基本信息
殷战 男 博导 水生生物研究所
电子邮件:zyin@ihb.ac.cn
通信地址:湖北省武汉市东湖南路7号
邮政编码:430072

研究领域

鱼类内分泌学研究。主要以模式鱼类斑马鱼为实验材料,开展鱼类生长、繁殖的内分泌调控机制的基础和应用研究。同时,针对环境化合物的内分泌干扰效应的评价模型开展研究。

教育背景

1994-08--1999-08 新加坡国立大学 动物学博士
1986-09--1989-07 中国科学院水生生物研究所 水生生物学硕士
1982-09--1986-07 武汉大学 理学学士

工作经历

1989年7月-1994年7月:中国科学院水生生物研究所,助理研究员
1999年6月-2000年2月: 印第安纳大学医学院癌症研究中心,Yu-Chung Yang教授实验室博士后,美国印第安纳州印第安纳泼利斯市
2000年2月-2002年9月: 凯斯西部保留地大学医学院药学系, Yu-Chung Yang教授实验室博士后研究助理, 美国俄亥俄州克利夫兰市
2002年9月-2003年2月: 克利夫兰临床医学基金会Lerner研究所癌症研究系,Robert Silverman教授实验室博士后研究助理,美国俄亥俄州克利夫兰市
2003年2月-2005年5月: 宾夕伐尼亚大学医学院医学系分子心脏病研究中心,Jonathan A. Epstein教授实验室博士后研究助理,美国宾夕伐尼亚州费城 
2005年5月-:现在:中国科学院水生生物研究所水环境与人类健康研究中心,责任研究员
2009年7月-现在:中国科学院水生生研究所水环境与人类健康研究中心主任
2012年5月-现在:中国科学院水生生物研究所 所长助理

