钟瑾-中国科学院大学-UCAS

基本信息

钟瑾女博导中国科学院微生物研究所
电子邮件： zhongj@im.ac.cn
通信地址：北京朝阳区北辰西路1号院3号
邮政编码： 100101

研究领域

乳酸菌(Lactic Acid Bacteria, LAB)是一类能代谢产乳酸的细菌的总称，它们广泛应用于食品行业，也是肠道等重要的益生菌，还具备产生多种抗菌多肽的能力。因安全、耐酸及肠道定殖力等，乳酸菌还是酶及疫苗抗原良好的口服呈递载体。本研究组主要从事乳酸菌分子遗传及资源利用研究，具体包括：（1）乳酸菌生物活性产物如细菌素的生物合成、代谢调控、作用机制、结构功能等研究；（2）益生菌的益生分子机制研究；（3）肠道/生殖道及发酵食品/饲料的功能微生物组解析及调控研究；（4）功能乳酸菌及其代谢产物在健康、食品和农业等领域的应用基础研究等。

招生信息

招生专业

071007-遗传学
085238-生物工程

招生方向

乳酸菌分子遗传学
乳酸菌分子遗传工程

教育背景

1999-09--2003-07 北京大学生命科学学院博士

工作经历

工作简历

2011-07~现在, 中科院微生物研究所, 研究员
2009-10~现在, 中科院微生物所, 课题组长
2008-12~2011-07,中科院微生物所, 副研究员
2003-09~2008-12,中科院微生物所, 助理研究员

教授课程

普通生物学实验
微生物遗传与分子生物学
微生物学实验技术

专利与奖励

奖励信息

（1）全国巾帼建功标兵, , 国家级, 2021
（2）中科院科技促进发展奖, , 院级, 2020
（3）中科院年度人物, , 院级, 2020
（4）《微生物学报》优秀编委, , 其他, 2020
（5）中科院大学生命科学学院精品课程, , 院级, 2019
（6）《微生物学报》优秀编委, 其他, 2018

专利成果

[1] 钟瑾, 王天威, 李黄轲轶, 张嘉琦, 滕坤玲, 邓娴, 宋显伟, 赵庆华, 曹晓风. 一种提高田菁和全株玉米混合青贮有氧稳定性的微生物添加剂及发酵方法. 202310810897.3, 2023-07-04.

[2] 张玉苗, 刘雪红, 刘龙祥, 王天威, 王君, 王燕, 尚帅, 许骥坤, 赵帅鹏, 钟瑾. 一种食叶草的组培快繁方法. CN: CN116649215A, 2023-08-29.

[3] 钟瑾. 一株可抑制致病菌和缓解便秘的唾液乳杆菌LSJ-2及其应用. 202211453978.4, 2022-11-21.

[4] 钟瑾. 一株可抑制致病菌和促排便的鼠李糖乳杆菌LRJ-1及其应用. 202211453868.8, 2022-11-21.

[5] 钟瑾. 一种利用拉巴豆与甜高粱混合发酵制备饲料的方法. 202110911164.X, 2021-08-09.

[6] 钟瑾, 孙佳豪, 王天威, 石伟雄, 马翠. 一种油莎豆茎叶和油菜秸秆混合青贮的方法. CN: CN115702668A, 2023-02-17.

[7] 钟瑾. 一种油莎豆茎叶和油菜秸秆混合青贮的方法. 202110907083.2, 2021-08-09.

[8] 钟瑾, 孙佳豪, 王天威, 石伟雄, 马翠. 一种利用拉巴豆与甜高粱混合发酵制备饲料的方法. CN: CN115702669A, 2023-02-17.

[9] 钟瑾. 一种田菁和甜高粱混合青贮的方法. 202110907045.7, 2021-08-09.

[10] 钟瑾, 石伟雄, 王天威, 孙佳豪, 马翠. 一种田菁和甜高粱混合青贮的方法. CN: CN115702667A, 2023-02-17.

[11] 钟瑾, 刘亚勇, 滕坤玲, 王天威, 夏天奇. 一株产羊毛硫肽和拉索肽的地衣芽孢杆菌. CN: CN114644688A, 2022-06-21.

