朱义广 男 博导 中国科学院南海海洋研究所
电子邮件： zhuyiguang2003@163.com
通信地址： 广州市海珠区新港西路164号
邮政编码： 510301
研究领域
（1）海洋微生物次级代谢产物生物合成机制研究
（2）基因组信息指导的海洋微生物隐性次级代谢产物挖掘
教育背景
2006-09--2011-06 华中农业大学 博士
2003-09--2006-06 河北大学 硕士
2000-08--2003-08 山东大学 学士
2003-09--2006-06 河北大学 硕士
2000-08--2003-08 山东大学 学士
工作经历
工作简历
2020-01~现在, 中国科学院南海海洋研究所, 研究员
2014-01~2019-12,中国科学院南海海洋研究所, 副研究员
2011-07~2013-12,中国科学院南海海洋研究所, 助理研究员
2014-01~2019-12,中国科学院南海海洋研究所, 副研究员
2011-07~2013-12,中国科学院南海海洋研究所, 助理研究员
获得荣誉
中国科学院广州教育基地“优秀研究生导师”（2021年）
中科院南海海洋研究所优秀研究生指导教师（2020年）
"广东特支计划"科技创新青年拔尖人才（2019年），
中科院南海海洋研究"南海新星"（2017年）,
出版信息
发表论文
[1] Tan, Bin, Zhang, Qingbo, Xiao, Ji, Yuan, Chengshan, Chen, Yuchan, Chen, Siqiang, Zhang, Weimin, Zhu, Yiguang, Zhang, Changsheng. Characterization of the P450 Monooxygenase LobP1 as C-32 Hydroxylase in Lobophorin Biosynthesis. CHINESE JOURNAL OF CHEMISTRY[J]. 2023, 第 8 作者 通讯作者 41(12): 1478-1484, http://dx.doi.org/10.1002/cjoc.202200818.
[2] Sun, Lili, Zhu, Hanning, Zhang, Liping, Zhu, Yiguang, Ratnasekera, Disna, Zhang, Changsheng, Zhang, Qingbo. Aromatic Polyketides from the Mangrove-Derived Streptomyces sp. SCSIO 40069. JOURNAL OF NATURAL PRODUCTS[J]. 2023, 第 4 作者86(4): 979-985, http://dx.doi.org/10.1021/acs.jnatprod.2c01169.
[3] Zhao, XiaoYang, Chen, Youzhe, Long, Ting, Liu, Zhiying, Zhang, Qingbo, Zhang, Haibo, Yan, Yan, Zhang, Changsheng, Zhu, Yiguang. Genome Mining and Biosynthetic Reconstitution of Fungal Depsidones Reveal a Dual Functional Cytochrome P450 for Ether Formation. JOURNAL OF NATURAL PRODUCTS[J]. 2023, 第 9 作者 通讯作者 86(8): 2046-2053,
[4] Bin Tan, Zhang Liping, Zhang, Qingbo, Chen Siqiang, Xiong Weiliang, Zhu Yiguang, Zhang Changsheng. A Widespread Glycosidase Confers Lobophorin Resistance and Host-Dependent Structural Diversity. Angewandte Chemie International Edition[J]. 2023, 第 6 作者 通讯作者 62(27): e202302043,
[5] Cheng, Ziqian, Zhang, Qingbo, Peng, Jing, Zhao, Xiaoyang, Ma, Liang, Zhang, Changsheng, Zhu, Yiguang. Genomics-Driven Discovery of Benzoxazole Alkaloids from the Marine-Derived Micromonospora sp. SCSIO 07395. MOLECULES[J]. 2023, 第 11 作者28(2): http://dx.doi.org/10.3390/molecules28020821.
[6] 朱义广, 牟鹏云, 张庆波, 张长生. ������������������������Penicillium sp.SCSIO 40438������������������������. 热带海洋学报[J]. 2023, 第 1 作者42(1): 161-167, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=7427277&detailType=1.
[7] Liu, Kai, Zhang, Jinyan, Zhang, Guangtao, Zhang, Liping, Meng, Zhen, Ma，Liang, Zhang, Wenjun, Xiong，Weiliang, Zhu，Yiguang, Wang, Binju, Zhang, Changsheng. Deciphering Deoxynybomycin Biosynthesis Reveals Fe(II)/��-Ketoglutarate-Dependent Dioxygenase-Catalyzed Oxazoline Ring Formation and Decomposition. , 2023, .. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2023, 第 9 作者145(50): 27886-27889,
[8] Yang, Chunfang, Zhang, Liping, Zhang, Wenjun, Huang, Chunshuai, Zhu, Yiguang, Jiang, Xiaodong, Liu, Wei, Zhao, Mengran, De, Bidhan Chandra, Zhang, Changsheng. Biochemical and structural insights of multifunctional flavin-dependent monooxygenase FlsO1-catalyzed unexpected xanthone formation. NATURE COMMUNICATIONS[J]. 2022, 第 5 作者13(1): http://dx.doi.org/10.1038/s41467-022-33131-0.
