基本信息
孙中生 男 博导 心理研究所
电子邮件:sunzs@mail.biols.ac.cn
通信地址:北京市朝阳区北辰西路1号院5号
邮政编码:100101

招生信息

   
招生专业
071007-遗传学
招生方向
基因组学
行为遗传学

教育背景

1988-06--1992-12 美国德克萨斯州A&M大学化学系 博士学习
1978-09--1982-07 北京大学 本科学习

工作经历

   
工作简历
2010-09--今 中国科学院北京生命科学研究院 研究员
2005-09--2010-08 中国科学院心理研究所 研究员
1999-09--2005-08 美国康奈尔大学威尔医学院特护医学实验室 助理教授
1998-09--1999-08 路易斯安那州立大学神经科学中心 助理教授
1994-07--1998-08 贝勒医学院分子人类遗传学系 博士后
1993-01--1994-06 德克萨斯州大学安德生癌症研究中心 博士后

教授课程

表观基因组学研究进展、 博导论坛(行为遗传学)

专利与奖励

   
专利成果
[1] 梁加龙, 张坤, 滕花景, 孙中生. 一种具有单碱基分辨率的检测DNA甲基化和单核苷酸变异的测序文库及应用. CN: CN108949945B, 2021-02-26.

[2] 梁加龙, 滕花景, 李津臣, 孙中生. 一种甲状腺癌致病相关的基因融合变异检测试剂盒. CN: CN106591431B, 2019-09-10.

