基本信息

朱强 男 汉族 博导 广州生物医药与健康研究院
电子邮件:zhu_qiang@gibh.ac.cn
联系电话:020-32015287
手机号码:
通信地址:广州市萝岗区开源大道190号
邮政编码:510530
电子邮件:zhu_qiang@gibh.ac.cn
联系电话:020-32015287
手机号码:
通信地址:广州市萝岗区开源大道190号
邮政编码:510530
研究领域
(1) 过渡金属参与的 C-H 键官能化反应用于合成杂环化合物的方法研究;
(2) Cu/O2 体系对小分子的选择性氧化;
(3) 多组分、多反应中心、串联反应等一步形成多个碳碳键或碳杂键的高效的杂环化合物合成方法研究;
(4) 抗肺癌和抗 TB 活性先导化合物的发现与结构修饰;
(2) Cu/O2 体系对小分子的选择性氧化;
(3) 多组分、多反应中心、串联反应等一步形成多个碳碳键或碳杂键的高效的杂环化合物合成方法研究;
(4) 抗肺癌和抗 TB 活性先导化合物的发现与结构修饰;
招生信息
招生专业
100701-药物化学
070303-有机化学
070303-有机化学
招生方向
抗肺癌、抗 TB 药物设计与合成
教育背景
1、1995.9 ~ 2000.6 中国科学院上海有机化学研究所,有机化学,博士
2、1991.9 ~ 1995.6 南京大学化学化工学院,有机化学,本科
2、1991.9 ~ 1995.6 南京大学化学化工学院,有机化学,本科
学历
-- 研究生
学位
-- 博士
出国学习工作
2000.8 ~ 2001.4 美国科罗拉多州立大学 (CSU) 化学系博士后.
工作经历
工作简历
1、2008.5 至今 中科院广州生物医药与健康研究院,研究员;
2、2005.9 ~ 2008.2 美国 XTL Biopharmaceuticals Inc., 研究员;
3、2001.4 ~ 2005.9 美国 Vivoquest, Inc., 研究员.
专利与奖励
专利成果
[1] 朱强, 罗宇, 罗爽, 王希龙, 彭燕, 王潮琴. 有机化合物及其制备方法. 202110022559.4, 2022-01-08.[2] 朱强, 赵昕, 涂正超, 彭江灵, 贺益苗, 毛婷婷, 罗爽. 多取代吲哚类化合物及其应用. CN: CN109665985A, 2019-04-23.[3] 涂正超, 朱强, 张天宇, 黄金波, 徐晓冰, 万军庭, 黎敏科, 李登科, 周亚丽, 刘志永, 王邦兴, 米琦.托特雷拉. 吲哚-2-酮-3-螺噻嗪酮或噻唑酮化合物及其应用. CN: CN107722044B, 2020-11-03.[4] 朱强, 张天宇, 刘兰英, 鲁明辉, 毛婷婷, 黄金波. 吲哚3,2-c喹啉类化合物或其药学上可接受的盐及其制备方法和应用. 中国: CN103554103A, 2014-02-05.[5] 朱强, 王洪根, 王勇, 梁冬冬, 刘兰英, 张健存. 咪唑1,2-a吡啶和咪唑醛类化合物的合成方法. CN: CN102358739A, 2012-02-22.[6] 吴东海, 朱强, 杨松, 刘兰英, 彭长兰. 青蒿素衍生物的新应用. CN: CN101879158A, 2010-11-10.