[9] Fang, Chunyan, Zhang, Qingbo, Zhang, Wenjun, Zhang, Changsheng, Zhu, Yiguang. Discovery of Efrotomycin Congeners and Heterologous Expression-Based Insights into the Self-Resistance Mechanism. JOURNAL OF NATURAL PRODUCTS[J]. 2022, 第 5 作者 通讯作者 85(12): 2865-2872, http://dx.doi.org/10.1021/acs.jnatprod.2c00986.
[10] Yang, Chunfang, Zhang, Liping, Zhang, Wenjun, Huang, Chunshuai, Zhu, Yiguang, Jiang, Xiaodong, Liu, Wei, Zhao, Mengran, De, Bidhan Chandra, Zhang, Changsheng. Biochemical and structural insights of multifunctional flavin-dependent monooxygenase FlsO1-catalyzed unexpected xanthone formation. NATURE COMMUNICATIONS[J]. 2022, 第 5 作者13(1): http://dx.doi.org/10.1038/s41467-022-33131-0.
[11] De, Bidhan Chandra, Zhang, Wenjun, Yang, Chunfang, Mandi, Attila, Huang, Chunshuai, Zhang, Liping, Liu, Wei, Ruszczycky, Mark W, Zhu, Yiguang, Ma, Ming, Bashiri, Ghader, Kurtan, Tibor, Liu, Hungwen, Zhang, Changsheng. Flavin-enabled reductive and oxidative epoxide ring opening reactions. NATURE COMMUNICATIONS[J]. 2022, 第 9 作者13(1): http://dx.doi.org/10.1038/s41467-022-32641-1.
[12] Li, Kunlong, Chen, Siqiang, Pang, Xiaoyan, Cai, Jian, Zhang, Xinya, Liu, Yonghong, Zhu, Yiguang, Zhou, Xuefeng. Natural products from mangrove sediments-derived microbes: Structural diversity, bioactivities, biosynthesis, and total synthesis. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY[J]. 2022, 第 7 作者 通讯作者 230: http://dx.doi.org/10.1016/j.ejmech.2022.114117.
[13] Huang, Chunshuai, Yang, Chunfang, Zhang, Wenjun, Zhang, Liping, Zhu, Yiguang, Zhang, Changsheng. Discovery of an Unexpected 1,4-Oxazepine-Linked seco-Fluostatin Heterodimer by Inactivation of the Oxidoreductase-Encoding Gene flsP. JOURNAL OF NATURAL PRODUCTS[J]. 2021, 第 5 作者84(8): 2336-2344, http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000692038100029.
[14] Peng, Jing, Zhang, Qingbo, Jiang, Xiaodong, Ma, Liang, Long, Ting, Cheng, Ziqian, Zhang, Changsheng, Zhu, Yiguang. New piericidin derivatives from the marine-derived streptomyces sp. SCSIO 40063 with cytotoxic activity. NATURAL PRODUCT RESEARCH[J]. 2021, 第 11 作者36(10): 2458-2464, http://dx.doi.org/10.1080/14786419.2021.1901699.
[15] Peng, jing, Zhang, Qingbo, Jiang, Xiaodong, Ma, Liang, Long, Ting, Cheng, Ziqian, Zhang, Changsheng, Zhu, Yiguang. New piericidin derivatives from a marine-derived Streptomyces sp. SCSIO 40063 with cytotoxicity activity. Natural Product Research[J]. 2021, 第 11 作者
[16] 金红波, 张丽萍, 张文军, 张光涛, 朱义广, 刘威, 张长生. ���������������������CftA������������������������. 微生物学通报[J]. 2021, 第 5 作者48(7): 2389-2397, http://lib.cqvip.com/Qikan/Article/Detail?id=7105380936.
