1. 发展新型优势手性配体

2. 发展新型高效的不对称催化反应​

3. 设计和合成新型光学活性聚合物

   

070303-有机化学

2008-10--2011-09   日本东京大学药学部   博士学位

   

2016-05~现在, 中国科学院上海有机化学研究所, **** ** 研究员 博士生导师 课题组长
2012-11~2016-05,美国麻省理工学院化学系, 博士后
2011-10~2012-10,日本东京大学药学部, JSPS博士后

   

（1） “****(青年项目)”, 国家级, 2016
（2） 国家优秀自费留学生奖, 国家级, 2010

[1] 施世良, 马俊宝. 一种咪唑盐、其制备方法、其应用及含氟聚合物的制备方法. CN2022102735026, 2022-03-19.
[2] 施世良, 申迪. 钯复合物、其制备方法、轴手性联芳香化合物的制备方法. CN: CN112300214A, 2021-02-02.
[3] 施世良, 蔡援, 杨新拓, 李峰. 手性1,3-二芳基咪唑盐卡宾前体、其合成方法、金属盐复合物和应用. CN: CN109776422A, 2019-05-21.

   

[1] Zhang, WuBin, Chen, Guang, Shi, ShiLiang. Enantioselective Ni/N-Heterocyclic Carbene-Catalyzed Redox-Economical Coupling of Aldehydes, Alkynes, and Enones for Rapid Construction of Acyclic All-Carbon Quaternary Stereocenters. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2022, 144(1): 130-136, http://dx.doi.org/10.1021/jacs.1c12625.
[2] Wang Zichao, Gao Jian, Cai Yuan, Ye Xiaodong, Shi Shiliang. Chemo- and Enantioselective Arylation and Alkenylation of Aldehydes Enabled by Nickel/N-Heterocyclic Carbene Catalysis. CCS CHEMISTRY[J]. 2022, 4(4): 1169-1179, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=7296316&detailType=1.
[3] 蒋滨阳, 施世良. 醇与胺的不对称脱氢偶联升级反应研究进展. 有机化学[J]. 2022, 42(10): 3263-3279, http://lib.cqvip.com/Qikan/Article/Detail?id=7108543136.
[4] Ma, JunBao, Zhao, Xia, Zhang, Dongju, Shi, ShiLiang. Enantio- and Regioselective Ni-Catalyzed para-C-H Alkylation of Pyridines with Styrenes via Intermolecular Hydroarylation. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2022, 144(30): 13643-13651, [5] Gao, Lei, Liu, Sheng, Wang, ZiChao, Mao, Yongjun, Shi, ShiLiang. Ligand- and Additive-Free CuCl2-Catalyzed para-C-H Alkylation of Aniline Derivatives via Carbene Insertion. ASIAN JOURNAL OF ORGANIC CHEMISTRY[J]. 2022, 11(2): http://dx.doi.org/10.1002/ajoc.202100723.
[6] Zhang, Yurong, Wang, Han, Mao, Yongjun, Shi, Shiliang. Ni-Catalyzed Three-Component Coupling Reaction of Butadiene, Aldimines and Alkenylboronic Acids. CHINESE JOURNAL OF ORGANIC CHEMISTRY[J]. 2022, 42(4): 1198-1209, http://dx.doi.org/10.6023/cjoc202110042.
[7] Liu, ChenFei, Wang, ZiChao, Luo, Xiaohua, Lu, Jiawei, Ko, Charyl Hui Min, Shi, ShiLiang, Koh, Ming Joo. Synthesis of tri- and tetrasubstituted stereocentres by nickel-catalysed enantioselective olefin cross-couplings. NATURE CATALYSIS[J]. 2022, 5(10): 934-942, [8] Jiang, Binyang, Shi, ShiLiang. Pd-Catalyzed Cross-Coupling of Alkylzirconocenes and Aryl Chlorides. CHINESE JOURNAL OF CHEMISTRY[J]. 2022, 40(15): 1813-1820, http://dx.doi.org/10.1002/cjoc.202200132.
[9] Wang, ZiChao, Xie, PeiPei, Xu, Youjun, Hong, Xin, Shi, ShiLiang. Low-Temperature Nickel-Catalyzed C-N Cross-Coupling via Kinetic Resolution Enabled by a Bulky and Flexible Chiral N-Heterocyclic Carbene Ligand. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2021, 60(29): 16077-16084, http://dx.doi.org/10.1002/anie.202103803.
[10] Li, YuQing, Chen, Guang, Shi, ShiLiang. Regio- and Trans-Selective Ni-Catalyzed Coupling of Butadiene, Carbonyls, and Arylboronic Acids to Homoallylic Alcohols under Base-Free Conditions. ORGANIC LETTERS[J]. 2021, 23(7): 2571-2577, http://dx.doi.org/10.1021/acs.orglett.1c00488.
