荧光共振能量转移、生物发光、单分子分析与检测、纳米分析检测、核酸检测、微流控芯片

招收化学、生物学相关背景硕士、博士

0703Z1-化学生物学
071010-生物化学与分子生物学
083100-生物医学工程

化学生物学
生物化学与分子生物学
生物医学工程

2005-02--2010-01   韩国科学技术院（KAIST）   博士
2003-02--2005-01   韩国科学技术员（KAIST）   硕士

2010年韩国科学技术院（KAIST）博士学位

生物科学，工学博士

2011-04~2014-03,巴黎十一大学（U-PSUD), 博士后
2010-02~2014-03,韩国科学技术院（KAIST）, 博士后

   

（1） 食品中农兽残留和非法添加物等系列快速检测技术的研究与产业化, 二等奖, 省级, 2017

（ 1 ） 一种荧光素酶互补量子点生物传感器及其构建方法及其应用, 发明, 2017, 第 1 作者, 专利号: 201410854006.5
（ 2 ） 基于FRET用于检测样品中核酸靶标的试剂盒及其应用, 发明, 2015, 第 1 作者, 专利号: 201511026984.1
（ 3 ） 一种可调节的荧光素酶分段融合蛋白、其制备方法及应用, 发明, 2015, 第 1 作者, 专利号: 201510981857.0
（ 4 ） 一种荧光共振探针及其应用和试剂盒, 发明, 2016, 第 1 作者, 专利号: 201611174024.4
（ 5 ） 基于Gluc荧光素酶的二硫键蛋白及制备方法, 发明, 2016, 第 1 作者, 专利号: 201611175664.7
（ 6 ） 201711338526.0, 发明, 2017, 第 1 作者, 专利号: 一种检测探针及其应用
（ 7 ） 一种荧光素酶荧光互补体系及其制备方法和应用, 发明, 2017, 第 1 作者, 专利号: 201711420283.5
（ 8 ） 一种定点标记的泛素特异性蛋白酶7及其制备方法和应用, 发明, 2017, 第 1 作者, 专利号: 201711436434.6
（ 9 ） 一种荧光探针的制备及其制备方法和应用, 发明, 2017, 第 2 作者, 专利号: 201711094673.8
（ 10 ） 生物能量转移发光分析仪, 发明, 2017, 第 3 作者, 专利号: 201710695840.8
（ 11 ） 生物能量转移发光分析仪, 实用新型, 2017, 第 3 作者, 专利号: 201721017575.X
（ 12 ） 生物能量转移发光分析仪, 外观设计, 2017, 第 3 作者, 专利号: 201730373743.8

（1） A Rapid, Amplification-Free, and Sensitive Diagnostic Assay for Single-Step Multiplexed Fluorescence Detection of MicroRNA, Angew. Chem. Int. Ed. In Eng., 2015

（2） Size-controlled construction of magnetic nanoparticle clusters using DNA-binding zinc finger protein, Angew. Chem. Int. Ed. In Eng., 2015

（3）Semiconductor quantum dots for in vitro diagnostics and cellular imaging. Trends Biotechnol., 2012, Jul;30(7), 394-403. doi: 10.1016/j.tibtech.2012.04.005.  

（4）Magnetic Nanoclusters for Ultrasensitive Magnetophoretic Assays.” Small 2009, 5, 2243-2246

（5） A Rapid, Ratiometric, Enzyme-free, Sensitive Single-Step miRNA Detection using Three-Way Junction based FRET Probes, Nanotechnology 29 (2018) 114001 (5pp)

（6）Molecular Tweezers-like Calix[4]arene Based Alkaline Earth Metal Cation (Ca2+, Sr2+, and Ba2+) Chemosensor and Its Imaging in Living Cells and Zebrafish, Inorg. Chem., 2019, DOI: 10.1021/acs.inorgchem.9b02364

（7）Distance dependent fluorescence enhancement of silver nanowires deposited on AAO, Optical Materials 83 (2018) 241–244

（8）Highly selective recognition of Al3+ and I− ions using a bi-functional fluorescent probe, Org. Biomol. Chem., 2017, 15, 8627

