• 病原-宿主互作机制
• 病原细菌表型耐药
• 微生物亚细胞时空动态解析
• 高通量表型组学分析

2011-09--2017-07   北京大学生命科学学院   博士学位
2007-09--2011-07   北京大学生命科学学院   学士学位

   

2023-09~现在, 中国科学院微生物研究所, 研究员
2021-03~2023-08,哈佛大学公共微生物学院, 助理研究员
2017-11~2021-03,哈佛大学公共微生物学院, 博士后

   

（1） Targeted protein degradation in mycobacteria uncovers antibacterial effects and potentiates antibiotic efficacy, Nature Communications, 2024, 通讯作者
（2） Genetically encoded transcriptional plasticity underlies stress adaptation in Mycobacterium tuberculosis, Nature Communications, 2024, 第 2 作者
（3） Spatiotemporal perspectives on tuberculosis chemotherapy., Current Opinion in Microbiology, 2023, 第 1 作者
（4） Mycobacterial nucleoid-associated protein Lsr2 is required for productive mycobacteriophage infection., Nature Microbiology, 2023, 第 10 作者
（5） Peptidyl tRNA Hydrolase Is Required for Robust Prolyl-tRNA Turnover in Mycobacterium tuberculosis., mBio, 2023, 第 4 作者
（6） Transposon mutagenesis in Mycobacterium abscessus identifies an essential penicillin-binding protein involved in septal peptidoglycan synthesis and antibiotic sensitivity., ELife, 2022, 第 3 作者
（7） Tuberculosis treatment failure associated with evolution of antibiotic resilience, Science, 2022, 第 2 作者
（8） Spatiotemporal localization of proteins in mycobacteria, Cell Reports, 2021, 第 1 作者
（9） A Mycobacterial Systems Resource for the Research Community., mBio, 2021, 其他（合作组作者）
（10） ClpX is essential and activated by single-strand DNA binding protein in mycobacteria., Journal of Bacteriology, 2021, 第 5 作者
（11） Pyrazinamide triggers degradation of its target aspartate decarboxylase., Nature Communications, 2020, 第 7 作者
（12） Clinically relevant mutations in mycobacterial LepA cause rifampicin-specific phenotypic resistance., Scientific Reports, 2020, 第 2 作者
（13） Itaconyl-CoA forms a stable biradical in methylmalonyl-CoA mutase and derails its activity and repair., Science, 2019, 第 8 作者
（14） HspX promotes the polar localization of mycobacterial protein aggregates., Scientific Reports, 2019, 第 2 作者
（15） Kasugamycin potentiates rifampicin and limits emergence of resistance in Mycobacterium tuberculosis by specifically decreasing mycobacterial mistranslation., Elife, 2018, 第 10 作者
（16） Rifampicin can induce antibiotic tolerance in mycobacteria via paradoxical changes in rpoB transcription, Nature Communications, 2018, 第 1 作者
（17） The essential mycobacterial amidotransferase GatCAB is a modulator of specific translational fidelity, Nature Microbiology, 2016, 第 2 作者
（18） Protein mistranslation: friend or foe?, Trends in Biochemical Sciences, 2014, 第 3 作者