新型磁共振造影剂的研发及生物医学成像应用

   

070302-分析化学
0703J1-纳米科学与技术
0703Z1-化学生物学

化学

2012-08--2017-08   美国得克萨斯大学达拉斯分校 化学专业   博士
2007-09--2011-06   四川大学化学学院   学士

   

2021-08~现在, 中国科学院精密测量科学与技术创新研究院, 研究员
2018-01~2021-08,中国科学院长春应用化学研究所, 副研究员

   

[1] Maosong Qiu, Lei Zhang, Yu Li, Ruifang Wang, Long Xiao, Shizhen Chen, Xin Zhou. An acid microenvironment-driven theranostics platform for lung cancer 19F MR/PA/FL multimodal imaging-guided photothermal therapy. MATERIALS RESEARCH BULLETIN. 2024, 174: http://dx.doi.org/10.1016/j.materresbull.2024.112731.
[2] Long Xiao, Lei Zhang, Sha Li, Yue Zhu, Qiao Yu, Zhaoqing Liu, Maosong Qiu, Yu Li, Shizhen Chen, Xin Zhou. Visualization and Quantification of Drug Release by GSH-Responsive Multimodal Integrated Micelles. JACS Au[J]. 2024, 4(2): 1193-1206, https://pubs.acs.org/doi/10.1021/jacsau.4c00009.
[3] Angewandte Chemie International Edition. 2024, 
[4] Wang, Ruifang, Qiu, Maosong, Zhang, Lei, Sui, Meiju, Xiao, Long, Yu, Qiao, Ye, Chaohui, Chen, Shizhen, Zhou, Xin. Augmenting Immunotherapy via Bioinspired MOF-Based ROS Homeostasis Disruptor with Nanozyme-Cascade Reaction. ADVANCED MATERIALS. 2023, http://dx.doi.org/10.1002/adma.202306748.
[5] Zhu, Lijun, Li, Yu, Jiang, Mou, Ke, Changsheng, Long, Hanxiong, Qiu, Maosong, Zhang, Lei, Ye, Chaohui, Zhou, Xin, Jiang, ZhongXing, Chen, Shizhen. Self-Assembly of Precisely Fluorinated Albumin for Dual Imaging- Guided Synergistic Chemo-Photothermal-Photodynamic Cancer Therapy. ACS APPLIED MATERIALS & INTERFACES. 2023, 
[6] 张磊. An NIR Fluorescence Turn-on and MRI Bimodal Probe for Concurrent Real-time in Vivo Sensing and Labeling of β-Galactosidase.. Angewandte Chemie International Edition[J]. 2023, 
[7] Guo, Xin, Zhang, Lei, Hu, Jiesheng, Szilagyi, Balazs, Yu, Meng, Chen, Shizhen, Tircso, Gyula, Zhou, Xin, Tao, Jun. Improving the potential of paraCEST through magnetic-coupling induced line sharpening. CHEMICAL SCIENCE[J]. 2023, 14(48): 14157-14165, http://dx.doi.org/10.1039/d3sc04770a.
[8] Ma, Chao, Sun, Jing, Li, Bo, Feng, Yang, Sun, Yao, Xiang, Li, Wu, Baiheng, Xiao, Lingling, Liu, Baimei, Petrovskii, Vladislav S, Liu, Bin, Zhang, Jinrui, Wang, Zili, Li, Hongyan, Zhang, Lei, Li, Jingjing, Wang, Fan, Goestl, Robert, Potemkin, Igor I, Chen, Dong, Zeng, Hongbo, Zhang, Hongjie, Liu, Kai, Herrmann, Andreas. Ultra-strong bio-glue from genetically engineered polypeptides. NATURE COMMUNICATIONS[J]. 2021, 12(1): https://doaj.org/article/0eddeb95f0a14c6b90ee911d32d65f9b.
[9] Yu, Yibin, Cheng, Yi, Tong, Junye, Zhang, Lei, Wei, Yen, Tian, Mei. Recent advances in thermo-sensitive hydrogels for drug delivery. JOURNAL OF MATERIALS CHEMISTRY B. 2021, 9(13): 2979-2992, https://www.webofscience.com/wos/woscc/full-record/WOS:000631591000001.
[10] Zhang, Yi, Zhao, Kelu, He, Haonan, Wan, Sikang, Martins, Andre F, Zhang, Lei, Liu, Kai. A T-2ex MRI Dy-based contrast agent for direct pH imaging using a ratiometric approach. DALTON TRANSACTIONS[J]. 2021, 50(6): 2014-2017, https://www.webofscience.com/wos/woscc/full-record/WOS:000618444900007.
[11] Wan, Sikang, Cui, Fengzhi, Li, Bo, Zhao, Kelu, He, Haonan, Zhang, Yi, Liu, Jianhua, Zhang, Lei, Liu, Kai. Dysprosium-Modified Gold Nanoparticles as T-2ex Contrast Agents for Magnetic Resonance Imaging. ACS APPLIED NANO MATERIALS[J]. 2020, 3(9): 9433-9439, https://www.webofscience.com/wos/woscc/full-record/WOS:000575846000091.