[11] ShiLiang Shi. Low-Temperature Ni-Catalyzed C−N Cross-Coupling via Kinetic Resolution Enabled by a Bulky yet Flexible Chiral N-Heterocyclic Carbene Ligand. Angew. Chem. Int. Ed.. 2021, [12] Cai, Yuan, Ruan, LinXin, Rahman, Abdul, Shi, ShiLiang. Fast Enantio- and Chemoselective Arylation of Ketones with Organoboronic Esters Enabled by Nickel/N-Heterocyclic Carbene Catalysis. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2021, 60(10): 5262-5267, https://www.webofscience.com/wos/woscc/full-record/WOS:000610876400001.
[13] Li YuQing, Shi ShiLiang. Nickel-Catalyzed Multicomponent Coupling of Butadiene, Aldehydes, Alkynes and Schwartz Reagent to Form 1,4-Dienes. CHINESE JOURNAL OF ORGANIC CHEMISTRY[J]. 2021, 41(5): 1939-1948, http://dx.doi.org/10.6023/cjoc202101019.
[14] Wei, Shichao, Mao, Yongjun, Shi, ShiLiang. Nickel-Catalyzed Ligand-Free Hiyama Coupling of Aryl Bromides and Vinyltrimethoxysilane. SYNLETT[J]. 2021, 32(16): 1670-1674, http://dx.doi.org/10.1055/a-1379-1584.
[15] Li, YuQing, Shi, ShiLiang. Ni-Catalyzed Coupling of Butadiene, Aldimines, and Arylboronic Acids to Homoallylic Amines under Base-Free Conditions. ORGANOMETALLICS[J]. 2021, 40(14): 2345-2353, http://dx.doi.org/10.1021/acs.organomet.1c00096.
[16] Cai, Yuan, Shi, ShiLiang. ANIPE-Cu Catalyst Enables Highly Enantioselective Markovnikov Hydroboration of alpha-Olefins. SYNLETT[J]. 2021, 32(6): 545-550, https://www.webofscience.com/wos/woscc/full-record/WOS:000593002300001.
[17] 蒋滨阳, 施世良. 光-钴协同催化的高区域、高对映选择性醛-炔还原偶联反应. 有机化学[J]. 2021, 41(8): 3342-3343, http://lib.cqvip.com/Qikan/Article/Detail?id=7105681187.
[18] ShiLiang Shi. Chemo- and Enantioselective Arylation and Alkenylation of Aldehydes Enabled by Nickel/ N-Heterocyclic Carbene Catalysis. CCS Chemistry. 2021, [19] Cai, Yuan, Shi, ShiLiang. Enantioconvergent Arylation of Racemic Secondary Alcohols to Chiral Tertiary Alcohols Enabled by Nickel/N-Heterocyclic Carbene Catalysis. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2021, 143(31): 11963-11968, http://dx.doi.org/10.1021/jacs.1c06614.
[20] Li Yuqing, Li Feng, Shi Shiliang. Expedient Synthesis of Ketones via N-Heterocyclic Carbene/Nickel-Catalyzed Redox-Economical Coupling of Alcohols and Alkynes. CHINESE JOURNAL OF CHEMISTRY[J]. 2020, 38(10): 1035-1039, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=6836673&detailType=1.
[21] Shen, Di, Zhang, WuBin, Li, Zhiyang, Shi, ShiLiang, Xu, Youjun. Nickel/NHC-Catalyzed Enantioselective Cyclization of Pyridones and Pyrimidones with Tethered Alkenes. ADVANCED SYNTHESIS & CATALYSIS[J]. 2020, 362(5): 1125-1130, https://www.webofscience.com/wos/woscc/full-record/WOS:000508461400001.
[22] 王子超, 许佑君, 施世良. 碱促进醛亚胺的快速氢硅化反应. 有机化学[J]. 2020, 40(10): 3463-3466, http://lib.cqvip.com/Qikan/Article/Detail?id=7103355117.
[23] Wang, Zichao, Xu, Youjun, Shi, Shiliang. Base-Promoted Rapid Hydrosilylation of Aldimine. CHINESE JOURNAL OF ORGANIC CHEMISTRY[J]. 2020, 40(10): 3463-3466, http://dx.doi.org/10.6023/cjoc202005085.
[24] 蔡援, 施世良. 钯催化芳基三氟甲磺酸酯与炔烃的不对称Heck偶联反应. 有机化学[J]. 2020, 40(3): 810-811, http://lib.cqvip.com/Qikan/Article/Detail?id=7101408046.
[25] Li, YuQing, Li, Feng, Shi, ShiLiang. Expedient Synthesis of KetonesviaN-HeterocyclicCarbene/Nickel-Catalyzed Redox-EconomicalCoupling of Alcohols and Alkynes(dagger). CHINESE JOURNAL OF CHEMISTRY[J]. 2020, 38(10): 1035-1039, https://www.webofscience.com/wos/woscc/full-record/WOS:000569922900001.
