-等离子体物理，应用等离子体

-生物医学，肿瘤治疗

-医疗器械

   

080803-高电压与绝缘技术
083100-生物医学工程
086000-生物与医药

2022-现在  中国科学院深圳先进技术研究院，医工所，研究员

2022-现在  国家高性能医疗器械创新中心，双聘研究员，创新研究院院长助理、先进治疗中心主任

2021-2022 国家高性能医疗器械创新中心，研究员，先进治疗中心主任

2018-2021 加州大学洛杉矶分校，机械与航空航天，博士后

2014-2017 乔治华盛顿大学，机械与航空航天，工学博士

2012-2014 夏威夷腐蚀实验室，研究助理

2011-2012 北京柏悦惠灵咨询有限公司，联合策划人

2008-2011 中国科学院力学研究所，工程力学，工学硕士

2004-2008 东北农业大学，机械设计制造及其自动化，工学学士

[8] 国家自然基金委优青青年基金（海外）

[7] 中国电工技术学会等离子体及应用专业委员会，委员

[6] 中国生物医学工程学会生物电磁学分会, 委员

[5] 中国电工技术学会生物电工专业委会，委员

[4] 中国技术市场协会医疗器械科技创新专业委员会，常务委员

[3]  IEEE Senior Member

[2] 深圳市青年科技人才协会，理事

[1] BMEMat期刊, 青年编委

论文：

[60] Hao Chen, Xianzhe Tang, Yueye Huang, Chen Chen, Yuheng Yang, Chaojie Hao, Wenqi Xie, Tingjing Huang, Xiaofeng Cheng, Qingnan Xu, Shicong Huang, Zhi Ye, Xucong Lin, Zhaowei Chen*, Zhitong Chen*, Remodel the Perifollicular Microenvironment via Minoxidil-loaded Microneedle Patch and Cold Atmospheric Plasma for Treating Androgenetic Alopecia, Nano Research 17(7) (2024) 6411-6419

[59] Fan Bai#, Yueyang Deng#, Long Li, Ming Lv, Jamoliddin Razzokov, Qingnan Xu, Zhen Xu, Zhaowei Chen, Guojun Chen*, Zhitong Chen*, Advancements and Challenges in Brain Cancer Therapeutics, Exploration 20230177, 2024

[58] Yueye Huang#, Rui Zhang#, Xiao Chen, Fei Cao, Qiujie Fang, Qingnan Xu, Shicong Huang, Yufan Wang, Guojun Chen*, Zhitong Chen*, Cold plasma with zirconia nanoparticles for lung cancer via TGF-β signaling pathway, arXiv:2408.11838 (2024)

[57] Yuanchi Zhang, Cairong Li, Along Guo, Jie Gu, Jiaxin Liao, Ben Liu, Yanmei Zhou, Yipei Yang, Zhitong Chen, Wei Zhang, Ling Qin, Yuxiao Lai*, Black phosphorus boosts wet-tissue adhesion of composite patches by enhancing water absorption and mechanical properties, Nature Communications 15 (2024) 1618

[56] Xiaona Cao, Tianxu Fang, Mo Chen, Tianqin Ning, Jianyu Li, Peter Siegel, Morag Park, Zhitong Chen, Guojun Chen*, Trehalose Enhanced Cold Atmospheric Plasma-Mediated Cancer Treatment, Biomaterials 309 (2024) 122582

[55] Xiao Xu#, Wenqi Xie#, Ting Wu#, Chen Chen, Xiaoning Chen, Yuheng Yang, Hao Lian, Hao Chen, Xiaofeng Cheng, Zhitong Chen, Guojun Chen, Chaoqun Liu, Yu He, Zhaowei Chen*, Bernard P. Binks*, Huanghao Yang*, Bacterial Microcompartment-Mimicking Pickering Emulsion Droplets for Detoxification of Chemical Threats under Sweet Conditions, Science China Chemistry 67 (2024) 3039–3049

[54] Tian Zhou*, Yue Zhong, Shoujun Yu, Ruibing Sun, Zhenwei Zhang, Xiaoyan Du, Simon Ming Yuen Lee, Zhitong Chen, Yuxiao Lai, Bing Song*, Yiming Zheng*, Zhen Xu*, Gamma-type immunoglobulin enhances phagocytosis of amyloid-beta fibrils by microglia, Neural Regeneration Research 2024

