基本信息

张小飞  男  博导  中国科学院广州生物医药与健康研究院
电子邮件: zhang_xiaofei@gibh.ac.cn
通信地址: 广州市黄埔区开源大道190号
邮政编码: 510530

研究领域

主要研究领域:利用蛋白质谱和相关细胞生物学技术研究信号转导的机制;非蛋白酶体降解的多聚泛素化功能以及它们在细胞命运转换中的作用。


招生信息

招收干细胞命运调控、泛素化信号通路调节、定量蛋白质谱方向硕士及博士


招生专业
071009-细胞生物学
071010-生物化学与分子生物学
招生方向
胚胎干细胞多能性
定量蛋白质谱
泛素化

教育背景

2009-04--2013-04   荷兰莱顿大学   博士
2005-09--2008-12   中国科学技术大学   硕士
2001-09--2005-07   安徽农业大学   学士

工作经历

   
工作简历
2017-03~现在, 中国科学院广州生物医药与健康研究院, 研究员
2014-09~2017-03,荷兰内梅亨大学, 博士后
2013-09~2014-09,荷兰莱顿大学, 博士后

专利与奖励

   
奖励信息
(1) 干细胞多能性与重编程机理研究, 二等奖, 国家级, 2013
(2) 诱导多能干细胞机理与技术研究, 一等奖, 省级, 2010
专利成果
[1] 裴端卿, 张 娟, 张小飞. 分选蛋白33在肿瘤治疗中的应用. CN: CN101591706B, 2012-05-30.

[2] 裴端卿, 张娟, 张小飞. Nanog抑制型突变体及其在Nanog功能研究中的应用. CN: CN101492502A, 2009-07-29.

[3] 裴端卿, 张小飞, 张 娟, 王 涛. 雌激素相关受体2在维持小鼠胚胎干细胞多能性中的应用. CN: CN101492677A, 2009-07-29.

