基本信息
左之利  男  博导  中国科学院昆明植物研究所
电子邮件: zuozhili@mail.kib.ac.cn
通信地址: 云南昆明市蓝黑路132号
邮政编码: 650201

研究领域

药物设计与药物研发——利用计算机辅助药物设计,以及体内外活性筛选、结构优化,开展神经退行性疾病、抗肿瘤和糖尿病及其他重大疾病相关的活性先导化合物的发现、结构修饰、优化与新药研究与开发,为分子作用机制和新药研发奠定科学基础。


招生信息

   
招生专业
100701-药物化学
070303-有机化学
招生方向
药物发现与设计,药物化学
药物设计

教育背景

2002-09--2005-07   上海药物研究所   理学博士
1999-09--2002-07   四川大学化工学院   理学硕士

工作经历

2020-至今:中国科学院昆明植物研究所,研究员,课题组长

2013--2020:昆明植物研究所,副研究员,课题组长 
2008-2013: 澳大利亚科廷大学,博士后 
2005--2008: 新加坡理工学院,讲师 


教授课程

生物信息
药物信息学
分子模拟与药物设计
药物设计在新药研发的应用

专利与奖励

   
奖励信息
(1) 抗老年痴呆潜在靶标的抑制药物, 二等奖, 研究所(学校), 2008
专利成果
( 1 ) 一种酰腙类化合物及其药物组合物和其应用, 发明专利, 2019, 第 1 作者, 专利号: 2019104153668

( 2 ) [吡咯并呋喃]-螺环茚酮类化合物及药物组合物和应用, 发明专利, 2019, 第 1 作者, 专利号: 201910133443.0

( 3 ) 2,3-二氢-4(1H)-喹唑啉酮类化合物及其药物组合物和其应用, 发明专利, 2019, 第 1 作者, 专利号: 201910016442.8

( 4 ) 二芳基乙烯类化合物及其药物组合物和其应用, 发明专利, 2018, 第 1 作者, 专利号: 201811600348.9

( 5 ) 吡咯烷酮类化合物及其药物组合物和其应用, 发明专利, 2017, 第 1 作者, 专利号: 201510197263.0

( 6 ) 2-[3-氰基-[R1-R2-R3-氮杂苯基]-R4-硫代类化合物及其药物组合物和其应用, 发明专利, 2015, 第 1 作者, 专利号: 201510212286.4