出版信息
发表论文
[1] Yu Luo, Shuang Luo, Qiang Zhu. Inherently chiral azaheterocycles: Asymmetric synthesis via (dynamic) kinetic resolution. CHEM CATALYSIS. 2024, 第 3 作者4(1): http://dx.doi.org/10.1016/j.checat.2023.100864.[2] Yu, Ting, Cheng, Sidi, Luo, Yu, Li, Jing, Liang, Yingxiang, Luo, Shuang, Zhu, Qiang. Immobilizing Stereogenic Nitrogen Center in Doubly Fused Triarylamines through Palladium-Catalyzed Asymmetric C-H Activation/Seven-Membered-Ring Formation. ACS CATALYSIS[J]. 2023, 第 7 作者 通讯作者 13(14): 9688-9694, http://dx.doi.org/10.1021/acscatal.3c02253.[3] Luo, Yu, Wang, Xilong, Liu, Qianwen, He, Yimiao, Li, Jing, Luo, Shuang, Zhu, Qiang. Palladium-catalyzed alkyne hydrocarbonylation under atmospheric pressure of carbon monoxide in the presence of hydrosilane. GREEN CHEMISTRY[J]. 2023, 第 7 作者 通讯作者 25(3): 1120-1127, [4] Qiang Zhu, Lei Deng, Jie Chen, Gustavo R. Rodríguez, chuanlong sun, Zeqian Chang, Tianxia Yang, Huawei Zhai, Hongling Jiang, Yasin Topcu, David Francis, Samuel Hutton, Liang Sun, Chang-Bao Li, Esther Van der Knaap, Chuanyou Li. Redesigning the tomato fruit shape for mechanized production. Nature Plants[J]. 2023, 第 1 作者9: 1659-1674, [5] Cui, Haitao, Ban, Caijin, Zhu, Fengting, Yuan, Jingmei, Du, Juan, Huang, Yanmin, Xiao, Qi, Huang, Chusheng, Huang, Jun, Zhu, Qiang. Difluorocarbene-Triggered Acyl Rearrangement Reaction: A Strategy for the Direct Introduction of the gem-Difluoromethylene Group. ORGANIC LETTERS[J]. 2023, 第 10 作者 通讯作者 25(1): 99-103, http://dx.doi.org/10.1021/acs.orglett.2c03907.[6] Xu, Wenwen, Chen, Hao, Li, Yiting, Cheng, Hu, Deng, Yi, Zheng, Peiyan, Li, Jingzhi, Yang, Lan, He, Shiping, Ma, Dongli, Zhu, Qiang, Gu, Dayong, Han, Jun, Sun, Baoqing, Ma, Hongwei. Removing Negative Impacts from Inevitable Nonreproducible and Nonspecific Antibody-Probe Interactions in Viral Serology. ANALYTICAL CHEMISTRY. 2023, 第 11 作者[7] Wang, Xilong, Luo, Yu, Li, Jing, Wang, Chaoqin, Liu, Qianwen, He, Yimiao, Luo, Shuang, Zhu, Qiang. Parallel Kinetic Resolution through Palladium-Catalyzed Enantioselective Cycloimidoylation: En Route to Divergent N-Heterocycles Bearing a Quaternary Stereogenic Center. ACS CATALYSIS[J]. 2022, 第 8 作者 通讯作者 12(24): 14918-14925, [8] Hussain Muzammal, Yongzhi Lu, Muqddas Tariq, Hao Jiang, Yahai Shu, Shuang Luo, Qiang Zhu, Jiancun Zhang, Jinsong Liu. A small-molecule Skp1 inhibitor elicits cell death by p53-dependent mechanism. iScience[J]. 2022, 第 7 作者[9] Hu, Weiming, Wang, Xilong, Peng, Yan, Luo, Shuang, Zhao, Jiaji, Zhu, Qiang. Synthesis of 7-Arylthiomethyl Dibenzob,dazepines through Imidoylative Heck Cyclization and CPA-Catalyzed Thio-Michael Addition/Enantioselective Protonation. ORGANIC LETTERS[J]. 