[53] 卢新培, 罗婧怡, 聂兰兰, 刘大伟, 张冠军, 刘定新, 邵涛, 方志, 金珊珊, 赵亚军, 张远涛, 邹亮, 王晓龙, 李和平, 张宇, 刘东平, 杨德正, 陈支通, 黄青, 程诚, 吴淑群, 刘巧珏, 裴学凯, 闫旭, 程鹤, 熊青, 石琦, 宋珂, 曹颖光, 陈宏翔, 冯爱平, 夏育民, 白帆, 杨春俊, 杨润功, 何光源，等离子体医学研究进展，高电压技术 50 (2024) 3555-3579

[52] Mukhammadali Niyozaliev, Jakhongir Matyakubov, Davronjon Abduvokhidov, Pankaj Attri, Zhitong Chen, Jamoliddin Razzokov*, Unraveling the Influence of Nitration on Pore Formation Time in Electroporation of Cell Membranes: A Molecular Dynamics Simulation Approach, Journal of Physics D: Applied Physics 57 (2024) 285202

[51] Xiaojiao Zhang, Yinglong Li, Ruonan Ma, Zhitong Chen, Ruixue Wang*, Zuomin Wang*, The Biosafety of Periodontal Ligament Fibroblasts Induced by Cold Atmospheric Plasma in vitro: Cytotoxicity, Genotoxicity and Mechanisms, Plasma Chemistry and Plasma Processing 44 (2024) 1635–1653

[50] Huiyan Wang, Yuchen Liu, Shuang Xue, Pengcheng Xie, Jianyun He, Olga Koval, Zhitong Chen, Ruixue Wang*, Silicon Oxide Anticorrosion Coating Deposition on Alloy Steel Surface by Low Temperature Plasma, Surface & Coatings Technology 477 (2024) 130338

[49] Tianxu Fang, Xiaona Cao, Bingzheng Shen, Zhitong Chen*, Guojun Chen*, Injectable Cold Atmospheric Plasma-Activated Immunotherapeutic Hydrogel for Enhanced Cancer Treatment, Biomaterials 300 (2023) 122189

[48] Zhitong Chen#,*, Richard Obenchain#, Richard E. Wirz*, Cold plasma treatment for biomedical applications: using aluminum foam to reduce risk while increasing efficacy, arXiv preprint arXiv: 2305.18349 (2023)

[47] Fan Bai, Yingjie Lu, Yujie Zhi, Yueye Huang, Long Li, Jiaoxiao Luo, Jamoliddin Razzokov, Olga Koval, Maksudbek Yusupov, Guojun Chen, Zhitong Chen*, Air cold atmospheric plasma with patterns for anaplastic squamous cell carcinoma treatment, arXiv preprint arXiv: 2304.10380 (2023)

[46] Guiqiang Wang, Dehua Kong, Wei Tang, Jie Fang, Zhitong Chen*, Mechanisms and safety of air plasma inactivated SARS-CoV-2, arXiv preprint arXiv:2304.02470 (2023)

[45] Dongling Jia*, Yifan Zhang, Yimin Xie, Xue Zhang, Hongzhi Pan*, Zhitong Chen*, Ni2P nanocrystallines anchored on black phosphorus nanosheets enable highly selective and sensitive non-enzymatic electrochemical detection of L-cysteine over glutathione, Sensors and Actuators B: Chemical 377 (2023) 133095

[44] Shoujun Yu, Wenji Yue, Yue Ruan, Peng Dong, Zhitong Chen, Simon Ming-yuen Lee, Bing Song, Hao Wang*, Qualitative analysis of instability on electrical nerve stimulation based on circuit-probability theory (基于电路-概率理论的对神经电刺激不稳定性的定性分析). Journal of Integration Technology 12(2) (2023) 20-28

[43] Wenji Yue, Shoujun Yu, Yue Ruan, Peng Dong, Zhitong Chen, Bing Song, Hao Wang*, Shaking pulse generator based on programmable triboelectric nanogenerators (基于可编程摩擦电原理的晃动式脉冲发生器). Journal of Integration Technology 12(2) (2023) 64-74

[42] Jamoliddin Razzokov, Sunnatullo Fazliev, Dinora Erkinova, Shavkat Mamatkulov, Zhitong Chen, Understanding the effect of nitrosylation on dynamics of human epidermal growth factor: a µs simulation study, Journal of Physics D: Applied Physics 55 (47) (2022) 475201

[41] Jamoliddin Razzokov, Sunnatullo Fazliev, Akbar Kodirov, Pankaj Attri, Zhitong Chen, Masaharu Shiratani, Mechanistic Insight into Permeation of Plasma-Generated Species from Vacuum into Water Bulk, International Journal of Molecular Sciences 23 (2022) 6330

