1. 基于GPCR的药物发现与作用机理

2. 基于大数据与人工智能的药物-靶点的作用机理

3. 蛋白结合口袋与复合物预测

   

070302-分析化学

分析化学
生物信息学
生物化学

2007-09--2014-01   Northeastern University   研究生学历 博士学位
2003-09--2007-07   中国科学技术大学   本科学历 学士学位

   

2019-05~2020-06,Columbia University, 访问学者
2018-06~现在, 中国科学院大连化学物理研究所, 副研究员
2016-09~2018-06,中国科学院大连化学物理研究所, 助理研究员
2014-02~2016-06,Northeastern University, 博士后

   

[1] Wuxiyar Otkur, Jixia Wang, Tao Hou, Fan Liu, Renyu Yang, Yirong Li, Kaijing Xiang, Shaojun Pei, Huan Qi, Hanchen Lin, Han Zhou, Xiuli Zhang, Hailong Piao, Xinmiao Liang. Aminosalicylates target GPR35, partly contributing to the prevention of DSS-induced colitis. EUROPEAN JOURNAL OF PHARMACOLOGY. 2023, 949: http://dx.doi.org/10.1016/j.ejphar.2023.175719.
[2] Zhao, Yaopeng, Wang, Jixia, Hou, Tao, Yu, Yancheng, Zhou, Han, Han, Yang, Cheng, Junxiang, Liu, Yanfang, Wang, Chaoran, Chen, Long, Liang, Xinmiao. Design and synthesis of 2-(2,2-diarylethyl)-cyclamine derivatives as M3 receptor antagonists and functional evaluation on COPD. BIOORGANIC CHEMISTRY[J]. 2023, 131: http://dx.doi.org/10.1016/j.bioorg.2022.106308.
[3] Hui Jiang, Yanfang Liu, Chaoran Wang, Dongping Yu, Han Zhou, Xingya Xue, Xinmiao Liang. Decoloration and alkaloid enrichment of Dactylicapnos scandens extracts based on the use of strong anion-exchange resins in tandem with strong cation-exchange silica-based materials. JOURNAL OF CHROMATOGRAPHY B. 2023, 1218: http://dx.doi.org/10.1016/j.jchromb.2023.123637.
[4] Xu, Yang, Liu, Yanfang, Zhou, Han, Wang, Rong, Yu, Dongping, Guo, Zhimou, Liang, Xinmiao. A guide of column selection for two-dimensional liquid chromatography method development of natural alkaloids. TALANTA[J]. 2023, 251: http://dx.doi.org/10.1016/j.talanta.2022.123738.
[5] Minmin Li, Yuting Xiong, Yuchen Cao, Chen Zhang, Yuting Li, Hanwen Ning, Fan Liu, Han Zhou, Xiaonong Li, Xianlong Ye, Yue Pang, Jiaming Zhang, Xinmiao Liang, Guangyan Qing. Identification of tagged glycans with a protein nanopore. NATURE COMMUNICATIONS[J]. 2023, 14(1): 1-12, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10050315/.
[6] Xinwei Zhao, Tao Hou, Han Zhou, Ziling Liu, Yanfang Liu, Chaoran Wang, Zhimou Guo, Dongping Yu, Qing Xu, Jixia Wang, Xinmiao Liang. Multi-effective components and their target mechanism of Ziziphi Spinosae Semen in the treatment of insomnia. FITOTERAPIA. 2023, 171: http://dx.doi.org/10.1016/j.fitote.2023.105712.
[7] Zhao, Xinwei, Yu, Dongping, Zhou, Weijia, Yu, Long, Zhou, Han, Liu, Yanfang, Guo, Zhimou, Shen, Aijing, Han, Ziwei, Wang, Chaoran, Wang, Jixia, Liang, Xinmiao. Chemical profiling of Ziziphi spinosae semen using on-line comprehensive two-dimensional liquid chromatography-mass spectrometry based on a novel phthalic anhydride bonded stationary phase. JOURNAL OF SEPARATION SCIENCE[J]. 2023, 46(10): http://dx.doi.org/10.1002/jssc.202200704.