出版信息

   
发表论文
[1] Wei Song, Quan Li, Tao Wang, Yuanyuan Li, Tianda Fan, Jianghong Zhang, Qingqing Wang, Jinrong Pan, Qiwen Dong, Zhong Sheng Sun, Yan Wang. Putative complement control protein CSMD3 dysfunction impairs synaptogenesis and induces neurodevelopmental disorders. Brain Behavior and Immunity. 2022, 102: 237-250, [2] Miao, Zhuang, Li, Yuanyuan, Mao, Fengbiao, Zhang, Jianghong, Sun, Zhong Sheng, Wang, Yan. Prenatal witness stress induces intergenerational anxiety-like behaviors and altered gene expression profiles in male mice. NEUROPHARMACOLOGY[J]. 2022, 202: http://dx.doi.org/10.1016/j.neuropharm.2021.108857.
[3] Kaifan Zhang, Yan Wang, Tianda Fan, Cheng Zeng, Zhong Sheng Sun. The p21-activated kinases in neural cytoskeletal remodeling and related neurological disorders. Protein & Cell[J]. 2022, 13(1): 6-25, [4] Zhang, Chunbo, Zhong, Tianyu, Li, Yuanyuan, Li, Xianfeng, Yuan, Xiaopeng, Liu, Linlin, Wu, Weilin, Wu, Jing, Wu, Ye, Liang, Rui, Xie, Xinhua, Kang, Chuanchuan, Liu, Yuwen, Lai, Zhonghong, Xiao, Jianbo, Tang, Zhixian, Jin, Riqun, Wang, Yan, Xiao, Yongwei, Zhang, Jin, Li, Jian, Liu, Qian, Sun, Zhongsheng, Zhong, Jianing. The hepatic AMPK-TET1-SIRT1 axis regulates glucose homeostasis. ELIFE[J]. 2021, 10: http://dx.doi.org/10.7554/eLife.70672.sa2.
[5] Mei, Yue, Teng, Huajing, Li, Zhigang, Zeng, Cheng, Li, Yuanyuan, Song, Wei, Zhang, Kaifan, Sun, Zhong Sheng, Wang, Yan. Restricted Feeding Resets Endogenous Circadian Rhythm in Female Mice Under Constant Darkness. NEUROSCIENCE BULLETINnull. 2021, 37(7): 1005-1009, http://dx.doi.org/10.1007/s12264-021-00669-w.
[6] Zhang, Yi, Wang, Tao, Wang, Yan, Xia, Kun, Li, Jinchen, Sun, Zhongsheng. Targeted sequencing and integrative analysis to prioritize candidate genes in neurodevelopmental disorders. MOLECULAR NEUROBIOLOGY[J]. 2021, 58(8): 3863-3873, http://dx.doi.org/10.1007/s12035-021-02377-y.
[7] Tao Wang, Yi Zhang, Liqui Liu, Yan Wang, Huiqian Chen, Tianda Fan, Jinchen Li, Kun Xia, Zhongsheng Sun. Targeted sequencing and integrative analysis of 3,195 Chinese patients with neurodevelopmental disorders prioritized 26 novel candidate genes. JOURNAL OF GENETICS AND GENOMICS[J]. 2021, 48(4): 312-323, [8] Wang, Tao, Ruan, Shasha, Zhao, Xiaolu, Shi, Xiaohui, Teng, Huajing, Zhong, Jianing, You, Mingcong, Xia, Kun, Sun, Zhongsheng, Mao, Fengbiao. OncoVar: an integrated database and analysis platform for oncogenic driver variants in cancers. NUCLEIC ACIDS RESEARCH[J]. 2021, 49(D1): D1289-D1301, http://dx.doi.org/10.1093/nar/gkaa1033.
[9] Jialong Liang, Kun Zhang, Jie Yang, Xianfeng Li, Qinglan Li, Yan Wang, Wanshi Cai, Huajing Teng, Zhongsheng Sun. A new approach to decode DNA methylome and genomic variants simultaneously from double strand bisulfite sequencing. Briefings in Bioinformatics[J]. 2021, 22(6): [10] Ran, Xia, Xiao, Jinyuan, Zhang, Yi, Teng, Huajing, Cheng, Fang, Chen, Huiqian, Zhang, Kaifan, Sun, Zhongsheng. Low intratumor heterogeneity correlates with increased response to PD-1 blockade in renal cell carcinoma. THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY[J]. 2020, 12: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7758866/.
[11] Teng, Huajing, Xue, Meiying, Liang, Jialong, Wang, Xingxing, Wang, Lu, Wei, Wenqing, Li, Chao, Zhang, Ze, Li, Qinglan, Ran, Xia, Shi, Xiaohui, Cai, Wanshi, Wang, Weihu, Gao, Hengjun, Sun, Zhongsheng. Inter- and intratumor DNA methylation heterogeneity associated with lymph node metastasis and prognosis of esophageal squamous cell carcinoma. THERANOSTICS[J]. 2020, 10(7): 3035-3048, https://www.webofscience.com/wos/woscc/full-record/WOS:000514452800012.
[12] Zhang, Jianghong, Xue, Meiying, Mei, Yue, Li, Zhigang, Ceng, Zeng, Li, Yuanyuan, Zhang, Yi, Li, Na, Teng, Huajing, Sun, Zhong Sheng, Wang, Yan. Co-expression Network of mRNAs and lncRNAs Regulated by Stress-Linked Behavioral Assays. PSYCHOPHARMACOLOGY[J]. 2020, 237(2): 571-582, https://www.webofscience.com/wos/woscc/full-record/WOS:000498109500002.
[13] Miao, Zhuang, Wang, Yan, Sun, Zhongsheng. The Relationships Between Stress, Mental Disorders, and Epigenetic Regulation of BDNF. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCESnull. 2020, 21(4): https://doaj.org/article/fccd2f25888740fab1b65a6bb497a03b.
[14] Teng, Huajing, Wei, Wenqing, Li, Qinglan, Xue, Meiying, Shi, Xiaohui, Li, Xianfeng, Mao, Fengbiao, Sun, Zhongsheng. Prevalence and architecture of posttranscriptionally impaired synonymous mutations in 8,320 genomes across 22 cancer types. NUCLEIC ACIDS RESEARCH[J]. 2020, 48(3): 1192-1205, https://www.webofscience.com/wos/woscc/full-record/WOS:000515121900021.
[15] Wang, Lin, Zhang, Yi, Li, Kuokuo, Wang, Zheng, Wang, Xiaomeng, Li, Bin, Zhao, Guihu, Fang, Zhenghuan, Ling, Zhengbao, Luo, Tengfei, Xia, Lu, Li, Yanping, Guo, Hui, Hu, Zhengmao, Li, Jinchen, Sun, Zhongsheng, Xia, Kun. Functional relationships between recessive inherited genes and genes with de novo variants in autism spectrum disorder. MOLECULAR AUTISM[J]. 2020, 11(1): http://dx.doi.org/10.1186/s13229-020-00382-x.
[16] 孙中生. The p21-activated kinases in synaptic cytoskeletal remodeling and related neurological disorders.. Protein & Cell. 2020, [17] Wang, Haoxuan, Wang, Tao, Zhao, Xiaolu, Wu, Honghu, You, Mingcong, Sun, Zhongsheng, Mao, Fengbiao. AI-Driver: an ensemble method for identifying driver mutations in personal cancer genomes. NAR GENOMICS AND BIOINFORMATICS[J]. 2020, 2(4): http://dx.doi.org/10.1093/nargab/lqaa084.