( 7 ) 一类取代苯腙类化合物,及其制备方法和用途, 发明专利, 2010, 第 2 作者, 专利号: 200910047268

出版信息

   
发表论文
[1] Feng Xiong, Lingmei Kong, Liang Chen, Minggao Xue, Feng Cao, Shuqun Zhang, Hongmei Li, Hui Yan, Yan Li, Zhili Zuo. Discovery of potential novel CRBN modulators by virtual screening and bioassay. European Journal of Medicinal Chemistry. 2022, 236: [2] Munikishore, Rachakunta, Wang, LiangLiang, Zhang, Shuqun, Zhao, QinShi, Zuo, Zhili. An efficient and concise synthesis of a selective small molecule non-peptide inhibitor of cathepsin L: KGP94. BIOORGANIC CHEMISTRY[J]. 2021, 116: http://dx.doi.org/10.1016/j.bioorg.2021.105317.
[3] Yin, Ronghua, Zhou, Lutan, Gao, Na, Lin, Lisha, Sun, Huifang, Chen, Dingyuan, Cai, Ying, Zuo, Zhili, Hu, Kaifeng, Huang, Shengxiong, Liu, Jikai, Zhao, Jinhua. Unveiling the Disaccharide-Branched Glycosaminoglycan and Anticoagulant Potential of Its Derivatives. BIOMACROMOLECULES[J]. 2021, 22(3): 1244-1255, https://www.webofscience.com/wos/woscc/full-record/WOS:000627592800019.
[4] Zhou, Lutan, Yin, Ronghua, Gao, Na, Sun, Huifang, Chen, Dingyuan, Cai, Ying, Ren, Lin, Yang, Lian, Zuo, Zhili, Zhang, Hongbin, Zhao, Jinhua. Oligosaccharides from fucosylated glycosaminoglycan prevent breast cancer metastasis in mice by inhibiting heparanase activity and angiogenesis. PHARMACOLOGICAL RESEARCH[J]. 2021, 166: http://dx.doi.org/10.1016/j.phrs.2021.105527.
[5] Min Jin, Congyun Tang, Yingying Li, Shuai Yang, YingTao Yang, Lin Peng, XiaoNian Li, Wenjing Zhang, Zhili Zuo, Fabien Gagosz, LiangLiang Wang. Enantioselective access to tricyclic tetrahydropyran derivatives by a remote hydrogen bonding mediated intramolecular IEDHDA reaction. Nature Communications. 2021, 12: [6] Wang, LiangLiang, Kong, Lingmei, Liu, Hui, Zhang, Yunqin, Zhang, Li, Liu, Xingyong, Yuan, Feng, Li, Yan, Zuo, Zhili. Design and synthesis of novel artemisinin hybrids with potent activities against human colorectal cancer cells in vitro and in vivo (vol 182, 111665, 2019). EUROPEAN JOURNAL OF MEDICINAL CHEMISTRYnull. 2020, 194: https://www.webofscience.com/wos/woscc/full-record/WOS:000525871500013.
[7] 左之利. NMR characterization and anticoagulant activity of the oligosaccharides from the fucosylated glycosaminoglycan isolated from Holothuria coluber Carbohydrate Polymers. Carbohydrate Polymers. 2020, [8] Xu, Guowei, Yang, Yaqing, Yang, Yanming, Song, Gao, Li, Shanshan, Zhang, Jiajun, Yang, Weimin, Wang, LiangLiang, Weng, Zhiying, Zuo, Zhili. The discovery, design and synthesis of potent agonists of adenylyl cyclase type 2 by virtual screening combining biological evaluation. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY[J]. 2020, 191: http://dx.doi.org/10.1016/j.ejmech.2020.112115.
[9] 左之利. The Discovery, Design and Synthesis of Selective Agonist of Adenylyl Cyclase Type 2 by Virtual Screening Combining Biological Evaluation. European Journal of Medicinal Chemistry. 2020, [10] Yang, Wenjiao, Chen, Dingyuan, He, Zhicheng, Zhou, Lutan, Cai, Ying, Mao, Hui, Gao, Na, Zuo, Zhili, Yin, Ronghua, Zhao, Jinhua. NMR characterization and anticoagulant activity of the oligosaccharides from the fucosylated glycosaminoglycan isolated from Holothuria coluber. CARBOHYDRATE POLYMERS[J]. 2020, 233: http://dx.doi.org/10.1016/j.carbpol.2020.115844.
