基本信息

范祖森,二级研究员,创新课题组组长,国科大微免教研室副主任,中国科学院特聘核心骨干研究员,国科大岗位教授(A类)。范祖森1998年获上海交通大学医学院免疫学博士学位,随后到哈佛大学医学院从事博士后研究,于2003年晋升为哈佛大学讲师。2004年作为中国科学院****研究员回到生物物理所工作,2005年获杰出青年基金资助,2006年入选新世纪百千万人才工程国家级人才。2010年享受国务院特殊津贴专家。2014年获得谈家桢生命科学创新奖,20162018年评为中科院优秀研究生导师等,2018年获得北京市科技进步一等奖,2019年基金委创新群体首席科学家,2020年国家重点研发专项首席科学家。课题组长期从事天然免疫抗感染/抗肿瘤应答调控、肿瘤干细胞和肿瘤免疫治疗等研究,在天然免疫细胞新亚群发现、天然免疫抗感染识别机制、肿瘤干细胞自我更新机制等方面,取得了一系列有重要国际影响力的原创性成果。Cell2篇)Nat Immunol6篇)Immunity3篇)Cell Stem Cell2篇)、Nat Cell BiolJEM5篇)JCINSMBNat Commun9篇) EMBO J4篇)Blood等国际权威学术期刊发表SCI高水平研究论文80余篇,研究处于国际前沿。课题组经过多年的研究积累业已形成一流的免疫生物学研究平台和优秀的科研文化氛围,在天然免疫抗感染应答与肿瘤免疫领域培养出一支优秀的科研团队。已培养了30余位博士毕业生和10余位博士后,10余人获得中科院院长特别奖、优秀奖及优秀博士论文,10余人晋升为教授岗位(包括中科院、北大、清华、复旦等教授),10余人获得中组部****、基金委优青等。


研究领域

1、         天然免疫新亚群发现与抗感染/抗肿瘤机制

2、         非编码RNA与免疫调控

3、         肿瘤干细胞与肿瘤免疫


招生信息

   
招生专业
071010-生物化学与分子生物学
100102-免疫学
招生方向
肿瘤免疫
肿瘤干细胞
免疫细胞发育

专利与奖励

   
奖励信息
(1) 2009年度北京市自然科学奖,三等奖,省级,2010
专利成果
(1) 人膀胱癌肿瘤标志物及其抗体和应用,发明,2010,第2作者,专利号:201010251384.6