[8] Wei, Lai, Xiang, Kaijing, Kang, Hongjian, Yu, Yancheng, Fan, Hongjie, Zhou, Han, Hou, Tao, Ge, Yonglin, Wang, Jixia, Guo, Zhimou, Chen, Yang, Zhao, Yaopeng, Liang, Xinmiao. Development and Characterization of Fluorescent Probes for the G Protein-Coupled Receptor 35. ACS MEDICINAL CHEMISTRY LETTERS[J]. 2023, 14(4): 411-416, http://dx.doi.org/10.1021/acsmedchemlett.2c00461.
[9] Wei, HongLi, Han, Yang, Zhou, Han, Hou, Tao, Yao, YuMin, Wen, ChunMei, Wang, ChaoRan, Wang, JiXia, Shen, AiJin, Zhang, XiuLi, Li, Hao, Liu, YanFang. Isoquinoline alkaloid dimers with dopamine D1 receptor activities from Menispermum dauricum DC. PHYTOCHEMISTRY[J]. 2022, 194: http://dx.doi.org/10.1016/j.phytochem.2021.113015.
[10] Pan Wang, Xingrong Peng, Tao Hou, Fangfang Xu, Han Zhou, Yancheng Yu, Minghua Qiu, Yanfang Liu, Yaopeng Zhao, Zhimou Guo, Jixia Wang, Xinmiao Liang. Discovery and characterization of novel ATP citrate lyase inhibitors from natural products by a luminescence-based assay. CHEMICO-BIOLOGICAL INTERACTIONS. 2022, 367: http://dx.doi.org/10.1016/j.cbi.2022.110199.
[11] HongLi Wei, YaoPeng Zhao, JiXia Wang, Yang Han, Hao Li, Han Zhou, Tao Hou, ChangJian Wang, YuMin Yao, XiuLi Zhang, YanFang Liu, XinMiao Liang. Menisperdaurines A-W, structurally diverse isoquinoline alkaloids from Menispermum dauricum and their dopamine D1 receptor activities. BIOORGANIC CHEMISTRY. 2022, 127: http://dx.doi.org/10.1016/j.bioorg.2022.106027.
[12] Song, Chunying, Yu, Dongping, Jin, Gaowa, Ding, Junjie, Zhou, Han, Guo, Zhimou, Liang, Xinmiao. High-performance liquid chromatography quantitative analysis of ephedrine alkaloids in Ephedrae Herba on a perfluorooctyl stationary phase. JOURNAL OF SEPARATION SCIENCE[J]. 2022, 45(5): 1051-1058, http://dx.doi.org/10.1002/jssc.202100645.
[13] Song, Chunying, Yu, Dongping, Jin, Gaowa, Zhou, Yongzheng, Han, Ziwei, Zhou, Han, Huo, Liduo, Liu, Lijie, Guo, Zhimou, Liang, Xinmiao. Synthesis and Chromatographic Evaluation of Perfluorooctyl Stationary Phase for Separation of Basic Compounds. CHROMATOGRAPHIA[J]. 2022, 85(5): 447-454, http://dx.doi.org/10.1007/s10337-022-04152-0.
[14] Wei Si, Lele Xiong, Han Zhou, Huimin Wu, Zhe Liu, Guoqiang Liu, Yanfang Liu, Aijin Shen, Xinmiao Liang. Comprehensive characterization of ingredients in Crocus sativus L. from different origins based on the combination of targeted and nontargeted strategies. FOOD CHEMISTRY. 2022, 397: http://dx.doi.org/10.1016/j.foodchem.2022.133777.
[15] Han, Yang, Hou, Tao, Zhang, ZiHui, Wang, YaoDong, Cheng, JunXiang, Zhou, Han, Wang, JiXia, Feng, JiaTao, Liu, YanFang, Guo, ZhiMou, Liang, XinMiao. Structurally diverse isoquinoline and amide alkaloids with dopamine D2 receptor antagonism from Corydalis bungeana. FITOTERAPIA[J]. 2022, 159: http://dx.doi.org/10.1016/j.fitote.2022.105175.
[16] Han, Yang, Hou, Tao, Zhang, ZiHui, Zhu, YunHui, Cheng, JunXiang, Zhou, Han, Wang, JiXia, Feng, JiaTao, Liu, YanFang, Guo, ZhiMou, Liang, XinMiao. Corybungines A-K: Isoquinoline alkaloids from Corydalis bungeana with dopamine D2 receptor activity. PHYTOCHEMISTRY[J]. 2022, 199: http://dx.doi.org/10.1016/j.phytochem.2022.113209.