[11] Li, Yaping, Liu, Xingyong, Zhang, Shuqun, Wang, Liangliang, Zhang, Li, Zuo, Zhili. Computational simulation studies on the binding selectivity of Wee1 and Checkpoint kinase 1 by molecular dynamics simulation combined with free energy calculations. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS. 2020, https://www.webofscience.com/wos/woscc/full-record/WOS:000575222300001.
[12] Cai, Ying, Yang, Wenjiao, Li, Xiaomei, Zhou, Lutan, Wang, Zhongjuan, Lin, Lisha, Chen, Dingyuan, Zhao, Longyan, Li, Zhongkun, Liu, Shubai, Yin, Ronghua, Zuo, Zhili, Gao, Na, Zhao, Jinhua. Precise structures and anti-intrinsic tenase complex activity of three fucosylated glycosaminoglycans and their fragments. CARBOHYDRATE POLYMERS[J]. 2019, 224: http://dx.doi.org/10.1016/j.carbpol.2019.115146.
[13] Zhou, Yeheng, Sun, Wei, Peng, Jiale, Yan, Hui, Zhang, Li, Liu, Xingyong, Zuo, Zhili. Design, synthesis and biological evaluation of novel copper-chelating acetylcholinesterase inhibitors with pyridine and N-benzylpiperidine fragments. BIOORGANIC CHEMISTRY[J]. 2019, 93: http://dx.doi.org/10.1016/j.bioorg.2019.103322.
[14] Li, Yingying, Peng, Jiale, Li, Penghua, Du, Haibo, Li, Yaping, Liu, Xingyong, Zhang, Li, Wang, LiangLiang, Zuo, Zhili. Identification of potential AMPK activator by pharmacophore modeling, molecular docking and QSAR study. COMPUTATIONAL BIOLOGY AND CHEMISTRY[J]. 2019, 79: 165-176, http://dx.doi.org/10.1016/j.compbiolchem.2019.02.007.
[15] 潘陈玲, 孟浩, 汪亮亮, 沈悦海, 左之利, 王冠林, 张宽仁. 阿片类药物研发近期热点. 有机化学. 2018, 38(10): 2625-2632, http://lib.cqvip.com/Qikan/Article/Detail?id=676702605.
[16] Wang, LiangLiang, Jiang, Ting, Li, PengHua, Sun, RouJing, Zuo, Zhili. Asymmetric Syntheses of Spirooxindole-dihydroquinazolinones by Cyclization Reactions between N-substituted Anthranilamides and Isatins. ADVANCED SYNTHESIS & CATALYSIS[J]. 2018, 360(24): 4832-4836, http://ir.kib.ac.cn/handle/151853/64658.
[17] Wang, Dong, Zhang, Shuqun, Chang, Zhe, Kong, DeXin, Zuo, Zhili. Quebrachitol: Global Status and Basic Research. NATURAL PRODUCTS AND BIOPROSPECTINGnull. 2017, 7(1): 113-122, http://ir.kib.ac.cn/handle/151853/64856.
[18] Shao, LiDong, Su, Jia, Ye, Baixin, Liu, JiangXin, Zuo, ZhiLi, Li, Yan, Wang, YueYing, Xia, Chengfeng, Zhao, QinShi. Design, Synthesis, and Biological Activities of Vibsanin B Derivatives: A New Class of HSP90 C-Terminal Inhibitors. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2017, 60(21): 9053-9066, https://www.webofscience.com/wos/woscc/full-record/WOS:000415140600028.
[19] 左之利. Discovery of a class of dual binding sites TNKS inhibitors against Wnt Signaling by pharmacophore modeling, molecular docking and bioassay. Molecular BioSystems. 2017, [20] Zhang, Shuqun, Lin, Zichun, Pu, Yinglan, Zhang, Yunqin, Zhang, Li, Zuo, Zhili. Comparative QSAR studies using HQSAR, CoMFA, and CoMSIA methods on cyclic sulfone hydroxyethylamines as BACE1 inhibitors. COMPUTATIONAL BIOLOGY AND CHEMISTRY[J]. 2017, 67(1): 38-47, http://dx.doi.org/10.1016/j.compbiolchem.2016.12.008.
[21] 左之利. Melokhanines A–J, Bioactive Monoterpenoid Indole Alkaloids with Diverse Novel Skeletons from Melodinus khasianus. Journal of Natural Products. 2016, [22] Zhang, Yunqin, Zhang, Shuqun, Xu, Guowei, Yan, Hui, Pua, Yinglan, Zuo, Zhili. The discovery of new acetylcholinesterase inhibitors derived from pharmacophore modeling, virtual screening, docking simulation and bioassays. MOLECULAR BIOSYSTEMS[J]. 2016, 12(12): 3734-3742, http://www.irgrid.ac.cn/handle/1471x/1175723.