出版信息

   
发表论文
[1] Nat Commun. 2024,   通讯作者  
[2] Guo, Hui, Zhang, Jiahang, Jiang, Zhimin, Zhu, Xiaoxiao, Yang, Jing, Mu, Rui, Du, Ying, Tian, Yong, Zhu, Pingping, Fan, Zusen. Noncoding RNA circBtnl1 suppresses self-renewal of intestinal stem cells via disruption of Atf4 mRNA stability. EMBO JOURNAL. 2023, 第 10 作者  通讯作者  42(6): 
[3] Shao, Fei, Liu, Zhen, Wei, Qinglin, Yu, Dou, Zhao, Min, Zhang, Xusheng, Gao, Xintong, Fan, Zusen, Wang, Shuo. FOXO1 orchestrates the intestinal homeostasis via neuronal signaling in group 3 innate lymphoid cells. JOURNAL OF EXPERIMENTAL MEDICINE[J]. 2023, 第 8 作者220(10): http://dx.doi.org/10.1084/jem.20230133.
[4] Pingping Zhu, Benyu Liu, Zusen Fan. Noncoding RNAs in tumorigenesis and tumor therapy. FUNDAMENTAL RESEARCH[J]. 2023, 第 3 作者3(5): 692-706, http://lib.cqvip.com/Qikan/Article/Detail?id=7110912718.
[5] Liu Benyu, Zhang Lingwei, Zhu Pingping, Fan Zusen. Regulation of noncoding RNAs in innate lymphoid cells. CELLULAR & MOLECULAR IMMUNOLOGY[J]. 2023, 第 4 作者  通讯作者  20(5): 543-545, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=7719302&detailType=1.
[6] Pingping Zhu, Lu Tiankun, Zhenzhen Chen, Benyu Liu, Dongdong Fan, Chong Li, Jiayi Wu, Luyun He, Xiaoxiao Zhu, Ying Du, Yong Tian, Zusen Fan. 5-hydroxytryptamine produced by enteric serotonergic neurons initiates colorectal cancer stem cell self-renewal and tumorigenesis. Neuron[J]. 2022, 第 12 作者  通讯作者  110(14): 2268-2282, https://www.sciencedirect.com/science/article/pii/S0896627322003695?via%3Dihub.
[7] pingping zhu, 范祖森. 5-hydroxytryptamine produced by enteric serotonergic neurons initiates colorectal cancer stem cell self-renewal.. Neuron[J]. 2022, 第 2 作者  通讯作者  https://pubmed.ncbi.nlm.nih.gov/35550066/.
[8] Xiong, Zhen, Zhu, Xiaoxiao, Geng, Jingjing, Xu, Yuwei, Wu, Runyuan, Li, Cunzhen, Fan, Dongdong, Qin, Xiwen, Du, Ying, Tian, Yong, Fan, Zusen. Intestinal Tuft-2 cells exert antimicrobial immunity via sensing bacterial metabolite N-undecanoylglycine. IMMUNITY[J]. 2022, 第 11 作者  通讯作者  55(4): 686-700, http://dx.doi.org/10.1016/j.immuni.2022.03.001.
[9] 范祖森, Nian Liu. circTmem241 drives group III innate lymphoid cell differentiation via initiation of Elk3 transcription.. Nature Communications[J]. 2022, 第 1 作者  通讯作者  https://pubmed.ncbi.nlm.nih.gov/35953472/.
[10] Ye, Buqing, Yang, Liuliu, Liu, Benyu, Liu, Nian, Fan, Dongdong, Li, Huimu, Sun, Lei, Du, Ying, Wang, Shuo, Tian, Yong, Fan, Zusen. Induction of functional neutrophils from mouse fibroblasts by thymidine through enhancement of Tet3 activity. CELLULAR & MOLECULAR IMMUNOLOGY[J]. 2022, 第 11 作者  通讯作者  19(5): 619-633, http://dx.doi.org/10.1038/s41423-022-00842-9.
[11] Zhu, Pingping, Lu, Tiankun, Wu, Jiayi, Fan, Dongdong, Liu, Benyu, Zhu, Xiaoxiao, Guo, Hui, Du, Ying, Liu, Feng, Tian, Yong, Fan, Zusen. Gut microbiota drives macrophage-dependent self-renewal of intestinal stem cells via niche enteric serotonergic neurons. CELL RESEARCH[J]. 2022, 第 11 作者  通讯作者  32(6): 555-569, http://dx.doi.org/10.1038/s41422-022-00645-7.
[12] Chen, Zhenzhen, Lu, Tiankun, Huang, Lan, Wang, Zhiwei, Yan, Zhongyi, Guan, Yubo, Hu, Wenjing, Fan, Zusen, Zhu, Pingping. Circular RNA cia-MAF drives self-renewal and metastasis of liver tumor-initiating cells via transcription factor MAFF. JOURNAL OF CLINICAL INVESTIGATION[J]. 2021, 第 8 作者  通讯作者  131(19): http://dx.doi.org/10.1172/JCI148020.
[13] Benyu Liu, Nian Liu, Xiaoxiao Zhu, Liuliu Yang, Buqing Ye, Huimu Li, Pingping Zhu, Tiankun Lu, Yong Tian, Zusen Fan. Circular RNA circZbtb20 maintains ILC3 homeostasis and function via Alkbh5-dependent m(6)A demethylation of Nr4a1 mRNA. CELLULAR & MOLECULAR IMMUNOLOGY[J]. 2021, 第 10 作者  通讯作者  18(6): 1412-1424, http://dx.doi.org/10.1038/s41423-021-00680-1.
[14] 范祖森. N1-methyladenosinemethylation 1 in tRNA drives liver tumourigenesis by regulating cholesterol metabolism. Nat Commun. 2021, 第 1 作者  通讯作者  
[15] Gu, Yang, Wang, Yanying, He, Luyun, Zhang, Jiahang, Zhu, Xiaoxiao, Liu, Nian, Wang, Jianyi, Lu, Tiankun, He, Lei, Tian, Yong, Fan, Zusen. Circular RNA circIPO11 drives self-renewal of liver cancer initiating cells via Hedgehog signaling. MOLECULAR CANCER[J]. 2021, 第 11 作者  通讯作者  20(1): https://doaj.org/article/310ce313ee4c4028940c524a143437d2.