[12] 钟瑾. 一株产羊毛硫肽和拉索肽的地衣芽孢杆菌. 202011498305.1, 2020-12-17.

[13] 钟瑾, 王天威, 曹艳红, 骆爱群, 宣泽义. 一种发酵罗汉果渣及其制备方法与应用. CN: CN111718879A, 2020-09-29.

[14] 钟瑾, 王天威, 曹艳红, 骆爱群, 宣泽义. 一种发酵马蹄渣及其制备方法与应用. CN: CN111838406A, 2020-10-30.

[15] 钟瑾, 王天威, 曹艳红, 骆爱群, 宣泽义. 一种复合乳酸菌剂及其在甘蔗尾叶青贮中的应用. CN: CN111534456B, 2021-12-14.

[16] 钟瑾, 苏日娜, 骆爱群, 杨小盼, 刘亚勇, 王天威, 陶勇, 张杰. 一种利用发酵乳杆菌和纤维素酶制备青贮苜蓿的方法. CN: CN111434238A, 2020-07-21.

[17] 钟瑾, 骆爱群, 苏日娜, 倪奎奎, 陶勇. 一株高产阿魏酸酯酶的发酵乳杆菌及其应用. CN: CN108823131A, 2018-11-16.

[18] 钟瑾, 倪奎奎, 赵晶云, 朱保葛, 苏日娜, 刘小荣, 潘毅, 吕新云, 周国安, 骆爱群, 陶勇. 一种饲用大豆与甜高粱混贮的方法. CN: CN108935972B, 2022-03-22.

[19] 钟瑾, 倪奎奎, 赵晶云, 朱保葛, 苏日娜, 刘小荣, 潘毅, 吕新云, 周国安, 骆爱群, 陶勇. 一种饲用大豆与甜高粱混贮的方法. CN: CN108935972B, 2022-03-22.

[20] 钟瑾, 倪奎奎, 骆爱群, 苏日娜, 王天威. 一株高产阿魏酸酯酶的约氏乳杆菌及其应用. CN: CN108359624A, 2018-08-03.

[21] 钟瑾, 张丽, 王宁. 启动子增强系统及其在细菌中的应用. CN: CN108504656A, 2018-09-07.

[22] 钟瑾, 张杰, 张彤, 芦颖. 一株卷曲乳杆菌及其应用. CN: CN107937324A, 2018-04-20.

[23] 董恩球, 钟瑾, 张敏, 张欣, 王天威, 滕坤玲, 陶勇, 赵煜炜. 一株具益生特性且拮抗产肠毒性大肠杆菌的罗伊氏乳杆菌及应用. CN: CN108004179A, 2018-05-08.

[24] 钟瑾, 滕坤玲, 王天威, 陶勇, 宫俊杰, 张敏, 赵煜炜. 一种仔猪源解淀粉芽孢杆菌及其应用. CN: CN107723267A, 2018-02-23.

[25] 钟瑾, 葛晓璇, 滕坤玲. 一种提高乳酸菌NICE表达系统中nisin诱导效率的方法. CN: CN105950582A, 2016-09-21.

[26] 钟瑾, 赵方圆. 一种通过糖代谢调控因子提高乳链菌肽nisin产量的方法. CN: CN104387458A, 2015-03-04.

[27] 钟瑾, 王剑. 一种新型高效的羊毛硫细菌素cerecidin及其应用. CN: CN103483433A, 2014-01-01.

[28] 钟瑾, 芦颖, 陈美玲, 高涌, 滕坤玲. 一株来源于妇女生殖道产细菌素的益生乳酸菌. CN: CN102181383A, 2011-09-14.

[29] 钟瑾, 路遥, 陈美玲, 还连栋. 乳链菌肽突变体蛋白及其编码基因与应用. CN: CN101691397A, 2010-04-07.

[30] 钟瑾, 胡红梅, 孙志增, 刘家乐, 还连栋. 能与乳链菌肽结合的突变体蛋白及其编码基因与应用. CN: CN102002097A, 2011-04-06.

[31] 钟瑾, 张秋香, 还连栋. 含有重组人α－2b干扰素的重组乳酸菌及其应用. CN: CN101538572A, 2009-09-23.