[26] ShiLiang Shi. Expedient Synthesis of Ketones via NHC/Nickel-Catalyzed Redox-Economical Coupling of Alcohols and Alkynes.. CHINJCHEM2020381035. 2020, [27] Cai, Yuan, Shi, ShiLiang. Palladium-Catalyzed Asymmetric Heck Coupling of Aryl Triflates and Alkynes. CHINESE JOURNAL OF ORGANIC CHEMISTRY. 2020, 40(3): 810-811, http://dx.doi.org/10.6023/cjoc202000013.
[28] Shen, Di, Xu, Youjun, Shi, ShiLiang. A Bulky Chiral N-Heterocyclic Carbene Palladium Catalyst Enables Highly Enantioselective Suzuki-Miyaura Cross-Coupling Reactions for the Synthesis of Biaryl Atropisomers. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2019, 141(37): 14938-14945, [29] Wang, ZiChao, Shen, Di, Gao, Jian, Jia, Xian, Xu, Youjun, Shi, ShiLiang. Base-catalysed reductive relay hydroboration of allylic alcohols with pinacolborane to form alkylboronic esters. CHEMICAL COMMUNICATIONS[J]. 2019, 55(60): 8848-8851, [30] Cai, Yuan, Zhang, JiaWen, Li, Feng, Liu, JiaMing, Shi, ShiLiang. Nickel/N-Heterocyclic Carbene Complex-Catalyzed Enantioselective Redox-Neutral Coupling of Benzyl Alcohols and Alkynes to Allylic Alcohols. ACS CATALYSIS[J]. 2019, 9(1): 1-6, https://www.webofscience.com/wos/woscc/full-record/WOS:000455286600001.
[31] Wang, ZiChao, Wang, Min, Gao, Jian, Shi, ShiLiang, Xu, Youjun. (BuLi)-Bu-n-promoted anti-Markovnikov selective hydroboration of unactivated alkenes and internal alkynes. ORGANIC CHEMISTRY FRONTIERS[J]. 2019, 6(16): 2949-2953, https://www.webofscience.com/wos/woscc/full-record/WOS:000484262900016.
[32] Cai, Yuan, Ye, Xiaodong, Liu, Sheng, Shi, ShiLiang. Nickel/NHC-Catalyzed Asymmetric C-H Alkylation of Fluoroarenes with Alkenes: Synthesis of Enantioenriched Fluorotetralins. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2019, 58(38): 13433-13437, https://www.webofscience.com/wos/woscc/full-record/WOS:000480145600001.
[33] Zhang, WuBin, Yang, XinTuo, Ma, JunBao, Su, ZhiMing, Shi, ShiLiang. Regio- and Enantioselective C-H Cyclization of Pyridines with Alkenes Enabled by a Nickel/N-Heterocyclic Carbene Catalysis. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2019, 141(14): 5628-5634, https://www.webofscience.com/wos/woscc/full-record/WOS:000464769000010.
[34] ShiLiang Shi. nBuLi-promoted anti -Markovnikov selective hydroboration of unactivated alkenes and internal alkynes. ORGANICCHEMISTRYFRONTIERS201962949. 2019, [35] Li, Feng, Bai, Xu, Cai, Yuan, Li, Han, Zhang, ShuoQing, Liu, FengHua, Hong, Xin, Xu, Youjun, Shi, ShiLiang. Aluminum-Catalyzed Selective Hydroboration of Alkenes and Alkynylsilanes. ORGANIC PROCESS RESEARCH & DEVELOPMENT[J]. 2019, 23(8): 1703-1708, https://www.webofscience.com/wos/woscc/full-record/WOS:000481979500028.
[36] Cai, Yuan, Yang, XinTuo, Zhang, ShuoQing, Li, Feng, Li, YuQing, Ruan, LinXin, Hong, Xin, Shi, ShiLiang. Copper-Catalyzed Enantioselective Markovnikov Protoboration of alpha-Olefins Enabled by a Buttressed N-Heterocyclic Carbene Ligand. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2018, 57(5): 1376-1380, https://www.webofscience.com/wos/woscc/full-record/WOS:000422940600043.
[37] Cai, Yuan, Li, Feng, Li, YuQing, Zhang, WuBin, Liu, FengHua, Shi, ShiLiang. Base metal-catalyzed alcohol C-C couplings under hydrogen transfer conditions. TETRAHEDRON LETTERS[J]. 2018, 59(12): 1073-1079, http://dx.doi.org/10.1016/j.tetlet.2018.01.077.