2022, 第 6 作者 通讯作者 24(20): 3642-3646, http://dx.doi.org/10.1021/acs.orglett.2c01217.[10] Luo, Yu, Wang, Xilong, Hu, Weiming, Peng, Yan, 王潮琴, Yu, Ting, Cheng, Sidi, He, Yimiao, Gan, Chunfang, 罗爽, Zhu, Qiang. Inherently Chiral 6,7-Diphenyldibenzo[e,g][1,4]diazocine: Enantioselective Synthesis and Application as a Ligand Platform.. CCS Chemistry[J]. 2022, 第 11 作者 通讯作者 https://www.chinesechemsoc.org/doi/full/10.31635/ccschem.022.202201901.[11] Cheng, Sidi, Luo, Yu, Yu, Ting, Li, Jing, Gan, Chunfang, 罗爽, Zhu, Qiang. Palladium-Catalyzed Four-Component Cascade Imidoyl-Carbamoylation of Unactivated Alkenes. ACS Catalysis[J]. 2022, 第 7 作者 通讯作者 12(2): 837-845, https://pubs.acs.org/doi/10.1021/acscatal.1c05319.[12] Hu, Huaanzi, Yu, Ting, Cheng, Sidi, Li, Jing, Gan, Chunfang, Luo, Shuang, Zhu, Qiang. Palladium-catalyzed tandem Heck/carbonylation/aminocarbonylation en route to chiral heterocyclic alpha-ketoamides. ORGANIC CHEMISTRY FRONTIERS[J]. 2022, 第 7 作者 通讯作者 9(4): 939-945, http://dx.doi.org/10.1039/d1qo01680f.[13] Cui, Haitao, Ban, Caijin, Zhu, Fengting, Yuan, Jingmei, Du, Juan, Huang, Yanmin, Xiao, Qi, Huang, Chusheng, Huang, Jun, Zhu, Qiang. Difluorocarbene-Triggered Acyl Rearrangement Reaction: A Strategy for the Direct Introduction of the gem-Difluoromethylene Group. ORGANIC LETTERS. 2022, 第 10 作者 通讯作者 [14] Tianxia Yang, Muhammad Ali, Lihao Lin, Ping Li, Hongju He, Qiang Zhu, Chuanlong Sun, Ning Wu, Xiaofei Zhang, Tingting Huang, Chang-Bao Li, Chuanyou Li, Lei Deng. Recoloring tomato fruit by CRISPR/Cas9-mediated multiplex gene editing. Horticulture Research[J]. 2022, 第 6 作者8: uhac214, [15] Yu, Ting, Li, ZhongQiu, Li, Jing, Cheng, Sidi, Xu, Jiali, Huang, Jun, Zhong, YuWu, Luo, Shuang, Zhu, Qiang. Palladium-Catalyzed Modular Synthesis of Enantioenriched Pyridohelicenes through Double Imidoylative Cyclization. ACS CATALYSIS[J]. 2022, 第 9 作者 通讯作者 12(20): 13034-13041, http://dx.doi.org/10.1021/acscatal.2c04461.[16] 胡华安子, Yu, Ting, Cheng, Sidi, Li, Jing, Gan, Chunfang, 罗爽, Zhu, Qiang. Palladium-Catalyzed Tandem Heck/Carbonylation/Aminocarbonylation En Route to Chiral Heterocyclic α-Ketoamides.. ORGANICCHEMISTRYFRONTIERS[J]. 2022, 第 7 作者 通讯作者 9: 939-945, https://pubs.rsc.org/en/content/articlelanding/2022/qo/d1qo01680f.[17] Luo Yu, Cheng, Sidi, Peng, Yan, Wang, Xilong, Li, Jing, Gan, Chunfang, 罗爽, Zhu, Qiang. A New Saddle-Shaped Aza Analog of Tetraphenylene: Atroposelective Synthesis and Application as a Chiral Acylating Reagent.. CCS Chemistry[J]. 2021, 第 8 作者 通讯作者 3: 3427-3435, https://www.chinesechemsoc.org/doi/10.31635/ccschem.021.202101486.[18] Teng, Fan, Yu, Ting, Peng, Yan, Hu, Weiming, Hu, Huaanzi, He, Yimiao, Luo, Shuang, Zhu, Qiang. Palladium-Catalyzed Atroposelective Coupling-Cyclization of 2-Isocyanobenzamides to Construct Axially Chiral 2-Aryl- and 2,3-Diarylquinazolinones. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2021, 第 8 作者 通讯作者 143(7): 2722-2728, https://www.webofscience.com/wos/woscc/full-record/WOS:000623246000017.[19] Hu, Huaanzi, Peng, Yan, Yu, Ting, Cheng, Sidi, Luo, Shuang, Zhu, Qiang. Palladium-Catalyzed Enantioselective 7-exo-Trig Carbopalladation/Carbonylation: Cascade Reactions To Achieve Atropisomeric Dibenzob,dazepin-6-ones. ORGANIC LETTERS[J]. 2021, 第 6 作者 通讯作者 23(9): 3636-3640, http://dx.doi.org/10.1021/acs.orglett.1c01036.[20] Liu, Kun, Chang, Xuexue, He, Yimiao, Su, Zhongfu, Huang, Yanmin, Huang, Chusheng, Lei, Jian, Zhu, Qiang. Tunable synthesis of chalcophosphinic amides and tertiary phosphinates using tert-butyl N,N-dialkylperoxyamidate. ORGANIC CHEMISTRY FRONTIERS[J]. 2021, 第 8 作者8(17): 4860-4864, http://dx.doi.org/10.1039/d1qo00542a.[21] Cheng, Sidi, Luo, Yu, Yu, Ting, Li, Jing, Gan, Chunfang, Luo, Shuang, Zhu, Qiang. Palladium-Catalyzed Four-Component Cascade Imidoyl-Carbamoylation of Unactivated Alkenes. ACS CATALYSIS. 2021, 第 7 作者 通讯作者 837-845, [22] Wang, Jian, Li, Lianjie, Chai, Minxue, Ding, Shumin, Li, Jing, Shang, Yongjia, Zhao, Haixia, Li, Dan, Zhu, Qiang. Enantioselective Construction of 1H-Isoindoles Containing Tri- and Difluoromethylated Quaternary Stereogenic Centers via Palladium-Catalyzed C-H Bond Imidoylation. ACS CATALYSIS[J]. 2021, 第 9 作者 通讯作者 11(19): 12367-12374, http://dx.doi.org/10.1021/acscatal.1c03682.[23] Ting Yu, Qiang Zhu, Shuang Luo. Pd-catalyzed imine-directed intramolecular CsbndN bond formation through C(sp3)sbndH activation: An efficient approach to multisubstituted pyrroles. TETRAHEDRON LETTERS[J]. 2020, 第 2 作者 通讯作者 61(21): http://dx.doi.org/10.1016/j.tetlet.2020.151887.[24] Yu, Ting, Zhu, Qiang, Luo, Shuang. Pd-catalyzed imine-directed intramolecular C-N bond formation through C(sp(3))-H activation: An efficient approach to multisubstituted pyrroles. TETRAHEDRON LETTERS[J]. 2020, 第 2 作者 通讯作者 61(21): https://www.webofscience.com/wos/woscc/full-record/WOS:000531102800007.[25] Teng, Fan, Peng, Yan, Wang, Xilong, Hu, Weiming, Hu, Huaanzi, He, Yimiao, Luo, Shuang, Zhu, Qiang. Pd-Catalyzed Domino Imidoylation/Heck/C(sp(2))-H Cyclization: Isocyanide Relay Strategy toward Tricyclic-Fused Heterocycles Containing an All-Carbon Quaternary Center. ORGANIC LETTERS[J]. 2020, 第 8 作者 通讯作者 22(21): 8188-8192, http://dx.doi.org/10.1021/acs.orglett.0c02503.[26] Hu, Huaanzi, Teng, Fan, Liu, Jian, Hu, Weiming, Luo, Shuang, Zhu, Qiang. Enantioselective Synthesis of 2-Oxindole Spirofused Lactones and Lactams by Heck/Carbonylative Cylization Sequences: Method Development and Applications. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2019, 第 6 作者 通讯作者 58(27): 9225-9229, https://www.webofscience.com/wos/woscc/full-record/WOS:000476691200047.[27] Teng, Fan, Hu, Weiming, Hu, Huaanzi, Luo, Shuang, Zhu, Qiang. Selective C-H or N-H Imidoylative Annulation of 2-(2-Isocyanophenyl)-1H-indoles Leading to Diverse Indole-fused Scaffolds. ADVANCED SYNTHESIS & CATALYSIS[J]. 2019, 第 5 作者 通讯作者 361(6): 1414-1418, [28] Hu, Weiming, Teng, Fan, Hu, Huaanzi, Luo, Shuang, Zhu, Qiang. Pd-Catalyzed C(sp(2))-H Imidoylative Annulation: A General Approach To Construct Dibenzoox(di)azepines. JOURNAL OF ORGANIC CHEMISTRY[J]. 2019, 第 5 作者 通讯作者 84(10): 6524-6535, https://www.webofscience.com/wos/woscc/full-record/WOS:000468696400050.[29] Makafe, Gaelle G, Hussain, Muzammal, Surineni, Goverdhan, Tan, Yaoju, Wong, NaiKei, Julius, Mugweru, Liu, Lanying, Gift, Chiwala, Jiang, Huofeng, Tang, Yunxiang, Liu, Jianxiong, Tan, Shouyong, Yu, Zhijun, Liu, Zhiyong, Lu, Zhili, Fang, Cuiting, Zhou, Yang, Zhang, Jiancun, Zhu, Qiang, Liu, Jinsong, Zhang, Tianyu. Quinoline Derivatives Kill Mycobacterium tuberculosis by Activating Glutamate Kinase. CELL CHEMICAL BIOLOGY[J]. 2019, 第 19 作者26(8): 1187-+, http://dx.doi.org/10.1016/j.chembiol.2019.05.003.[30] 朱强. Pd-Catalzed Divergent C(sp2)–H Activation/Cycloimidlylation of 2-Isocyano-2,3-diarylpropanoates. Org. Lett.. 2018, 第 1 作者 通讯作者 [31] Luo, Shuang, Xiong, Zhuang, Lu, Yongzhi, Zhu, Qiang. Enantioselective Synthesis of Planar Chiral Pyridoferrocenes via Palladium-Catalyzed Imidoylative Cyclization Reactions. ORGANIC LETTERS[J]. 2018, 第 4 作者 通讯作者 20(7): 1837-1840, https://www.webofscience.com/wos/woscc/full-record/WOS:000429886900034.[32] Sun, Hongwei, Tang, Shi, Li, Dengke, Zhou, Yali, Huang, Jinbo, Zhu, Qiang. Cascade double isocyanide insertion and C-N coupling of 2-iodo-2-isocyano-1,1-biphenyls. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2018, 第 6 作者 通讯作者 16(21): 3893-3896, https://www.webofscience.com/wos/woscc/full-record/WOS:000434260600007.[33] Tang, Shi, Yang, ShengWen, Sun, Hongwei, Zhou, Yali, Li, Juan, Zhu, Qiang. Pd-Catalyzed Divergent C(sp(2))-H Activation/Cycloimidoylation of 2-lsocyano-2,3-diarylpropanoates. ORGANIC LETTERS[J]. 2018, 第 6 作者 通讯作者 20(7): 1832-1836, https://www.webofscience.com/wos/woscc/full-record/WOS:000429886900033.[34] Zhou, Yali, Li, Dengke, Tang, Shi, Sun, Hongwei, Huang, Jinbo, Zhu, Qiang. PhI(OAc)(2)-mediated dearomative C-N coupling: facile construction of the spiroindoline-3,2 '-pyrrolidine skeleton. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2018, 第 6 作者 通讯作者 16(12): 2039-2042, https://www.webofscience.com/wos/woscc/full-record/WOS:000428808500004.