[32] 钟瑾, 陈思维, 还连栋. 一种重组人胰岛素及其编码基因与应用. CN: CN101148473A, 2008-03-26.

[33] 钟瑾, 梁小波, 还连栋. 一种纳豆激酶的表达方法及其专用表达载体和工程菌. CN: CN1900289A, 2007-01-24.

[34] 钟瑾, 梁小波, 贾士芳, 孙玉芳, 陈美玲, 陈秀珠, 还连栋. 一株产生纳豆激酶的枯草芽孢杆菌. CN: CN100436576C, 2008-11-26.

[35] 钟瑾, 梁小波, 贾士芳, 孙玉芳, 陈美玲, 陈秀珠, 还连栋. 一种纳豆激酶及其编码基因与克隆和表达方法. CN: CN1814746A, 2006-08-09.

[36] 钟瑾, 张杰, 李丽丽, 陈莹, 曾家伟, 严景华. 一株具有较强黏附能力及抑菌活性的副干酪乳酪杆菌及其应用. CN: CN118240702A, 2024-06-25.

[37] 钟瑾, 王天威, 张嘉琦, 夏天奇, 付志慧. 植物乳杆菌在苜蓿青贮发酵中的应用. CN: CN118000322A, 2024-05-10.

[38] 钟瑾, 付志慧, 王天威, 张嘉琦, 李黄轲轶, 金思杰, 刘善级, 戴绍军, 孙美红. 一种藜麦与甜高粱混合青贮的发酵方法. CN: CN117617372A, 2024-03-01.

[39] 张玉苗, 刘雪红, 刘龙祥, 王天威, 范延辉, 许卉, 许骥坤, 尚帅, 赵帅鹏, 钟瑾. 一种盐地碱蓬的组培方法. CN: CN116806700A, 2023-09-29.

[40] 钟瑾, 王天威, 李黄轲轶, 张嘉琦, 滕坤玲, 邓娴, 宋显伟, 赵庆华, 曹晓风. 一种提高田菁和全株玉米混合青贮有氧稳定性的微生物添加剂及发酵方法. CN: CN116875496A, 2023-10-13.

[41] 张玉苗, 刘雪红, 刘龙祥, 王天威, 王君, 王燕, 尚帅, 许骥坤, 赵帅鹏, 钟瑾. 一种食叶草的组培快繁方法. CN: CN116649215B, 2024-04-19.

[42] 钟瑾, 滕坤玲, 黄福青, 王玉东, 夏天奇, 张嘉琦, 孙佳豪, 顾舒婕, 刘亚勇, 李丽丽, 张杰, 王天威. 一株可抑制致病菌和缓解便秘的唾液乳杆菌及其应用. CN: CN118056896A, 2024-05-21.

[43] 钟瑾, 滕坤玲, 黄福青, 王玉东, 刘亚勇, 张嘉琦, 孙佳豪, 顾舒婕, 夏天奇, 李丽丽, 张杰, 王天威. 一株可抑制致病菌和促排便的鼠李糖乳杆菌及其应用. CN: CN115992075B, 2024-06-21.

[44] 钟瑾, 石伟雄, 王天威, 孙佳豪, 马翠. 一种田菁和甜高粱混合青贮的方法. CN: CN115702667B, 2024-03-08.