[17] Zhu, Yiguang, Wang, Junfeng, Mou, Pengyun, Yan, Yan, Chen, Mengbin, Tang, Yi. Genome mining of cryptic tetronate natural products from a PKS-NRPS encoding gene cluster in Trichoderma harzianum t-22. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2021, 第 1 作者19(9): 1985-1990,
[18] Mou, Pengyun, Zhang, Qingbo, Peng, Jing, Jiang, Xiaodong, Zhang, Liping, Zhou, Zhongbo, Zhang, Changsheng, Zhu, Yiguang. Antibacterial phenylspirodrimanes from the marine-derived fungus Stachybotrys sp. SCSIO 40434. FITOTERAPIA[J]. 2021, 第 8 作者 通讯作者 152:
[19] Zhang, Haibo, Zhang, Liping, Khan, Imran, Zhang, Guangtao, Zhu, Yiguang, Zhang, Changsheng. A simple and facile iodination method of didechlorotiacumicin B and aromatic compounds. SCIENCE CHINA-CHEMISTRY[J]. 2021, 第 5 作者64(10): 1736-1742, http://dx.doi.org/10.1007/s11426-021-1072-6.
[20] Ma, Liang, Zhang, Wenjun, Liu, Zhiwen, Huang, Yanbing, Zhang, Qingbo, Tian, Xinpeng, Zhang, Changsheng, Zhu, Yiguang. Complete genome sequence of Streptomyces sp. SCSIO 03032 isolated from Indian Ocean sediment, producing diverse bioactive natural products. MARINE GENOMICS[J]. 2021, 第 11 作者55:
[21] Jiang, Xiaodong, Fang, Zhuangjie, Zhang, Qingbo, Liu, Wei, Zhang, Liping, Zhang, Wenjun, Yang, Chunfang, Zhang, Haibo, Zhu, Yiguang, Zhang, Changsheng. Discovery of a new asymmetric dimer nenestatin B and implications of a dimerizing enzyme in a deep sea actinomycete. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2021, 第 9 作者19(19): 4243-4247, http://dx.doi.org/10.1039/d1ob00310k.
[22] Fang, Zhuangjie, Jiang, Xiaodong, Zhang, Qingbo, Zhang, Liping, Zhang, Wenjun, Yang, Chunfang, Zhang, Haibo, Zhu, Yiguang, Zhang, Changsheng. S-Bridged Thioether and Structure-Diversified Angucyclinone Derivatives from the South China Sea-Derived Micromonospora echinospora SCSIO 04089. JOURNAL OF NATURAL PRODUCTS[J]. 2020, 第 8 作者83(10): 3122-3130, https://www.webofscience.com/wos/woscc/full-record/WOS:000586023100031.
[23] Chen, Siqiang, Zhang, Qingbo, Zhang, Xinya, Jiang, Xiaodong, Zhang, Haibo, Zhu, Yiguang, Zhang, Changsheng, Zhang, Liping. A new xanthostatin analogue from the marine sponge-associated actinomycete Streptomyces sp. SCSIO 40064. NATURAL PRODUCT RESEARCH[J]. 2020, 第 6 作者36(14): 3529-3537,
[24] Zhu, Yiguang, Zhang, Qingbo, Fang, Chunyan, Zhang, Yingli, Ma, Liang, Liu, Zhiwen, Zhai, Shilan, Peng, Jing, zhang, Liping, Zhu, Weiming, Zhang, Changsheng. Refactoring the concise biosynthetic pathway of cyanogramide unveils a P450 enzyme-catalyzed spirooxindole formation. Angewandte Chemie International Edition[J]. 2020, 第 1 作者59(33): 14065-14069,
[25] Zhu, Yiguang, Zhang, Qingbo, Fang, Chunyan, Zhang, Yingli, Ma, Liang, Liu, Zhiwen, Zhai, Shilan, Peng, Jing, Zhang, Liping, Zhu, Weiming, Zhang, Changsheng. Refactoring the Concise Biosynthetic Pathway of Cyanogramide Unveils Spirooxindole Formation Catalyzed by a P450 Enzyme. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2020, 第 1 作者59(33): 14065-14069, http://dx.doi.org/10.1002/anie.202004978.
[26] Liping Zhang, Bidhan Chandra De, Wenjun Zhang, Attila Mándi, 方壮杰, 杨春芳, 朱义广, Tibor Kurtán, Changsheng Zhang. Mutation of an atypical oxirane oxyanion hole improves regioselectivity of the ��/��-fold epoxide hydrolase Alp1U. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2020, 第 7 作者295(50): 16987-16997,
[27] Zhang, Liping, De, Bidhan Chandra, Zhang, Wenjun, Mandi, Attila, Fang, Zhuangjie, Yang, Chunfang, Zhu, Yiguang, Kurtan, Tibor, Zhang, Changsheng. Mutation of an atypical oxirane oxyanion hole improves regioselectivity of the alpha/beta-fold epoxide hydrolase Alp1U. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2020, 第 7 作者295(50): 16987-16997, http://dx.doi.org/10.1074/jbc.RA120.015563.