[23] Wan, LuoSheng, Nian, Yin, Ye, ChenJun, Shao, LiDong, Peng, XingRong, Geng, ChangAn, Zuo, ZhiLi, Li, XiaoNian, Yang, Jian, Zhou, Ming, Qiu, MingHua. Three Minor Diterpenoids with Three Carbon Skeletons from Euphorbia peplus. ORGANIC LETTERS[J]. 2016, 18(9): 2166-2169, http://ir.kib.ac.cn/handle/151853/26248.
[24] Feng, Liang, Liu, Yuehui, Hou, Bo, Yuan, Zaifeng, Yu, FuChao, Yan, Tingbin, Qin, Qi, Ji, Ruigeng, Li, YaMin, Shen, Yuehai, Zuo, ZhiLi. Hydrogen bonding-promoted efficient Ru-catalyzed ring-closing metathesis of demanding homoallyl 2-(hydroxymethyl)acrylates. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2016, 14(45): 10705-10713, http://www.irgrid.ac.cn/handle/1471x/1175736.
[25] 左之利. Novel inhibitors of acetylcholinesterase derived from pharmacophore modeling, virtual screening, docking simulation and bioassay. Molecular BioSystems. 2016, [26] Yan, YongMing, Wang, XinLong, Zhou, LiLi, Zhou, FengJiao, Li, Rong, Tian, Yuan, Zuo, ZhiLi, Fang, Ping, Chung, Arthur C K, Hou, FanFan, Cheng, YongXian. Lingzhilactones from Ganoderma lingzhi ameliorate adriamycin-induced nephropathy in mice. JOURNAL OF ETHNOPHARMACOLOGY[J]. 2015, 176: 385-393, http://www.irgrid.ac.cn/handle/1471x/1029018.
[27] Yan, YongMing, Wang, XinLong, Luo, Qi, Jiang, LiPing, Yang, CuiPing, Hou, Bo, Zuo, ZhiLi, Chen, YongBin, Cheng, YongXian. Metabolites from the mushroom Ganoderma lingzhi as stimulators of neural stem cell proliferation. PHYTOCHEMISTRY[J]. 2015, 114(SI): 155-162, http://dx.doi.org/10.1016/j.phytochem.2015.03.013.
[28] Di, Lei, Shi, YanNi, Yan, YongMing, Jiang, LiPing, Hou, Bo, Wang, XinLong, Zuo, ZhiLi, Chen, YongBin, Yang, CuiPing, Cheng, YongXian. Nonpeptide small molecules from the insect Aspongopus chinensis and their neural stem cell proliferation stimulating properties. RSC ADVANCES[J]. 2015, 5(87): 70985-70991, http://www.irgrid.ac.cn/handle/1471x/1028944.
[29] Peng, XingRong, Wang, Xia, Zhou, Lin, Hou, Bo, Zuo, ZhiLi, Qiu, MingHua. Ganocochlearic acid A, a rearranged hexanorlanostane triterpenoid, and cytotoxic triterpenoids from the fruiting bodies of Ganoderma cochlear. RSC ADVANCES[J]. 2015, 5(115): 95212-95222, http://www.irgrid.ac.cn/handle/1471x/1029000.
[30] Ding, Ming, Tong, Xiaogang, Li, Dashan, Liang, Kangjiang, Zhou, Ankun, Zuo, Zhili, Xia, Chengfeng. Asymmetric synthesis of common aza-tricyclic core of various alkaloids. TETRAHEDRON LETTERS[J]. 2015, 56(40): 5460-5464, http://dx.doi.org/10.1016/j.tetlet.2015.08.017.
[31] Yan, YongMing, Ai, Jun, Shi, YanNi, Zuo, ZhiLi, Hou, Bo, Luo, Jie, Cheng, YongXian. (+/-)-Aspongamide A, an N-Acetyldopamine Trimer Isolated from the Insect Aspongopus chinensis, Is an Inhibitor of p-Smad3. ORGANIC LETTERS[J]. 2014, 16(2): 532-535, http://www.irgrid.ac.cn/handle/1471x/832463.
[32] Shi, YanNi, Tu, ZhengChao, Wang, XinLong, Yan, YongMing, Fang, Ping, Zuo, ZhiLi, Hou, Bo, Yang, TongHua, Cheng, YongXian. Bioactive compounds from the insect Aspongopus chinensis. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS[J]. 2014, 24(22): 5164-5169, http://dx.doi.org/10.1016/j.bmcl.2014.09.083.
[33] Tang, JianJun ab, Zhang, Li, Jiang, LiPing, Di, Lei, Yan, YongMing, Tu, ZhengChao, Yang, CuiPing, Zuo, ZhiLi, Hou, Bo, Xia, HouLin, Chen, YongBin, Cheng, YongXian. Dopamine derivatives from the insect Polyrhachis dives as inhibitors of ROCK1/2 and stimulators of neural stem cell proliferation. TETRAHEDRON[J]. 2014, 70(46): 8852-8857, http://dx.doi.org/10.1016/j.tet.2014.09.095.