[17] Xu, Fangfang, Wang, Jun, Wang, Pan, Hou, Tao, Zhou, Han, Zhao, Yaopeng, Wang, Jixia, Liu, Yanfang, Liang, Xinmiao. Ursodesoxycholic acid is an FFA4 agonist and reduces hepatic steatosis via FFA4 signaling. EUROPEAN JOURNAL OF PHARMACOLOGY[J]. 2022, 917: http://dx.doi.org/10.1016/j.ejphar.2022.174760.
[18] Wang, Pan, Hou, Tao, Xu, Fangfang, Luo, Fengbin, Zhou, Han, Liu, Fan, Xie, Xiaomin, Liu, Yanfang, Wang, Jixia, Guo, Zhimou, Liang, Xinmiao. Discovery of Flavonoids as Novel Inhibitors of ATP Citrate Lyase: Structure-Activity Relationship and Inhibition Profiles. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES[J]. 2022, 23(18): http://dx.doi.org/10.3390/ijms231810747.
[19] Yu, Wenyi, Fu, Cai, Zhou, Han, Liu, Guoqiang, Zheng, Jinlei, Liu, Hongjiang, Li, Meng, Shen, Aijin, Liu, Yanfang, Liang, Xinmiao. Integrated strategy for identifying isoflavones in Belamcandae Rhizoma based on the combination of mass defect filtering and neutral-loss-triggered multistage fragmentation. JOURNAL OF CHROMATOGRAPHY A[J]. 2022, 1679: http://dx.doi.org/10.1016/j.chroma.2022.463379.
[20] Xiang, Kaijing, Zhou, Weijia, Hou, Tao, Yu, Long, Zhou, Han, Zhou, Liangliang, Liu, Yanfang, Wang, Jixia, Guo, Zhimou, Liang, Xinmiao. Integration of Two-Dimensional Liquid Chromatography-Mass Spectrometry and Molecular Docking to Characterize and Predict Polar Active Compounds in Curcuma kwangsiensis. MOLECULES[J]. 2022, 27(22): http://dx.doi.org/10.3390/molecules27227715.
[21] Han, Yang, Hou, Tao, Zhang, ZiHui, Wang, YaoDong, Cheng, JunXiang, Zhou, Han, Wang, JiXia, Feng, JiaTao, Liu, YanFang, Guo, ZhiMou, Liang, XinMiao. Structurally diverse isoquinoline and amide alkaloids with dopamine D2 receptor antagonism from Corydalis bungeana. FITOTERAPIA[J]. 2022, 159: http://dx.doi.org/10.1016/j.fitote.2022.105175.
[22] Wei, Lai, Hou, Tao, Li, Jiaqi, Zhang, Xiuli, Zhou, Han, Wang, Zhenyu, Cheng, Junxiang, Xiang, Kaijing, Wang, Jixia, Zhao, Yaopeng, Liang, Xinmiao. Structure-Activity Relationship Studies of Coumarin-like Diacid Derivatives as Human G Protein-Coupled Receptor-35 (hGPR35) Agonists and a Consequent New Design Principle. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2021, 64(5): 2634-2647, http://dx.doi.org/10.1021/acs.jmedchem.0c01624.
[23] Chen, Cheng, Zhang, Xiaofei, Dong, Xuefang, Zhou, Han, Li, Xiuling, Liang, Xinmiao. TiO2 Simultaneous Enrichment, On-Line Deglycosylation, and Sequential Analysis of Glyco- and Phosphopeptides. FRONTIERS IN CHEMISTRY[J]. 2021, 9: http://dx.doi.org/10.3389/fchem.2021.703176.
[24] Hou, Tao, Xu, Fangfang, Peng, Xingrong, Zhou, Han, Zhang, Xiuli, Qiu, Minghua, Wang, Jixia, Liu, Yanfang, Liang, Xinmiao. Label-free cell phenotypic study of opioid receptors and discovery of novel mu opioid ligands from natural products. JOURNAL OF ETHNOPHARMACOLOGY[J]. 2021, 270: http://dx.doi.org/10.1016/j.jep.2021.113872.