[40] Yingjie Lu#, Huanyu Song#, Fan Bai, Long Li, Qiu Wang, Guojun Chen, Zhitong Chen*, Cold atmospheric plasma for cancer treatment: molecular and immunological mechanisms, IEEE Transactions on Radiation and Plasma Medical Sciences 6(8) (2022) 916

[39] Zhitong Chen#, Guojun Chen#, Richard Obenchain, Rui Zhang, Tianyu Tang, Zhuo Chen, Richard E. Wirz*, Zhen Gu*, Cold atmospheric plasma delivery for biomedical applications, Materials Today, 54 (2022) 153-188

[38] Zhitong Chen, Fan Bai, Steven J. Jonas*, Richard E. Wirz*, Cold Atmospheric Plasma for addressing the COVID-19 pandemic, Plasma Processes and Polymers, 19(9) (2022) e2200012

[37] Rongguang Xu*, Zhitong Chen*, Peijian Chen*, Guangjian Peng*, Mechanical Properties of Advanced Multifunctional Coatings, Coatings 12 (2022) 599

[36] Zhitong Chen*, Pankaj Attri*, Qiu Wang*, Special Issue on “Advances in Plasma Diagnostics and Applications, Processes 10 (2022) 654

[35] Zhitong Chen*, Cold atmospheric plasma activated deionized water using helium, argon, and nitrogen as feeding gas for cancer therapy, arXiv:2203.06121 (2022)

[34] Guojun Chen#, Zhitong Chen#, Zejun Wang, Richard Obenchain, Di Wen, Hongjun Li, Richard Wirz*, Zhen Gu*, Portable air-fed cold atmospheric plasma device for postsurgical cancer treatment. Science Advances, 7 (2021) eabg5686

[33] Mengzhe Li, Zhikai Wang, Rong-Guang Xu, Xiaoliang Zhang, Zhitong Chen*, Qiu Wang*, Advances in plasma-assisted ignition and combustion for combustors of aerospace engines, Aerospace Science and Technology, 117 (2021) 106952

[32] Angelica Ottaviano, Anirudh Thuppul, John Hayes, Christopher A. Dodson, Gary Z Li, Zhitong Chen, Richard E. Wirz, In situ microscopy for plasma erosion of complex surfaces， Review of Scientific Instruments, 92 (2021) 073701

[31] Hui Zheng, Peijian Chen*, Zhitong Chen*, Cold-atmospheric-plasma–induced skin wrinkle, Europhysics Letters, 133 (2021) 15001

[30] Zhitong Chen*#, Richard Obenchain#, Richard Wirz*, Tiny cold atmospheric plasma jet for biomedical applications, Processes, 9 (2021) 249

[29] Zhitong Chen*, Effect of He Self-organized pattern plasma-activated media with different conductivity on cancer cells, arXiv:2111.01793 (2021)

[28] Wang Guo, Peijian Chen, Hao Liu, Yugui Yang, Guangjian Peng, Zhitong Chen, On the strength and interfacial properties of square wave joints with defects and mismatches, The Journal of Adhesion, 97(13) (2021) 1211-1233

[27] Guojun Chen#, Zhitong Chen#, Di Wen, Zejun Wang, Hongjun Li, Yi Zeng, Gianpietro Dotti, Richard Wirz*, Zhen Gu*, Transdermal cold atmospheric plasma-mediated immune checkpoint blockade therapy, Proceedings of the National Academy of Sciences, 117.7 (2020) 3687–3692

[26] Zhitong Chen, Gustavo Garcia Jr, Vaithilingaraja Arumugaswami*, Richard E. Wirz*, Cold atmospheric plasma for SARS-CoV-2 Inactivation, Physics of Fluids, 32 (2020) 111702

[25] Zhitong Chen, Rongguang Xu, Peijian Chen, Guangjian Peng, Qiu Wang*, Potential agricultural and biomedical applications of cold atmospheric plasma-activated liquids with self-organized patterns formed at the interface, IEEE Transactions on Plasma Science, 48 (2020) 3455-3471

[24] Guangjian Peng, Guijing Dou, Yahao Hu, Yiheng Sun, Zhitong Chen*, Phase change material (PCM) microcapsules for thermal energy storage, Advances in Polymer Technology, 2020 (2020) 9490873

[23] Zhitong Chen, Richard Wirz, Cold atmospheric plasma for COVID-19, (2020), doi: 10.20944/preprints202004.0126.v1

[22] Peijian Chen*, Juan Peng, Zhitong Chen, Guangjian Peng, On the interfacial behavior of a piezoelectric actuator bonded to a homogeneous half plane with an arbitrarily varying graded coating, Engineering Fracture Mechanics 220 (2019) 106645

[21] Zhitong Chen*, Cold atmospheric plasma with self-organized patterns for cancer therapy, Frontiers in Nanoscience and Nanotechnology 5 (2019) 1-4.

