乳酸菌(Lactic Acid Bacteria, LAB)是一类能代谢产乳酸的细菌的总称，它们广泛应用于食品行业，也是肠道等重要的益生菌，还具备产生多种抗菌多肽的能力。因安全、耐酸及肠道定殖力等，乳酸菌还是酶及疫苗抗原良好的口服呈递载体。本研究组主要从事乳酸菌分子遗传及资源利用研究，具体包括：（1）乳酸菌生物活性产物如细菌素的生物合成、代谢调控、作用机制、结构功能等研究；（2）益生菌的益生分子机制研究；（3）肠道/生殖道及发酵食品/饲料的功能微生物组解析及调控研究；（4）功能乳酸菌及其代谢产物在健康、食品和农业等领域的应用基础研究等。

   

071007-遗传学
085238-生物工程

乳酸菌分子遗传学
乳酸菌分子遗传工程

1999-09--2003-07   北京大学生命科学学院   博士

2011-07~现在, 中科院微生物研究所, 研究员
2009-10~现在, 中科院微生物所, 课题组长
2008-12~2011-07,中科院微生物所, 副研究员
2003-09~2008-12,中科院微生物所, 助理研究员

普通生物学实验
微生物遗传与分子生物学
微生物学实验技术

（1） 全国巾帼建功标兵, , 国家级, 2021
（2） 中科院科技促进发展奖, , 院级, 2020
（3） 中科院年度人物, , 院级, 2020
（4） 《微生物学报》优秀编委, , 其他, 2020
（5） 中科院大学生命科学学院精品课程, , 院级, 2019
（6） 《微生物学报》优秀编委, 其他, 2018

[1] 张玉苗, 刘雪红, 刘龙祥, 王天威, 王君, 王燕, 尚帅, 许骥坤, 赵帅鹏, 钟瑾. 一种食叶草的组培快繁方法. CN: CN116649215A, 2023-08-29.

[2] 钟瑾, 王天威, 李黄轲轶, 张嘉琦, 滕坤玲, 邓娴, 宋显伟, 赵庆华, 曹晓风. 一种提高田菁和全株玉米混合青贮有氧稳定性的微生物添加剂及发酵方法. 202310810897.3, 2023-07-04.

[3] 钟瑾, 孙佳豪, 王天威, 石伟雄, 马翠. 一种油莎豆茎叶和油菜秸秆混合青贮的方法. CN: CN115702668A, 2023-02-17.

[4] 钟瑾, 孙佳豪, 王天威, 石伟雄, 马翠. 一种利用拉巴豆与甜高粱混合发酵制备饲料的方法. CN: CN115702669A, 2023-02-17.

[5] 钟瑾, 石伟雄, 王天威, 孙佳豪, 马翠. 一种田菁和甜高粱混合青贮的方法. CN: CN115702667A, 2023-02-17.

[6] 钟瑾. 一株可抑制致病菌和缓解便秘的唾液乳杆菌LSJ-2及其应用. 202211453978.4, 2022-11-21.

[7] 钟瑾. 一株可抑制致病菌和促排便的鼠李糖乳杆菌LRJ-1及其应用. 202211453868.8, 2022-11-21.

[8] 钟瑾, 刘亚勇, 滕坤玲, 王天威, 夏天奇. 一株产羊毛硫肽和拉索肽的地衣芽孢杆菌. CN: CN114644688A, 2022-06-21.

[9] 钟瑾, 倪奎奎, 赵晶云, 朱保葛, 苏日娜, 刘小荣, 潘毅, 吕新云, 周国安, 骆爱群, 陶勇. 一种饲用大豆与甜高粱混贮的方法. CN: CN108935972B, 2022-03-22.

[10] 钟瑾, 倪奎奎, 赵晶云, 朱保葛, 苏日娜, 刘小荣, 潘毅, 吕新云, 周国安, 骆爱群, 陶勇. 一种饲用大豆与甜高粱混贮的方法. CN: CN108935972B, 2022-03-22.

[11] 钟瑾, 王天威, 曹艳红, 骆爱群, 宣泽义. 一种复合乳酸菌剂及其在甘蔗尾叶青贮中的应用. CN: CN111534456B, 2021-12-14.

[12] 钟瑾. 一种利用拉巴豆与甜高粱混合发酵制备饲料的方法. 202110911164.X, 2021-08-09.