[18] Zhou, Hao, Xu, Xiu, Yan, Weili, Zou, Xiaobing, Wu, Lijie, Luo, Xuerong, Li, Tingyu, Huang, Yi, Guan, Hongyan, Chen, Xiang, Mao, Meng, Xia, Kun, Zhang, Lan, Li, Erzhen, Ge, Xiaoling, Zhang, Lili, Li, Chunpei, Zhang, Xudong, Zhou, Yuanfeng, Ding, Ding, Shih, Andy, Fombonne, Eric, Zheng, Yi, Han, Jisheng, Sun, Zhongsheng, Jiang, Yonghui, Wang, Yi, LATENTNHC Study Team. Prevalence of Autism Spectrum Disorder in China: A Nationwide Multi-center Population-based Study Among Children Aged 6 to 12 Years. NEUROSCIENCE BULLETIN[J]. 2020, 36(9): 961-971, http://lib.cqvip.com/Qikan/Article/Detail?id=7103003870.
[19] Miao, Zhuang, Zhang, Jianghong, Li, Yuanyuan, Li, Xianfeng, Song, Wei, Sun, Zhong Sheng, Wang, Yan. Presence of the pregnant partner regulates microRNA-30a and BDNF levels and protects male mice from social defeat-induced abnormal behaviors. NEUROPHARMACOLOGY[J]. 2019, 159: https://www.webofscience.com/wos/woscc/full-record/WOS:000493220100011.
[20] Li, Jinchen, Hu, Shanshan, Zhang, Kun, Shi, Leisheng, Zhang, Yi, Zhao, Tingting, Wang, Lin, He, Xin, Xia, Kun, Liu, Chunyu, Sun, Zhongsheng. A comparative study of the genetic components of three subcategories of autism spectrum disorder. MOLECULAR PSYCHIATRY[J]. 2019, 24(11): 1720-1731, [21] Wang, Yan, Wu, Haodo, Sun, Zhong Sheng. The biological basis of sexual orientation: How hormonal, genetic, and environmental factors influence to whom we are sexually attracted. FRONTIERS IN NEUROENDOCRINOLOGYnull. 2019, 55: [22] Yongqing Wang, Yan Wang, Jialong Liang, Wanshi Cai, Zhongsheng Sun, Yan Wang, Huajing Teng. Androgen deprivation drives variation of androgen receptor trinucleotide repeats. 生物化学与生物物理学报:英文版null. 2019, 51(9): 972-975, http://lib.cqvip.com/Qikan/Article/Detail?id=7100194918.
[23] Chen, YueLei, Zhang, Yihe, Wang, Junwen, Chen, Na, Fang, Weiying, Zhong, Jianing, Liu, Yi, Qin, Rui, Yu, Xinxin, Sun, Zhongsheng, Gao, Fei. A 17 gene panel for non-small-cell lung cancer prognosis identified through integrative epigenomic-transcriptomic analyses of hypoxia-induced epithelial-mesenchymal transition. MOLECULAR ONCOLOGY[J]. 2019, 13(7): 1490-1502, https://doaj.org/article/f2bcf0153a7741a9b1f4613277b2293b.
[24] Li, Xianfeng, Shi, Leisheng, Wang, Yan, Zhong, Jianing, Zhao, Xiaolu, Teng, Huajing, Shi, Xiaohui, Yang, Haonan, Ruan, Shasha, Li, MingKun, Sun, Zhong Sheng, Zhan, Qimin, Mao, Fengbiao. OncoBase: a platform for decoding regulatory somatic mutations in human cancers. NUCLEIC ACIDS RESEARCH[J]. 2019, 47(D1): D1044-D1055, [25] 孙中生. Genetic evidence of gender difference in autism spectrum disorder supports a female protective effect.. Translational Psychiatry. 2019, [26] Li, Xianfeng, Shi, Leisheng, Zhang, Kun, Wei, Wenqing, Liu, Qi, Mao, Fengbiao, Li, Jinchen, Cai, Wanshi, Chen, Huiqian, Teng, Huajing, Li, Jiada, Sun, Zhongsheng. CirGRDB: a database for the genome-wide deciphering circadian genes and regulators. NUCLEIC ACIDS RESEARCH[J]. 2018, 46(D1): D64-D70, https://www.webofscience.com/wos/woscc/full-record/WOS:000419550700011.
[27] Wang, Lin, Sun, Zhong Sheng, Xiang, Bingwu, Wei, Chiju, Wang, Yan, Sun, Kevin, Chen, Guanjie, Lan, Michael S, Carmona, Gilberto N, Notkins, Abner L, Cai, Tao. Targeted deletion of Insm2 in mice result in reduced insulin secretion and glucose intolerance. JOURNAL OF TRANSLATIONAL MEDICINE[J]. 2018, 16(1): https://doaj.org/article/4f93136204af45539819c336a08ee249.
[28] Liang, Jialong, Cai, Wanshi, Feng, Dongdong, Teng, Huajing, Mao, Fengbiao, Jiang, Yi, Hu, Shanshan, Li, Xianfeng, Zhang, Yujie, Liu, Baoguo, Sun, Zhong Sheng. Genetic landscape of papillary thyroid carcinoma in the Chinese population. JOURNAL OF PATHOLOGY[J]. 2018, 244(2): 215-226, https://www.webofscience.com/wos/woscc/full-record/WOS:000422751200009.
[29] Miao, Zhuang, Mao, Fengbiao, Liang, Jialong, Szyf, Moshe, Wang, Yan, Sun, Zhong Sheng. Anxiety-Related Behaviours Associated with microRNA-206-3p and BDNF Expression in Pregnant Female Mice Following Psychological Social Stress. MOLECULAR NEUROBIOLOGY[J]. 2018, 55(2): 1097-1111, [30] Wang, Yan, Zeng, Cheng, Li, Jinchen, Zhou, Zikai, Ju, Xingda, Xia, Shuting, Li, Yuanyuan, Liu, An, Teng, Huajing, Zhang, Kun, Shi, Leisheng, Bi, Cheng, Xie, Wei, He, Xin, Jia, Zhengping, Jiang, Yonghui, Cai, Tao, Wu, Jinyu, Xia, Kun, Sun, Zhong Sheng. PAK2 Haploinsufficiency Results in Synaptic Cytoskeleton Impairment and Autism-Related Behavior. CELL REPORTS[J]. 2018, 24(8): 2029-2041, http://dx.doi.org/10.1016/j.celrep.2018.07.061.
[31] Wu, Jinyu, Yu, Ping, Jin, Xin, Xu, Xiu, Li, Jinchen, Li, Zhongshan, Wang, Mingbang, Wang, Tao, Wu, Xueli, Jiang, Yi, Cai, Wanshi, Mei, Junpu, Min, Qingjie, Xu, Qiong, Zhou, Bingrui, Guo, Hui, Wang, Ping, Zhou, Wenhao, Hu, Zhengmao, Li, Yingrui, Cai, Tao, Wang, Yi, Xia, Kun, Jiang, YongHui, Sun, Zhong Sheng. Genomic landscapes of Chinese sporadic autism spectrum disorders revealed by whole-genome sequencing. JOURNAL OF GENETICS AND GENOMICS[J]. 2018, 45(10): 527-538, http://lib.cqvip.com/Qikan/Article/Detail?id=676889504.