出版信息

   
发表论文
[1] HUANG QIULING, QIN DAJIANG, Pei Duanqing, Michiel Vermeulen, zhang_xiaofei. UBE2O and USP7 co‐regulate RECQL4 ubiquitinylation and homologous recombination‐mediated DNA repair. FASEB JOURNAL[J]. 2021, [2] Xu, Xueting, Ahmed, Tanveer, Wang, Lulu, Cao, Xintao, Zhang, Zeyu, Wang, Ming, Lv, Yuan, Kanwal, Shahzina, Tariq, Muqddas, Lin, Runxia, Zhang, Hui, Huang, Yinghua, Peng, Hao, Lin, Danni, Shi, Xue, Geng, Didi, Liu, Baohua, Zhang, Xiaofei, Yi, Wen, Qin, Yan, Esteban, Miguel A, Qin, Baoming. The mTORC1-eIF4F axis controls paused pluripotency. EMBO REPORTS. 2021, [3] Liu, Jiadong, Gao, Mingwei, He, Jiangping, Wu, Kaixin, Lin, Siyuan, Jin, Lingmei, Chen, Yaping, Liu, He, Shi, Junjie, Wang, Xiwei, Chang, Lei, Lin, Yingying, Zhao, YuLi, Zhang, Xiaofei, Zhang, Man, Luo, GuanZheng, Wu, Guangming, Pei, Duanqing, Wang, Jie, Bao, Xichen, Chen, Jiekai. The RNA m(6)A reader YTHDC1 silences retrotransposons and guards ES cell identity. NATURE[J]. 2021, 591(7849): 322-+, http://dx.doi.org/10.1038/s41586-021-03313-9.
[4] Ruona Shi, Zhenhuan Feng, Xiaofei Zhang. Integrative Multi-omics Landscape of Non-structural Protein 3 of Severe Acute Respiratory Syndrome Coronaviruses. Genomics, Proteomics & Bioinformatics. 2021, http://dx.doi.org/10.1016/j.gpb.2021.09.007.
[5] Shi, Ruona, Shi, Xue, Qin, Dajiang, Tang, Shibing, Vermeulen, Michiel, Zhang, Xiaofei. SNX27-driven membrane localisation of OTULIN antagonises linear ubiquitination and NF-kappa B signalling activation. CELL AND BIOSCIENCE[J]. 2021, 11(1): [6] Hou, Linlin, Wei, Yuanjie, Lin, Yingying, Wang, Xiwei, Lai, Yiwei, Yin, Menghui, Chen, Yanpu, Guo, Xiangpeng, Wu, Senbin, Zhu, Yindi, Yuan, Jie, Tariq, Muqddas, Li, Na, Sun, Hao, Wang, Huating, Zhang, Xiaofei, Chen, Jiekai, Bao, Xichen, Jauch, Ralf. Concurrent binding to DNA and RNA facilitates the pluripotency reprogramming activity of Sox2. NUCLEIC ACIDS RESEARCH[J]. 2020, 48(7): 3869-3887, http://dx.doi.org/10.1093/nar/gkaa067.
[7] Huang, Qiuling, Zhang, Xiaofei. Emerging Roles and Research Tools of Atypical Ubiquitination. PROTEOMICSnull. 2020, 20(9): https://www.webofscience.com/wos/woscc/full-record/WOS:000510123000001.
[8] Wu, Kaixin, Liu, He, Wang, Yaofeng, He, Jiangping, Xu, Shuyang, Chen, Yaping, Kuang, Junqi, Liu, Jiadong, Guo, Lin, Li, Dongwei, Shi, Ruona, Shen, Li, Wang, Yangming, Zhang, Xiaofei, Wang, Jie, Pei, Duanqing, Chen, Jiekai. SETDB1-Mediated Cell Fate Transition between 2C-Like and Pluripotent States. CELL REPORTS[J]. 2020, 30(1): 25-+, http://dx.doi.org/10.1016/j.celrep.2019.12.010.
[9] Zhang, Xiaofei, Smits, Arne H, van Tilburg, Gabrielle B A, Ovaa, Huib, Huber, Wolfgang, Vermeulen, Michiel. Proteome-wide identification of ubiquitin interactions using UbIA-MS. NATURE PROTOCOLS[J]. 2018, 13(3): 530-550, https://www.webofscience.com/wos/woscc/full-record/WOS:000427648000003.
[10] Zhang, Xiaofei, Smits, Arne H, van Tilburg, Gabrielle B A, Jansen, Pascal W T C, Makowski, Matthew M, Ovaa, Huib, Vermeulen, Michiel. An Interaction Landscape of Ubiquitin Signaling. MOLECULAR CELL[J]. 2017, 65(5): 941-+, http://dx.doi.org/10.1016/j.molcel.2017.01.004.
[11] Zhang Juan, Zhang Xiaofei, Xie Feng, Zhang Zhengkui, Dam Hans van, Zhang Long, Zhou Fangfang. The regulation of TGF-β/SMAD signaling by protein deubiquitination. Protein & Cell[J]. 2014, 5(7): 503-517, [12] Zhang Xiaofei, Zhang Juan, Zhang Long, Hans van Dam, Peter ten Dijke. UBE2O negatively regulates TRAF6-mediated NF-κB activation by inhibiting TRAF6 polyubiquitination. Cell Research[J]. 2013, 23(3): 366-377, [13] Zhang, Xiaofei, Zhang, Juan, Bauer, Andreas, Zhang, Long, Selinger, Douglas W, Lu, Chris X, ten Dijke, Peter. Fine-tuning BMP7 signalling in adipogenesis by UBE2O/E2-230K-mediated monoubiquitination of SMAD6. EMBO JOURNAL[J]. 2013, 32(7): 996-1007, https://www.webofscience.com/wos/woscc/full-record/WOS:000317040600010.
[14] Zhou, FangFang, Zhang, Xiaofei, van Dam, Hans, ten Dijke, Peter, Huang, Huizhe, Zhang, Long. Ubiquitin-specific Protease 4 Mitigates Toll-like/Interleukin-1 Receptor Signaling and Regulates Innate Immune Activation. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2012, 287(14): 11002-11010, http://dx.doi.org/10.1074/jbc.M111.328187.
[15] Zhang, Juan, Zhang, Xiaofei, Zhang, Long, Zhou, Fangfang, van Dinther, Maarten, ten Dijke, Peter. LRP8 mediates Wnt/ss-catenin signaling and controls osteoblast differentiation. JOURNAL OF BONE AND MINERAL RESEARCH[J]. 2012, 27(10): 2065-2074, https://www.webofscience.com/wos/woscc/full-record/WOS:000308925800004.
[16] Xu, Jianyong, Li, Huapeng, Wang, Bo, Xu, Yan, Yang, Jiayin, Zhang, Xiaofei, Harten, Sarah K, Shukla, Deepa, Maxwell, Patrick H, Pei, Duanqing, Esteban, Miguel A. VHL Inactivation Induces HEF1 and Aurora Kinase A. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY[J]. 2010, 21(12): 2041-2046, https://www.webofscience.com/wos/woscc/full-record/WOS:000285533300009.
[17] ZHANG Juan, ZHANG XiaoFei, PEI DuanQing. Mutations of nuclear localization signals in mNANOG generate dominant negative mutants. 中国科学通报:英文版. 2009, 1361-1368, http://lib.cqvip.com/Qikan/Article/Detail?id=29938192.
[18] Zhang, Juan, Zhang, Xiaofei, Guo, Yunqian, Xu, Liangliang, Pei, Duanqing. Sorting Nexin 33 Induces Mammalian Cell Micronucleated Phenotype and Actin Polymerization by Interacting with Wiskott-Aldrich Syndrome Protein. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2009, 284(32): 21659-21669, http://dx.doi.org/10.1074/jbc.M109.007278.
[19] Zhang Juan, Zhang XiaoFei, Pei DuanQing. Mutations of nuclear localization signals in mNANOG generate dominant negative mutants. CHINESE SCIENCE BULLETIN[J]. 2009, 54(8): 1361-1368, http://lib.cqvip.com/Qikan/Article/Detail?id=29938192.
[20] Zhang, Xiaofei, Zhang, Juan, Wang, Tao, Esteban, Miguel A, Pei, Duanqing. Esrrb Activates Oct4 Transcription and Sustains Self-renewal and Pluripotency in Embryonic Stem Cells. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2008, 283(51): 35825-35833, http://dx.doi.org/10.1074/jbc.M803481200.
[21] Zhang Juan, Zhang Xiaofei, Guo Yunqian, Xu Liangliang, Pei Duanqing. Sorting Nexin 33 Induces Mammalian Cell Micronucleated Phenotype and Actin Polymerization by Interacting with Wiskott-Aldrich Syndrome Protein *. The Journal of Biological Chemistry. 284(32): 21659-21669, http://dx.doi.org/10.1074/jbc.M109.007278.