[38] Wei, XiaoFeng, Shi, ShiLiang, Xie, XiaoWei, Shimizu, Yohei, Kanai, Motomu. Copper(I)-Catalyzed Dehydrative C-Glycosidation of Unprotected Pyranoses with Ketones. ACS CATALYSIS[J]. 2016, 6(10): 6718-6722, https://www.webofscience.com/wos/woscc/full-record/WOS:000385057900050.
[39] ShiLiang Shi, Zackary L Wong, Stephen L Buchwald. Copper-catalyzed enantioselective stereodivergent synthesis of amino alcohols. NATURE. 2016, 532(7599): 353-356, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844805/.
[40] Shi, ShiLiang, Buchwald, Stephen L. Palladium-Catalyzed Intramolecular C-H Difluoroalkylation: Synthesis of Substituted 3,3-Difluoro-2-oxindoles. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2015, 54(5): 1646-1650, https://www.webofscience.com/wos/woscc/full-record/WOS:000348713900048.
[41] Yang, Yang, Shi, ShiLiang, Niu, Dawen, Liu, Peng, Buchwald, Stephen L. Catalytic asymmetric hydroamination of unactivated internal olefins to aliphatic amines. SCIENCE[J]. 2015, 349(6243): 62-66, https://www.webofscience.com/wos/woscc/full-record/WOS:000357280800058.
[42] Shi, ShiLiang, Buchwald, Stephen L. Copper-catalysed selective hydroamination reactions of alkynes. NATURE CHEMISTRY[J]. 2015, 7(1): 38-44, https://www.webofscience.com/wos/woscc/full-record/WOS:000346409400010.
[43] ShiLiang Shi. Copper(I)-Catalyzed Enantioselective Incorporation of Ketones to Cyclic Hemiaminals for the Synthesis of Versatile Alkaloid Precursor. J. Am. Chem. Soc.. 2012, [44] Shi, ShiLiang, Wei, XiaoFeng, Shimizu, Yohei, Kanai, Motomu. Copper(I)-Catalyzed Enantioselective Incorporation of Ketones to Cyclic Hemiaminals for the Synthesis of Versatile Alkaloid Precursors. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2012, 134(41): 17019-17022, https://www.webofscience.com/wos/woscc/full-record/WOS:000309854700026.
[45] Shi, ShiLiang, Kanai, Motomu, Shibasaki, Masakatsu. Asymmetric Synthesis of Dihydropyranones from Ynones by Sequential Copper(I)-Catalyzed Direct Aldol and Silver(I)-Catalyzed Oxy-Michael Reactions. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2012, 51(16): 3932-3935, https://www.webofscience.com/wos/woscc/full-record/WOS:000302607500033.
[46] Shi, ShiLiang, Xu, LiWen, Oisaki, Kounosuke, Kanai, Motomu, Shibasaki, Masakatsu. Identification of Modular Chiral Bisphosphines Effective for Cu(I)-Catalyzed Asymmetric Allylation and Propargylation of Ketones. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2010, 132(19): 6638-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000277721500013.
[47] Shimizu, Yohei, Shi, ShiLiang, Usuda, Hiroyuki, Kanai, Motomu, Shibasaki, Masakatsu. Catalytic Asymmetric Total Synthesis of ent-Hyperforin. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2010, 49(6): 1103-1106, https://www.webofscience.com/wos/woscc/full-record/WOS:000274571500018.
[48] Sun, Yongbing, Sun, Jin, Wen, Bing, Shi, Shiliang, Xu, Youjun, Chen, Ying, Wang, Yongjun, Pan, Changqi, Zhang, Chunyu, Zhang, Tianhong, He, Zhonggui. High-performance liquid chromatography/tandem mass spectrometry method for the simultaneous determination of cytarabine and its valyl prodrug valcytarabine in rat plasma. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES[J]. 2008, 870(1): 121-125, http://dx.doi.org/10.1016/j.jchromb.2008.05.033.