社会兼职
2006-01--2011-12 市(地级)人大代表

教授课程

细胞生物学、 发育生物学

出版信息

   
发表论文
[1] Shengchi Shi, Tingting Shu, Xi Li, Qiyong Lou, Xia Jin, Jiangyan He, Zhan Yin, Gang Zhai. Characterization of the interrenal gland and sexual traits development in cyp17a2-deficient zebrafish. Frontiers in Endocrinology[J]. 2022, [2] Gang Zhai, Tingting Shu, Guangqing Yu, Haipei Tang, Chuang Shi, Jingyi Jia, Qiyong Lou, Xiangyan Dai, Xia Jin, Jiangyan He, Wuhan Xiao, Xiaochun Liu, Zhan Yin, Cunming Duan, Didier YR Stainier. Augmentation of progestin signaling rescues testis organization and spermatogenesis in zebrafish with the depletion of androgen signaling. eLife[J]. 2022, 11: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8912926/.
[3] Zhai, Gang, Shu, Tingting, Chen, Kuangxin, Lou, Qiyong, Jia, Jingyi, Huang, Jianfei, Shi, Chuang, Jin, Xia, He, Jiangyan, Jiang, Donghuo, Qian, Xueqiao, Hu, Wei, Yin, Zhan. Successful Production of an All-female Common Carp (Cyprinus carpio L.) Population Using cyp17a1-deficient Neomale Carps. Engineering[J]. 2021, [4] Xu, Shaohua, Zhou, Lingling, Chen, Xingyuan, Hu, Qiongyao, Shi, Xuetao, Xia, Chuanhui, Zhang, Huiying, Jia, Jingyi, Yin, Zhan, Hu, Guangfu. Novel pituitary actions of NKB for anorectic peptides regulation in grass carp. AQUACULTURE[J]. 2021, 531: http://dx.doi.org/10.1016/j.aquaculture.2020.735857.
[5] Song, Jia, Lu, Yao, Cheng, Xiaoxia, Shi, Chuang, Lou, Qiyong, Jin, Xia, He, Jiangyan, Zhai, Gang, Yin, Zhan. Functions of the Thyroid-Stimulating Hormone on Key Developmental Features Revealed in a Series of Zebrafish Dyshormonogenesis Models. CELLS[J]. 2021, 10(8): http://dx.doi.org/10.3390/cells10081984.
[6] Xuetao Shi, Cheng Ye, Xiangfeng Qin, Lingling Zhou, Chuanhui Xia, Tianyi Cai, Yunyi Xie, Zhan Yin, Guangfu Hu, Berta LevaviSivan. Novel Pituitary Actions of TAC4 Gene Products in Teleost. International Journal of Molecular Sciences[J]. 2021, 22(23): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657723/.
[7] Dai, Xiangyan, Cheng, Xinkai, Huang, Jianfei, Gao, Yanping, Wang, Deshou, Feng, Zhi, Zhai, Gang, Lou, Qiyong, He, Jiangyan, Wang, Zhijian, Yin, Zhan. Rbm46, a novel germ cell-specific factor, modulates meiotic progression and spermatogenesis. BIOLOGY OF REPRODUCTION[J]. 2021, 104(5): 1139-1153, http://dx.doi.org/10.1093/biolre/ioab016.
[8] Shi, Chuang, Lou, Qiyong, Fu, Beide, Jin, Junyan, Huang, Jianfei, Lu, Yao, Jin, Xia, He, Jiangyan, Zhai, Gang, Xie, Shouqi, Tong, Jingou, Gui, Jianfang, Yin, Zhan. Genomic polymorphisms at the crhr2 locus improve feed conversion efficiency through alleviation of hypothalamus-pituitary-interrenal axis activity in gibel carp (Carassius gibelio). SCIENCE CHINA-LIFE SCIENCES. 2021, http://dx.doi.org/10.1007/s11427-020-1924-4.
[9] Luo, Jing, Zhang, Xiaokang, He, Siying, Lou, Qiyong, Zhai, Gang, Shi, Chuang, Yin, Zhan, Zheng, Fang. Deletion of narfl leads to increased oxidative stress mediated abnormal angiogenesis and digestive organ defects in zebrafish. REDOX BIOLOGY[J]. 2020, 28: http://dx.doi.org/10.1016/j.redox.2019.101355.
