1. Free Radical Biology & Medicine
2. Congestive Heart Failure

September 2003 – September 2006:  Institute of Biophysics, Chinese Academy of Sciences,graduated and PhD degree awarded in September 2006,Supervisor: Prof. Baolu Zhao.

September 2000 - July 2003: The Key Laboratory of Leather Chemistry and Engineering of Ministry of Education, Sichuan University (Sichuan, P.R. China), graduated and MS degree awarded in July 2003. Supervisor: Prof. Bi Shi.

September 1996 - July 2000: Department of Leather Engineering, College of Light Industry, Sichuan University, graduated and BS degree awarded in July 2000

   

2006.9-2009.8, University of Minnesota, Postdoctoral Associate 
2009.8-2012.1, University of Minnesota, Resaerch Associate 
2012.2-present, Graduate University of Chinese Academy of Science, Professor

   

1.    Wei Feng, Tong Lei, Yue Wang, Run Feng, Juntao Yuan, Xiyue Shen, Yongguang Wu, Junling Gao, Wenjun Ding*, Zhongbing Lu*. GCN2 deficiency ameliorates cardiac dysfunction in diabetic mice by reducing lipotoxicity and oxidative stress. Free Radical Biology and Medicine. 2019, 130:128-139.

2.    Shasha Liu, Juntao Yuan, Wenhui Yue, Yanwei Bi, Xiyue Shen, Junlin Gao, Xin Xu*, Zhongbing Lu*. GCN2 deficiency protects against high fat diet induced hepatic steatosis and insulin resistance in mice. Biochimica et Biophysica Acta - Molecular Basis of Disease. 2018,1864:3257-3267.

3.    Hongyun Wang, Xiyue Shen, Guoxiong Tian, Xili Shi, Wei Huang, Yongguang Wu, Lei Sun, Can Peng, Shasha Liu, Ying Huang, Xiaoyu Chen, Fang Zhang, Yingjie Chen, Wenjun Ding*, Zhongbing Lu*. AMPKα2 deficiency exacerbates long-term PM_2.5 exposure-induced lung injury and cardiac dysfunction. Free Radical Biology and Medicine. 2018, 121:202-214.

4.    Yue Wang, Tong Lei, Juntao Yuan, Yongguang Wu, Xiyue Shen, Junling Gao, Wei Feng, Zhongbing Lu*. GCN2 deficiency ameliorates doxorubicin-induced cardiotoxicity by decreasing cardiomyocyte apoptosis and myocardial oxidative stress. Redox Biol. 2018, 17:25-34.

5.    Ting Wang, Beibei Mao^#, Chi Cheng, Zhuangzhi Zou, Junling Gao, Yanglu Yang, Tong Lei, Xiaolong Qi, Zengqiang Yuan*, Wentong Xu*, Zhongbing Lu*. Yap promotes breast cancer metastasis by repressing growth differentiation factor-15. Biochimica et Biophysica Acta - Molecular Basis of Disease. 2018, 1864:1744-1753.

6.    Yuting Guo, Huiwen Wang^#, Yinglong Tang^#, Yue Wang, Mengqi Zhang, Zhiguang Yang, Eric Nyirimigabo, Bin Wei, Zhongbing Lu*, Guangju Ji2*. Loss of eIF2α Kinase GCN2 Protects Mice from Denervation-induced Skeletal Muscle Atrophy. Protein and Cell. 2018, 9:966-970.

7.    Linlin Shi, Chenyang Zhao^#, Hongyun Wang^#, Tong lei, Shasha Liu, Jianwei Cao, Zhongbing Lu*. Dimethylarginine dimethylaminohydrolase 1 deficiency induces the epithelial to mesenchymal transition in renal proximal tubular epithelial cells and exacerbates kidney damage in aged and diabetic mice. Antioxidants & Redox Signaling. 2017;27:1347-1360.

8.    Tianhe Li, Run Feng^#, Chenyang Zhao^#, Yue Wang, Jing Wang, Shasha Liu, Jianwei Cao, Hongyun Wang, Ting Wang, Yuting Guo, Zhongbing Lu*. Dimethylarginine dimethylaminohydrolase 1 protects against high-fat diet-induced hepatic steatosis and insulin resistance in mice. Antioxidants & Redox Signaling. 2017;26:598-609.