[32] Zhang, Hang, Cai, Wanshi, Chen, Siyu, Liang, Jialong, Wang, Zhanjun, Ren, Yuting, Liu, Wenxiu, Zhang, Xiaolan, Sun, Zhongsheng, Huang, Xusheng. Screening for possible oligogenic pathogenesis in Chinese sporadic ALS patients. AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION[J]. 2018, 19(5-6): 419-425, https://www.webofscience.com/wos/woscc/full-record/WOS:000435582800011.
[33] Jie Yang, Yun Chen, Jingxiao Lu, Xingxing Wang, Lu Wang, Jialong Liang, Zhong Sheng Sun. Identification and characterization of novel fusion genes in prostate cancer by targeted RNA capture and next-generation sequencing. 生物化学与生物物理学报:英文版[J]. 2018, 50(11): 1166-1172, http://lib.cqvip.com/Qikan/Article/Detail?id=6100232413.
[34] Teng, Huajing, Mao, Fengbiao, Liang, Jialong, Xue, Meiying, Wei, Wenqing, Li, Xianfeng, Zhang, Kun, Feng, Dongdong, Liu, Baoguo, Sun, Zhongsheng. Transcriptomic signature associated with carcinogenesis and aggressiveness of papillary thyroid carcinoma. THERANOSTICS[J]. 2018, 8(16): 4345-4358, https://www.webofscience.com/wos/woscc/full-record/WOS:000444104300006.
[35] Li, Jinchen, Shi, Leisheng, Zhang, Kun, Zhang, Yi, Hu, Shanshan, Zhao, Tingting, Teng, Huajing, Li, Xianfeng, Jiang, Yi, Ji, Liying, Sun, Zhongsheng. VarCards: an integrated genetic and clinical database for coding variants in the human genome. NUCLEIC ACIDS RESEARCH[J]. 2018, 46(D1): D1039-D1048, https://www.webofscience.com/wos/woscc/full-record/WOS:000419550700151.
[36] Li, Jinchen, Zhao, Tingting, Zhang, Yi, Zhang, Kun, Shi, Leisheng, Chen, Yun, Wang, Xingxing, Sun, Zhongsheng. Performance evaluation of pathogenicity-computation methods for missense variants. NUCLEIC ACIDS RESEARCH[J]. 2018, 46(15): 7793-7804, https://www.webofscience.com/wos/woscc/full-record/WOS:000444148100029.
[37] Yue Mei, Jianghong Zhang, Zhigang Li, Huajing Teng, Yan Wang, Zhongsheng Sun. Altered expressions of memory genes in food-entrained circadian rhythm. 生物化学与生物物理学报:英文版null. 2018, 50(10): 1068-1071, http://lib.cqvip.com/Qikan/Article/Detail?id=676886736.
[38] Mao, Fengbiao, Liu, Qi, Zhao, Xiaolu, Yang, Haonan, Guo, Sen, Xiao, Luoyuan, Li, Xianfeng, Teng, Huajing, Sun, Zhongsheng, Dou, Yali. EpiDenovo: a platform for linking regulatory de novo mutations to developmental epigenetics and diseases. NUCLEIC ACIDS RESEARCH[J]. 2018, 46(D1): D92-D99, https://www.webofscience.com/wos/woscc/full-record/WOS:000419550700015.
[39] Li, Jinchen, Wang, Lin, Yu, Ping, Shi, Leisheng, Zhang, Kun, Sun, Zhong Sheng, Xia, Kun. Vitamin D-related genes are subjected to significant de novo mutation burdens in autism spectrum disorder. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS[J]. 2017, 174(5): 568-577, https://www.webofscience.com/wos/woscc/full-record/WOS:000403502500005.
[40] Guo, Sen, Yang, Liu, Liu, Huijie, Chen, Wei, Li, Jinchen, Yu, Ping, Sun, Zhong Sheng, Chen, Xiang, Du, Jie, Cai, Tao. Identification of Novel Compound Mutations in PLA2G6-Associated Neurodegeneration Patient with Characteristic MRI Imaging. MOLECULAR NEUROBIOLOGY[J]. 2017, 54(6): 4636-4643, https://www.webofscience.com/wos/woscc/full-record/WOS:000405710900057.
[41] Zhong, Jianing, Li, Xianfeng, Cai, Wanshi, Wang, Yan, Dong, Shanshan, Yang, Jie, Zhang, Jianan, Wu, Nana, Li, Yuanyuan, Mao, Fengbiao, Zeng, Cheng, Wu, Jinyu, Xu, Xingzhi, Sun, Zhong Sheng. TET1 modulates H4K16 acetylation by controlling auto-acetylation of hMOF to affect gene regulation and DNA repair function. NUCLEIC ACIDS RESEARCH[J]. 2017, 45(2): 672-684, [42] Wang, Jiesi, Zhang, Ke, Chen, Xiaojuan, Liu, Xiaoqian, Teng, Huajing, Zhao, Mei, Sun, Zhongsheng, Mei Zhao, Zhongsheng Sun. Epigenetic Activation of ASCT2 in the Hippocampus Contributes to Depression-Like Behavior by Regulating D-Serine in Mice. FRONTIERS IN MOLECULAR NEUROSCIENCE[J]. 2017, 10: http://dx.doi.org/10.3389/fnmol.2017.00139.
[43] 孙中生. A Web Server for Prioritizations of Pathogenic Sequence Variants from Exome Sequencing Data via Classifications.. Human Mutation. 2017, [44] Li, Zhongshan, Liu, Zhenwei, Jiang, Yi, Chen, Denghui, Ran, Xia, Sun, Zhong Sheng, Wu, Jinyu. mirVAFC: A Web Server for Prioritizations of Pathogenic Sequence Variants from Exome Sequencing Data via Classifications. HUMAN MUTATION[J]. 2017, 38(1): 25-33, https://www.webofscience.com/wos/woscc/full-record/WOS:000390349700003.
[45] Zhong, Jianing, Ji, Liying, Chen, Huiqian, Li, Xianfeng, Zhang, Jianan, Wang, Xingxing, Wu, Weilin, Xu, Ying, Huang, Fei, Cai, Wanshi, Sun, Zhong Sheng. Acetylation of hMOF Modulates H4K16ac to Regulate DNA Repair Genes in Response to Oxidative Stress. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES[J]. 2017, 13(7): 923-934, https://www.webofscience.com/wos/woscc/full-record/WOS:000408370300010.
[46] Li, Jinchen, Wang, Lin, Guo, Hui, Shi, Leisheng, Zhang, Kun, Tang, Meina, Hu, Shanshan, Dong, Shanshan, Liu, Yanling, Wang, Tianyun, Yu, Ping, He, Xin, Hu, Zhengmao, Zhao, Jinping, Liu, Chunyu, Sun, Zhong Sheng, Xia, Kun. Targeted sequencing and functional analysis reveal brain-size-related genes and their networks in autism spectrum disorders. MOLECULAR PSYCHIATRY[J]. 2017, 22(9): 1282-1290, https://www.webofscience.com/wos/woscc/full-record/WOS:000408191000008.
[47] Teng, Huajing, Zhang, Yaohua, Shi, Chengmin, Mao, Fengbiao, Cai, Wanshi, Lu, Liang, Zhao, Fangqing, Sun, Zhongsheng, Zhang, Jianxu. Population Genomics Reveals Speciation and Introgression between Brown Norway Rats and Their Sibling Species. MOLECULAR BIOLOGY AND EVOLUTION[J]. 2017, 34(9): 2214-2228, https://www.webofscience.com/wos/woscc/full-record/WOS:000408307400008.