[13] 钟瑾. 一种油莎豆茎叶和油菜秸秆混合青贮的方法. 202110907083.2, 2021-08-09.

[14] 钟瑾. 一种田菁和甜高粱混合青贮的方法. 202110907045.7, 2021-08-09.

[15] 钟瑾. 一株产羊毛硫肽和拉索肽的地衣芽孢杆菌. 202011498305.1, 2020-12-17.

[16] 钟瑾, 王天威, 曹艳红, 骆爱群, 宣泽义. 一种发酵马蹄渣及其制备方法与应用. CN: CN111838406A, 2020-10-30.

[17] 钟瑾, 王天威, 曹艳红, 骆爱群, 宣泽义. 一种发酵罗汉果渣及其制备方法与应用. CN: CN111718879A, 2020-09-29.

[18] 钟瑾, 苏日娜, 骆爱群, 杨小盼, 刘亚勇, 王天威, 陶勇, 张杰. 一种利用发酵乳杆菌和纤维素酶制备青贮苜蓿的方法. CN: CN111434238A, 2020-07-21.

[19] 钟瑾, 骆爱群, 苏日娜, 倪奎奎, 陶勇. 一株高产阿魏酸酯酶的发酵乳杆菌及其应用. CN: CN108823131A, 2018-11-16.

[20] 钟瑾, 张丽, 王宁. 启动子增强系统及其在细菌中的应用. CN: CN108504656A, 2018-09-07.

[21] 钟瑾, 倪奎奎, 骆爱群, 苏日娜, 王天威. 一株高产阿魏酸酯酶的约氏乳杆菌及其应用. CN: CN108359624A, 2018-08-03.

[22] 董恩球, 钟瑾, 张敏, 张欣, 王天威, 滕坤玲, 陶勇, 赵煜炜. 一株具益生特性且拮抗产肠毒性大肠杆菌的罗伊氏乳杆菌及应用. CN: CN108004179A, 2018-05-08.

[23] 钟瑾, 张杰, 张彤, 芦颖. 一株卷曲乳杆菌及其应用. CN: CN107937324A, 2018-04-20.

[24] 钟瑾, 滕坤玲, 王天威, 陶勇, 宫俊杰, 张敏, 赵煜炜. 一种仔猪源解淀粉芽孢杆菌及其应用. CN: CN107723267A, 2018-02-23.

[25] 钟瑾, 葛晓璇, 滕坤玲. 一种提高乳酸菌NICE表达系统中nisin诱导效率的方法. CN: CN105950582A, 2016-09-21.

[26] 钟瑾, 赵方圆. 一种通过糖代谢调控因子提高乳链菌肽nisin产量的方法. CN: CN104387458A, 2015-03-04.

[27] 钟瑾, 王剑. 一种新型高效的羊毛硫细菌素cerecidin及其应用. CN: CN103483433A, 2014-01-01.

[28] 钟瑾, 芦颖, 陈美玲, 高涌, 滕坤玲. 一株来源于妇女生殖道产细菌素的益生乳酸菌. CN: CN102181383A, 2011-09-14.

[29] 钟瑾, 胡红梅, 孙志增, 刘家乐, 还连栋. 能与乳链菌肽结合的突变体蛋白及其编码基因与应用. CN: CN102002097A, 2011-04-06.

[30] 钟瑾, 路遥, 陈美玲, 还连栋. 乳链菌肽突变体蛋白及其编码基因与应用. CN: CN101691397A, 2010-04-07.

[31] 钟瑾, 张秋香, 还连栋. 含有重组人α－2b干扰素的重组乳酸菌及其应用. CN: CN101538572A, 2009-09-23.

[32] 钟瑾, 梁小波, 贾士芳, 孙玉芳, 陈美玲, 陈秀珠, 还连栋. 一株产生纳豆激酶的枯草芽孢杆菌. CN: CN100436576C, 2008-11-26.

[33] 钟瑾, 陈思维, 还连栋. 一种重组人胰岛素及其编码基因与应用. CN: CN101148473A, 2008-03-26.

[34] 钟瑾, 梁小波, 还连栋. 一种纳豆激酶的表达方法及其专用表达载体和工程菌. CN: CN1900289A, 2007-01-24.

[35] 钟瑾, 梁小波, 贾士芳, 孙玉芳, 陈美玲, 陈秀珠, 还连栋. 一种纳豆激酶及其编码基因与克隆和表达方法. CN: CN1814746A, 2006-08-09.

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