia, J.-B. Recent Advances of CO2 Fixation via Asymmetric Catalysis for the Direct Synthesis of Optically Active Small Molecules. Chin. J. Org. Chem. 2020, 40, 2208-2220. [HTML]

l  Invited review on transformation of C1 feedstock.

28.  Zhang, Z.-B.; Yang Y.; Yu, Z.-X.; Xia, J.-B. Lewis Base-Catalyzed Amino-Acylation of Arylallenes via C–N Bond Cleavage: Reaction Development and Mechanistic Studies. ACS Catal. 2020, 10, 5419-5429. [HTML]

27.  Li, Y.-L.; Li W.-D.; Gu, Z.-Y.; Chen, J.; Xia, J.-B. Photoredox Ni-catalyzed Branch-Selective Reductive Coupling of Aldehydes with 1,3-Dienes. ACS Catal. 2020, 10, 1528-1534. [HTML]

26.  Li, W.-D.; Zhu, D.-Y.; Li, G.; Chen, J.; Xia, J.-B. Iron-Catalyzed Selective N-Methylation and N-Formylation of Amines with CO2. Adv. Synth. Catal. 2019, 361, 5098-5104. [HTML]

l  VIP Paper; Front Cover

25.  Yuan, S.-W.; Han, H.; Li, Y.-L.; Wu, X.; Bao, X.; Gu, Z.-Y.; Xia, J.-B. Intermolecular C–H Amidation of (Hetero)arenes to Produce Amides through Rhodium-Catalyzed Carbonylation of Nitrene Intermediate. Angew. Chem. Int. Ed. 2019, 58, 8887-8892. [HTML]

l  Highlighted in Chin. J. Org. Chem. 2019, 39, 2681.

24.  Han, H.; Fang, L.; Chen, J.; Yang, S.-D.; Xia, J.-B. Tetramethylguanidine (TMG)-Catalyzed Reductive Spirocyclization of Tryptamine Derivatives with Formic Acid as a C1 Synthon. Tetrahedron Lett. 2019, 60, 1487-1489. [HTML]

23.  Han, H.; Zhang, T.; Yang, S.-D.; Lan, Y.; Xia, J.-B. Palladium-Catalyzed Enantioselective C–H Aminocarbonylation: Synthesis of Chiral Isoquinolinones. Org. Lett. 2019, 21, 1749-1754. [HTML]

22.  Han, H.; Yang, S.-D.; Xia, J.-B. Pd/Cu Cocatalyzed Oxidative Tandem C–H Aminocarbonylation and Dehydrogenation of Tryptamines: Synthesis of Carbolinones. J. Org. Chem. 2019, 84, 3357-3369. [HTML]

21.  Zhang, Z.-B.; Ji, C.-L.; Yang, C.; Chen, J.; Hong, X.; Xia, J.-B. Nickel-Catalyzed Kumada Coupling of Boc-Activated Aromatic Amines via Nondirected Selective Aryl C−N Bond Cleavage. Org. Lett. 2019, 21, 1226-1231. [HTML]

l  Highlighted by P. Knochel and S. Graβl in Synfacts 2019, 15, 526.

20.  Li, G.; Chen, Y.; Xia, J.-B. Progress on Transition-Metal-Catalyzed Cross-coupling Reactions of Ammonium Salts via C–N Bond Cleavage. Chin. J. Org. Chem. 2018, 38, 1949-1962. [HTML]

19.  Li, G.; Chen, J.; Zhu, D.-Y.; Chen, Y.; Xia, J.-B. DBU-Catalyzed Selective N-Methylation and N-Formylation of Amines with CO2 and Polymethylhydrosiloxane. Adv. Synth. Catal. 2018, 360, 2364-2369. [HTML]

18.  Zhu, D.-Y.; Li, W.-D.; Yang, C.; Chen. J.; Xia, J.-B. Transition-Metal-Free Reductive Deoxygenative Olefination with CO2. Org. Lett. 2018, 20, 3282-3285. [HTML]

17.  Zhu, D.-Y.; Fang, L.; Han, H.; Wang Y.; Xia, J.-B. Reductive CO2 Fixation via Tandem C–C and C–N Bond Formation: Synthesis of Spiro-indolepyrrolidines. Org. Lett. 2017, 19, 4259-4262. [HTML]

16.  Zhu, D.-Y.; Chen, P.; Xia, J.-B. Synthesis of Planar Chiral Ferrocenes by Transition-Metal-Catalyzed Enantioselective C–H Activation. ChemCatChem, 2016, 8, 68-73. [HTML]

 

Publications from Graduate and Postdoctoral Studies:

15.  Han, L.; Xia, J.-B.; You, L.; Chen, C. Ketone-catalyzed photochemical C(sp3)H chlorination. Tetrahedron 2017, 73, 3696-3701.

14.  Xia, J.-B.; Zhu, C.; Chen, C. Visible Light-Promoted Metal-Free sp3-CH Fluorination Chem. Commun. 2014, 50, 11701-11704.

13.  Xia, J.-B.; Ma, Y.; Chen, C. Vanadium-Catalyzed C(sp3)–H Fluorination Reactions. Org. Chem. Front. 2014, 1, 468-472.

l  One of three hot articles in April, 2014.

l  One of top ten most-read articles from April to June, 2014.