[28] Liu, Wei, Jannu, Vinay Gopal, Liu, Zhiwen, Zhang, Qingbo, Jiang, Xiaodong, Ma, Liang, Zhang, Wenjun, Zhang, Changsheng, Zhu, Yiguang. Heterologous expression of the trichostatin gene cluster and functional characterization of N-methyltransferase TsnB8. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2020, 第 9 作者 通讯作者 18(19): 3649-3653,
[29] Chen, Siqiang, Zhang, Qingbo, Zhang, Xinya, Jiang, Xiaodong, Zhang, Haibo, Zhu, Yiguang, Zhang, Changsheng, Zhang, Liping. A new xanthostatin analogue from the marine sponge-associated actinomycete Streptomyces sp. SCSIO 40064. NATURAL PRODUCT RESEARCH. 2020, 第 6 作者https://www.webofscience.com/wos/woscc/full-record/WOS:000603899300001.
[30] Huang, Chunshuai, Yang, Chunfang, Zhu, Yiguang, Zhang, Wenjun, Yuan, Chengshan, Zhang, Changsheng. Marine Bacterial Aromatic Polyketides From Host-Dependent Heterologous Expression and Fungal Mode of Cyclization. FRONTIERS IN CHEMISTRY[J]. 2018, 第 11 作者6:
[31] Chen, Ruidong, Zhang, Qingbo, Tan, Bin, Zheng, Liujuan, Li, Huixian, Zhu, Yiguang, Zhang, Changsheng. Genome Mining and Activation of a Silent PKS/NRPS Gene Cluster Direct the Production of Totopotensamides. ORGANIC LETTERS[J]. 2017, 第 6 作者19(20): 5697-5700, https://www.webofscience.com/wos/woscc/full-record/WOS:000413709600051.
[32] Zhu, Yiguang, Picard, MarieEve, Zhang, Qingbo, Barma, Julie, Despres, Xavier Murphy, Mei, Xiangui, Zhang, Liping, Duvignaud, JeanBaptiste, Couture, Manon, Zhu, Weiming, Shi, Rong, Zhang, Changsheng. Flavoenzyme CrmK-mediated substrate recycling in caerulomycin biosynthesis. CHEMICAL SCIENCE[J]. 2017, 第 1 作者7(8): 4867-4874,
[33] Wang, Pengxia, Zhu, Yiguang, Zhang, Yuyang, Zhang, Chunyi, Xu, Jianyi, Deng, Yun, Peng, Donghai, Ruan, Lifang, Sun, Ming. Mob/oriT, a mobilizable site-specific recombination system for unmarked genetic manipulation in Bacillus thuringiensis and Bacillus cereus. MICROBIAL CELL FACTORIES[J]. 2016, 第 2 作者15(1): https://www.webofscience.com/wos/woscc/full-record/WOS:000378575100008.
[34] Zhu, Yiguang, Xu, Jinxin, Mei, Xiangui, Feng, Zhan, Zhang, Liping, Zhang, Qingbo, Zhang, Guangtao, Zhu, Weiming, Liu, Jinsong, Zhang, Changsheng. Biochemical and Structural Insights into the Aminotransferase CrmG in Caerulomycin Biosynthesis. ACS CHEMICAL BIOLOGY[J]. 2016, 第 1 作者11(4): 943-952,
[35] Zhu, Yiguang, Zhang, Wenjun, Chen, Yaolong, Yuan, Chengshan, Zhang, Haibo, Zhang, Guangtao, Ma, Liang, Zhang, Qingbo, Tian, Xinpeng, Zhang, Si, Zhang, Changsheng. Characterization of Heronamide Biosynthesis Reveals a Tailoring Hydroxylase and Indicates Migrated Double Bonds. CHEMBIOCHEM[J]. 2015, 第 1 作者16(14): 2086-2093,
[36] Chen, Yaolong, Zhang, Wenjun, Zhu, Yiguang, Zhang, Qingbo, Tian, Xinpeng, Zhang, Si, Zhang, Changsheng. Elucidating Hydroxylation and Methylation Steps Tailoring Piericidin A1 Biosynthesis. ORGANIC LETTERS[J]. 2014, 第 3 作者 通讯作者 16(3): 736-739,
[37] Zhang, Wenjun, Li, Sumei, Zhu, Yiguang, Chen, Yuchan, Chen, Yaolong, Zhang, Haibo, Zhang, Guangtao, Tian, Xinpeng, Pan, Yu, Zhang, Si, Zhang, Weimin, Zhang, Changsheng. Heronamides D-F, Polyketide Macrolactams from the Deep-Sea-Derived Streptomyces sp SCSIO 03032. JOURNAL OF NATURAL PRODUCTS[J]. 2014, 第 3 作者77(2): 388-391, http://dx.doi.org/10.1021/np400665a.