[35] Hu, Huaanzi, Xie, Zeqiang, Luo, Shuang, Zhu, Qiang. Stirring-controlled mono or double aminocarbonylation of 1,3-bis(2-iodoaryl)propan-2-amines. TETRAHEDRON LETTERS[J]. 2018, 第 4 作者 通讯作者 59(11): 1034-1037, http://dx.doi.org/10.1016/j.tetlet.2018.01.092.[36] Li, Dengke, Mao, Tingting, Huang, Jinbo, Zhu, Qiang. Copper-Catalyzed Bromodifluoroacetylation of Alkenes with Ethyl Bromodifluoroacetate. JOURNAL OF ORGANIC CHEMISTRY[J]. 2018, 第 4 作者 通讯作者 83(17): 10445-10452, https://www.webofscience.com/wos/woscc/full-record/WOS:000444364600077.[37] Wang, Jian, Gao, DeWei, Huang, Jinbo, Tang, Shi, Xiong, Zhuang, Hu, Huaanzi, You, ShuLi, Zhu, Qiang. Palladium-Catalyzed Enantioselective C(sp(2))-H lmidoylation by Desymmetrization. ACS CATALYSIS[J]. 2017, 第 8 作者 通讯作者 7(6): 3832-3836, [38] Xiong, Zhuang, Wang, Jian, Wang, Yanbo, Luo, Shuang, Zhu, Qiang. Palladium-catalyzed C(sp(2))-H aminoimidoylation of isocyano-containing arenes: synthesis of amino substituted N-heterocycles. ORGANIC CHEMISTRY FRONTIERS[J]. 2017, 第 5 作者 通讯作者 4(9): 1768-1771, https://www.webofscience.com/wos/woscc/full-record/WOS:000408263400009.[39] 朱强. A one-pot synthesis of [1,2,3]triazolo[1,5- a]quinoxalines from 1-azido-2-isocyanoarenes with high bond-forming efficiency. Chem. Commun.. 2017, 第 1 作者 通讯作者 [40] Li, Dengke, Mao, Tingting, Huang, Jinbo, Zhu, Qiang. Copper-catalyzed regioselective 1,2-thioamidation of alkenes. CHEMICAL COMMUNICATIONS[J]. 2017, 第 4 作者 通讯作者 53(24): 3450-3453, https://www.webofscience.com/wos/woscc/full-record/WOS:000398999600012.[41] 朱强. Palladium-Catalyzed Enantioselective C(sp2 )−H Imidoylation by Desymmetrization. ACS Catal.. 2017, 第 1 作者 通讯作者 [42] Li, Dengke, Mao, Tingting, Huang, Jinbo, Zhu, Qiang. A one-pot synthesis of 1,2,3triazolo1,5-aquinoxalines from 1-azido-2-isocyanoarenes with high bond-forming efficiency. CHEMICAL COMMUNICATIONS[J]. 2017, 第 4 作者 通讯作者 53(7): 1305-1308, https://www.webofscience.com/wos/woscc/full-record/WOS:000394244000022.[43] Li, Dengke, Mao, Tingting, Huang, Jinbo, Zhu, Qiang. Denitrogenative Imidoyl Radical Cyclization: Synthesis of 2-Substituted Benzoimidazoles from 1-Azido-2-isocyanoarenes. ORGANIC LETTERS[J]. 2017, 第 4 作者 通讯作者 19(12): 3223-3226, https://www.webofscience.com/wos/woscc/full-record/WOS:000403854300047.[44] Tang, Shi, Wang, Jian, Xiong, Zhuang, Xie, Zeqiang, Li, Dengke, Huang, Jinbo, Zhu, Qiang. Palladium-Catalyzed Imidoylative Cyclization of Tryptophan-Derived Isocyanides: Access to beta-Carbolines. ORGANIC LETTERS[J]. 2017, 第 7 作者 通讯作者 19(20): 5577-5580, https://www.webofscience.com/wos/woscc/full-record/WOS:000413709600021.[45] Xie, Zeqiang, Peng, Jiangling, Zhu, Qiang. Copper-mediated C(sp(3))-H amination in a multiple C-N bond-forming strategy for the synthesis of N-heterocycles. ORGANIC CHEMISTRY FRONTIERS[J]. 