12.  Zhu, C.; Xia, J.-B.; Chen, C. A Simple Method for the Electrophilic Cyanation of Secondary Amines. Org. Lett. 2014, 16, 247-250.

11.  Zhu, C.; Xia, J.-B.; Chen, C. Vanadium-Catalyzed Oxidative Strecker Reaction: α-C–H Cyanation of para-Methoxyphenyl (PMP)-Protected Primary Amines. Tetrahedron Lett. 2014, 55, 232-234.

10.  Xia, J.-B.; Zhu, C.; Chen, C. Visible Light-Promoted Metal-Free C–H Activation: Diarylketone-Catalyzed Selective Benzylic Mono- and Difluorination. J. Am. Chem. Soc. 2013, 135, 17494-17500.

l  Highlighted in Synfacts 2014, 10, 85; Org. Chem. Front. 2014, 1, 434-438.

9.    Xia, J.-B.; Cormier, K. W.; Chen, C. A Highly Selective Vanadium Catalyst for Benzylic CH Oxidation. Chem. Sci. 2012, 3, 2240-2245.

l  One of top ten most accessed articles in April, 2012.

8.    Liu, W.-B.; Xia, J.-B.; You, S.-L. Iridium-Catalyzed Asymmetric Allylic Substitutions Top. Organomet. Chem. 2012, 38, 155-208.

7.    Xia, J.-B.; Liu, W.-B.; Wang, T.-M.; You, S.-L. Enantioselective Synthesis of 3-Azabicyclo[4.1.0]heptanes and 3-Azabicyclo[3.2.0]heptanes via Ir-Catalyzed Asymmetric Allylic Amination of N-Tosyl Propynylamine and Pt-Catalyzed Cycloisomerization Reaction. Chem. Eur. J. 2010, 16, 6442-6446.

l  Highlighted in Synfacts 2010, 8, 909.

6.    Xia, J.-B.; Zhuo, C.-X.; You, S.-L. Synthesis of Cyclopropane-containing Building Blocks via Ir-Catalyzed Enantioselective Allylic Substitution Reaction. Chin. J. Chem. 2010, 28, 1525-1528.

l  Invited paper for celebrating the 60th Anniversary of SIOC.

5.    You, S.-L.; Xia, J.-B. Palladium-Catalyzed Aryl–Aryl Bond Formation through Double C–H Activation. Top. Curr. Chem. 2010, 292, 165-194.

4.    Xia, J.-B.; You, S.-L. Synthesis of 3-Haloindolizines by Copper(II) Halides Mediated Direct Functionalization of Indolizines. Org. Lett. 2009, 11, 1187-1190.

3.    Xia, J.-B.; Wang, X.-Q.; You, S.-L. Synthesis of Biindolizines through Highly Regioselective Palladium-Catalyzed C–H Functionalization. J. Org. Chem. 2009, 74, 456-458.

2.    Wang, X.-Q.; Xia, J.-B.; Dai, X.-Y.; You, S.-L. Preparation of Ferrocenyl Imidazolines using Bis(triphenyl)oxodiphosphonium Trifluoromethansulfonate. Sci. China Chem. 2009, 52, 1331-1336.

l  Invited paper for the 90th Anniversary of Nankai University.

1.    Xia, J.-B.; You, S.-L. CarbonCarbon Bond Formation through Double sp2 C–H Activations: Synthesis of Ferrocenyl Oxazoline Derivatives. Organometallics 2007, 26, 4869-4871.

l  One of the most-accessed articles in July-September 2007.

 

Book Chapters                                                            

2.    Xia, J.-B.; You, S.-L. CC Bond Formation via Double CH Bond Activation. in Science of Synthesis, Yu, J.-Q., Ed, Thieme: Stuttgart, 2015 115-136.

       1.    Xia, J.-B.; Jamison, T. F.; You, S.-L. Monodentate Chiral Ferrocenyl Ligands. in Chiral Ferrocenes in Asymmetric Catalysis, Dai, L.-X., Hou,   X.-L., Eds, WILEY-VCH: Weinheim, 2010, pp. 55-71.


科研活动

科研项目
( 1 ) 兰化所特聘人才计划, 主持, 市地级, 2015-05--2018-12
( 2 ) 中科院****, 主持, 部委级, 2016-01--2018-12
( 3 ) 国家自然科学基金面上项目, 主持, 国家级, 2016-01--2017-12
( 4 ) 江苏省自然科学基金面上基金, 主持, 省级, 2016-07--2019-06
( 5 ) 国家自然科学基金面上项目, 主持, 国家级, 2018-01--2021-12
( 6 ) 国家自然科学基金青年项目, 参与, 国家级, 2017-01--2019-12
( 7 ) 过渡金属催化的选择性碳氢羰基化反应研究, 主持, 省级, 2020-07--2023-06
( 8 ) 手性化合物高效合成, 主持, 部委级, 2020-01--2021-12
( 9 ) 碳-氢羰基化反应研究, 主持, 市地级, 2020-06--2021-05