[1] Luo, QingYing, Jin, Zongwen, Liu, Cui, Wei, Xiaoyuan, Zhang, Huimin, Zhang, Mingzhen, Yu, XueFeng, Hildebrandt, Niko. Nucleic Acid Hybridization Enhanced Luminescence for Rapid and Sensitive RNA and DNA Based Diagnostics. ANALYTICAL CHEMISTRY[J]. 2022, 94(46): 15964-15970, http://dx.doi.org/10.1021/acs.analchem.2c02673.
[2] Zhao, JiangLin, Xuan, Shuguang, Chen, Kai, Redshaw, Carl, Chen, Yan, Jin, Zongwen. Highly selective recognition of the Al(ClO4)(3) molecule by a mono-pyrene substituted thiacalix4arene chemosensor. CHEMICAL COMMUNICATIONS[J]. 2022, 58(41): 6112-6115, http://dx.doi.org/10.1039/d2cc01609e.
[3] Zhao, JiangLin, Wu, Chong, Redshaw, Carl, Jin, Zongwen. Synthesis, structure and gas adsorption properties of coordination polymers based on mixed imidazole-containing ligands and carboxylate ligands. INORGANICA CHIMICA ACTA[J]. 2021, 517: http://dx.doi.org/10.1016/j.ica.2020.120193.
[4] Zhao, JiangLin, Luo, QingYing, Ruan, Qin, Chen, Kai, Liu, Cui, Redshaw, Carl, Jin, Zongwen. Red/Green Tunable-Emission Carbon Nanodots for Smart Visual Precision pH Sensing. CHEMISTRY OF MATERIALS[J]. 2021, 33(15): 6091-6098, http://dx.doi.org/10.1021/acs.chemmater.1c01620.
[5] Feng, Hongtao, Liu, Lin, Chen, Yi, Shu, Weiliang, Huang, Yuqing, Zhang, Baoyue, Wu, Tianzhun, Jin, Zongwen, Chen, Yan. A compact fiber-integrated optofluidic platform for highly specific microRNA Forster resonance energy transfer detection. ANALYST[J]. 2021, 146(14): 4454-4460, http://dx.doi.org/10.1039/d1an00324k.
[6] Liu, Cui, Yang, Mengli, Hu, Jiao, Bao, Lei, Tang, Bo, Wei, Xiaoyuan, Zhao, JiangLin, Jin, Zongwen, Luo, QingYing, Pang, DaiWen. Quantitatively Switchable pH-Sensitive Photoluminescence of Carbon Nanodots. JOURNAL OF PHYSICAL CHEMISTRY LETTERS[J]. 2021, 12(11): 2727-2735, http://dx.doi.org/10.1021/acs.jpclett.1c00287.
[7] Deng, Mengying, Yuan, Jing, Yang, Haibin, Wu, Xuli, Wei, Xiaoyuan, Du, Yang, Wong, Garry, Tao, Yuyong, Liu, Gang, Jin, Zongwen, Chu, Jun. A Genetically Encoded Bioluminescent System for Fast and Highly Sensitive Detection of Antibodies with a Bright Green Fluorescent Protein. ACS NANO[J]. 2021, 15(11): 17602-17612, [8] Zhang, Hong, Sun, Tao, Ruan, Qin, Zhao, JiangLin, Mu, Lan, Zeng, Xi, Jin, Zongwen, Su, Shaobo, Luo, Qingying, Yan, Yiyong, Redshaw, Carl. A multifunctional tripodal fluorescent probe for the recognition of Cr3+, Al3+, Zn2+ and F- with controllable ESIPT processes. DYES AND PIGMENTS[J]. 2019, 162: 257-265, http://ir.siat.ac.cn:8080/handle/172644/14297.
[9] Han, XinYue, Chen, ZiHan, Fan, QianXi, Li, KangNi, Mu, FangYa, Luo, Qingying, Jin, Zongwen, Shi, Guoyue, Zhang, Min. Manganese(II)-doped zinc/germanium oxide nanoparticles as a viable fluorescent probe for visual and time-resolved fluorometric determination of ascorbic acid and its oxidase. MICROCHIMICA ACTA[J]. 2019, 186(7): https://www.webofscience.com/wos/woscc/full-record/WOS:000472970000002.
[10] Zongwen Jin. The Marriage of Protein and Lanthanide: Unveiling A Novel Time-Resolved Fluorescence Sensor Array Regulated by pH Toward High-Throughput Assay of Metal Ions in Biofluids. Anal. Chem.. 2019, [11] Song, Mingxia, Zhou, Xinyue, He, Xin, Cao, Hanqin, Liu, Junyan, Qiu, Hui, Jin, Zongwen. Distance dependent fluorescence enhancement of silver nanowires deposited on AAO. OPTICAL MATERIALS[J]. 2018, 83: 241-244, http://ir.siat.ac.cn:8080/handle/172644/14288.
[12] Luo, Qingying, Liu, Lin, Yang, Cai, Yuan, Jing, Feng, Hongtao, Chen, Yan, Zhao, Peng, Yu, Zhiqiang, Jin, Zongwen. A rapid, ratiometric, enzyme-free, and sensitive single-step miRNA detection using three-way junction based FRET probes. NANOTECHNOLOGY[J]. 2018, 29(11): http://ir.siat.ac.cn:8080/handle/172644/14272.
[13] 曾莉, 赵江林, 牟兰, 曾晞, 卫钢, Redshaw, Carl, 金宗文. 一种同时分辨识别Zn2＋和F-离子的双功能探针. 无机化学学报[J]. 2017, 33(5): 769-778, http://lib.cqvip.com/Qikan/Article/Detail?id=671999594.
[14] Wu, YaTian, Zhao, JiangLin, Mu, Lan, Zeng, Xi, Wei, Gang, Redshaw, Carl, Jin, Zongwen. A 2-Styryl-1,8-naphthyridine derivative as a versatile fluorescent probe for the selective recognition of Hg2+ Ag+ and F- ions by tuning the solvent. SENSORS AND ACTUATORS B-CHEMICAL[J]. 2017, 252: 1089-1097, http://dx.doi.org/10.1016/j.snb.2017.06.057.
[15] Zeng Li, Zhao Jianglin, Mu Lan, Zeng Xi, Wei Gang, Redshaw Carl, Redshaw Car, Jin Zongwen. 一种同时分辨识别Zn2＋和F-离子的双功能探针. 无机化学学报[J]. 2017, 33(5): 769-778, http://lib.cqvip.com/Qikan/Article/Detail?id=671999594.
[16] Qiu, Xue, Guo, Jiajia, Jin, Zongwen, Petreto, Alexandra, Medintz, Igor L, Hildebrandt, Niko. Multiplexed Nucleic Acid Hybridization Assays Using Single-FRET-Pair Distance-Tuning. SMALL[J]. 2017, 13(25): https://www.webofscience.com/wos/woscc/full-record/WOS:000404553100010.
[17] Li, Zhao, Zhao, JiangLin, Wu, YuTian, Mu, Lan, Zeng, Xi, Jin, Zongwen, Wei, Gang, Xie, Ning, Redshaw, Carl. Highly selective recognition of Al3+ and I- ions using a bi-functional fluorescent probe. ORGANICBIOMOLECULARCHEMISTRY[J]. 2017, 15(40): 8627-8633, http://dx.doi.org/10.1039/c7ob02301drsc.li/obc.
[18] Zeng Li, Zhao JiangLin, Mu Lan, Zeng Xi, Wei Gang, Carl, Redshaw, Jin Zongwen. A Readily Accessible Difunctional Probe: Simultaneous Recognition of Cation Zn2+ and Anion F- via Distinguishable Wavelengths. CHINESE JOURNAL OF INORGANIC CHEMISTRY[J]. 2017, 33(5): 769-778, https://www.webofscience.com/wos/woscc/full-record/WOS:000405542200006.
[19] YuTian Wu, JiangLin Zhao, Lan Mu, Xi Zeng, Gang Wei, Carl Redshaw, Zongwen Jin. A 2-Styryl-1,8-naphthyridine derivative as a versatile fluorescent probe for the selective recognition of Hg2+, Ag+ and F− ions by tuning the solvent. SENSORS & ACTUATORS: B. CHEMICAL. 2017, 252: 1089-1097, http://dx.doi.org/10.1016/j.snb.2017.06.057.
[20] Jin, Zongwen, Geissler, Daniel, Qiu, Xue, Wegner, K David, Hildebrandt, Niko. A Rapid, Amplification-Free, and Sensitive Diagnostic Assay for Single-Step Multiplexed Fluorescence Detection of MicroRNA. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2015, 54(34): 10024-10029, https://www.doi.org/10.1002/anie.201504887.
[21] Ryu, Yiseul, Jin, Zongwen, Lee, Joongjae, Noh, Seunghyun, Shin, TaeHyun, Jo, SeongMin, Choi, Joonsung, Park, HyunWook, Cheon, Jinwoo, Kim, HakSung. Size-Controlled Construction of Magnetic Nanoparticle Clusters Using DNA-Binding Zinc Finger Protein. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2015, 54(3): 923-926, https://www.webofscience.com/wos/woscc/full-record/WOS:000348372200034.