[12] He, Haonan, Zhao, Kelu, Xiao, Long, Zhang, Yi, Cheng, Yi, Wan, Sikang, Chen, Shizhen, Zhang, Lei, Zhou, Xin, Liu, Kai, Zhang, Hongjie. Detection and Chiral Recognition of alpha-Hydroxyl Acid through H-1 and CEST NMR Spectroscopy Using a Ytterbium Macrocyclic Complex. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2019, 58(50): 18286-18289, http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000493157400001.
[13] Liu, Yang, Zhen, Wenyao, Wang, Yinghui, Liu, Jianhua, Jin, Longhai, Zhang, Tianqi, Zhang, Songtao, Zhao, Ying, Yin, Na, Niu, Rui, Song, Shuyan, Zhang, Lei, Zhang, Hongjie. Double Switch Biodegradable Porous Hollow Trinickel Monophosphide Nanospheres for Multimodal Imaging Guided Photothermal Therapy. NANO LETTERS[J]. 2019, 19(8): 5093-5101, http://dx.doi.org/10.1021/acs.nanolett.9b01370.
[14] Zhang Lei, Li JingJing, Liu Kai. Recent advances in gadolinium-based MRI metal responsive agent. SCIENCE CHINA-TECHNOLOGICAL SCIENCES[J]. 2018, 61(9): 1329-1333, http://lib.cqvip.com/Qikan/Article/Detail?id=676287570.
[15] Zhang, Lei, Martins, Andre F, Zhao, Piyu, Tieu, Michael, EstebanGomez, David, McCandless, Gregory T, PlatasIglesias, Carlos, Sherry, A Dean. Enantiomeric Recognition of D- and L-Lactate by CEST with the Aid of a Paramagnetic Shift Reagent. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2017, 139(48): 17431-17437, https://www.webofscience.com/wos/woscc/full-record/WOS:000417669000040.
[16] Zhang, Lei, Martins, Andre F, Mai, Yuyan, Zhao, Piyu, Funk, Alexander M, Jordan, M Veronica Clavijo, Zhang, Shanrong, Chen, Wei, Wu, Yunkou, Sherry, A Dean. Imaging Extracellular Lactate In Vitro and In Vivo Using CEST MRI and a Paramagnetic Shift Reagent. CHEMISTRY-A EUROPEAN JOURNAL[J]. 2017, 23(8): 1752-1756, https://www.webofscience.com/wos/woscc/full-record/WOS:000395754800004.
[17] Lei Zhang, Andr F Martins, Piyu Zhao, Yunkou Wu, Gyula Tircs, A Dean Sherry. Lanthanide-based T 2ex and CEST complexes provide new insights into the design of pH sensitive MRI agents. ANGEWANDTECHEMIEINTERNATIONALEDINENGLISH. 2017, 56(52): 16626-16630, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5879776/.
[18] Dong, FengXia, Zhang, Lei, Tong, XiaoZuo, Chen, HongBing, Wang, XiuLi, Wang, YuZhong. Ionic liquid coated lipase: Green synthesis of high molecular weight poly(1,4-dioxan-2-one). JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC[J]. 2012, 77: 46-52, http://dx.doi.org/10.1016/j.molcatb.2012.01.006.
[19] Zhang Lei, Evbuomwan Osasere M., Tieu Michael, Zhao Piyu, Martins Andre F., Sherry A. Dean. Protonation of carboxyl groups in EuDOTA-tetraamide complexes results in catalytic prototropic exchange and quenching of the CEST signal. PHILOSOPHICAL TRANSACTIONS. SERIES A, MATHEMATICAL, PHYSICAL, AND ENGINEERING SCIENCES. 375(2107): https://www.webofscience.com/wos/woscc/full-record/WOS:000413121000007.

   

（ 1 ） 基于T2ex原理的新型镧系金属造影剂的设计及应用, 负责人, 国家任务, 2019-01--2021-12
（ 2 ） 基于T2ex原理的新型镧系金属造影剂活体应用研究, 负责人, 中国科学院计划, 2019-01--2021-12
（ 3 ） 超灵敏磁共振造影剂用于脑疾病的精准成像, 负责人, 研究所自选, 2021-08--2024-08
（ 4 ） 武汉英才项目, 负责人, 其他任务, 2022-04--2023-03