[20] Guangjian Peng, Qi Yan, Peijian Chen, Zhitong Chen*, Taihua Zhang*, Effect of Forced Air Cooling on the Microstructures, Tensile Strength, and Hardness Distribution of Dissimilar Friction Stir Welded AA5A06-AA6061 Joints, Metals, 9 (2019) 304

[19] Zhitong Chen, Guangjian Peng*, Peijian Chen, Yuan Xia, Guang Li*, Investigation of the tribological behavior of chromium aluminum silicon nitride coatings via both scratch sliding test and FEM simulation, AIP Advances, 9 (2019) 025116

[18] Wentong Li, Hongli Yu, Dejun Ding, Zhitong Chen*, Yonghong Wang, Saisai Wang, Xujing Li, Michael Keidar*, Weifen Zhang*, Cold atmospheric plasma and iron oxide-based magnetic nanoparticles for synergetic lung cancer therapy, Free Radical Biology & Medicine, 130 (2019) 71–81

[17] Juan Peng, Zhengjin Wang, Peijian Chen*, Feng Gao, Zhitong Chen, Yugui Yang, Surface contact behavior of an arbitrarily oriented graded substrate with a spatially varying friction coefficient, International Journal of Mechanical Sciences, 151 (2019) 410–423

[16] Rongguang Xu*, Zhitong Chen*, Michael Keidar, Yongsheng Leng, The impact of radicals in cold atmospheric plasma on the structural modification of gap junction: a reactive molecular dynamics study, International Journal of Smart and Nano Materials, 10 (2019) 144-155

[15] Guangjian Peng, Yi Ma, Yong Huan, Weifeng Jiang, Zhitong Chen*, Taihua Zhang*, Nanoindentation hardness distribution and strain field and fracture evolution in dissimilar friction stir-welded AA 6061-AA 5A06 aluminum alloy joints, Advances in Materials Science and Engineering, 2018(2018) 4873571. 

[14] Zhitong Chen*, Li Lin, Qinmin Zheng, Jonathan H. Sherman, Jerome Canady, Barry Trink, Michael Keidar*, Micro-Sized Cold Atmospheric Plasma Source for Brain and Breast Cancer Treatment, Plasma Medicine, 8(2) (2018)203–215

[13] Zhitong Chen*, Shengxi Li, Lloyd Hihara*. Electrochemical and mechanical behaviors of dissimilar friction stir welding between 5086 and 6061 aluminum alloy, arXiv:1802.03460 (2018)

[12] Zhitong Chen*, Li Lin, Eda Gjika, Michael Keidar*, Selective treatment of pancreatic cancer cells by plasma-activated saline solutions, IEEE Transactions on Radiation and Plasma Medical Sciences, 2 (2018) 116-120

[11] Zhitong Chen, Shiqiang Zhang, Igor Levchenko, Isak. I. Beilis, Michael Keidar*, In vitro demonstration of cancer inhibiting properties from stratified self-organized plasma-liquid interface, Scientific Reports, 7 (2017)12163

[10] Zhitong Chen, Hayk Simonyan, Xiaoqian Cheng, Eda Gjika, Li Lin, Jerome Canady, Jonathan H. Sherman, Colin Young*, Michael Keidar*, A novel micro cold atmospheric plasma device for glioblastoma both in vitro and in vivo, Cancers 9(2017)61

[9] Zhitong Chen*, Xiaoqian Cheng, Li Lin, Michael Keidar*, Cold atmospheric plasma discharged in water and its potential use in cancer therapy, Journal of Physics D: Applied Physics 50 (2017), 015208

[8] Zhitong Chen*, Li Lin, Xiaoqian Cheng, Eda Gjika, Michael Keidar*, Effects of cold atmospheric plasma generated in deionized water in cell cancer therapy, Plasma Processes and Polymers, 13 (2016) 1151–1156

[7] Zhitong Chen*, Li Lin, Xiaoqian Cheng, Eda Gjika, Michael Keidar*, Treatment of gastric cancer cells with non-thermal atmospheric plasma generated in water, Biointerphases, 11 (2016) 031010

[6] Zhitong Chen*, Shengxi Li, Lloyd Hihara*. Microstructure, Mechanical Properties and Corrosion of Friction Stir Welded 6061 Aluminum Alloy, arXiv:1511.05507 (2015).