   

（ 1 ） 均相检测用荧光素酶互补量子点生物传感器作用机理的研究, 主持, 国家级, 2015-01--2017-12
（ 2 ） 全集成微流控液滴数字PCR芯片系统研发和应用, 主持, 省级, 2016-01--2018-12
（ 3 ） 新型均相定量生物传感器检测系统关键技术研究, 参与, 省级, 2014-10--2017-10
（ 4 ） 均相多组分体外检测生物传感器新机理的研究, 主持, 省级, 2014-10--2016-10
（ 5 ） 中国科学院深圳先进技术研究院—深圳易瑞生物技术有限公司 纳米生物传感器及微流控芯片工程技术联合实验室, 主持, 院级, 2016-02--2019-02
（ 6 ） 片上集成免疫荧光检测微机电系统关键技术研究, 参与, 省级, 2017-06--2020-06
（ 7 ） 中国科学院深圳先进技术研究院-山西瑞亚力-阳城科技产业园-生物技术联合实验室, 主持, 院级, 2017-12--2020-12
（ 8 ） 水产品药物残留快速检测关键技术研发, 参与, 省级, 2016-06--2018-06
（ 9 ） BRET技术在血清抗体即时检测中关键问题的研究, 参与, 省级, 2018-02--2021-02
（ 10 ） 中国科学院-珠海健帆仿生智能生物联合实验室, 主持, 院级, 2018-02--2021-02