[38] Fu, Peng, Zhu, Yiguang, Mei, Xiangui, Wang, Yi, Jia, Haijian, Zhang, Changsheng, Zhu, Weiming. Acyclic Congeners from Actinoalloteichus cyanogriseus Provide Insights into Cyclic Bipyridine Glycoside Formation. ORGANIC LETTERS[J]. 2014, 第 2 作者16(16): 4264-4267,
[39] Zhu, Yiguang, Zhang, Qingbo, Li, Sumei, Lin, Qinheng, Fu, Peng, Zhang, Guangtao, Zhang, Haibo, Shi, Rong, Zhu, Weiming, Zhang, Changsheng. Insights into Caerulomycin A Biosynthesis: A Two-Component Monooxygenase CrmH-Catalyzed Oxime Formation. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2013, 第 1 作者135(50): 18750-18753,
[40] Chen, Ruidong, Zhang, Haibo（共同第一作者）, Zhang, Gaiyun, Li, Sumei, Zhang, Guangtao, Zhu, Yiguang, Liu, Jinsong, Zhang, Changsheng. Characterizing Amosamine Biosynthesis in Amicetin Reveals AmiG as a Reversible Retaining Glycosyltransferase. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2013, 第 6 作者135(33): 12152-12155, http://ir.gibh.ac.cn/handle/344009/703.
[41] Zhang, Gaiyun, Li, Sumei, Zhang, Haibo, Xiao, Ji, Zhang, Guangtao, Zhu, Yiguang, Niu, Siwen, Ju, Jianhua, Zhang, Changsheng. Characterization of the Amicetin Biosynthetic Gene Cluster from Streptomyces vinaceusdrappus NRRL 2363 Implicates Two Alternative Strategies for Amide Bond Formation.. Applied and Environmental Microbiology[J]. 2012, 第 6 作者78(7): 2393-2401,
[42] Zhu, Yiguang, Fu, Peng, Lin, Qinheng, Zhang, Guangtao, Zhang, Haibo, Li, Sumei, Ju, Jianhua, Zhu, Weiming, Zhang, Changsheng. Identification of Caerulomycin A Gene Cluster Implicates a Tailoring Amidohydrolase. ORGANIC LETTERS[J]. 2012, 第 1 作者14(11): 2666-2669,
[43] Zhu, Yiguang, Ji, Fang, Shang, Hui, Zhu, Qian, Wang, Pengxia, Xu, Chengchen, Deng, Yun, Peng, Donghai, Ruan, Lifang, Sun, Ming. Gene Clusters Located on Two Large Plasmids Determine Spore Crystal Association (SCA) in Bacillus thuringiensis Subsp finitimus Strain YBT-020. PLOS ONE[J]. 2011, 第 11 作者6(11):
[44] Zhu, Yiguang, Shang, Hui, Zhu, Qian, Ji, Fang, Wang, Pengxia, Fu, Jingjing, Deng, Yun, Xu, Chengchen, Ye, Weixing, Zheng, Jinshui, Zhu, Lei, Ruan, Lifang, Peng, Donghai, Sun, Ming. Complete Genome Sequence of Bacillus thuringiensis Serovar finitimus Strain YBT-020. JOURNAL OF BACTERIOLOGY[J]. 2011, 第 1 作者193(9): 2379-2380,
[2] Sun, Lili, Zhu, Hanning, Zhang, Liping, Zhu, Yiguang, Ratnasekera, Disna, Zhang, Changsheng, Zhang, Qingbo. Aromatic Polyketides from the Mangrove-Derived Streptomyces sp. SCSIO 40069. JOURNAL OF NATURAL PRODUCTS[J]. 2023, 第 4 作者86(4): 979-985, http://dx.doi.org/10.1021/acs.jnatprod.2c01169.
