真核生物的多种生命活动，如DNA复制、基因转录、DNA损伤修复、基因组稳定性维持等，均受到表观遗传机制的调控。

染色质的动态变化调节DNA的折叠方式，是表观遗传调控的重要基础。DNA和组蛋白的分子结构、组成形式的改变能够造成

染色质结构的动态变化，并与众多表观因子（如组蛋白变体、组蛋白伴侣、组蛋白修饰酶、染色质重塑复合物、非编码RNA

等）一起调控染色质动态，确保生命活动的有序进行。本课题组致力于研究染色质动态的调控及其表观遗传功能。其主要

发现包括组蛋白变体的识别机制、"核小体编辑"的基本规律、DNA损伤修复途径的决定机制等。

　 "核小体编辑"是染色质重构复合物催化组蛋白变体H2A.Z替换常规H2A，并将H2A.Z精准定位到基因组特定区域的过程，其

功能异常与癌症等多种疾病密切相关。我们希望阐明核小体编辑的作用机制，实现核小体编辑的人工操控。细胞对DNA损伤

修复途径的决定机制对于基因组稳定性维持至关重要，DNA损伤"合成致死"效应的发现，催生了PAPR抑制剂等一线抗癌药物。

我们希望研究细胞选择不同修复途径进行DNA损伤修复的作用机制，寻找新的药物靶点用于抗癌药物的研发。

  我们将运用生物化学、生物物理学、结构生物学、酵母遗传学、单分子力谱等方法开展上述研究。

  主页：https://ibp.cas.cn/kydw_157813/cxyjqtxmhdz/201912/t20191202_5447222.html

  Email:zhouzh@ibp.ac.cn

  Tel:010-64889862

欢迎对表观遗传和蛋白质分子设计感兴趣的同学加入我们的集体！

071010-生物化学与分子生物学
071007-遗传学
071011-生物物理学

染色质结构及表观调控
结构生物学
蛋白质工程

1999-09--2003-08   中科院上海生物化学与细胞生物学研究所   理学博士
1992-09--1999-07   湖南师范大学   理学学士硕士

   

2008-09~2011-09,美国国立健康研究院癌症研究所, Research Fellow
2003-09~2008-09,美国国立健康研究院癌症研究所, Visiting Fellow

2018-08-01-2021-10-31,中国生物物理学会11届理事会, 会员工作委员会主任
2017-11-30-今,《生命科学研究》学术期刊, 编委

结构生物学技术
细胞的物理生物学
高等生物物理学

   

   

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（1） 蛋白质折叠方法学：利用氢氘交换介导的蛋白质工程富集蛋白折叠中间体及利用核磁共振进行结构研究, Protein folding protocols: Population and structure determination of hidden folding intermediates by native-state hydrogen exchange-directed protein engineering and nuclear magnetic resonance, Humana Press, 2006-02, 第 3 作者

   

（ 1 ） 组蛋白变体结构及其参与的表观遗传调控机理研究, 主持, 国家级, 2012-01--2015-12
（ 2 ） 组蛋白二聚体的动态结构及其生物学功能研究, 主持, 国家级, 2013-01--2016-12
（ 3 ） 表观遗传信息建立与解读的分子基础, 参与, 国家级, 2015-01--2016-08
（ 4 ） 染色质结构及其调控, 参与, 国家级, 2016-01--2021-12
（ 5 ） 染色质重构复合物SRCAP/SWR1介导的H2A.Z染色质组装机制研究, 主持, 国家级, 2017-01--2020-12

（1）Preferential recognition of H2A.Z-H2B by Mps3 direct DNA double-strand breaks to nuclear periphery   2017-09-06
（2）Structural basis of H2A.Z recognition by SRCAP subunit YL1   2016-07-28
（3）Structural basis of H2A.Z recognition by SRCAP chromatin-remodeling subunit YL1   Zheng Zhou   2016-05-09
（4）Structural basis of H2A.Z recognition by its chaperones   2016-04-09
（5）Structural study of H2A.Z specific histone chaperone   2014-08-04
（6）Structural basis for recognition of centromere specific histone H3 variant by nonhistone Scm3   Zheng Zhou, Hanqiao Feng, Yawen Bai   2010-03-01

已指导学生

梁小平  博士研究生  071010-生物化学与分子生物学  

潘露  博士研究生  071010-生物化学与分子生物学  

王云云  博士研究生  071010-生物化学与分子生物学  

谢晓燕  博士研究生  071010-生物化学与分子生物学  

周驹俊  博士研究生  071010-生物化学与分子生物学  

吴飞  硕士研究生  085238-生物工程  

戴亚鑫  博士研究生  071010-生物化学与分子生物学  

黄艳  博士研究生  071010-生物化学与分子生物学  

现指导学生

黄莉  博士研究生  071010-生物化学与分子生物学  

周宁  博士研究生  071010-生物化学与分子生物学  

谌姣  博士研究生  071010-生物化学与分子生物学  

周英博  硕士研究生  077802-免疫学  

史刘歆  博士研究生  071010-生物化学与分子生物学  

王龙歌  博士研究生  071010-生物化学与分子生物学  

朱浩强  博士研究生  071010-生物化学与分子生物学