[34] Hou, Bo, Yi, Pinggui, Wang, Zhaoxu, Zhang, Shuqun, Zhao, Jinhua, Mancera, Ricardo L, Cheng, Yongxian, Zuo, Zhili. Assignment of aromaticity of the classic heterobenzenes by three aromatic criteria. COMPUTATIONAL AND THEORETICAL CHEMISTRY[J]. 2014, 1046: 20-24, http://dx.doi.org/10.1016/j.comptc.2014.07.012.
[35] Zhi-Li Zuo, Ling Guo, Ricardo L. Mancera. Free energy of binding of coiled-coil complexes with different electrostatic environments: the influence of force field polarisation and capping.. Natural products and bioprospecting[J]. 2014, 4(5): 285-95, http://ir.kib.ac.cn/handle/151853/64909.
[36] Xu, FengQing, Xu, FangCheng, Hou, Bo, Fan, WeiWei, Zi, ChengTing, Li, Yan, Dong, FaWu, Liu, YuQing, Sheng, Jun, Zuo, ZhiLi, Hu, JiangMiao. Cytotoxic bibenzyl dimers from the stems of Dendrobium fimbriatum Hook. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS[J]. 2014, 24(22): 5268-5273, http://dx.doi.org/10.1016/j.bmcl.2014.09.052.
[37] Kong, LingMei, Deng, Xu, Zuo, ZhiLi, Sun, HanDong, Zhao, QinShi, Li, Yan. Identification and validation of p50 as the cellular target of eriocalyxin B. ONCOTARGET[J]. 2014, 5(22): 11354-11364, http://ir.kib.ac.cn/handle/151853/20409.
[38] Zuo, Zhili, Gandhi, Neha S, Arndt, Katja M, Mancera, Ricardo L. Free energy calculations of the interactions of c-Jun-based synthetic peptides with the c-Fos protein. BIOPOLYMERS[J]. 2012, 97(11): 899-909, https://www.webofscience.com/wos/woscc/full-record/WOS:000307544800006.
[39] Deng, Jing, Li, Ning, Liu, Hongchuan, Zuo, Zhili, Liew, Oi Wah, Xu, Weijun, Chen, Gang, Tong, Xiankun, Tang, Wei, Zhu, Jin, Zuo, Jianping, Jiang, Hualiang, Yang, CaiGuang, Li, Jian, Zhu, Weiliang. Discovery of Novel Small Molecule Inhibitors of Dengue Viral NS2B-NS3 Protease Using Virtual Screening and Scaffold Hopping. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2012, 55(14): 6278-6293, https://www.webofscience.com/wos/woscc/full-record/WOS:000306764600003.
[40] Hu, Chaoxin, Lancaster, Cynthia S, Zuo, Zhili, Hu, Shuiying, Chen, Zhaoyuan, Rubnitz, Jeffrey E, Baker, Sharyn D, Sparreboom, Alex. Inhibition of OCTN2-Mediated Transport of Carnitine by Etoposide. MOLECULAR CANCER THERAPEUTICS[J]. 2012, 11(4): 921-929, https://www.webofscience.com/wos/woscc/full-record/WOS:000302809200012.
[41] Chen, Xiaoquan, Zuo, Zhili, Qiu, Yuqin, Zhou, Xiuyan, Zhang, Changjun, Zhai, Hu, Shao, Huiying, Li, Baoqing. Technological Improvement of Synthesis for Nabumetone. CHINESE JOURNAL OF ORGANIC CHEMISTRY[J]. 2010, 30(7): 1069-1071, http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000281722600020.
[42] 左之利. Calculations of the Free Energy of Interaction of the c-Fos-c-Jun Coiled-Coil: Effect of the Solvation Model and the Inclusion of Polarisation Effects. 2010, [43] 左之利. Identification of a sub-micromolar, Nonpeptide Inhibitor of BACE-1 with low neural cytotoxicity through In-silico Screening. Bioorganic and Medicinal Chemistry Letters. 2010, [44] Wang, Rong Wei, Zhou, Lu, Zuo, Zhili, Ma, Xiang, Yang, Min. 3D-QSAR studies of checkpoint kinase 1 inhibitors based on molecular docking and CoMFA. MOLECULAR SIMULATION[J]. 2010, 36(2): 87-110, https://www.webofscience.com/wos/woscc/full-record/WOS:000274421300001.