出版信息

发表论文

[1] Tianqi Xia, Muhammad Tahir, Tianwei Wang, Yudong Wang, Xiumin Zhang, Shanji Liu, Kunling Teng, Zhihui Fu, Fangfei Yun, Siyue Wang, Sijie Jin, Jiachen Hu, Jin Zhong. Lactobacillus cocktail and cellulase synergistically improve the fiber transformation rate in Sesbania cannabina and sweet sorghum mixed silage. CHEMICAL AND BIOLOGICAL TECHNOLOGIES IN AGRICULTURE[J]. 2024, 第 13 作者  通讯作者  11(1): 1-12, http://dx.doi.org/10.1186/s40538-024-00605-w.
[2] 钟瑾, 郭旭升, 邵涛, 杨富裕. 草产品加工及利用的生物学基础及研究进展. 中国科学基金[J]. 2024, 第 1 作者  通讯作者  null(null):
[3] Tianqi Xia, Fuqing Huang, Fangfei Yun, Yayong Liu, Tianwei Wang, Siyue Wang, Sijie Jin, Xingwang Ma, Wenhan Wang, Jianzhuo He, Kunling Teng, Jin Zhong. Lacticaseibacillus rhamnosus LRJ-1 alleviates constipation through promoting gut Bacteroides-derived r-aminobutyric acid production. Current Research in Food Science[J]. 2024, 第 12 作者  通讯作者  9(100924): https://www.sciencedirect.com/science/article/pii/S266592712400251X?via%3Dihub.
[4] Sijie Jin, Muhammad Tahir, Fuqing Huang, Tianwei Wang, Huangkeyi Li, Weixiong Shi, Yayong Liu, Weichun Liu, Jin Zhong. Fermentation quality, amino acids profile, and microbial communities of whole-plant soybean silage in response to Lactiplantibacillus plantarum B90 alone or in combination with functional microbes. Frontiers in Microbiology[J]. 2024, 第 9 作者  通讯作者  null(null):
[5] Li, Lili, Zhang, Jie, Zhou, Liyan, Shi, Haijuan, Mai, Hong, Su, Junchang, Ma, Xingwang, Zhong, Jin. The First Lanthipeptide from Lactobacillus iners, Inecin L, Exerts High Antimicrobial Activity against Human Vaginal Pathogens. APPLIED AND ENVIRONMENTAL MICROBIOLOGY. 2023, 第 8 作者  通讯作者  89(3): http://dx.doi.org/10.1128/aem.02123-22.
[6] Teng, Kunling, Huang, Fuqing, Liu, Yayong, Wang, Yudong, Xia, Tianqi, Yun, Fangfei, Zhong, Jin. Food and gut originated bacteriocins involved in gut microbe-host interactions. CRITICAL REVIEWS IN MICROBIOLOGY. 2023, 第 7 作者  通讯作者  49(4): 515-527, http://dx.doi.org/10.1080/1040841X.2022.2082860.
[7] Huang, Fuqing, Wang, Tianwei, Zhang, Jiaqi, Tahir, Muhammad, Sun, Jiahao, Liu, Yayong, Yun, Fangfei, Xia, Tianqi, Teng, Kunling, Wang, Jiwen, Zhong, Jin. Exploring the bacterial community succession and metabolic profiles of Lonicera japonica Thunb. residues during anaerobic fermentation. BIORESOURCE TECHNOLOGY[J]. 2023, 第 11 作者  通讯作者  367: http://dx.doi.org/10.1016/j.biortech.2022.128264.
[8] Haiwen Xu, Yanlin Xue, Na Na, Nier Wu, Yi Zhao, Lin Sun, Moge Qili, Tianwei Wang, Jin Zhong. Fermentation quality, bacterial community, and aerobic stability of ensiling Leymus chinensis with lactic acid bacteria or/and water after long-term storage. FRONTIERS IN MICROBIOLOGY[J]. 2022, 第 9 作者  通讯作者  13: https://doaj.org/article/fd95b652289446718ce74e9f65ec8576.
[9] Tianwei Wang, Jiaqi Zhang, Weixiong Shi, Jiahao Sun, Tianqi Xia, Fuqing Huang, Yayong Liu, Huangkeyi Li, Kunling Teng, Jin Zhong. Dynamic Changes in Fermentation Quality and Structure and Function of the Microbiome during Mixed Silage of Sesbania cannabina and Sweet Sorghum Grown on Saline-Alkaline Land. MICROBIOLOGY SPECTRUM[J]. 2022, 第 10 作者  通讯作者  10(5): https://doaj.org/article/6c1ca44fb73549b4b379a95a27f63d39.