[48] Wang, Yan, Liu, Huijie, Sun, Zhongsheng. Lamarck rises from his grave: parental environment-induced epigenetic inheritance in model organisms and humans. BIOLOGICAL REVIEWSnull. 2017, 92(4): 2084-2111, https://www.webofscience.com/wos/woscc/full-record/WOS:000412314400012.
[49] Li, Jinchen, Cai, Tao, Jiang, Yi, Chen, Huiqian, He, Xin, Chen, Chao, Li, Xianfeng, Shao, Qianzhi, Ran, Xia, Li, Zhongshan, Xia, Kun, Liu, Chunyu, Sun, Zhong Sheng, Wu, Jinyu. Genes with de novo mutations are shared by four neuropsychiatric disorders discovered from NPdenovo database. MOLECULAR PSYCHIATRY[J]. 2016, 21(2): 290-297, https://www.webofscience.com/wos/woscc/full-record/WOS:000370817800016.
[50] Tian, Weiping, 王杰思, Zhang, Ke, Teng, Huajing, Li, Chong, Szyf, Moshe, Sun, Zhong Sheng, Zhao, Mei. Demethylation of c-MYB binding site mediates upregulation of Bdnf IV in cocaine-conditioned place preference. SCIENTIFIC REPORTS[J]. 2016, 6(22): http://dx.doi.org/10.1038/srep22087.
[51] Mei, Yue, Wang, Yan, Chen, Huiqian, Sun, Zhong Sheng, Ju, XingDa. Recent Progress in CRISPR/Cas9 Technology. JOURNAL OF GENETICS AND GENOMICSnull. 2016, 43(2): 63-75, http://dx.doi.org/10.1016/j.jgg.2016.01.001.
[52] Yu, Ping, Yang, Wenli, Han, Dong, Wang, Xi, Guo, Sen, Li, Jinchen, Li, Fang, Zhang, Xiaoxia, Wong, SingWai, Bai, Baojing, Liu, Yao, Du, Jie, Sun, Zhong Sheng, Shi, Songtao, Feng, Hailan, Cai, Tao. Mutations in WNT10B Are Identified in Individuals with Oligodontia. AMERICAN JOURNAL OF HUMAN GENETICS[J]. 2016, 99(1): 195-201, https://www.webofscience.com/wos/woscc/full-record/WOS:000381616600016.
[53] Hongling Guo, Zhongsheng Sun, Jianxu Zhang, Chengmin Shi, Fengbiao Mao, Huajing Teng, Lingling Hou, Yaohua Zhang. Whole-Genome Sequencing Reveals Genetic Variation in the Asian House Rat. Genetics Society of America. 2016, http://oa.las.ac.cn/oainone/service/browseall/read1?ptype=JA&workid=JA201902010205098ZK.
[54] Chen, Siyu, Li, Mao, Zhu, Wenjia, Mao, Fengbiao, Wang, Jiesi, Sun, Zhongsheng, Huang, Xusheng. A novel 10-base pair insertion mutation in exon 5 of the SOD1 gene in a Chinese family with amyotrophic lateral sclerosis. NEUROBIOLOGY OF AGING[J]. 2016, 45: 212.e1-212.e4, http://www.corc.org.cn/handle/1471x/2374393.
[55] Cui, Chenghua, Lu, Zheming, Yang, Liu, Gao, Yanhong, Liu, Wei, Gu, Liankun, Yang, Chen, Wilson, James, Zhang, Zhiqian, Xing, Baocai, Deng, Dajun, Sun, Zhong Sheng. Genome-Wide Identification of Differential Methylation Between Primary and Recurrent Hepatocellular Carcinomas. MOLECULAR CARCINOGENESIS[J]. 2016, 55(7): 1163-1174, https://www.webofscience.com/wos/woscc/full-record/WOS:000379787600004.
[56] Zhang, Tianwei, Lu, Yachao, Ye, Qingqing, Zhang, Meizhuo, Zheng, Li, Yin, Xiaolu, Gavine, Paul, Sun, Zhongsheng, Ji, Qunsheng, Zhu, Guanshan, Su, Xinying. An Evaluation and Recommendation of the Optimal Methodologies to Detect RET Gene Rearrangements in Papillary Thyroid Carcinoma. GENES CHROMOSOMES & CANCER[J]. 2015, 54(3): 168-176, https://www.webofscience.com/wos/woscc/full-record/WOS:000348577000004.
[57] Yu, Ping, Cui, Yun, Cai, Wanshi, Wu, Honghu, Xiao, Xiaoqiang, Shao, Qianzhi, Ma, Liang, Guo, Sen, Wu, Nana, Jin, ZiBing, Wang, Yongjin, Cai, Tao, Sun, Zhong Sheng, Qu, Jia. Lysosomal storage disease in the brain: mutations of the beta-mannosidase gene identified in autosomal dominant nystagmus. GENETICS IN MEDICINE[J]. 2015, 17(12): 971-979, https://www.webofscience.com/wos/woscc/full-record/WOS:000365977400005.
[58] 孙中生. RBP-Var: a database of functional variants involved in regulation mediated by RNA-binding proteins.. Nucleic Acids Research. 2015, [59] Li, Jinchen, Jiang, Yi, Wang, Tao, Chen, Huiqian, Xie, Qing, Shao, Qianzhi, Ran, Xia, Xia, Kun, Sun, Zhong Sheng, Wu, Jinyu. mirTrios: an integrated pipeline for detection of de novo and rare inherited mutations from trios-based next-generation sequencing. JOURNAL OF MEDICAL GENETICS[J]. 2015, 52(4): 275-281, https://www.webofscience.com/wos/woscc/full-record/WOS:000351182000009.
[60] Cai, Wanshi, Mao, Fengbiao, Teng, Huajing, Cai, Tao, Zhao, Fangqing, Wu, Jinyu, Sun, Zhong Sheng. MBRidge: an accurate and cost-effective method for profiling DNA methylome at single-base resolution. JOURNAL OF MOLECULAR CELL BIOLOGY[J]. 2015, 7(4): 299-313, [61] Wang, Kangli, Li, Xianfeng, Dong, Shanshan, Liang, Jialong, Mao, Fengbiao, Zeng, Cheng, Wu, Honghu, Wu, Jinyu, Cai, Wanshi, Sun, Zhong Sheng. Q-RRBS: a quantitative reduced representation bisulfite sequencing method for single-cell methylome analyses. EPIGENETICS[J]. 2015, 10(9): 775-783, [62] Cai, Tao, Yang, Liu, Cai, Wanshi, Guo, Sen, Yu, Ping, Li, Jinchen, Hu, Xueyu, Yan, Ming, Shao, Qianzhi, Jin, Yan, Sun, Zhong Sheng, Luo, ZhuoJing. Dysplastic spondylolysis is caused by mutations in the diastrophic dysplasia sulfate transporter gene. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2015, 112(26): 8064-8069, https://www.webofscience.com/wos/woscc/full-record/WOS:000357079400056.