[16] Wang, Yanying, Wang, Jing, Li, Xiaoyu, Xiong, Xushen, Wang, Jianyi, Zhou, Ziheng, Zhu, Xiaoxiao, Gu, Yang, Dominissini, Dan, He, Lei, Tian, Yong, Yi, Chengqi, Fan, Zusen. N-1-methyladenosine methylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism. NATURE COMMUNICATIONS[J]. 2021, 第 13 作者  通讯作者  12(1): https://doaj.org/article/13c5a25590da4573bc3cc56bbda89738.
[17] 范祖森. Circular RNA circIPO11 drives self-renewal of liver cancer initiating cells via Hedgehog signalling.. Mol Cancer. 2021, 第 1 作者  通讯作者  
[18] Ye, Buqing, Yang, Liuliu, Qian, Guomin, Liu, Benyu, Zhu, Xiaoxiao, Zhu, Pingping, Ma, Jing, Xie, Wei, Li, Huimu, Lu, Tianku, Wang, Yanying, Wang, Shuo, Du, Ying, Wang, Zhimin, Jiang, Jing, Li, Jinsong, Fan, Dongdong, Meng, Shu, Wu, Jiayi, Tian, Yong, Fan, Zusen. The chromatin remodeler SRCAP promotes self-renewal of intestinal stem cells. EMBO JOURNAL[J]. 2020, 第 21 作者  通讯作者  39(13): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327502/.
[19] Buqing Ye, Liuliu Yang, Guomin Qian, Benyu Liu, Xiaoxiao Zhu, Pingping Zhu, Jing Ma, Wei Xie, Huimu Li, Tianku Lu, Yanying Wang, Shuo Wang, Ying Du, Zhimin Wang, Jing Jiang, Jinsong Li, Dongdong Fan, Shu Meng, Jiayi Wu, Yong Tian, Zusen Fan. The chromatin remodeler SRCAP promotes self‐renewal of intestinal stem cells. THE EMBO JOURNAL. 2020, 第 21 作者39(13): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327502/.
[20] Wang, Shuo, Qu, Yuan, Xia, Pengyan, Chen, Yi, Zhu, Xiaoxiao, Zhang, Jing, Wang, Guan, Tian, Yong, Ying, Jianming, Fan, Zusen. Transdifferentiation of tumor infiltrating innate lymphoid cells during progression of colorectal cancer. CELL RESEARCH[J]. 2020, 第 10 作者30(7): 610-622, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=6760043&detailType=1.
[21] Benyu Liu, Buqing Ye, Xiaoxiao Zhu, Liuliu Yang, Huimu Li, Nian Liu, Pingping Zhu, Tiankun Lu, Luyun He, Yong Tian, Zusen Fan. An inducible circular RNA circKcnt2 inhibits ILC3 activation to facilitate colitis resolution. NATURE COMMUNICATIONS[J]. 2020, 第 11 作者  通讯作者  11(1): 1-14, http://dx.doi.org/10.1038/s41467-020-17944-5.
[22] Xiong, Zhen, Xia, Pengyan, Zhu, Xiaoxiao, Geng, Jingjing, Wang, Shuo, Ye, Buqing, Qin, Xiwen, Qu, Yuan, He, Luyun, Fan, Dongdong, Du, Ying, Tian, Yong, Fan, Zusen. Glutamylation of deubiquitinase BAP1 controls self-renewal of hematopoietic stem cells and hematopoiesis. JOURNAL OF EXPERIMENTAL MEDICINE[J]. 2020, 第 13 作者  通讯作者  217(2): https://www.webofscience.com/wos/woscc/full-record/WOS:000523657100013.
[23] Zhu, Pingping, Zhu, Xiaoxiao, Wu, Jiayi, He, Luyun, Lu, Tiankun, Wang, Yanying, Liu, Benyu, Ye, Buqing, Sun, Lei, Fan, Dongdong, Wang, Jing, Yang, Liuliu, Qin, Xiwen, Du, Ying, Li, Chong, He, Lei, Ren, Weizheng, Wu, Xin, Tian, Yong, Fan, Zusen. IL-13 secreted by ILC2s promotes the self-renewal of intestinal stem cells through circular RNA circPan3. NATURE IMMUNOLOGY[J]. 2019, 第 20 作者  通讯作者  20(2): 183-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000456279100016.
[24] 夏朋延, 王硕, Buqing, Ye, Ying, Du, 李翀, Zhen, Xiong, Yuan, Qu, 范祖森. 环状RNA抑制了cGAS介导的造血干细胞衰竭. 科学新闻[J]. 2019, 第 12 作者79-79, http://lib.cqvip.com/Qikan/Article/Detail?id=75888869504849574850485356.
[25] Zhen Xiong, Pengyan Xia, Xiaoxiao Zhu, Jingjing Geng, Shuo Wang, Buqing Ye, Xiwen Qin, Yuan Qu, Luyun He, Dongdong Fan, Ying Du, Yong Tian, Zusen Fan. Glutamylation of deubiquitinase BAP1 controls self-renewal of hematopoietic stem cells and hematopoiesis. THE JOURNAL OF EXPERIMENTAL MEDICINE. 2019, 第 13 作者217(2): 
[26] Liu, Benyu, Yang, Liuliu, Zhu, Xiaoxiao, Li, Huimu, Zhu, Pingping, Wu, Jiayi, Lu, Tiankun, He, Luyun, Liu, Nian, Meng, Shu, Zhou, Liang, Ye, Buqing, Tian, Yong, Fan, Zusen. Yeats4 drives ILC lineage commitment via activation of Lmo4 transcription. JOURNAL OF EXPERIMENTAL MEDICINE[J]. 2019, 第 14 作者  通讯作者  216(11): 2653-2668, 
[27] Benyu Liu, Liuliu Yang, Xiaoxiao Zhu, Huimu Li, Pingping Zhu, Jiayi Wu, Tiankun Lu, Luyun He, Nian Liu, Shu Meng, Liang Zhou, Buqing Ye, Yong Tian, Zusen Fan. Yeats4 drives ILC lineage commitment via activation of Lmo4 transcription. THE JOURNAL OF EXPERIMENTAL MEDICINE[J]. 2019, 第 14 作者  通讯作者  216(11): 2653-2668, https://www.webofscience.com/wos/woscc/full-record/WOS:000495355800016.
[28] Li, Jing, Li, Na, Chen, Yunfei, Hui, Shangyi, Fan, Junfen, Ye, Buqing, Fan, Zusen, Zhang, Jianguo, Zhao, Robert Chunhua, Zhuang, Qianyu. SPRY4 is responsible for pathogenesis of adolescent idiopathic scoliosis by contributing to osteogenic differentiation and melatonin response of bone marrow-derived mesenchymal stem cells. CELL DEATH & DISEASE[J]. 2019, 第 7 作者10(11): http://dx.doi.org/10.1038/s41419-019-1949-7.