2016, 第 3 作者3(1): 82-86, http://ir.gibh.ac.cn/handle/344009/926.[46] Xie, Zeqiang, Luo, Shuang, Zhu, Qiang. Pd-Catalyzed C(sp(2))-H carbonylation of 2-benzylpyridines for the synthesis of pyridoisoquinolinones. CHEMICAL COMMUNICATIONS[J]. 2016, 第 3 作者 通讯作者 52(87): 12873-12876, http://dx.doi.org/10.1039/c6cc07612b.[47] Wang, Jian, Tang, Shi, Zhu, Bang. Intramolecular Imidoylative Heck Reaction: Synthesis of Cyclic Ketoimines from Functionalized Isocyanide. ORGANIC LETTERS[J]. 2016, 18(13): 3074-3077, http://ir.foo.ac.cn/handle/2SETSVCV/403.[48] Qiang Zhu, Bing Wang, De-Zhi Xiong, Bao-Long Lu. Signature of Critical Point in Momentum Profile of Trapped Ultracold Bose Gases. 中国物理快报:英文版[J]. 2016, 第 1 作者16-20, http://lib.cqvip.com/Qikan/Article/Detail?id=669386598.[49] 朱强. Recent progress in imydoyl radical-involved reactions. Org. Biomol. Chem. 2016, 14, 2593-2602.. 2016, 第 1 作者 通讯作者 [50] Xie, Zeqiang, Deng, Jiaojiao, Qiu, Zhiping, Li, Juan, Zhu, Qiang. Copper-mediated C(sp(3))-H azidation with Me3SiN3: synthesis of imidazoles from ketones and aldehydes. CHEMICAL COMMUNICATIONS[J]. 2016, 第 5 作者 通讯作者 52(38): 6467-6470, http://ir.foo.ac.cn/handle/2SETSVCV/389.[51] Zhou, Yonghong, Zhu, Qiang, Salstein, David A, Xu, Xueqing, Shi, Si, Liao, Xinhao. Estimation of the free core nutation period by the sliding-window complex least-squares fit method. ADVANCES IN SPACE RESEARCH[J]. 2016, 第 2 作者57(10): 2136-2140, http://dx.doi.org/10.1016/j.asr.2016.03.028.[52] Lei, Jian, Huang, Jinbo, Zhu, Qiang. Recent progress in imidoyl radical-involved reactions. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2016, 第 3 作者 通讯作者 14(9): 2593-2602, http://ir.gibh.ac.cn/handle/344009/175.[53] Zhu, Qiang, Wang, Bing, Xiong, DeZhi, Lu, BaoLong. Signature of Critical Point in Momentum Profile of Trapped Ultracold Bose Gases. CHINESE PHYSICS LETTERS[J]. 2016, 第 1 作者33(7): 070306, http://lib.cqvip.com/Qikan/Article/Detail?id=669386598.[54] Luo, Shuang, Hu, Ziwei, Zhu, Qiang. 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Synthesis of 2-alkoxy(aroxy)-3-substitued quinolines by DABCO-promoted cyclization of ortho-alkynylaryl isocyanides. Journal of Organic Chemistry. 2010, 第 1 作者 通讯作者 [114] Zhou, Yi, Wang, Dongye, Zhu, Qiang, Gao, Xuefei, Yang, Song, Xu, Aimin, Wu, Donghai. Inhibitory Effects of A-769662, a Novel Activator of AMP-Activated Protein Kinase, on 3T3-L1 Adipogenesis. BIOLOGICAL & PHARMACEUTICAL BULLETIN[J]. 2009, 第 3 作者32(6): 993-998, http://ir.gibh.ac.cn/handle/344009/209.[115] Liu, Lanying, Wang, Yong, Wang, Honggen, Peng, Changlan, Zhao, Jiaji, Zhu, Qiang. Tetrabutylammonium chloride-triggered 6-endo cyclization of o-alkynylisocyanobenzenes: an efficient synthesis of 2-chloro-3-substituted quinolines. TETRAHEDRON LETTERS[J]. 