[63] Guo, Jun, Cai, Lun, Jia, Lixin, Li, Xiaoyan, Xi, Xin, Zheng, Shuai, Liu, Xuxia, Piao, Chunmei, Liu, Tingting, Sun, Zhongsheng, Cai, Tao, Du, Jie. Wide mutation spectrum and frequent variant Ala27Thr of FBN1 identified in a large cohort of Chinese patients with sporadic TAAD. SCIENTIFIC REPORTS[J]. 2015, 5: https://www.webofscience.com/wos/woscc/full-record/WOS:000359489500001.
[64] Li, Zhigang, Wang, Yan, Sun, Kevin Kai, Wang, Kangli, Sun, Zhong Sheng, Zhao, Mei, Wang, Jundong. Sex-related difference in food-anticipatory activity of mice. HORMONES AND BEHAVIOR[J]. 2015, 70: 38-46, http://dx.doi.org/10.1016/j.yhbeh.2015.02.004.
[65] Wang, Guan, Li, Xianfeng, Tian, Weiping, Wang, Yan, Wu, Dandan, Sun, Zhongsheng, Zhao, Enfeng. Promoter DNA methylation is associated with KLF11 expression in epithelial ovarian cancer. GENES CHROMOSOMES & CANCER[J]. 2015, 54(7): 453-462, http://dx.doi.org/10.1002/gcc.22257.
[66] Nemoda, Z, Massart, R, Suderman, M, Hallett, M, Li, T, Coote, M, Cody, N, Sun, Z S, Soares, C N, Turecki, G, Steiner, M, Szyf, M. Maternal depression is associated with DNA methylation changes in cord blood T lymphocytes and adult hippocampi. TRANSLATIONAL PSYCHIATRY[J]. 2015, 5: e545-, http://dx.doi.org/10.1038/tp.2015.32.
[67] Xu, Jing, Li, Zhongshan, Ren, Xianguo, Dong, Ming, Li, Jinxin, Shi, Xingjuan, Zhang, Yu, Xie, Wei, Sun, Zhongsheng, Liu, Xiangdong, Dai, Qiming. Investigation of Pathogenic Genes in Chinese sporadic Hypertrophic Cardiomyopathy Patients by Whole Exome Sequencing. SCIENTIFIC REPORTS[J]. 2015, 5: https://www.webofscience.com/wos/woscc/full-record/WOS:000364751900001.
[68] Wang, Jiesi, Luo, YongLun, Wang, KangLi, Wang, Yan, Zhang, Xiaolin, Teng, Huajing, Sun, Zhongsheng. Clock-controlled StAR's expression and corticosterone production contribute to the endotoxemia immune response. CHRONOBIOLOGY INTERNATIONAL[J]. 2015, 32(3): 358-367, [69] Qing Xie, Qi Liu, Fengbiao Mao, Wanshi Cai, Honghu Wu, Mingcong You, Zhen Wang, Bingyu Chen, Zhong Sheng Sun, Jinyu Wu. A Bayesian Framework to Identify Methylcytosines from High-Throughput Bisulfite Sequencing Data. PLOS COMPUTATIONAL BIOLOGY[J]. 2014, 10(9): https://doaj.org/article/17f21706f5e54475b523a39cb8f4cb9c.
[70] Liang, Jialong, Cai, Wanshi, Sun, Zhongsheng. Single-Cell Sequencing Technologies: Current and Future. JOURNAL OF GENETICS AND GENOMICSnull. 2014, 41(10): 513-528, http://dx.doi.org/10.1016/j.jgg.2014.09.005.
[71] Wang, Tao, Liu, Qi, Li, Xianfeng, Wang, Xiaobing, Li, Jinchen, Zhu, Xiaochun, Sun, Zhong Sheng, Wu, Jinyu. RRBS-Analyser: A Comprehensive Web Server for Reduced Representation Bisulfite Sequencing Data Analysis. HUMAN MUTATION[J]. 2013, 34(12): 1606-1610, https://www.webofscience.com/wos/woscc/full-record/WOS:000326864200003.
[72] Teng, Huajing, Cai, Wanshi, Zeng, Kun, Mao, Fengbiao, You, Mingcong, Wang, Tao, Zhao, Fangqing, Sun, Zhongsheng. Genome-wide identification and divergent transcriptional expression of StAR-related lipid transfer (START) genes in teleosts. GENE[J]. 2013, 519(1): 18-25, http://dx.doi.org/10.1016/j.gene.2013.01.058.
[73] 孙中生. Identification of a novel missense (C7W) mutation of SOD1 in a large familial amyotrophic lateral sclerosis pedigree.. 2013, [74] Wu, Jinyu, Liu, Qi, Wang, Xin, Zheng, Jiayong, Wang, Tao, You, Mingcong, Sun, Zhong Sheng, Shi, Qinghua. mirTools 2.0 for non-coding RNA discovery, profiling and functional annotation based on high-throughput sequencing. RNA BIOLOGY[J]. 2013, 10(7): 1087-1092, https://www.webofscience.com/wos/woscc/full-record/WOS:000327572300007.
[75] 孙中生. Mutations of ANK3 identified by exome sequencing are associated with autism ausceptibility.. 2012, [76] Zhang, Jing, Li, Huili, Teng, Huajing, Zhang, Ting, Luo, Yonglun, Zhao, Mei, Li, YunQing, Sun, Zhong Sheng, Sun, ZS reprint author, Chinese Acad Sci, Beijing Inst Life Sci, BeiChen W Rd, Beijing, Peoples R China. Regulation of Peripheral Clock to Oscillation of Substance P Contributes to Circadian Inflammatory Pain. ANESTHESIOLOGY[J]. 2012, 117(1): 149-160, http://www.irgrid.ac.cn/handle/1471x/970984.
[77] Wu, Jinyu, Shen, Enjian, Shi, Dashuang, Sun, ZhongSheng, Cai, Tao. Identification of a novel Cys146X mutation of SOD1 in familial amyotrophic lateral sclerosis by whole-exome sequencing. GENETICS IN MEDICINE[J]. 2012, 14(9): 823-826, https://www.webofscience.com/wos/woscc/full-record/WOS:000308767600009.
[78] Wu, Jianmin, Wu, Gang, Lv, Lu, Ren, YongFeng, Zhang, XueJiao, Xue, YongFeng, Li, Guiling, Lu, Xincheng, Sun, ZhongSheng, Tang, KaiFu. MicroRNA-34a inhibits migration and invasion of colon cancer cells via targeting to Fra-1. CARCINOGENESIS[J]. 2012, 33(3): 519-528, https://www.webofscience.com/wos/woscc/full-record/WOS:000300988100006.
[79] Liu, Qi, Chen, Chong, Shen, Enjian, Zhao, Fangqing, Sun, Zhongsheng, Wu, Jinyu. Detection, annotation and visualization of alternative splicing from RNA-Seq data with SplicingViewer. GENOMICS[J]. 2012, 99(3): 178-182, http://dx.doi.org/10.1016/j.ygeno.2011.12.003.
[80] Liu, Qi, Shen, Enjian, Min, Qingjie, Li, Xueying, Wang, Xin, Li, Xianfeng, Sun, Zhong Sheng, Wu, Jinyu. Exome-assistant: a rapid and easy detection of disease-related genes and genetic variations from exome sequencing. BMC GENOMICS[J]. 2012, 13(1): 692-692, http://dx.doi.org/10.1186/1471-2164-13-692.