[29] Song, Xiaosheng, Yang, Liuliu, Wang, Mingzhu, Gu, Yue, Ye, Buqing, Fan, Zusen, Xu, RuiMing, Yang, Na. A higher-order configuration of the heterodimeric DOT1L-AF10 coiled-coil domains potentiates their leukemogenenic activity. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2019, 第 6 作者116(40): 19917-19923, http://dx.doi.org/10.1073/pnas.1904672116.
[30] 范祖森. The long noncoding RNA LncHDAC2 drives the self-renewal of liver cancer stem cells via activation of Hedgehog Signaling.. J Hepatol.. 2019, 第 1 作者  通讯作者  
[31] Wu, Jiayi, Zhu, Pingping, Lu, Tiankun, Du, Ying, Wang, Yanying, He, Luyun, Ye, Buqing, Liu, Benyu, Yang, Liuliu, Wang, Jing, Gu, Yang, Lan, Jie, Hao, Yajing, He, Lei, Fan, Zusen. The long non-coding RNA LncHDAC2 drives the self-renewal of liver cancer stem cells via activation of Hedgehog signaling. JOURNAL OF HEPATOLOGY[J]. 2019, 第 15 作者  通讯作者  70(5): 918-929, http://dx.doi.org/10.1016/j.jhep.2018.12.015.
[32] 陈玲玲, 冯珊珊, 范祖森, 龚畅, 刘本宇, 刘子豪, 李传伟, 宋尔卫, 孙树汉, 吴庚泽, 吴煌, 吴缅, 许光, 袁继行, 曾春雨, 朱友明. 非编码RNA研究进展. 中国科学:生命科学[J]. 2019, 第 3 作者49(12): 1573-1605, https://www.sciengine.com/doi/10.1360/SSV-2019-0179.
[33] Zhuang, Qianyu, Ye, Buqing, Hui, Shangyi, Du, Ying, Zhao, Robert Chunhua, Li, Jing, Wu, Zhihong, Li, Na, Zhang, Yanbin, Li, Hongling, Wang, Shengru, Yang, Yang, Li, Shugang, Zhao, Hong, Fan, Zusen, Qiu, Guixing, Zhang, Jianguo. Long noncoding RNA lncAIS downregulation in mesenchymal stem cells is implicated in the pathogenesis of adolescent idiopathic scoliosis. CELL DEATH AND DIFFERENTIATION[J]. 2019, 第 15 作者  通讯作者  26(9): 1700-1715, 
[34] Wang, Yanying, Zhu, Pingping, Luo, Jianjun, VVang, Jing, Liu, Zhiwei, Wu, Wei, Du, Ying, Ye, Buqing, Wang, Dongpeng, He, Lei, Ren, Weizheng, Wang, Jianyi, Sun, Xianhui, Chen, Runsheng, Tian, Yong, Fan, Zusen. LncRNA HAND2-AS1 promotes liver cancer stem cell self-renewal via BMP signaling. EMBO JOURNAL[J]. 2019, 第 16 作者  通讯作者  38(17): 
[35] 范祖森. Circular RNA cia-cGAS protects dormant hematopoietic stem cells from DNA sensor cGAS-mediated exhaustion.. Immunity. 2018, 第 1 作者  通讯作者  
[36] 范祖森. Long noncoding RNA lncAIS downregulation in mesenchymal stem cells is implicated in the pathogenesis of adolescent idiopathic scoliosis.. Cell Death Diferentiation. 2018, 第 1 作者  通讯作者  
[37] 范祖森. LncKdm2b controls self-renewal of embryonic stem cells via activation of transcription factor Zbtb3.. EMBO J.. 2018, 第 1 作者  通讯作者  
[38] 渠源, 王硕, 范祖森. ILC细胞的生物学功能与免疫调节作用. 生物化学与生物物理进展[J]. 2018, 第 3 作者45(9): 897-914, http://lib.cqvip.com/Qikan/Article/Detail?id=676250511.
[39] Buqing Ye, Benyu Liu, Lu Hao, Xiaoxiao Zhu, Liuliu Yang, Shuo Wang, Pengyan Xia, Ying Du, Shu Meng, Guanling Huang, Xiwen Qin, Yanying Wang, Xinlong Yan, Chong Li, Junfeng Hao, Pingping Zhu, Luyun He, Yong Tian, Zusen Fan. Klf4 glutamylation is required for cell reprogramming and early embryonic development in mice. NATURE COMMUNICATIONS[J]. 2018, 第 19 作者  通讯作者  9(1): https://doaj.org/article/d42e411aa3ed40bc8f508b220288075a.
[40] Qu Yuan, Wang Shuo, Fan ZuSen. Research Progress on The Biological Functions and Immunoregulatory Effects of Innate Lymphoid Cells. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS[J]. 2018, 第 3 作者  通讯作者  45(9): 897-914, http://dx.doi.org/10.16476/j.pibb.2018.0188.
[41] Pingping Zhu, Zusen Fan. Cancer stem cells and tumorigenesis. 生物物理学报:英文版[J]. 2018, 第 2 作者4(4): 178-188, http://lib.cqvip.com/Qikan/Article/Detail?id=676327036.
[42] Zhu Pingping, Fan Zusen. Cancer stem cells and tumorigenesis. 生物物理学报:英文版[J]. 2018, 第 2 作者4(4): 178-188, http://lib.cqvip.com/Qikan/Article/Detail?id=676327036.
[43] Wang, Yanying, Zhu, Pingping, Wang, Jing, Zhu, Xiaoxiao, Luo, Jianjun, Meng, Shu, Wu, Jiayi, Ye, Buqing, He, Luyun, Du, Ying, He, Lei, Chen, Runsheng, Tian, Yong, Fan, Zusen. Long noncoding RNA lncHand2 promotes liver repopulation via c-Met signaling. JOURNAL OF HEPATOLOGY[J]. 2018, 第 14 作者  通讯作者  69(4): 861-872, http://dx.doi.org/10.1016/j.jhep.2018.03.029.
[44] Xia, Pengyan, Wang, Shuo, Xiong, Zhen, Zhu, Xiaoxiao, Ye, Buqing, Du, Ying, Meng, Shu, Qu, Yuan, Liu, Jing, Gao, Guangxia, Tian, Yong, Fan, Zusen. The ER membrane adaptor ERAdP senses the bacterial second messenger c-di-AMP and initiates anti-bacterial immunity. NATURE IMMUNOLOGY[J]. 2018, 第 12 作者  通讯作者  19(2): 141-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000423435200014.