[25] Ho, Thanh C, Tius, Marcus A, Nikas, Spyros P, Tran, Ngan K, Tong, Fei, Zhou, Han, Zvonok, Nikolai, Makriyannis, Alexandros. Oxa-adamantyl cannabinoids. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS[J]. 2021, 38: http://dx.doi.org/10.1016/j.bmcl.2021.127882.
[26] Zhou, Han, Hou, Tao, Gao, Zhenhua, Guo, Xiujie, Wang, Chaoran, Wang, Jixia, Liu, Yanfang, Liang, Xinmiao. Discovery of eight alkaloids with D1 and D2 antagonist activity in leaves of Nelumbo nucifera Gaertn. Using FLIPR assays. JOURNAL OF ETHNOPHARMACOLOGY[J]. 2021, 278: http://dx.doi.org/10.1016/j.jep.2021.114335.
[27] Liu, Dian, Han, Yang, Zhou, Han, Jin, Hongli, Kang, Hongjian, Huang, FeiFei, Liu, Yanfang, Liang, Xinmiao. Offline preparative three-dimensional HPLC for systematic and efficient purification of alkaloids from Gelsemium elegans Benth. JOURNAL OF CHROMATOGRAPHY A[J]. 2021, 1640: http://dx.doi.org/10.1016/j.chroma.2021.461935.
[28] Si, Wei, Yu, Dongping, Zhou, Han, Guo, Zhimou, Lu, Shubin, Peng, Ting, Liu, Yanming, Shen, Aijin, Liu, Yanfang, Liang, Xinmiao. A strategy for efficient enrichment of steroidal alkaloids from Fritillaria based on fluorinated reversed-phase stationary phase. JOURNAL OF SEPARATION SCIENCE[J]. 2021, 44(18): 3441-3449, http://dx.doi.org/10.1002/jssc.202100379.
[29] Wei Si, Yanfang Liu, Yuansheng Xiao, Zhimou Guo, Gaowa Jin, Jingyu Yan, Aijin Shen, Han Zhou, Fan Yang, Xinmiao Liang. An offline two-dimensional supercritical fluid chromatography × reversed phase liquid chromatography tandem quadrupole time-of-flight mass spectrometry system for comprehensive gangliosides profiling in swine brain extract. TALANTA. 2020, 208: http://dx.doi.org/10.1016/j.talanta.2019.120366.
[30] Zhou, Han, Peng, Xingrong, Hou, Tao, Zhao, Nan, Qiu, Minghua, Zhang, Xiuli, Liang, Xinmiao. Identification of novel phytocannabinoids from Ganoderma by label-free dynamic mass redistribution assay. JOURNAL OF ETHNOPHARMACOLOGY[J]. 2020, 246: http://dx.doi.org/10.1016/j.jep.2019.112218.
[31] Qu, Lala, Zhang, Xiuli, Wang, Jixia, Zhou, Han, Hou, Tao, Wei, Lai, Xu, Fangfang, Liang, Xinmiao. Phenotypic assessment and ligand screening of ETA/ETB receptors with label-free dynamic mass redistribution assay. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY[J]. 2020, 393(6): 937-950, http://dx.doi.org/10.1007/s00210-019-01756-6.
[32] Wang, Rong, Liu, Yanfang, Zhou, Han, Chen, Yue, Wang, Jixia, Zhang, Xiuli, Yu, Ruitao, Liang, Xinmiao. Integration of micro-fractionation, high-performance liquid chromatography-ultraviolet detector-charged aerosol detector-mass spectrometry analysis and cellular dynamic mass redistribution assay to accelerate alkaloid drug discovery. JOURNAL OF CHROMATOGRAPHY A[J]. 2020, 1616: http://dx.doi.org/10.1016/j.chroma.2019.460779.
[33] Qu, Lala, Wang, Jixia, Hou, Tao, Zhou, Han, Wang, Zhiwei, Zhang, Xiuli, Liang, Xinmiao. Systematic characterization of AT1 receptor antagonists with label-free dynamic mass redistribution assays. JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS[J]. 2020, 102: http://dx.doi.org/10.1016/j.vascn.2020.106682.