[10] Shu, Tingting, Zhai, Gang, Pradhan, Ajay, Olsson, PerErik, Yin, Zhan. Zebrafish cyp17a1 knockout reveals that androgen-mediated signaling is important for male brain sex differentiation. GENERAL AND COMPARATIVE ENDOCRINOLOGY[J]. 2020, 295: http://dx.doi.org/10.1016/j.ygcen.2020.113490.
[11] Qiongyao Hu, Qinbo Qin, Shaohua Xu, Lingling Zhou, Chuanhui Xia, Xuetao Shi, Huiying Zhang, Jingyi Jia, Cheng Ye, Zhan Yin, Guangfu Hu. Pituitary Actions of EGF on Gonadotropins, Growth Hormone, Prolactin and Somatolactins in Grass Carp. Biology[J]. 2020, 9(9): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564354/.
[12] Chuang Shi, Yao Lu, Gang Zhai, Jianfei Huang, Guohui Shang, Qiyong Lou, Dongliang Li, Xia Jin, Jiangyan He, Zhenyu Du, Jianfang Gui, Zhan Yin. Hyperandrogenism in POMCa-deficient zebrafish enhances somatic growth without increasing adiposity. Journal of Molecular Cell Biology. 2019, 12(4): 291-304, [13] Shang, Guohui, Peng, Xuyan, Ji, Cheng, Zhai, Gang, Ruan, Yonglin, Lou, Qiyong, Jin, Xia, He, Jiangyan, Wang, Han, Yin, Zhan. Steroidogenic acute regulatory protein and luteinizing hormone are required for normal ovarian steroidogenesis and oocyte maturation in zebrafish. BIOLOGY OF REPRODUCTION[J]. 2019, 101(4): 760-770, [14] Zhai, Gang, Shu, Tingting, Xia, Yuguo, Lu, Yao, Shang, Guohui, Jin, Xia, He, Jiangyan, Nie, Pin, Yin, Zhan. Characterization of Sexual Trait Development in cyp17a1-Deficient Zebrafish. ENDOCRINOLOGY[J]. 2018, 159(10): 3549-3562, https://www.webofscience.com/wos/woscc/full-record/WOS:000446428300008.
[15] Song, Guibo, Han, Mingjun, Li, Zuhua, Gan, Xuedong, Chen, Xiaowen, Yang, Jie, Dong, Sufang, Yan, Ming, Wan, Jun, Wang, Yanggan, Huang, Zhuliang, Yin, Zhan, Zheng, Fang. Deletion of Pr72 causes cardiac developmental defects in Zebrafish. PLOS ONE[J]. 2018, 13(11): http://202.127.146.157/handle/2RYDP1HH/3473.
[16] Shu, Tingting, Shu, Yuqin, Gao, Yanping, Jin, Xia, He, Jiangyan, Zhai, Gang, Yin, Zhan. Depletion of Tissue-Specific Ion Transporters Causes Differential Expression of PRL Targets in Response to Increased Levels of Endogenous PRL. FRONTIERS IN ENDOCRINOLOGY[J]. 2018, 9: http://202.127.146.157/handle/2RYDP1HH/6104.
[17] Gong, Yulong, Zhai, Gang, Su, Jingzhi, Yang, Binyuan, Jin, Junyan, Liu, Haokun, Yin, Zhan, Xie, Shouqi, Han, Dong. Different roles of insulin receptor a and b in maintaining blood glucose homeostasis in zebrafish. GENERAL AND COMPARATIVE ENDOCRINOLOGY[J]. 2018, 269: 33-45, http://dx.doi.org/10.1016/j.ygcen.2018.08.012.
[18] Wang, Xinhua, Gan, Baojiang, Yu, Xiaomu, Zhou, Li, Wang, Zhongwei, Gui, Jianfang, Yin, Zhan, Tong, Jingou. Transcript-associated microsatellites from gibel carpand their applicability of genetic analyses in Carassius auratus populations. JOURNAL OF APPLIED ICHTHYOLOGY[J]. 2018, 34(5): 1108-1116, http://202.127.146.157/handle/2RYDP1HH/5754.
[19] Yang, BinYuan, Zhai, Gang, Gong, YuLong, Su, JingZhi, Peng, XuYan, Shang, GuoHui, Han, Dong, Jin, JunYan, Liu, HaoKun, Du, ZhenYu, Yin, Zhan, Xie, ShouQi. Different physiological roles of insulin receptors in mediating nutrient metabolism in zebrafish. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM[J]. 2018, 315(1): E38-E51, https://www.webofscience.com/wos/woscc/full-record/WOS:000441172300005.