[45] 王硕, 夏朋延, 陈亿, Yuan, Qu, Zhen, Xiong, Buqing, Ye, Ying, Du, 田勇, 尹芝南, 许执恒, 范祖森. 调节性固有淋巴样细胞调节肠道炎症进程. 科学新闻[J]. 2018, 第 15 作者48-48, http://lib.cqvip.com/Qikan/Article/Detail?id=675303208.
[46] Zhu, Pingping, Wu, Jiayi, Wang, Yanying, Zhu, Xiaoxiao, Lu, Tiankun, Liu, Benyu, He, Luyun, Ye, Buqing, Wang, Shuo, Meng, Shu, Fan, Dongdong, Wang, Jing, Yang, Liuliu, Qin, Xiwen, Du, Ying, Li, Chong, He, Lei, Ren, Weizheng, Wu, Xin, Tian, Yong, Fan, Zusen. LncGata6 maintains stemness of intestinal stem cells and promotes intestinal tumorigenesis. NATURE CELL BIOLOGY[J]. 2018, 第 21 作者  通讯作者  20(10): 1134-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000445656400009.
[47] Ye, Buqing, Liu, Benyu, Yang, Liuliu, Zhu, Xiaoxiao, Zhang, Dongdong, Wu, Wei, Zhu, Pingping, Wang, Yanying, Wang, Shuo, Xia, Pengyan, Du, Ying, Meng, Shu, Huang, Guanling, Wu, Jiayi, Chen, Runsheng, Tian, Yong, Fan, Zusen. LncKdm2b controls self-renewal of embryonic stem cells via activating expression of transcription factor Zbtb3. EMBO JOURNAL[J]. 2018, 第 17 作者  通讯作者  37(8): https://www.webofscience.com/wos/woscc/full-record/WOS:000430061000001.
[48] Xia, Pengyan, Wang, Shuo, Ye, Buqing, Du, Ying, Li, Chong, Xiong, Zhen, Qu, Yuan, Fan, Zusen. A Circular RNA Protects Dormant Hematopoietic Stem Cells from DNA Sensor cGAS-Mediated Exhaustion. IMMUNITY[J]. 2018, 第 8 作者  通讯作者  48(4): 688-+, http://dx.doi.org/10.1016/j.immuni.2018.03.016.
[49] 王硕, 范祖森. 免疫细胞可塑性与免疫病理机制研究进展. 中国免疫学杂志[J]. 2018, 第 2 作者34(5): 641-646, http://lib.cqvip.com/Qikan/Article/Detail?id=675215522.
[50] 范祖森. WASH is required for the maintenance of NKp46+ ILC3 cells through promoting AHR expression. Nature Communications. 2017, 第 1 作者  通讯作者  
[51] Zhu PingPing, Fan ZuSen. Cancer Stem Cell Niches and Targeted Interventions. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS[J]. 2017, 第 2 作者  通讯作者  44(8): 697-708, https://www.webofscience.com/wos/woscc/full-record/WOS:000408292300008.
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[53] 范祖森. natural-killer-like B cell function as a separate subset of innate B cell. Immunity. 2017, 第 1 作者  通讯作者  
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[111] Wang, Shuo, Xia, Pengyan, Ye, Buqing, Huang, Guanling, Liu, Jing, Fan, Zusen. Transient Activation of Autophagy via Sox2-Mediated Suppression of mTOR Is an Important Early Step in Reprogramming to Pluripotency. CELL STEM CELL[J]. 2013, 第 6 作者  通讯作者  13(5): 617-625, http://dx.doi.org/10.1016/j.stem.2013.10.005.
[112] Qu, Qianhui, Chen, Jun, Wang, Yizhi, Gui, Wenjun, Wang, Li, Fan, Zusen, Jiang, Tao. Structural Characterization of the Self-Association of the Death Domain of p75(NTR). PLOS ONE[J]. 2013, 第 6 作者8(3): http://www.irgrid.ac.cn/handle/1471x/756528.
[113] Xia, Pengyan, Wang, Shuo, Du, Ying, Zhao, Zhenao, Shi, Lei, Sun, Lei, Huang, Guanling, Ye, Buqing, Li, Chong, Dai, Zhonghua, Hou, Ning, Cheng, Xuan, Sun, Qingyuan, Li, Lei, Yang, Xiao, Fan, Zusen. WASH inhibits autophagy through suppression of Beclin 1 ubiquitination. EMBO JOURNAL[J]. 2013, 第 16 作者32(20): 2685-2696, https://www.webofscience.com/wos/woscc/full-record/WOS:000325714100005.
[114] Wang, Li, Li, Qian, Wu, Lianfeng, Liu, Shengwu, Zhang, Yong, Yang, Xuan, Zhu, Pingping, Zhang, Honglian, Zhang, Kai, Lou, Jizhong, Liu, Pingsheng, Tong, Liang, Sun, Fei, Fan, Zusen. Identification of SERPINB1 As a Physiological Inhibitor of Human Granzyme H. JOURNAL OF IMMUNOLOGY[J]. 2013, 第 14 作者190(3): 1319-1330, http://www.irgrid.ac.cn/handle/1471x/756559.
[115] Honglian Zhang, Haidong Tang, Chong Li, Li Wang, Zusen Fan. Granzyme H of Cytotoxic Lymphocytes Is Required for Clearance of the Hepatitis B Virus through Cleavage of the Hepatitis B Virus X Protein. AMERICAN ASSOCIATION OF IMMUNOLOGISTS. 2012, 第 5 作者http://oa.las.ac.cn/oainone/service/browseall/read1?ptype=JA&workid=JA201902026567055ZK.
[116] Zhong, C, Li, C, Wang, X, Toyoda, T, Gao, G, Fan, Z. Granzyme K inhibits replication of influenza virus through cleaving the nuclear transport complex importin alpha 1/beta dimer of infected host cells. CELL DEATH AND DIFFERENTIATION[J]. 2012, 19(5): 882-890, http://www.irgrid.ac.cn/handle/1471x/756809.