2009, 第 6 作者 通讯作者 50(48): 6715-6719, http://dx.doi.org/10.1016/j.tetlet.2009.09.096.[116] Wang, Honggen, Liu, Lanying, Wang, Yong, Peng, Changlan, Zhang, Jiancun, Zhu, Qiang. 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Palladium-catalyzed cross-coupling reactions of 4-tosyl-2(5H)-furanone with boronic acids: A facile and efficient route to generate 4-substituted 2(5H)-furanones. JOURNAL OF ORGANIC CHEMISTRY[J]. 2003, 68(2): 670-673, https://www.webofscience.com/wos/woscc/full-record/WOS:000180540500070.[120] Liao, Y, Hu, YH, Wu, H, Zhu, Q, Donovan, M, Fathi, R, Yang, Z. Diversity oriented synthesis and branching reaction pathway to generate natural product-like compounds. CURRENT MEDICINAL CHEMISTRY[J]. 2003, 10(21): 2285-2316, https://www.webofscience.com/wos/woscc/full-record/WOS:000185946900006.[121] 朱强. Phenyliodonium Zwitterion as an Efficient Electrophile in the Palladium-Catalyzed Suzuki-type Reaction: a Novel Method for the Synthesis of 3-Aryl-4-ydroxycoumarins. ORGANICLETTERS. 2002, 第 1 作者 通讯作者 [122] 朱强. Observation and Elimination of N-Acetylation of Oligonucleotides Prepared Using Fast-Deprotection Phosphoramidites and Ultra-Mild Deprotection. Bioorganic Medicinal Chemistry Letters. 2001, 第 1 作者[123] Zhu, Q, Qiao, LX, Wu, YK, Wu, YL. Studies toward the total synthesis of clavulactone. JOURNAL OF ORGANIC CHEMISTRY[J]. 2001, 66(8): 2692-2699, http://www.irgrid.ac.cn/handle/1471x/583080.[124] Zhu, Q, Fan, KY, Ma, HW, Qiao, LX, Wu, YL, Wu, YK. Radical-mediated diastereoselective construction of a chiral synthon for synthesis of dolabellanes. ORGANIC LETTERS[J]. 1999, 1(5): 757-759, http://www.irgrid.ac.cn/handle/1471x/583052.[125] Zhu, Q, Qiao, LX, Wu, YK, Wu, YL. Radical-mediated construction of cyclopentane with concurrent formation of a well-defined quaternary center. JOURNAL OF ORGANIC CHEMISTRY[J]. 1999, 64(7): 2428-2432, http://www.irgrid.ac.cn/handle/1471x/583050.[126] Cu-Catalyzed Oxidative C(sp2)-H Cycloetherification of o-Arylphenols for the Preparation of Dibenzofurans. http://ir.gibh.ac.cn/handle/344009/145.
科研活动
科研项目
1、2008年自然科学基金主任基金 ( 20942001 ) 1项,“异腈参与的多取代喹啉的合成研究”,8万元,2009年已顺利结题。
2、2010自然科学基金面上项目“通过分子内C-H键官能化合成几类杂环化合物的新方法研究”( 21072190 ),36万元,2011年至2013年。
3、2010广州市科技计划项目“以邻炔基苯胺为原料合成几类重要的含氮杂环”( 2010Y1-C241 ),6万元,2011年。
2、2010自然科学基金面上项目“通过分子内C-H键官能化合成几类杂环化合物的新方法研究”( 21072190 ),36万元,2011年至2013年。
3、2010广州市科技计划项目“以邻炔基苯胺为原料合成几类重要的含氮杂环”( 2010Y1-C241 ),6万元,2011年。
参与会议
1、2009.8,参加中国化学会第六届有机化学学术会议
2、2009.11,参加第一届岭南有机化学论坛
3、2009.11,参加广东省药学会药物化学专业委员会
4、2010.10,参加第十六届全国金属有机化学学术讨论会
2、2009.11,参加第一届岭南有机化学论坛
3、2009.11,参加广东省药学会药物化学专业委员会
4、2010.10,参加第十六届全国金属有机化学学术讨论会
指导学生
现指导学生
彭江灵 硕士研究生 077901-药物化学
赵家冀 博士研究生 100701-药物化学