乳腺干细胞；乳腺癌；表观遗传

   

071009-细胞生物学
071007-遗传学

乳腺发育，表观遗传
进化发育

2003-09--2007-03 香港中文大学 博士
1996-09--2003-06 西南大学 硕士

-- 研究生

-- 博士

   

2008-10--2013-04 美国马萨诸塞大学医学院 博士后

2013-11--今 云南省细胞学会，秘书长

中国科学院大学**论坛

   

[1] Lu Guo, Hao Ke, Honglei Zhang, Li Zou, Qin Yang, Xuemei Lu, Limin Zhao, Baowei Jiao. TDP43 promotes stemness of breast cancer stem cells through CD44 variant splicing isoforms. Cell Death and Disease[J]. 2022, 13(5): 1-11, [2] 焦保卫. Rab13 Sustains Breast Cancer Stem Cells by Supporting Tumor-Stroma Cross-talk. CANCER RESEARCH[J]. 2022, [3] Li, Xiyin, Wang, Hairui, Yang, Xing, Wang, Xiaoqi, Zhao, Lina, Zou, Li, Yang, Qin, Hou, Zongliu, Tan, Jing, Zhang, Honglei, Nie, Jianyun, Jiao, Baowei. GABRP sustains the stemness of triple-negative breast cancer cells through EGFR signaling. CANCER LETTERS[J]. 2021, 514: 90-102, http://dx.doi.org/10.1016/j.canlet.2021.04.028.
[4] Zhao, Lina, Qiu, Ting, Jiang, Dewei, Xu, Haibo, Zou, Li, Yang, Qin, Chen, Ceshi, Jiao, Baowei. SGCE Promotes Breast Cancer Stem Cells by Stabilizing EGFR. ADVANCED SCIENCE[J]. 2020, 7(14): https://doaj.org/article/212269c52e6444efb47c9c20c8dcffd1.
[5] Limin Zhao, Hao Ke, Haibo Xu, GuoDong Wang, Honglei Zhang, Li Zou, Shu Xiang, Mengyuan Li, Li Peng, Mingfang Zhou, Lingling Li, Lei Ao, Qin Yang, CheKun James Shen, Ping Yi, Lu Wang, Baowei Jiao. TDP-43 facilitates milk lipid secretion by post-transcriptional regulation of Btn1a1 and Xdh. NATURE COMMUNICATIONS[J]. 2020, 11(1): http://dx.doi.org/10.1038/s41467-019-14183-1.
[6] Zhao, Limin, Li, Lingling, Xu, Haibo, Ke, Hao, Zou, Li, Yang, Qin, Shen, CheKun James, Nie, Jianyun, Jiao, Baowei. TDP-43 is Required for Mammary Gland Repopulation and Proliferation of Mammary Epithelial Cells. STEM CELLS AND DEVELOPMENT[J]. 2019, 28(14): 944-953, [7] Zhang, Honglei, Yang, Xing, Feng, Xu, Xu, Haibo, Yang, Qin, Zou, Li, Yan, Mei, Liu, Dequan, Su, Xiaosan, Jiao, Baowei. Chromosome-wide gene dosage rebalance may benefit tumor progression. MOLECULAR GENETICS AND GENOMICS[J]. 2018, 293(4): 895-906, http://159.226.149.26:8080/handle/152453/12389.
[8] Shaowei Wang, Hao Ke, Honglei Zhang, Yujie Ma, Lei Ao, Li Zou, Qin Yang, Hao Zhu, Jianyun Nie, Chunlian Wu, Baowei Jiao. LncRNA MIR100HG promotes cell proliferation in triple-negative breast cancer through triplex formation with p27 loci. Cell Death and Disease[J]. 2018, 9(8): 1-11, https://doaj.org/article/77a02454c9aa4ef0866aef0fb382211e.
[9] Haibo Xu, Xu Feng, Hao Ke, Limin Zhao, Honglei Zhang, Baowei Jiao, Jianyun Nie, Yang Wang, Chunlian Wu, Liqiong Wang, Xiaosan Su, Li Zou, Qin Yang, Shaowei Wang, Junjun Hao. Loss of TDP43 inhibits progression of triple-negative breast cancer in coordination with SRSF3. pnas[J]. 2018, 115(15): 3426–3435-, http://159.226.149.26:8080/handle/152453/12266.
[10] Wang H, Jiao B, Yang Q, Ni L, Zou L, Cheng M, Chen W, Cai X. Isoharringtonine inhibits breast cancer stem-like properties and stat3 signaling.. Biomed pharmacother[J]. 2018, Vol.103: 435-442, http://www.corc.org.cn/handle/1471x/2155499.
[11] Jiao Baowei. Paternal RLIM/Rnf12 is a survial factor for Milk-Producing alveolar cells. Cell. 2012, [12] Shin, JongDae, Bossenz, Michael, Chung, Young, Ma, Hong, Byron, Meg, TaniguchiIshigaki, Naoko, Zhu, Xiaochun, Jiao, Baowei, Hall, Lisa L, Green, Michael R, Jones, Stephen N, HermansBorgmeyer, Irm, Lawrence, Jeanne B, Bach, Ingolf. Maternal Rnf12/RLIM is required for imprinted X-chromosome inactivation in mice. NATURE[J]. 2010, 467(7318): 977-U157, https://www.webofscience.com/wos/woscc/full-record/WOS:000283254700041.

   

（1） 中科院B类先导专项课题，主持，部委级，2014-07--2019-06
（2） 自然科学基金面上项目，主持，国家级，2014-01--2017-12
（3） 青年****，主持，部委级，2013-06--2016-04
（4） 启动项目，主持，研究所（学校）级，2013-04--2016-04

（1） Sex-specific epigenetic regulation of mammary gland by the RLIM/Rnf12 in mice，遗传学与表观遗传学前沿暨第三届中国青年遗传学家论坛，2014-04，焦保卫
（2） Function of RLIM/Rnf12 in mammary gland development ，第二届中国乳腺癌干细胞高峰论坛，2013-10，焦保卫

现指导学生

赵丽敏  硕士研究生  071009-细胞生物学  

柯浩  博士研究生  071009-细胞生物学  

杨星  硕士研究生  071009-细胞生物学  

赵丽娜  博士研究生  071009-细胞生物学  

马玉洁  硕士研究生  071009-细胞生物学