[3] Zhao, XiaoYang, Chen, Youzhe, Long, Ting, Liu, Zhiying, Zhang, Qingbo, Zhang, Haibo, Yan, Yan, Zhang, Changsheng, Zhu, Yiguang. Genome Mining and Biosynthetic Reconstitution of Fungal Depsidones Reveal a Dual Functional Cytochrome P450 for Ether Formation. JOURNAL OF NATURAL PRODUCTS[J]. 2023, 第 9 作者 通讯作者 86(8): 2046-2053,
[4] Bin Tan, Zhang Liping, Zhang, Qingbo, Chen Siqiang, Xiong Weiliang, Zhu Yiguang, Zhang Changsheng. A Widespread Glycosidase Confers Lobophorin Resistance and Host-Dependent Structural Diversity. Angewandte Chemie International Edition[J]. 2023, 第 6 作者 通讯作者 62(27): e202302043,
[5] Cheng, Ziqian, Zhang, Qingbo, Peng, Jing, Zhao, Xiaoyang, Ma, Liang, Zhang, Changsheng, Zhu, Yiguang. Genomics-Driven Discovery of Benzoxazole Alkaloids from the Marine-Derived Micromonospora sp. SCSIO 07395. MOLECULES[J]. 2023, 第 11 作者28(2): http://dx.doi.org/10.3390/molecules28020821.
[6] 朱义广, 牟鹏云, 张庆波, 张长生. ������������������������Penicillium sp.SCSIO 40438������������������������. 热带海洋学报[J]. 2023, 第 1 作者42(1): 161-167, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=7427277&detailType=1.
[7] Liu, Kai, Zhang, Jinyan, Zhang, Guangtao, Zhang, Liping, Meng, Zhen, Ma，Liang, Zhang, Wenjun, Xiong，Weiliang, Zhu，Yiguang, Wang, Binju, Zhang, Changsheng. Deciphering Deoxynybomycin Biosynthesis Reveals Fe(II)/��-Ketoglutarate-Dependent Dioxygenase-Catalyzed Oxazoline Ring Formation and Decomposition. , 2023, .. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2023, 第 9 作者145(50): 27886-27889,
[8] Yang, Chunfang, Zhang, Liping, Zhang, Wenjun, Huang, Chunshuai, Zhu, Yiguang, Jiang, Xiaodong, Liu, Wei, Zhao, Mengran, De, Bidhan Chandra, Zhang, Changsheng. Biochemical and structural insights of multifunctional flavin-dependent monooxygenase FlsO1-catalyzed unexpected xanthone formation. NATURE COMMUNICATIONS[J]. 2022, 第 5 作者13(1): http://dx.doi.org/10.1038/s41467-022-33131-0.
[9] Fang, Chunyan, Zhang, Qingbo, Zhang, Wenjun, Zhang, Changsheng, Zhu, Yiguang. Discovery of Efrotomycin Congeners and Heterologous Expression-Based Insights into the Self-Resistance Mechanism. JOURNAL OF NATURAL PRODUCTS[J]. 2022, 第 5 作者 通讯作者 85(12): 2865-2872, http://dx.doi.org/10.1021/acs.jnatprod.2c00986.
[10] Yang, Chunfang, Zhang, Liping, Zhang, Wenjun, Huang, Chunshuai, Zhu, Yiguang, Jiang, Xiaodong, Liu, Wei, Zhao, Mengran, De, Bidhan Chandra, Zhang, Changsheng. Biochemical and structural insights of multifunctional flavin-dependent monooxygenase FlsO1-catalyzed unexpected xanthone formation. NATURE COMMUNICATIONS[J]. 2022, 第 5 作者13(1): http://dx.doi.org/10.1038/s41467-022-33131-0.
[11] De, Bidhan Chandra, Zhang, Wenjun, Yang, Chunfang, Mandi, Attila, Huang, Chunshuai, Zhang, Liping, Liu, Wei, Ruszczycky, Mark W, Zhu, Yiguang, Ma, Ming, Bashiri, Ghader, Kurtan, Tibor, Liu, Hungwen, Zhang, Changsheng. Flavin-enabled reductive and oxidative epoxide ring opening reactions. NATURE COMMUNICATIONS[J]. 2022, 第 9 作者13(1): http://dx.doi.org/10.1038/s41467-022-32641-1.
[12] Li, Kunlong, Chen, Siqiang, Pang, Xiaoyan, Cai, Jian, Zhang, Xinya, Liu, Yonghong, Zhu, Yiguang, Zhou, Xuefeng. Natural products from mangrove sediments-derived microbes: Structural diversity, bioactivities, biosynthesis, and total synthesis. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY[J]. 2022, 第 7 作者 通讯作者 230: http://dx.doi.org/10.1016/j.ejmech.2022.114117.