[34] Si, Wei, Qiao, Yali, Liu, Zhe, Jin, Gaowa, Liu, Yanfang, Xue, Xingya, Zhou, Han, Liu, Yanming, Shen, Aijin, Liang, Xinmiao. Combination of multi-model statistical analysis and quantitative fingerprinting in quality evaluation of Shuang-huang-lian oral liquid. ANALYTICAL AND BIOANALYTICAL CHEMISTRY[J]. 2020, 412(26): 7073-7083, http://dx.doi.org/10.1007/s00216-020-02841-z.
[35] Xu, Fangfang, Zhao, Yaopeng, Zhou, Han, Li, Chunzhi, Zhang, Xiuli, Hou, Tao, Qu, Lala, Wei, Lai, Wang, Jixia, Liu, Yanfang, Liang, Xinmiao. Synthesis and evaluation of 3-(4-(phenoxymethyl)phenyl)propanoic acid and N-phenylbenzenesulfonamide derivatives as FFA4 agonists. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS[J]. 2020, 30(24): http://dx.doi.org/10.1016/j.bmcl.2020.127650.
[36] Du, Nana, Zhou, Weijia, Jin, Hongli, Liu, Yanfang, Zhou, Han, Liang, Xinmiao. Characterization of tropane and cinnamamide alkaloids from Scopolia tangutica by high-performance liquid chromatography with quadrupole time-of-flight tandem mass spectrometry. JOURNAL OF SEPARATION SCIENCE[J]. 2019, 42(6): 1163-1173, http://www.corc.org.cn/handle/1471x/2372653.
[37] Yan, Jingyu, Ding, Junjie, Jin, Gaowa, Duan, Zhaojun, Yang, Fan, Li, Dandi, Zhou, Han, Li, Ming, Guo, Zhimou, Chai, Wengang, Liang, Xinmiao. Profiling of Human Milk Oligosaccharides for Lewis Epitopes and Secretor Status by Electrostatic Repulsion Hydrophilic Interaction Chromatography Coupled with Negative-Ion Electrospray Tandem Mass Spectrometry. ANALYTICAL CHEMISTRY[J]. 2019, 91(13): 8199-8206, [38] Du, Nana, Si, Wei, Liu, Yanfang, Guo, Zhimou, Zhou, Weijia, Zhou, Han, Liang, Xinmiao, Wang, Chaoran. Strong electrostatic repulsive interaction used for fast and effective alkaloid enrichment from plants. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES[J]. 2019, 1105: 148-155, http://www.corc.org.cn/handle/1471x/2372875.
[39] Xu, Fangfang, Zhou, Han, Liu, Xiumei, Zhang, Xiuli, Wang, Zhiwei, Hou, Tao, Wang, Jixia, Qu, Lala, Zhang, Pengyu, Piao, Hailong, Liang, Xinmiao. Label-free cell phenotypic study of FFA4 and FFA1 and discovery of novel agonists of FFA4 from natural products. RSC ADVANCES[J]. 2019, 9(26): 15073-15083, http://dx.doi.org/10.1039/c9ra02142f.
[40] Hu, Yancheng, Yuan, Lin, Zhang, Xiuli, Zhou, Han, Wang, Pan, Li, Guangyi, Wang, Aiqin, Cong, Yu, Zhang, Tao, Liang, Xinmiao, Li, Wei, Li, Ning. Production of 1,2-Cyclohexanedicarboxylates from Diacetone Alcohol and Fumarates. ACS SUSTAINABLE CHEMISTRY & ENGINEERING[J]. 2019, 7(3): 2980-2988, http://cas-ir.dicp.ac.cn/handle/321008/166068.