[45] Wang, Jinan, Yang, Huaiyu, Zuo, Zhili, Yan, Xiuhua, Wang, Yong, Luo, Xiaomin, Jiang, Hualiang, Chen, Kaixian, Zhu, Weiliang. Molecular Dynamics Simulations on the Mechanism of Transporting Methylamine and Ammonia by Ammonium Transporter AmtB. JOURNAL OF PHYSICAL CHEMISTRY B[J]. 2010, 114(46): 15172-15179, http://ir.simm.ac.cn/handle/153631/1930.
[46] Xu, Weijun, Chen, Gang, Zhu, Weiliang, Zuo, Zhili. Molecular docking and structure-activity relationship studies on benzothiazole based non-peptidic BACE-1 inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS[J]. 2010, 20(21): 6203-6207, http://dx.doi.org/10.1016/j.bmcl.2010.08.111.
[47] 左之利. Docking study and three-dimensional quantitative structure-activity relationship (3D-QSAR) analyses of transforming growth factor-β type I receptor kinase inhibitors. QSAR and Combinatorial Science. 2009, [48] 左之利. Mechanism of NS2B-mediated activation of NS3pro in Dengue Virus: Molecular Dynamics Simulations and Bioassay Studies.. 2009, [49] 左之利. Novel non-peptide b-secretase inhibitors derived from structure-based virtual screening and bioassay. Bioorganic and Medicinal Chemistry Letters,. 2009, [50] Ma, Xiang, Zhou, Lu, Zuo, ZhiLi, Liu, Jian, Yang, Min, Wang, RongWei. Molecular docking and 3-D QSAR studies of substituted 2,2-bisaryl-bicycloheptanes as human 5-Lipoxygenase-Activating Protein (FLAP) inhibitors. QSAR & COMBINATORIAL SCIENCE[J]. 2008, 27(9): 1083-1091, https://www.webofscience.com/wos/woscc/full-record/WOS:000259888600001.
[51] Yang, Min, Zhou, Lu, Zuo, Zhili, Tang, Xiangyang, Liu, Jian, Ma, Xiang. Structure-based virtual screening for glycosyltransferase(51). MOLECULAR SIMULATION[J]. 2008, 34(9): 849-856, https://www.webofscience.com/wos/woscc/full-record/WOS:000258688000005.
[52] Liu, Jian, Zhou, Lu, Zuo, Zhili. Antibacterial Activities of Carbapenem Derivatives and Quantitative Structure - Activity Relationship for Drug Design. QSAR & COMBINATORIAL SCIENCE[J]. 2008, 27(10): 1216-1226, https://www.webofscience.com/wos/woscc/full-record/WOS:000260683400004.
[53] Zhili Zuo, Chen Gang, Hanjun Zou, Puah Chum Mok, Weiliang Zhu, Kaixian Chen, Hualiang Jiang. Why does β-secretase zymogen possess catalytic activity? Molecular modeling and molecular dynamics simulation studies. Computational Biology and Chemistry. 2007, 31(3): 186-195, http://dx.doi.org/10.1016/j.compbiolchem.2007.03.007.
[54] 左之利. Pharmacophore-Directed Homology Modeling and MD Simulation of G-protein-Coupled Receptor: Study of Possible Binding Modes of the 5-HT2C Receptor Agonists. Acta Biochimica et Biophysica Sinica. 2007, [55] Qin, Yuxin, Meng, Linghua, Hu, Chaoxin, Duan, Wenhu, Zuo, Zhili, Lin, Liping, Zhang, Xiongwen, Ding, Jian. Gambogic acid inhibits the catalytic activity of human topoisomerase II alpha by binding to its ATPase domain. MOLECULAR CANCER THERAPEUTICS[J]. 2007, 6(9): 2429-2440, http://ir.simm.ac.cn/handle/153631/1708.
[56] Hu, CX, Zuo, ZL, Xiong, B, Ma, JG, Geng, MY, Lin, LP, Jiang, HL, Ding, J. Salvicine functions as novel topoisomerase II poison by binding to ATP pocket. MOLECULAR PHARMACOLOGY[J]. 2006, 70(5): 1593-1601, http://ir.simm.ac.cn/handle/153631/1448.
[57] Zuo, ZL, Luo, XM, Zhu, WL, Shen, JH, Shen, X, Jiang, HL, Chen, KX. Molecular docking and 3D-QSAR studies on the binding mechanism of statine-based peptidomimetics with beta-secretase. BIOORGANIC & MEDICINAL CHEMISTRY[J]. 2005, 13(6): 2121-2131, https://www.webofscience.com/wos/woscc/full-record/WOS:000227576700022.