[20] Wang, Jing, Luo, Jing, Chen, Qiuhong, Wang, Xi, He, Jiangyan, Zhang, Wei, Yin, Zhan, Zheng, Fang, Pan, Hong, Li, Tengyan, Lou, Qiyong, Wang, Binbin. Identification of LBX2 as a novel causal gene of atrial septal defect. INTERNATIONAL JOURNAL OF CARDIOLOGY[J]. 2018, 265(1): 188-194, http://dx.doi.org/10.1016/j.ijcard.2018.04.038.
[21] Peng, Xuyan, Shang, Guohui, Wang, Wenqing, Chen, Xiaowen, Lou, Qiyong, Zhai, Gang, Li, Dongliang, Du, Zhenyu, Ye, Yali, Jin, Xia, He, Jiangyan, Zhang, Yi, Yin, Zhan. Fatty Acid Oxidation in Zebrafish Adipose Tissue Is Promoted by 1 alpha,25(OH)(2)D-3. CELL REPORTS[J]. 2017, 19(7): 1444-1455, https://www.webofscience.com/wos/woscc/full-record/WOS:000402125100015.
[22] Gang Zhai, Tingting Shu, Yuguo Xia, Xia Jin, Jiangyan He, Zhan Yin. Androgen signaling regulates the transcription of anti-Müllerian hormone via synergy with SRY-related protein SOX9A. Science Bulletin. 2017, 62(3): 197-203, http://dx.doi.org/10.1016/j.scib.2017.01.007.
[23] Zhai Gang, Song Jia, Shu Tingting, Yan Junjun, Jin Xia, He Jiangyan, Yin Zhan. LRH-1 senses signaling from phosphatidylcholine to regulate the expansion growth of digestive organs via synergy with Wnt/b-catenin signaling in zebrafish. Journal of Genetics and Genomics[J]. 2017, 44(6): 307-317, [24] Dai, Xiangyan, Shu, Yuqin, Lou, Qiyong, Tian, Qiang, Zhai, Gang, Song, Jia, Lu, Suxiang, Yu, Hong, He, Jiangyan, Yin, Zhan. Tdrd12 Is Essential for Germ Cell Development and Maintenance in Zebrafish. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES[J]. 2017, 18(6): https://doaj.org/article/494c63ac378d444fac71d4a526028b49.
[25] Yang, Jie, Li, Zuhua, Gan, Xuedong, Zhai, Gang, Gao, Jiajia, Xiong, Chenling, Qiu, Xueping, Wang, Xuebin, Yin, Zhan, Zheng, Fang. Deletion of Pr130 Interrupts Cardiac Development in Zebrafish. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES[J]. 2016, 17(11): https://doaj.org/article/4e45d87ba2274597979390a2a40e34c8.
[26] 贺江燕. Androgen signaling regulates the transcription of anti-Müllerian hormone via synergy with SRY-Related Protein SOX9A Science Bulletin. Science Bulletin(In Press). 2016, [27] Shu, Yuqin, Lou, Qiyong, Dai, Ziru, Dai, Xiangyan, He, Jiangyan, Hu, Wei, Yin, Zhan. The basal function of teleost prolactin as a key regulator on ion uptake identified with zebrafish knockout models. SCIENTIFIC REPORTS[J]. 2016, 6: https://www.webofscience.com/wos/woscc/full-record/WOS:000391970300001.
[28] 殷战. Depletion of Myostatin b Promotes somatic growth and lipid Metabolism in Zebrafsh Front. Endocrinol.. Front. Endocrinol.. 2016, [29] Dai XiangYan, Zhang Wei, Zhuo ZiJian, He JiangYan, Yin Zhan. Neuroendocrine regulation of somatic growth in fishes. SCIENCE CHINA-LIFE SCIENCESnull. 2015, 58(2): 137-147, http://www.irgrid.ac.cn/handle/1471x/978688.
[30] Cheng, Xiaoxia, Chen, Xiaowen, Li, Dongliang, Jin, Xia, He, Jiangyan, Yin, Zhan. Effects of metronidazole on proopiomelanocortin a gene expression in zebrafish. GENERAL AND COMPARATIVE ENDOCRINOLOGY[J]. 2015, 214: 87-94, http://dx.doi.org/10.1016/j.ygcen.2014.05.029.