[117] Tang, Haidong, Li, Chong, Wang, Li, Zhang, Honglian, Fan, Zusen. Granzyme H of Cytotoxic Lymphocytes Is Required for Clearance of the Hepatitis B Virus through Cleavage of the Hepatitis B Virus X Protein. JOURNAL OF IMMUNOLOGY[J]. 2012, 第 5 作者  通讯作者  188(2): 824-831, http://www.irgrid.ac.cn/handle/1471x/756808.
[118] Wang, S, Xia, P, Shi, L, Fan, Z. FADD cleavage by NK cell granzyme M enhances its self-association to facilitate procaspase-8 recruitment for auto-processing leading to caspase cascade. CELL DEATH AND DIFFERENTIATION[J]. 2012, 19(4): 605-615, http://www.irgrid.ac.cn/handle/1471x/756797.
[119] Wang, Li, Zhang, Kai, Wu, Lianfeng, Liu, Shengwu, Zhang, Honglian, Zhou, Qiangjun, Tong, Liang, Sun, Fei, Fan, Zusen. Structural Insights into the Substrate Specificity of Human Granzyme H: The Functional Roles of a Novel RKR Motif. JOURNAL OF IMMUNOLOGY[J]. 2012, 第 9 作者188(2): 765-773, http://www.irgrid.ac.cn/handle/1471x/756943.
[120] 丁明霞, 李翀, 左毅刚, 范祖森, 王剑松. 人膀胱癌EJ细胞株CD44基因的小RNA干扰抑制细胞侵袭功能. 现代泌尿生殖肿瘤杂志[J]. 2011, 第 4 作者3(6): 345-347, http://lib.cqvip.com/Qikan/Article/Detail?id=40549274.
[121] 丁明霞, 李翀, 左毅刚, 詹辉, 范祖森, 王剑松. 膀胱癌EJ细胞的CD44异常糖基化及其单抗KMPl的生物学功能研究. 中国肿瘤临床[J]. 2011, 第 5 作者38(13): 759-762, http://lib.cqvip.com/Qikan/Article/Detail?id=38648188.
[122] 丁明霞, 李翀, 左毅刚, 詹辉, 范祖森, 王剑松. 膀胱癌EJ细胞的CD44异常糖基化及其单抗KMP1的生物学功能研究. 中国肿瘤临床[J]. 2011, 第 5 作者38(13): 759-762, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=4297257&detailType=1.
[123] Guo, Yuming, Chen, Jun, Shi, Lei, Fan, Zusen. Valosin-Containing Protein Cleavage by Granzyme K Accelerates an Endoplasmic Reticulum Stress Leading to Caspase-Independent Cytotoxicity of Target Tumor Cells. JOURNAL OF IMMUNOLOGY[J]. 2010, 第 4 作者  通讯作者  185(9): 5348-5359, http://www.irgrid.ac.cn/handle/1471x/757147.
[124] Hu, Deqing, Liu, Shengwu, Shi, Lei, Li, Chong, Wu, Lianfeng, Fan, Zusen. Cleavage of Survivin by Granzyme M Triggers Degradation of the Survivin-X-linked Inhibitor of Apoptosis Protein (XIAP) Complex to Free Caspase Activity Leading to Cytolysis of Target Tumor Cells. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2010, 第 6 作者  通讯作者  285(24): 18326-18335, http://dx.doi.org/10.1074/jbc.M109.083170.
[125] 范祖森. VCP cleavage by granzyme K disrupts endoplasmic reticulum associated protein degradation to force tumor target cell death.. 2010, 第 1 作者  通讯作者  
[126] Shi, L, Wu, L, Wang, S, Fan, Z. Granzyme F induces a novel death pathway characterized by Bid-independent cytochrome c release without caspase activation. CELL DEATH AND DIFFERENTIATION[J]. 2009, 16(12): 1694-1706, http://www.irgrid.ac.cn/handle/1471x/757967.
[127] 范祖森. Granulysin induces cathepsin B release of lysosomes of target tumor cells to target mitochondria through processing of Bid.. 2009, 第 1 作者  通讯作者  
[128] 范祖森. Ignition of p53 bomb by granzyme K sensitizes tumor cells to NK cell-mediated cytolysis.. 2009, 第 1 作者  通讯作者  
[129] Wu, Lianfeng, Wang, Li, Hua, Guoqiang, Liu, Kan, Yang, Xuan, Zhai, Yujia, Bartlam, Mark, Sun, Fei, Fan, Zusen. Structural Basis for Proteolytic Specificity of the Human Apoptosis-Inducing Granzyme M. JOURNAL OF IMMUNOLOGY[J]. 2009, 第 9 作者183(1): 421-429, http://www.irgrid.ac.cn/handle/1471x/757932.
[130] []. Structural Basis for Proteolytic Specificity of the Human Apoptosis-Inducing Granzyme M. AMERICAN ASSOCIATION OF IMMUNOLOGISTS. 2009, http://oa.las.ac.cn/oainone/service/browseall/read1?ptype=JA&workid=JA201902025244661ZK.
[131] Hua, Guoqiang, Wang, Shuo, Zhong, Chao, Xue, Peng, Fan, Zusen. Ignition of p53 Bomb Sensitizes Tumor Cells to Granzyme K-Mediated Cytolysis. JOURNAL OF IMMUNOLOGY[J]. 2009, 第 5 作者  通讯作者  182(4): 2152-2159, http://www.irgrid.ac.cn/handle/1471x/757917.
[132] Hou, Qiang, Zhao, Tongbiao, Zhang, Honglian, Lu, Hongxia, Zhang, Qixiang, Sun, Lei, Fan, Zusen. Granzyme H induces apoptosis of target tumor cells characterized by DNA fragmentation and Bid-dependent mitochondrial damage. MOLECULAR IMMUNOLOGY[J]. 2008, 第 7 作者  通讯作者  45(4): 1044-1055, http://dx.doi.org/10.1016/j.molimm.2007.07.032.
[133] Guo, Yuming, Chen, Jun, Zhao, Tongbiao, Fan, Zusen. Granzyme K degrades the redox/DNA repair enzyme Ape1 to trigger oxidative stress of target cells leading to cytotoxicity. MOLECULAR IMMUNOLOGY[J]. 2008, 第 4 作者  通讯作者  45(8): 2225-2235, http://dx.doi.org/10.1016/j.molimm.2007.11.020.
