Dr. Shiliang Shi, PI, Professor, State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
Phone: 86-21-54925580
Email: shiliangshi@sioc.ac.cn
Office: 345 Lingling Road, Shanghai, China, 200032
Research Areas
1) Development of novel, efficient, and practical synthetic organic reactions, with a focus on asymmetric syntheses and catalytic reactions. 2) Design and syntheses of new functional polymers.
Education
2011.9, Ph.D. in Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, the University of Tokyo (Advisor: Prof. Masakatsu Shibasaki and Prof. Motomu Kanai)
Experience
Work Experience
2011.10-2012.10, JSPS Postdoctoral Scholar in the Laboratory of Prof. Motomu Kanai, Graduate School of Pharmaceutical Sciences, the University of Tokyo;
2012.11-2016.5 Postdoctoral Fellow in the Group of Prof. Stephen L. Buchwald, Department of Chemistry, Massachusetts Institute of Technology;
2016.6-Present, PI, Professor, State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences;
Publications
Papers
1) Shi-Liang Shi, Zackary L. Wong, Stephen L. Buchwald*
“Copper-Catalyzed Enantioselective Stereodivergent Synthesis of Amino Alcohols”
Nature 2016, 532, 353–356.
2) Yang Yang†, Shi-Liang Shi†, Dawen Niu, Peng Liu, Stephen L. Buchwald*
“Catalytic Asymmetric Hydroamination of Unactivated Internal Olefins to Aliphatic Amines”
Science 2015, 349, 62–66. (†: Co-first author)
(Highlighted in Chemistry World and Chemical & Engineering News)
3) Shi-Liang Shi, Stephen L. Buchwald*
“Copper-catalysed Selective Hydroamination Reactions of Alkynes”
Nature Chemistry 2015, 7, 38–44. (Highlighted in Nature. Nature 517, 280–281)
4) Shi-Liang Shi, Stephen L. Buchwald*
“Palladium-Catalyzed Intramolecular C–H Difluoroalkylation: Synthesis of Substituted 3,3-Difluoro-2-oxindoles”
Angew. Chem. Int. Ed. 2015, 54, 1646-1650.
5) Shi-Liang Shi, Xiao-feng Wei, Yohei Shimizu, Motomu Kanai*
“Copper(I)-Catalyzed Enantioselective Incorporation of Ketones to Cyclic Hemiaminals for the Synthesis of Versatile Alkaloid Precursor”
J. Am. Chem. Soc. 2012, 134, 17019-17022.
6) Shi-Liang Shi, Motomu Kanai* and Masakatsu Shibasaki*
“Asymmetric Synthesis of Dihydropyranones from Ynones by Sequential Copper(I)-Catalyzed Direct Aldol and Silver(I)-Catalyzed Oxy-Michael Reactions”
Angew. Chem. Int. Ed. 2012, 51, 3932-3935.
7) Shi-Liang Shi, Li-Wen Xu, Kounosuke Oisaki, Motomu Kanai* and Masakatsu Shibasaki*
“Identification of Modular Chiral Bisphosphines Effective for Cu(I)-Catalyzed Asymmetric Allylation and Propargylation of Ketones”
J. Am. Chem. Soc. 2010, 132, 6638-6639.
8) Yohei Shimizu, Shi-Liang Shi, Hiroyuki Usuda, Motomu Kanai* and Masakatsu Shibasaki*
“Catalytic Asymmetric Total Synthesis of ent-Hyperforin”
Angew. Chem., Int. Ed. 2010, 49, 1103-1106.
Research Interests
1) Development of novel, efficient, and practical synthetic organic reactions, with a focus on asymmetric syntheses and catalytic reactions. 2) Design and syntheses of new functional polymers.
Honors & Distinctions
2010 Chinese Government Award for Outstanding Self-Financed Students Abroad
2008-2011 Japanese Government (Monbukagakusho: MEXT) Scholarship
2011-2013 Japan Society for the Promotion of Science (JSPS) Fellowships (DC2 and PD)
2016 “Thousand Talents Program” Young Investigator Award