[10] Jin Zhong. Repurposing the endogenous CRISPR-Cas9 system for high-efficiency genome editing in Lacticaseibacillus paracasei.. ACS SYNTHETIC BIOLOGY[J]. 2022, 第 1 作者  通讯作者
[11] 滕坤玲, 钟瑾. 益生菌产生的细菌素及其功能机制. 微生物学报[J]. 2022, 第 2 作者  通讯作者  62(3): 858-868, http://lib.cqvip.com/Qikan/Article/Detail?id=7106870819.
[12] Jin Zhong. High-throughput discovery of novel lanthipeptides and producers by metagenomic mining of isolates population (MMIP) from Chinese spicy cabbage. Food Research International[J]. 2022, 第 1 作者  通讯作者
[13] Zhang, Jie, Li, Lili, Gu, Shujie, Teng, Kunling, Ren, Jinwei, Liu, Guoxia, Zhong, Jin. Characterization of a Novel Fructosyltransferase from Lactobacillus crispatus, InuCA, That Attaches to the Cell Surface by Electrostatic Interaction. APPLIED AND ENVIRONMENTAL MICROBIOLOGY[J]. 2022, 第 7 作者  通讯作者  88(4): http://dx.doi.org/10.1128/aem.02399-21.
[14] 钟瑾. 益生菌、益生元、后生元与食物过敏. 微生物学报[J]. 2022, 第 1 作者  通讯作者
[15] 孙佳美, 刘智全, 钟瑾, 王天威, 王相权, 孙昌荣, 高树琴, 潘庆民. 云贵高原生态草牧业立体发展模式探索：以云南省永善县为例. 草业科学[J]. 2022, 第 3 作者39(2): 381-390, http://lib.cqvip.com/Qikan/Article/Detail?id=7106753832.
[16] Zhang, Jie, Li, Lili, Zhang, Tong, Zhong, Jin. Characterization of a novel type of glycogen-degrading amylopullulanase from Lactobacillus crispatus. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2022, 第 4 作者  通讯作者  106(11): 4053-4064, http://dx.doi.org/10.1007/s00253-022-11975-2.
[17] Jin Zhong. Fermentation weight loss, fermentation quality, and bacterial community of ensiling sweet sorghum with lactic acid bacterial and different silo density. Frontiers in Microbiology[J]. 2022, 第 1 作者  通讯作者
[18] Huang, Fuqing, Teng, Kunling, Liu, Yayong, Wang, Tianwei, Xia, Tianqi, Yun, Fangfei, Zhong, Jin. Nisin Z attenuates lipopolysaccharide-induced mastitis by inhibiting the ERK1/2 and p38 mitogen-activated protein kinase signaling pathways. JOURNAL OF DAIRY SCIENCE[J]. 2022, 第 7 作者  通讯作者  105(4): 3530-3543, http://dx.doi.org/10.3168/jds.2021-21356.
[19] Yang, Jing, Li, Yi, Tang, Na, Li, Juan, Zhou, Juan, Lu, Shan, Zhang, Gui, Song, Yuqin, Wang, Chao, Zhong, Jin, Xu, Jianguo, Feng, Jie. The human gut serves as a reservoir of hypervirulent Klebsiella pneumoniae. GUT MICROBES[J]. 2022, 第 10 作者14(1): http://dx.doi.org/10.1080/19490976.2022.2114739.
[20] Xia, Tianqi, Wang, Tianwei, Sun, Jiahao, Shi, Weixiong, Liu, Yayong, Huang, Fuqing, Zhang, Jiaqi, Zhong, Jin. Modulation of Fermentation Quality and Metabolome in Co-ensiling of Sesbania cannabina and Sweet Sorghum by Lactic Acid Bacterial Inoculants. FRONTIERS IN MICROBIOLOGY[J]. 2022, 第 8 作者  通讯作者  13: http://dx.doi.org/10.3389/fmicb.2022.851271.
[21] Jiahao Sun, Tianwei Wang, Fuqing Huang, Yayong Liu, Weixiong Shi, Cui Ma, Jin Zhong. Silage Fermentation: A Potential Microbial Approach for the Forage Utilization of Cyperus esculentus L. By-Product. FERMENTATION[J]. 2021, 第 7 作者7(4): https://doaj.org/article/aa5091af45764eb68d50695bfbfedcc7.
[22] Fuqing Huang, Kunling Teng, Yayong Liu, Yanhong Cao, Tianwei Wang, Cui Ma, Jie Zhang, Jin Zhong. Bacteriocins: Potential for Human Health. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY[J]. 2021, 第 8 作者  通讯作者  2021: http://dx.doi.org/10.1155/2021/5518825.
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