[81] Tian, Weiping, Zhao, Mei, Li, Min, Song, Tianbao, Zhang, Min, Quan, Li, Li, Shengbin, Sun, Zhong Sheng, Tian, WP reprint author, Xi An Jiao Tong Univ, Sch Med, Dept Forens Sci, Xian , Shanxi, Peoples R China. Reversal of Cocaine-Conditioned Place Preference through Methyl Supplementation in Mice: Altering Global DNA Methylation in the Prefrontal Cortex. PLOS ONE[J]. 2012, 7(3): http://dx.doi.org/10.1371/journal.pone.0033435.
[82] 孙中生. Mutations of ANK3 identified by exome sequencing are associated with autism ausceptibility.. 2012, [83] Zhang, Jing, Li, Huili, Teng, Huajing, Zhang, Ting, Luo, Yonglun, Zhao, Mei, Li, YunQing, Sun, Zhong Sheng, Sun, ZS reprint author, Chinese Acad Sci, Beijing Inst Life Sci, BeiChen W Rd, Beijing, Peoples R China. Regulation of Peripheral Clock to Oscillation of Substance P Contributes to Circadian Inflammatory Pain. ANESTHESIOLOGY[J]. 2012, 117(1): 149-160, http://www.irgrid.ac.cn/handle/1471x/970984.
[84] Wu, Jinyu, Shen, Enjian, Shi, Dashuang, Sun, ZhongSheng, Cai, Tao. Identification of a novel Cys146X mutation of SOD1 in familial amyotrophic lateral sclerosis by whole-exome sequencing. GENETICS IN MEDICINE[J]. 2012, 14(9): 823-826, https://www.webofscience.com/wos/woscc/full-record/WOS:000308767600009.
[85] Wu, Jianmin, Wu, Gang, Lv, Lu, Ren, YongFeng, Zhang, XueJiao, Xue, YongFeng, Li, Guiling, Lu, Xincheng, Sun, ZhongSheng, Tang, KaiFu. MicroRNA-34a inhibits migration and invasion of colon cancer cells via targeting to Fra-1. CARCINOGENESIS[J]. 2012, 33(3): 519-528, https://www.webofscience.com/wos/woscc/full-record/WOS:000300988100006.
[86] Liu, Qi, Chen, Chong, Shen, Enjian, Zhao, Fangqing, Sun, Zhongsheng, Wu, Jinyu. Detection, annotation and visualization of alternative splicing from RNA-Seq data with SplicingViewer. GENOMICS[J]. 2012, 99(3): 178-182, http://dx.doi.org/10.1016/j.ygeno.2011.12.003.
[87] Liu, Qi, Shen, Enjian, Min, Qingjie, Li, Xueying, Wang, Xin, Li, Xianfeng, Sun, Zhong Sheng, Wu, Jinyu. Exome-assistant: a rapid and easy detection of disease-related genes and genetic variations from exome sequencing. BMC GENOMICS[J]. 2012, 13(1): 692-692, http://dx.doi.org/10.1186/1471-2164-13-692.
[88] Tian, Weiping, Zhao, Mei, Li, Min, Song, Tianbao, Zhang, Min, Quan, Li, Li, Shengbin, Sun, Zhong Sheng, Tian, WP reprint author, Xi An Jiao Tong Univ, Sch Med, Dept Forens Sci, Xian , Shanxi, Peoples R China. Reversal of Cocaine-Conditioned Place Preference through Methyl Supplementation in Mice: Altering Global DNA Methylation in the Prefrontal Cortex. PLOS ONE[J]. 2012, 7(3): http://dx.doi.org/10.1371/journal.pone.0033435.
[89] 孙中生. 全基因组DNA甲基化片段富集技术的系统评估. BMC genomics.. 2011, [90] 孙中生. 全基因组DNA甲基化片段富集技术的系统评估. BMC genomics.. 2011, [91] 孙中生. Per1-/-小鼠急性束缚应激诱导的过度理毛行为和镇痛效应缺乏. PLoS One. 2010, [92] 孙中生. 前列腺癌细胞系小RNA转录组分析. PLoS One. 2010, [93] 孙中生. 脊椎动物NR2亚基的进化模式. PLoS One. 2010, [94] Zhu, Erle, Zhao, Fangqing, Xu, Gang, Hou, Huabin, Zhou, LingLin, Li, Xiaokun, Wu, Jinyu, 孙中生, Xiaokun Li, Jinyu Wu. mirTools: microRNA profiling and discovery based on high-throughput sequencing. NUCLEIC ACIDS RESEARCH[J]. 2010, 38(1): W392-W397, http://dx.doi.org/10.1093/nar/gkq393.
[95] Hou HB, Zhao FQ, Zhou LL, Zhu EL, Teng HJ, Li XK, Bao QY, Wu JY, 孙中生, Jinyu Wu. MagicViewer: integrated solution for next-generation sequencing data visualization and genetic variation detection and annotation. NUCLEIC ACIDS RESEARCH[J]. 2010, 38(5): W732-W736, http://dx.doi.org/10.1093/nar/gkq302.
[96] 孙中生. Per1-/-小鼠急性束缚应激诱导的过度理毛行为和镇痛效应缺乏. PLoS One. 2010, [97] 孙中生. 前列腺癌细胞系小RNA转录组分析. PLoS One. 2010, [98] 孙中生. 脊椎动物NR2亚基的进化模式. PLoS One. 2010, [99] Zhu, Erle, Zhao, Fangqing, Xu, Gang, Hou, Huabin, Zhou, LingLin, Li, Xiaokun, Wu, Jinyu, 孙中生, Xiaokun Li, Jinyu Wu. mirTools: microRNA profiling and discovery based on high-throughput sequencing. NUCLEIC ACIDS RESEARCH[J]. 2010, 38(1): W392-W397, http://dx.doi.org/10.1093/nar/gkq393.
[100] Hou HB, Zhao FQ, Zhou LL, Zhu EL, Teng HJ, Li XK, Bao QY, Wu JY, 孙中生, Jinyu Wu. MagicViewer: integrated solution for next-generation sequencing data visualization and genetic variation detection and annotation. NUCLEIC ACIDS RESEARCH[J]. 2010, 38(5): W732-W736, http://dx.doi.org/10.1093/nar/gkq302.
[101] Wang Yan, Li Guiling, Mao Fengbiao, Li Xianfeng, Liu Qi, Chen Lin, Lv Lu, Wang Xin, Wu Jinyu, Dai Wei, Wang Guan, Zhao Enfeng, Tang Kai-Fu, Sun Zhong Sheng. Ras-induced Epigenetic Inactivation of the RRAD (Ras-related Associated with Diabetes) Gene Promotes Glucose Uptake in a Human Ovarian Cancer Model *. The Journal of Biological Chemistry. 289(20): 14225-14238, http://dx.doi.org/10.1074/jbc.M113.527671.
[102] Lu Wang, Jinchen Li, Chan Wang, Ruqi Tang, Jialong Liang, Yuhua Gong, Yaping Dai, Ningling Ding, Jian Wu, Na Dai, Lei Liu, Yi Zhao, Youlin Shao, Weifeng Zhao, Peng Jiang, Xingjuan Shi, Weichang Chen, Ye Tian, Xiangdong Liu, Xiong Ma, Zhongsheng Sun. Mapping of de novo mutations in primary biliary cholangitis to a disease-specific co-expression network underlying homeostasis and metabolism. Journal of Genetics and Genomics. [103] Lu Wang, Jinchen Li, Chan Wang, Ruqi Tang, Jialong Liang, Yuhua Gong, Yaping Dai, Ningling Ding, Jian Wu, Na Dai, Lei Liu, Yi Zhao, Youlin Shao, Weifeng Zhao, Peng Jiang, Xingjuan Shi, Weichang Chen, Ye Tian, Xiangdong Liu, Xiong Ma, Zhongsheng Sun. Mapping of de novo mutations in primary biliary cholangitis to a disease-specific co-expression network underlying homeostasis and metabolism. Journal of Genetics and Genomics. 