[13] Huang, Chunshuai, Yang, Chunfang, Zhang, Wenjun, Zhang, Liping, Zhu, Yiguang, Zhang, Changsheng. Discovery of an Unexpected 1,4-Oxazepine-Linked seco-Fluostatin Heterodimer by Inactivation of the Oxidoreductase-Encoding Gene flsP. JOURNAL OF NATURAL PRODUCTS[J]. 2021, 第 5 作者84(8): 2336-2344, http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000692038100029.
[14] Peng, Jing, Zhang, Qingbo, Jiang, Xiaodong, Ma, Liang, Long, Ting, Cheng, Ziqian, Zhang, Changsheng, Zhu, Yiguang. New piericidin derivatives from the marine-derived streptomyces sp. SCSIO 40063 with cytotoxic activity. NATURAL PRODUCT RESEARCH[J]. 2021, 第 11 作者36(10): 2458-2464, http://dx.doi.org/10.1080/14786419.2021.1901699.
[15] Peng, jing, Zhang, Qingbo, Jiang, Xiaodong, Ma, Liang, Long, Ting, Cheng, Ziqian, Zhang, Changsheng, Zhu, Yiguang. New piericidin derivatives from a marine-derived Streptomyces sp. SCSIO 40063 with cytotoxicity activity. Natural Product Research[J]. 2021, 第 11 作者
[16] 金红波, 张丽萍, 张文军, 张光涛, 朱义广, 刘威, 张长生. ���������������������CftA������������������������. 微生物学通报[J]. 2021, 第 5 作者48(7): 2389-2397, http://lib.cqvip.com/Qikan/Article/Detail?id=7105380936.
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[20] Ma, Liang, Zhang, Wenjun, Liu, Zhiwen, Huang, Yanbing, Zhang, Qingbo, Tian, Xinpeng, Zhang, Changsheng, Zhu, Yiguang. Complete genome sequence of Streptomyces sp. SCSIO 03032 isolated from Indian Ocean sediment, producing diverse bioactive natural products. MARINE GENOMICS[J]. 2021, 第 11 作者55:
[21] Jiang, Xiaodong, Fang, Zhuangjie, Zhang, Qingbo, Liu, Wei, Zhang, Liping, Zhang, Wenjun, Yang, Chunfang, Zhang, Haibo, Zhu, Yiguang, Zhang, Changsheng. Discovery of a new asymmetric dimer nenestatin B and implications of a dimerizing enzyme in a deep sea actinomycete. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2021, 第 9 作者19(19): 4243-4247, http://dx.doi.org/10.1039/d1ob00310k.
[22] Fang, Zhuangjie, Jiang, Xiaodong, Zhang, Qingbo, Zhang, Liping, Zhang, Wenjun, Yang, Chunfang, Zhang, Haibo, Zhu, Yiguang, Zhang, Changsheng. S-Bridged Thioether and Structure-Diversified Angucyclinone Derivatives from the South China Sea-Derived Micromonospora echinospora SCSIO 04089. JOURNAL OF NATURAL PRODUCTS[J]. 2020, 第 8 作者83(10): 3122-3130, https://www.webofscience.com/wos/woscc/full-record/WOS:000586023100031.
[23] Chen, Siqiang, Zhang, Qingbo, Zhang, Xinya, Jiang, Xiaodong, Zhang, Haibo, Zhu, Yiguang, Zhang, Changsheng, Zhang, Liping. A new xanthostatin analogue from the marine sponge-associated actinomycete Streptomyces sp. SCSIO 40064. NATURAL PRODUCT RESEARCH[J]. 2020, 第 6 作者36(14): 3529-3537,
[24] Zhu, Yiguang, Zhang, Qingbo, Fang, Chunyan, Zhang, Yingli, Ma, Liang, Liu, Zhiwen, Zhai, Shilan, Peng, Jing, zhang, Liping, Zhu, Weiming, Zhang, Changsheng. Refactoring the concise biosynthetic pathway of cyanogramide unveils a P450 enzyme-catalyzed spirooxindole formation. Angewandte Chemie International Edition[J]. 2020, 第 1 作者59(33): 14065-14069,
[25] Zhu, Yiguang, Zhang, Qingbo, Fang, Chunyan, Zhang, Yingli, Ma, Liang, Liu, Zhiwen, Zhai, Shilan, Peng, Jing, Zhang, Liping, Zhu, Weiming, Zhang, Changsheng. Refactoring the Concise Biosynthetic Pathway of Cyanogramide Unveils Spirooxindole Formation Catalyzed by a P450 Enzyme. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2020, 第 1 作者59(33): 14065-14069, http://dx.doi.org/10.1002/anie.202004978.