[31] Dai, Xiangyan, Jin, Xia, Chen, Xiaowen, He, Jiangyan, Yin, Zhan. Sufficient Numbers of Early Germ Cells Are Essential for Female Sex Development in Zebrafish. PLOS ONE[J]. 2015, 10(2): http://www.irgrid.ac.cn/handle/1471x/978685.
[32] He, Wenxia, Dai, Xiangyan, Chen, Xiaowen, He, Jiangyan, Yin, Zhan. Zebrafish pituitary gene expression before and after sexual maturation. JOURNAL OF ENDOCRINOLOGY[J]. 2014, 221(3): 429-440, http://www.irgrid.ac.cn/handle/1471x/852663.
[33] Li, Dongliang, Lou, Qiyong, Zhai, Gang, Peng, Xuyan, Cheng, Xiaoxia, Dai, Xiangyan, Zhuo, Zijian, Shang, Guohui, Jin, Xia, Chen, Xiaowen, Han, Dong, He, Jiangyan, Yin, Zhan. Hyperplasia and Cellularity Changes in IGF-1-Overexpressing Skeletal Muscle of Crucian Carp. ENDOCRINOLOGY[J]. 2014, 155(6): 2199-2212, http://www.irgrid.ac.cn/handle/1471x/929276.
[34] 贺江燕. Effects of Metronidazole on Proopiomelanocortin a Gene Expression in Zebrafish.. General and Comparative Endocrinology. 2014, [35] Xiaoxia Cheng, Xiaowen Chen, Xia Jin, Jiangyan He, Zhan Yin. Generation and characterization of gsuα:EGFP transgenic zebrafish for evaluating endocrine-disrupting effects. Toxicology and Applied Pharmacology. 2014, 278(1): 78-84, http://dx.doi.org/10.1016/j.taap.2014.04.009.
[36] Chang Li, Lei Wang, Jing Zhang, Mi Huang, Fulton Wong, Xuexue Liu, Fei Liu, Xiukun Cui, Guohua Yang, Jiaxiang Chen, Ying Liu, Jiuxiang Wang, Shengjie Liao, Meng Gao, Xuebin Hu, Xinhua Shu, Qing Wang, Zhan Yin, Zhaohui Tang, Mugen Liu. CERKL interacts with mitochondrial TRX2 and protects retinal cells from oxidative stress-induced apoptosis. BBA - Molecular Basis of Disease. 2014, 1842(7): 1121-1129, http://dx.doi.org/10.1016/j.bbadis.2014.04.009.
[37] Zhai, Gang, Gu, Qilin, He, Jiangyan, Lou, Qiyong, Chen, Xiaowen, Jin, Xia, Bi, Erfei, Yin, Zhan. Sept6 Is Required for Ciliogenesis in Kupffer's Vesicle, the Pronephros, and the Neural Tube during Early Embryonic Development. MOLECULAR AND CELLULAR BIOLOGY[J]. 2014, 34(7): 1310-1321, http://www.irgrid.ac.cn/handle/1471x/852670.
[38] Mei, Yun, Yin, Naida, Jin, Xia, He, Jiangyan, Yin, Zhan. The Regulatory Role of the Adrenergic Agonists Phenylephrine and Isoproterenol on Fetal Hemoglobin Expression and Erythroid Differentiation. ENDOCRINOLOGY[J]. 2013, 154(12): 4640-4649, http://www.irgrid.ac.cn/handle/1471x/811650.
[39] Xiukun Cui, Lei Wang, Jing Zhang, Rong Du, Shengjie Liao, Duanzhuo Li, Chang Li, Tie Ke, David Wan-Cheng Li, Hua Huang, Zhan Yin, Zhaohui Tang, Mugen Liu. HSF4 regulates DLAD expression and promotes lens de-nucleation. BBA - Molecular Basis of Disease. 2013, 1832(8): 1167-1172, http://dx.doi.org/10.1016/j.bbadis.2013.03.007.
[40] Xiukun Cui, Jing Zhang, Rong Du, Lei Wang, Stephen Archacki, Yuexuan Zhang, Mingxiong Yuan, Tie Ke, Hui Li, Duanzhuo Li, Chang Li, David Wan-Cheng Li, Zhaohui Tang, Zhan Yin, Mugen Liu. HSF4 is involved in DNA damage repair through regulation of Rad51. BBA - Molecular Basis of Disease. 2012, 1822(8): 1308-1315, http://dx.doi.org/10.1016/j.bbadis.2012.05.005.
[41] Lou, Qiyong, He, Jiangyan, Hu, Liang, Yin, Zhan. Role of lbx2 in the noncanonical Wnt signaling pathway for convergence and extension movements and hypaxial myogenesis in zebrafish. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH[J]. 2012, 1823(5): 1024-1032, http://dx.doi.org/10.1016/j.bbamcr.2012.02.013.