科研活动

   
科研项目
( 1 ) 天然产物信息数据库建立, 负责人, 国家任务, 2013-07--2015-06
( 2 ) 中国科学院昆明植物研究所引进人才启动基金, 负责人, 研究所自选, 2013-03--2015-02
( 3 ) 抗阿尔茨海默病多靶标抑制剂的设计, 负责人, 国家任务, 2014-04--2015-05
( 4 ) 烟酰类化合物抗阿尔茨海默症的设计与合成, 负责人, 地方任务, 2014-10--2017-09
( 5 ) 中国科学院战略生物资源服务网络计划活性天然化合物发现、评价与转化, 负责人, 中国科学院计划, 2016-11--2018-06
( 6 ) 抗糖尿病新靶标TRPC4 的验证及抗糖尿病先导 化合物的设计与合成, 负责人, 中国科学院计划, 2018-01--2019-12
( 7 ) 糖尿病肾病药物先导化合物的设计优化与构效关系研究, 负责人, 地方任务, 2020-06--2022-05
( 8 ) 帕金森病候选创新药物MS-OPC15临床前研究, 负责人, 地方任务, 2022-01--2024-12
参与会议
(1)Mechanism of NS2B-Mediated Activation of NS3pro in Dengue Virus: Molecular Dynamics Simulations and Bioassays   第八届全国化学生物学学术会议   左之利   2013-09-15

指导学生

已指导学生

张云琴  硕士研究生  078001-药物化学  

徐国伟  硕士研究生  105500-药学  

孙柔婧  硕士研究生  105500-药学  

陈鼎元  硕士研究生  105500-药学  

刘斌  硕士研究生  105500-药学  

现指导学生

熊枫  硕士研究生  078001-药物化学  

潘颖  硕士研究生  105500-药学  

陈重良  硕士研究生  105500-药学  

马瑞  硕士研究生  105500-药学