科研活动

   
科研项目
(1) 抑制DNA去甲基化作为肝癌治疗新策略的机制,主持,国家级,2012-01--2014-12
(2) 表观基因组、转录组技术平台的搭建和优化,主持,国家级,2012-01--2015-12
(3) 抑郁症母亲影响子代行为的表观遗传标志物全基因组扫描,主持,国家级,2011-01--2013-12
(4) 精神分裂症和抑郁症的环境和表观遗传发病机理研究,参与,国家级,2007-06--2011-07

指导学生

已指导学生

王彦  博士研究生  040221-认知神经科学  

罗永伦  硕士研究生  040222-行为遗传学  

马云霞  硕士研究生  040222-行为遗传学  

张靖  博士研究生  077122-行为遗传学  

刘帅  硕士研究生  077122-行为遗传学  

王杰思  硕士研究生  077122-行为遗传学  

现指导学生

王永庆  博士研究生  040222-行为遗传学  

王嫣  博士研究生  040222-行为遗传学  

毕澄  博士研究生  040222-行为遗传学  

毛凤彪  硕士研究生  071007-遗传学  

王杰思  博士研究生  071007-遗传学  

蔡万世  博士研究生  071007-遗传学  

梁加龙  硕士研究生  071007-遗传学  

苗壮  博士研究生  071007-遗传学