[41] Liu, Dian, Jin, Hongli, Wang, Jixia, Zhou, Han, Liu, Yanfang, Feng, Jiatao, Liang, Xinmiao. Offline preparative 2-D polar-copolymerized reversed-phase chromatography x zwitterionic hydrophilic interaction chromatography for effective purification of polar compounds from Caulis Polygoni Multiflori. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES[J]. 2019, 1118: 70-77, [42] Dian Liu, Hongli Jin, Jixia Wang, Han Zhou, Yanfang Liu, Jiatao Feng, Xinmiao Liang. Offline preparative 2-D polar-copolymerized reversed-phase chromatography × zwitterionic hydrophilic interaction chromatography for effective purification of polar compounds from Caulis Polygoni Multiflori. JOURNALOFCHROMATOGRAPHYB. 2019, 1118-1119: 70-77, http://dx.doi.org/10.1016/j.jchromb.2019.04.039.
[43] Zhang Pengyu, Wang Jixia, Zhao Ying, Zhang Xiuli, Qu Lala, Wang Chaoran, Feng Jiatao, Wang Anhui, Zhou Weijia, Liu Yanfang, Hou Tao, Zhou Han, Wang Zhiwei, Liang Xinmiao. Discovery of novel antagonists on (2)-adrenoceptor from natural products using a label-free cell phenotypic assay. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY[J]. 2018, 391(12): 1411-1420, http://www.corc.org.cn/handle/1471x/2373130.
[44] Weijia Zhou, Jixia Wang, Yaopeng Zhao, Long Yu, Ye Fang, Hongli Jin, Han Zhou, Pengyu Zhang, Yanfang Liu, Xiuli Zhang, Xinmiao Liang. Discovery of β2- adrenoceptor agonists in Curcuma zedoaria Rosc using label-free cell phenotypic assay combined with two-dimensional liquid chromatography. JOURNAL OF CHROMATOGRAPHY A. 2018, 1577: 59-65, http://dx.doi.org/10.1016/j.chroma.2018.09.053.
[45] Jixia Wang, Huan Qi, Xiuli Zhang, Wei Si, Fangfang Xu, Tao Hou, Han Zhou, Anhui Wang, Guohui Li, Yanfang Liu, Ye Fang, Hailong Piao, Xinmiao Liang. Saikosaponin D from Radix Bupleuri suppresses triple-negative breast cancer cell growth by targeting β-catenin signaling. BIOMEDICINE & PHARMACOTHERAPY. 2018, 108: 724-733, http://dx.doi.org/10.1016/j.biopha.2018.09.038.
[46] Zhang, Pengyu, Wang, Jixia, Zhao, Ying, Zhang, Xiuli, Qu, Lala, Wang, Chaoran, Feng, Jiatao, Wang, Anhui, Zhou, Weijia, Liu, Yanfang, Hou, Tao, Zhou, Han, Wang, Zhiwei, Liang, Xinmiao. Discovery of novel antagonists on beta(2)-adrenoceptor from natural products using a label-free cell phenotypic assay. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY[J]. 2018, 391(12): 1411-1420, https://www.webofscience.com/wos/woscc/full-record/WOS:000448849700010.
[47] Zhou, Weijia, Wang, Jixia, Zhao, Yaopeng, Yu, Long, Fang, Ye, Jin, Hongli, Zhou, Han, Zhang, Pengyu, Liu, Yanfang, Zhang, Xiuli, Liang, Xinmiao. Discovery of beta(2)-adrenoceptor agonists in Curcuma zedoaria Rosc using label-free cell phenotypic assay combined with two-dimensional liquid chromatography. JOURNAL OF CHROMATOGRAPHY A[J]. 2018, 1577: 59-65, http://www.corc.org.cn/handle/1471x/2372969.
[48] Wang, Jixia, Qi, Huan, Zhang, Xiuli, Si, Wei, Xu, Fangfang, Hou, Tao, Zhou, Han, Wang, Anhui, Li, Guohui, Liu, Yanfang, Fang, Ye, Piao, Hailong, Liang, Xinmiao. Saikosaponin D from Radix Bupleuri suppresses triple-negative breast cancer cell growth by targeting beta-catenin signaling. BIOMEDICINE & PHARMACOTHERAPY[J]. 2018, 108: 724-733, http://cas-ir.dicp.ac.cn/handle/321008/166658.