[5] Biao Feng*, Zhitong Chen. Tribology behavior during indentation and scratch of thin films on substrates: effects of plastic friction, AIP Advances 5 (2015) 057152

[4] Zhitong Chen*, Shengxi Li, Kaimiao Liu, Lloyd Hihara*. A Study on The Mechanical Property and Corrosion Sensitivity of An AA 5086 Friction Stir Welded Joint, arXiv:1511.04990 (2015).

[3] Zhitong Chen, Guangjian Peng, Yuan Xia, Guang Li*. Effect of Si content on thermal stability of CrAl(Si)N coatings, Applied Mechanics and Materials. 799-800 (2015) 448-451.

[2] Zhitong Chen, Guang Li*, Yuan Xia*. Friction coefficient and error test via micro-rotation mechanics model, Theoretical and Applied Mechanics Letters 2 (2012) 021007

[1] Zhitong Chen, Guang Li*, Zhenqiang Wu, Yuan Xia*. The crack propagating behavior of composite coatings prepared by PEO on aluminized steel during in situ tensile processing, Materials science and engineering A, 528 (2011) 1409-1414

 

书与章节：

[5] Rong-Guang Xu, Zhitong Chen, Peijian Chen, Guangjian Peng, Mechancial Properties of Advanced Multifunctional Coatings, MDPI, 2023

[4] Zhitong Chen, Pankaj Attri, Qiu Wang, Advances in Plasma Diagnostics and Applications, MDPI, 2022

[3] Zhitong Chen, Richard Wirz, Cold Atmospheric Plasma (CAP) Technologies and Applications, Springer, 2021

[2] Davronjon Abduvokhidov, Zhitong Chen, Jamoliddin Razzokov, Computer Simulation Studies of Non-Thermal Plasma in Cancer Treatment: Understanding Protein Modifications for Enhanced Therapeutic Efficacy, Pages 97-112, IGI Global 2024 （章节）

[1] Tianyu Tang, Yingjie Lu, Fan Bai, Rong-Guang Xu, Zhitong Chen*, Cold Atmospheric Plasma for Biomedical and Agricultural Applications, Springer, 2023 （章节）

 

授权专利：

[5] 陈支通, 唐天宇, 白帆, 一种等离子体手术刀及其操作方法, 202111642517 .7

[4] Michael Keidar, Zhitong Chen, Xiaoqian Cheng, Li Lin, Compositions for treatment of cancer, methods and systems for forming the same, US11771770B2

[3] Zhitong Chen, Jerome Canady, Michael Keidar, System and method for micro-sized cold atmospheric plasma treatment, US11617610B2

[2] Zhitong Chen, Michael Keidar, Jerome Canady, System and method for treating cancer through DNA damage with cold atmospheric plasma with self-organized patterns, US10772671B2

[1] Jerome Canady, Michael Keidar, Zhitong Chen, Plasma-activated saline solutions and method of making plasma activated saline solutions, US10770271B2

‍‍[11] 深圳市科技重大专项，等离子体肿瘤适形低温消融系统的研发，起止日期：2024-2026，项目负责人

[10] 深圳市医学研究专项，等离子体对肿瘤微环境免疫编辑机制及其临床应用研究，起止日期：2024-2027，双PI

[9] 国家自然科学基金优青青年基金（海外），等离子体癌症治疗，起止日期：2023-2025，主持

[8] 国家重点研发计划政府间项目，开发新型等离子体免疫疗法用于肺肿瘤治疗，起止日期：2023-2024，主持

[7] 工业和信息化部揭榜挂帅项目，人造血管用体内植入聚氨酯材料的研发及其产业化，起止日期：2023-2025，参与

[6] 深圳科技创新委员会，深圳市医疗器械中小试基地，起止日期：2023-2025，参与

[5] 稳健医疗横向课题，等离子体消毒灭菌，起止日期：2022-2026，主持

[4] 广东省基础与应用基础研究基金，微创等离子体免疫治疗，起止日期：2022-2024，主持

[3] 深圳市工业和信息化产业发展专项资金，心脑血管介入器械关键原材料镍钛形状记忆合金成型工艺研发及国产化，起止日期：2022-2024，参与

[2] 美国空军科学研究局，原位诊断等离子体与材料相互作用，起止日期：2018-2022，参与

[1] 美国科学基金，探索大气压冷等离子体物理，起止日期：2015-2018，参与‍‍