[134] Lu, Hongxia, Hou, Qiang, Zhao, Tongbiao, Zhang, Honglian, Zhang, Qixiang, Wu, Lianfeng, Fan, Zusen. Granzyme M directly cleaves inhibitor of caspase-activated DNase (CAD) to unleash CAD leading to DNA fragmentation. JOURNAL OF IMMUNOLOGY[J]. 2006, 第 7 作者  通讯作者  177(2): 1171-1178, https://www.webofscience.com/wos/woscc/full-record/WOS:000238926500047.
[135] Fan, Zusen, Zhang, Qixiang. Molecular Mechanisms of Lymphocyte-Mediated Cytotoxicity. CELLULAR & MOLECULAR IMMUNOLOGY[J]. 2005, 第 1 作者  通讯作者  2(4): 259-264, http://lib.cqvip.com/Qikan/Article/Detail?id=20585116.
[136] 马宝骊, 范祖森. 环孢素A与抗B7—1单克隆抗体联用诱导T淋巴细胞耐受的研究. 中华器官移植杂志[J]. 2000, 第 2 作者21(3): 161, http://lib.cqvip.com/Qikan/Article/Detail?id=4202375.
[137] 范祖森, 马宝骊. B7—1单抗和CsA联用诱导人T细胞无能及其特性探讨. 中国肿瘤生物治疗杂志[J]. 1999, 第 1 作者6(2): 102-106, http://lib.cqvip.com/Qikan/Article/Detail?id=3554276.
[138] 范祖森, 马宝骊. 白细胞介素—10和天花粉蛋白抑制抗原提呈细胞表面分子表达及T—细?…. 中国药理学报[J]. 1999, 第 1 作者20(4): 353-357, http://lib.cqvip.com/Qikan/Article/Detail?id=3522295.
[139] 范祖森, 马宝骊. 共刺激对T细胞功能和细胞因子格局的作用. 免疫学杂志[J]. 1999, 第 1 作者15(4): 220, http://lib.cqvip.com/Qikan/Article/Detail?id=3648045.
[140] 范祖森, 马宝骊. B7/CD28和ICAM—1/LFA—1共刺激信号对T及B细胞功?…. 中华微生物学和免疫学杂志[J]. 1999, 第 1 作者19(6): 485-489, http://lib.cqvip.com/Qikan/Article/Detail?id=3843212.
[141] 范祖森, 敖世洲. 免疫耐受的基础研究与临床应用. 自然杂志[J]. 1999, 第 1 作者21(2): 77-81, http://lib.cqvip.com/Qikan/Article/Detail?id=3616483.
[142] 敖世洲, 范祖森, 马宝骊. 免疫耐受的形成机制. 生命科学[J]. 1999, 第 2 作者11(4): 160, http://lib.cqvip.com/Qikan/Article/Detail?id=3698333.
[143] 范祖森. HLA—G研究进展. 国外医学:分子生物学分册[J]. 1999, 第 1 作者21(1): 49-53, http://lib.cqvip.com/Qikan/Article/Detail?id=3428414.
[144] 马宝骊, 王利, 范祖森. B7/CD28和ICAM-1/LFA-1共刺激信号对T及B细胞功能影响的研究. 中华微生物学和免疫学杂志. 1999, 第 3 作者19(6): 485, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=889312&detailType=1.
[145] 范祖森, 敖世洲. 肿瘤抑制基因Rb与细胞周期调控研究新进展. 生物化学与生物物理进展[J]. 1999, 第 1 作者26(5): 429, http://lib.cqvip.com/Qikan/Article/Detail?id=3656320.
[146] 范祖森, 敖世洲. 蛋白质内在信号——控制其在细胞内的运输和定位. 自然杂志[J]. 1999, 第 1 作者21(6): 362-362, http://lib.cqvip.com/Qikan/Article/Detail?id=3876646.
[147] 范祖森, 敖世洲. 细胞周期抑制蛋白p27的研究进展. 生命科学[J]. 1999, 第 1 作者11(5): 2, http://lib.cqvip.com/Qikan/Article/Detail?id=3649706.
[148] 马宝骊, 范祖森. 白细胞介素-10和天花粉蛋白抑制抗原提呈细胞表面分子表达及T-细胞增殖. 中国药理学报[J]. 1999, 第 2 作者20(4): 353, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=498900&detailType=1.
[149] 柏峻, 范祖森, 王利, 马宝骊. T细胞无能与凋亡关系初探. 中国免疫学杂志[J]. 1999, 第 2 作者15(8): 342, http://lib.cqvip.com/Qikan/Article/Detail?id=3809115.
[150] 范祖森, 敖世洲. 细胞周期关卡调控与细胞癌变. 自然杂志[J]. 1999, 第 1 作者21(1): 8-11, http://lib.cqvip.com/Qikan/Article/Detail?id=3429336.
[151] 张汉明, 范祖森, 马宝骊. T细胞耐受的诱导及其机理研究. 中华微生物学和免疫学杂志[J]. 1999, 第 2 作者19(5): 387, http://lib.cqvip.com/Qikan/Article/Detail?id=3779343.
[152] 范祖森. B细胞程序性死亡的研究进展. 国外医学:免疫学分册[J]. 1998, 第 1 作者21(5): 231-234, http://lib.cqvip.com/Qikan/Article/Detail?id=3165741.
[153] 范祖森. 共刺激信号与免疫耐受. 国外医学:免疫学分册[J]. 1997, 第 1 作者20(5): 244-248, http://lib.cqvip.com/Qikan/Article/Detail?id=2593057.
[154] 孙汶生, 张庆殷, 范祖森, 马大龙, 狄春辉, 曹容华. IL—1ra对佐剂性关节炎大鼠腹腔Mφ细胞因子诱生的抑制作用. 中国免疫学杂志[J]. 1997, 第 3 作者13(5): 273, http://lib.cqvip.com/Qikan/Article/Detail?id=2770832.
[155] 范祖森. 口服耐受的研究进展. 国外医学:免疫学分册[J]. 1997, 第 1 作者20(2): 87-89, http://lib.cqvip.com/Qikan/Article/Detail?id=2546312.
[156] 张庆殷, 曹容华, 马大龙, 孙汶生, 范祖森, 袁勇. IL-10对佐剂性关节炎大鼠腹腔巨噬细胞及脾淋巴细胞诱生IL-8的影响. 上海免疫学杂志[J]. 1996, 第 5 作者16(4): 217, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=345502&detailType=1.
[157] 范祖森, 曹容华. IL—10对佐剂性关节炎大鼠腹腔巨噬细胞及脾淋巴细胞诱生IL…. 上海免疫学杂志[J]. 1996, 第 1 作者16(4): 217-220, http://lib.cqvip.com/Qikan/Article/Detail?id=2402657.
[158] 范祖森. 单克隆抗体治疗类风湿关节炎研究进展. 国外医学:内科学分册[J]. 1996, 第 1 作者23(10): 420-423, http://lib.cqvip.com/Qikan/Article/Detail?id=2370634.
[159] Xia Pengyan, Wang Shuo, Du Ying, Huang Guanling, Satoh Takashi, Akira Shizuo, Fan Zusen. Insulin–InsR signaling drives multipotent progenitor differentiation toward lymphoid lineages. THE JOURNAL OF EXPERIMENTAL MEDICINE. 第 7 作者212(13): 2305-2321, https://www.webofscience.com/wos/woscc/full-record/WOS:000368248500013.
[160] Xia Pengyan, Wang Shuo, Huang Guanling, Zhu Pingping, Li Man, Ye Buqing, Du Ying, Fan Zusen. WASH is required for the differentiation commitment of hematopoietic stem cells in a c-Myc–dependent manner. THE JOURNAL OF EXPERIMENTAL MEDICINE. 第 8 作者211(10): 2119-2134, https://www.webofscience.com/wos/woscc/full-record/WOS:000342744800017.
发表著作
(1) 免疫学前沿进展(第2版),免疫学前沿进展(第2版),人民卫生出版社,2011-07,第2作者
(2) 免疫学前沿进展(第1版),免疫学前沿进展(第1版),人民卫生出版社,2009-11,第2作者