[49] Malamas, Michael S, Raghav, Jimit Girish, Ma, Xiaoyu, Honrao, Chandrashekhar, Wood, JodiAnne T, Benchama, Othman, Zhou, Han, Mallipeddi, Srikrishnan, Makriyannis, Alexandros. Oximes short-acting CB1 receptor agonists. BIOORGANIC & MEDICINAL CHEMISTRY[J]. 2018, 26(18): 4963-4970, http://dx.doi.org/10.1016/j.bmc.2018.08.003.
[50] Liu, Yingpeng, Ji, Lipin, Eno, Marsha, Kudalkar, Shalley, Li, AiLing, Schimpgen, Marion, Benchama, Othman, Morales, Paula, Xu, Shu, Hurst, Dow, Wu, Simiao, Mohammad, Khadijah A, Wood, JodiAnne T, Zvonok, Nikolai, Papahatjis, Demetris P, Zhou, Han, Honrao, Chandrashekhar, Mackie, Ken, Reggio, Patricia, Hohmann, Andrea G, Marnett, Lawrence J, Makriyannis, Alexandros, Nikas, Spyros P. (R)-N-(1-Methyl-2-hydroxyethyl)-13-(S)-methyl-arachidonamide (AMG315): A Novel Chiral Potent Endocannabinoid Ligand with Stability to Metabolizing Enzymes. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2018, 61(19): 8639-8657, http://dx.doi.org/10.1021/acs.jmedchem.8b00611.
[51] Zhou, Weijia, Guo, Zhimou, Yu, Long, Zhou, Han, Shen, Aijin, Jin, Yan, Jin, Gaowa, Yan, Jingyu, Yang, Fan, Liu, Yanming, Wang, ChaoRan, Feng, JiaTao, Liu, Yanfang, Liang, Xinmiao. On-line comprehensive two-dimensional liquid chromatography tandem mass spectrometry for the analysis of Curcuma kwangsiensis. TALANTA[J]. 2018, 186: 73-79, http://dx.doi.org/10.1016/j.talanta.2018.04.014.
[52] Du, Nana, Liu, Yanfang, Zhang, Xiuli, Wang, Jixia, Zhao, Jianqiang, He, Jian, Zhou, Han, Mei, Lijuan, Liang, Xinmiao. Discovery of new muscarinic acetylcholine receptor antagonists from Scopolia tangutica. SCIENTIFIC REPORTS[J]. 2017, 7: http://210.75.249.4/handle/363003/6824.
[53] Zhou, Han, Peng, Yan, Halikhedkar, Aneetha, Fan, Pusheng, Janero, David R, Thakur, Ganesh A, Mercier, Richard W, Sun, Xin, Ma, Xiaoyu, Makriyannis, Alexandros. Human Cannabinoid Receptor 2 Ligand-Interaction Motif: Transmembrane Helix 2 Cysteine, C2.59(89), as Determinant of Classical Cannabinoid Agonist Activity and Binding Pose. ACS CHEMICAL NEUROSCIENCE[J]. 2017, 8(6): 1338-1347, https://www.webofscience.com/wos/woscc/full-record/WOS:000404098100024.
[54] Hua, Tian, Vemuri, Kiran, Pu, Mengchen, Qu, Lu, Han, Gye Won, Wu, Yiran, Zhao, Suwen, Shui, Wenqing, Li, Shanshan, Korde, Anisha, Laprairie, Robert B, Stahl, Edward L, Ho, JoHao, Zvonok, Nikolai, Zhou, Han, Kufareva, Irina, Wu, Beili, Zhao, Qiang, Hanson, Michael A, Bohn, Laura M, Makriyannis, Alexandros, Stevens, Raymond C, Liu, ZhiJie. Crystal Structure of the Human Cannabinoid Receptor CB1. CELL[J]. 2016, 167(3): 750-+, http://dx.doi.org/10.1016/j.cell.2016.10.004.

   

（ 1 ） G蛋白偶联受体预测结构的结合口袋开发, 负责人, 地方任务, 2023-01--2024-12
（ 2 ） 基于大数据和人工智能的药靶相互作用机理研究, 负责人, 研究所自选, 2021-01--2025-12

（1）分子模拟和AI辅助的纳米孔蛋白识别标签聚糖   第十一届(2023)国际分子模拟与人工智能应用学术会议   2023-05-06
（2）AM994-Binding Architecture of Human Cannabinoid Receptor 2 Using Ligand-Assisted Protein Structure Followed by Molecular Dynamics   2011-07-05