9.    Jinxia Xu, Wei Zhang, Zhongbing Lu*, Fang Zhang, Wenjun Ding*. Airborne PM_2.5-induced hepatic insulin resistance by Nrf2/JNK-mediated signaling pathway. International Journal of Environmental Research and Public Health. 2017,14: 787.

10.  Chenyang Zhao^#, Tianhe Li^#, Bingxing Han, Wenhui Yue, Linlin Shi, Hongyun Wang, Yuting Guo, Zhongbing Lu*. DDAH1 deficiency promotes intracellular oxidative stress and cell apoptosis via a miR-21-dependent pathway in mouse embryonic fibroblasts. Free Radical Biology and Medicine. 2016;92:50-60.

11.  Hongyun Wang, Yuting Guo, Limin Liu, Longfei Guan, Ting Wang, Luyao Zhang, Yue Wang, Jianwei Cao, Wenjun Ding, Fang Zhang*, Zhongbing Lu*. DDAH1 plays dual roles in PM_2.5 induced cell death in A549 cells. Biochimica et Biophysica Acta - General Subjects. 2016, 1860:2793-801.

12.  Yuting Guo^#, Meng Jin^#, Yinglong Tang, Ting Wang, Bin Wei, Run Feng, Bing Gong, Huiwen Wang , Guangju Ji*, Zhongbing Lu*. AMP-activated kinase α2 deficiency protects mice from denervation-induced skeletal muscle atrophy. Archives of Biochemistry and Biophysics. 2016;600:56-60.

13.  Yue Wang^#, Ping Zhang^#, Zhiyu Xu, Yan Zhuang, Yingjie Chen, Zhongbing Lu*. S-nitrosylation of PDE5 increases its ubiquitin-proteasomal degradation. Free Radical Biology and Medicine. 2015;86:343-51.

14.  Yingying Xing^#, Qiaoyun Chu^#, Run Feng, Wei Wang, Lixin Liu*, Zhongbing Lu*. hCLP46 increases Smad3 protein stability via inhibiting its ubiquitin-proteasomal degradation. Protein and Cell. 2015, 6: 767–770.

15.  Xin Quan^#, Wenhui Yue^#, Yunfeng Luo, Jianwei, Cao, Hongyun Wang, Yue Wang, Zhongbing Lu^*. PRMT5 regulated Aβ induced toxicity in human cell and Caenorhabditis elegans models of Alzheimer disease. Journal of Neurochemistry. 2015, 134:969-77

16.  Yunfeng Luo^#, Wenhui Yue^#, Xin Quan, Yue Wang, Baolu Zhao, Zhongbing Lu*. Asymmetric dimethylarginine exacerbates Aβ-induced toxicity and oxidative stress in human cell and Caenorhabditis elegans models of Alzheimer disease. Free Radical Biology and Medicine. 2015, 79:117-126.

1. The Role of GCN2 in heart failure
2. The Role of DDAH1 in AD/PD disease

已指导学生

岳文慧  博士研究生  071009-细胞生物学  

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郭玉婷  硕士研究生  085238-生物工程  

赵晨阳  博士研究生  071009-细胞生物学  

李天鹤  博士研究生  071009-细胞生物学  

邢莹莹  硕士研究生  071005-微生物学  

张士伟  硕士研究生  085238-生物工程  

杨金龙  硕士研究生  085238-生物工程  

石琳琳  硕士研究生  071009-细胞生物学  

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王婷  硕士研究生  071009-细胞生物学  

曹建伟  硕士研究生  085238-生物工程  

王月  博士研究生  071009-细胞生物学  

刘莎莎  硕士研究生  071009-细胞生物学  

王红云  博士研究生  071009-细胞生物学  

吴永光  硕士研究生  085238-生物工程  

冯玮  博士研究生  071009-细胞生物学  

袁军涛  博士研究生  071009-细胞生物学  

雷桐  博士研究生  071009-细胞生物学  

沈曦月  博士研究生  071009-细胞生物学  

高俊灵  博士研究生  071009-细胞生物学  

现指导学生

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崔冰清  博士研究生  071009-细胞生物学  

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贺煜寰  硕士研究生  086000-生物与医药  

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张兵旗  硕士研究生  086000-生物与医药  

罗家俐  硕士研究生  086000-生物与医药  

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赵越  博士研究生  071009-细胞生物学  

蓝婷  博士研究生  071009-细胞生物学