科研活动

   
科研项目
(1) 免疫应答效应相关蛋白质的生物学功能及其作用机制研究,主持,部委级,2010-01--2014-12
(2) SET蛋白复合体的结构与功能研究,主持,国家级,2009-01--2012-12

指导学生

已指导学生

侯强  博士研究生  071010-生物化学与分子生物学  

吕红霞  博士研究生  071010-生物化学与分子生物学  

华国强  博士研究生  071010-生物化学与分子生物学  

郭玉明  博士研究生  071010-生物化学与分子生物学  

张红莲  博士研究生  071010-生物化学与分子生物学  

胡德庆  博士研究生  071009-细胞生物学  

刘侃  硕士研究生  071010-生物化学与分子生物学  

吴连锋  博士研究生  071010-生物化学与分子生物学  

石磊  博士研究生  071010-生物化学与分子生物学  

现指导学生

安云鹤  博士研究生  071009-细胞生物学  

王丽  博士研究生  071010-生物化学与分子生物学  

唐海东  博士研究生  071010-生物化学与分子生物学  

王硕  博士研究生  071010-生物化学与分子生物学  

钟超  博士研究生  071010-生物化学与分子生物学  

杨轩  博士研究生  071010-生物化学与分子生物学  

刘圣武  博士研究生  071010-生物化学与分子生物学  

陈俊  博士研究生  071010-生物化学与分子生物学  

郝璐  硕士研究生  071010-生物化学与分子生物学  

杨昭  硕士研究生  071010-生物化学与分子生物学  

李倩  博士研究生  071010-生物化学与分子生物学  

夏朋延  博士研究生  071010-生物化学与分子生物学  

刘本宇  硕士研究生  071010-生物化学与分子生物学  

黄贯岭  硕士研究生  071010-生物化学与分子生物学  

李曼  博士研究生  071010-生物化学与分子生物学  

丁志超  博士研究生  071010-生物化学与分子生物学