[26] Liping Zhang, Bidhan Chandra De, Wenjun Zhang, Attila Mándi, 方壮杰, 杨春芳, 朱义广, Tibor Kurtán, Changsheng Zhang. Mutation of an atypical oxirane oxyanion hole improves regioselectivity of the ��/��-fold epoxide hydrolase Alp1U. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2020, 第 7 作者295(50): 16987-16997,
[27] Zhang, Liping, De, Bidhan Chandra, Zhang, Wenjun, Mandi, Attila, Fang, Zhuangjie, Yang, Chunfang, Zhu, Yiguang, Kurtan, Tibor, Zhang, Changsheng. Mutation of an atypical oxirane oxyanion hole improves regioselectivity of the alpha/beta-fold epoxide hydrolase Alp1U. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2020, 第 7 作者295(50): 16987-16997, http://dx.doi.org/10.1074/jbc.RA120.015563.
[28] Liu, Wei, Jannu, Vinay Gopal, Liu, Zhiwen, Zhang, Qingbo, Jiang, Xiaodong, Ma, Liang, Zhang, Wenjun, Zhang, Changsheng, Zhu, Yiguang. Heterologous expression of the trichostatin gene cluster and functional characterization of N-methyltransferase TsnB8. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2020, 第 9 作者 通讯作者 18(19): 3649-3653,
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[31] Chen, Ruidong, Zhang, Qingbo, Tan, Bin, Zheng, Liujuan, Li, Huixian, Zhu, Yiguang, Zhang, Changsheng. Genome Mining and Activation of a Silent PKS/NRPS Gene Cluster Direct the Production of Totopotensamides. ORGANIC LETTERS[J]. 2017, 第 6 作者19(20): 5697-5700, https://www.webofscience.com/wos/woscc/full-record/WOS:000413709600051.
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科研活动
科研项目
（ 1 ） 以结构多样化为导向海洋来源放线菌生物碱cyanogramide生物合成研究, 负责人, 国家任务, 2017-01--2020-12
（ 2 ） 海洋放线菌次生代谢产物Cyanogrisides生物合成后修饰酶的功能研究, 负责人, 国家任务, 2015-01--2018-12
（ 3 ） 海洋放线菌Actinoalloteichus cyanogriseus WH1-2216-6 次级代谢产物挖掘与生物合成, 负责人, 国家任务, 2017-04--2020-03
（ 4 ） 生物碱cyanogramide和spiroindimicins螺环成环机制, 负责人, 中国科学院计划, 2016-08--2021-07
（ 5 ） 海洋放线菌来源聚酮化合物nenestatin A生物合成 与结构多样化, 负责人, 研究所自主部署, 2017-07--2022-06
（ 6 ） 海洋放线菌来源聚酮类化合物Pteridic acids生物合成机制研究, 负责人, 地方任务, 2019-10--2022-09
（ 7 ） 聚酮天然产物合成体系的智能创建, 负责人, 国家任务, 2019-07--2024-06
（ 8 ） 生物碱cyanogramide生物合成中细胞色素P450酶CyaGHI的酶学机制研究, 负责人, 国家任务, 2022-01--2025-12
（ 2 ） 海洋放线菌次生代谢产物Cyanogrisides生物合成后修饰酶的功能研究, 负责人, 国家任务, 2015-01--2018-12
（ 3 ） 海洋放线菌Actinoalloteichus cyanogriseus WH1-2216-6 次级代谢产物挖掘与生物合成, 负责人, 国家任务, 2017-04--2020-03
（ 4 ） 生物碱cyanogramide和spiroindimicins螺环成环机制, 负责人, 中国科学院计划, 2016-08--2021-07
（ 5 ） 海洋放线菌来源聚酮化合物nenestatin A生物合成 与结构多样化, 负责人, 研究所自主部署, 2017-07--2022-06
（ 6 ） 海洋放线菌来源聚酮类化合物Pteridic acids生物合成机制研究, 负责人, 地方任务, 2019-10--2022-09
（ 7 ） 聚酮天然产物合成体系的智能创建, 负责人, 国家任务, 2019-07--2024-06
（ 8 ） 生物碱cyanogramide生物合成中细胞色素P450酶CyaGHI的酶学机制研究, 负责人, 国家任务, 2022-01--2025-12