[42] 殷战. The roles of follistatin1 in regulation of zebrafish fecundity and sexual differentiation. Biology of Reproduction.. Biology of Reproduction. 2012, [43] 殷战. 1. Chen, D., Li, L., Tu, X., Yin, Z., Wang, Q. 2012. Functional characterization of Klippel-Trenaunay syndrome gene AGGF1 identifies a novel angiogenic signaling pathway for specification of vein differentiation and angiogenesis during embryogenesis.. Human Molecular Genetics. 2012, [44] Cheng Ji, Xia Jin, Jiangyan He, Zhan Yin. Use of TSHβ:EGFP transgenic zebrafish as a rapid in vivo model for assessing thyroid-disrupting chemicals. Toxicology and Applied Pharmacology. 2012, 262(2): 149-155, http://dx.doi.org/10.1016/j.taap.2012.04.029.
[45] 殷战. Role of zebrafish Lbx2 for Embryonic Lateral Line Development.. PLoS ONE. 2011, [46] 殷战. In vivo alternative assessment of the chemicals that interferre with anterior pituitary POMC expression and interregnal steroidogenesis in POMC:EGFP transgenic zebrafish.. Toxicology and Applied Pharmacology. 2010, [47] Li, Xi, He, Jiangyan, Hu, Wei, Yin, Zhan. The Essential Role of Endogenous Ghrelin in Growth Hormone Expression during Zebrafish Adenohypophysis Development. ENDOCRINOLOGY[J]. 2009, 150(6): 2767-2774, http://ir.ihb.ac.cn/handle/152342/7736.
[48] Yin, Naida, Jin, Xia, He, Jiangyan, Yin, Zhan. Effects of adrenergic agents on the expression of zebrafish (Danio rerio) vitellogenin Ao1. TOXICOLOGY AND APPLIED PHARMACOLOGY[J]. 2009, 238(1): 20-26, http://dx.doi.org/10.1016/j.taap.2009.04.004.
[49] Ma, Liwen, Li, Dongliang, Wang, Jianwei, He, Jiangyan, Yin, Zhan. Effects of adrenergic agonists on the extrahepatic expression of vitellogenin Ao1 in heart and brain of the Chinese rare minnow (Gobiocypris rarus). AQUATIC TOXICOLOGY[J]. 2009, 91(1): 19-25, http://dx.doi.org/10.1016/j.aquatox.2008.09.015.
[50] 殷战. HDAC2 regulates the cardiac fetal gene program and hypertrophic responsiveness by modulating GSK3?.. Nat. Med.. 2007, [51] Yin, Zhan, Gonzales, Linda, Kolla, Venkatadri, Rath, Nibedita, Zhang, Yuzhen, Lu, Min Min, Kimura, Shioko, Ballard, Philip L, Beers, Michael F, Epstein, Jonathan A, Morrisey, Edward E. Hop functions downstream of Nkx2.1 and GATA6 to mediate HDAC-dependent negative regulation of pulmonary gene expression. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY[J]. 2006, 291(2): L191-L199, https://www.webofscience.com/wos/woscc/full-record/WOS:000238840900008.
[52] 殷战. C114 is a novel IL-11-inducible nuclear dsRNA-binding protein that inhibits Protein Kinase R. J. Biol. Chem. 2003, [53] Zhan Yin, Jennifer Haynie, Xiaoming Yang, Baoguang Han, Songsak Kiatchoosakun, Joseph Restivo, Saying Yuan, Nanduri R Prabhakar, Karl Herrup, Ronald A Conlon, Brian D Hoit, Michiko Watanabe, YuChung Yang. The essential role of Cited2, a negative regulator for HIF-1α, in heart development and neurulation. Proceedings of the National Academy of Sciences of the United States of America. 2002, 99(16): 10488-10493, 

招生信息

   
招生专业
071007-遗传学
071008-发育生物学
090801-水产养殖
招生方向
发育生物学
内分泌学
遗传学