1. 酶化学生物学与合成生物学、酶学与酶工程、细胞色素P450酶

2. 低碳分子酶催化

3. 生物质酶催化转化

4. 酶制剂污染物处理

071010-生物化学与分子生物学
071005-微生物学

酶学与酶工程
生物催化与生物转化
酶模拟与仿生催化

2006-04--2009-03   日本熊本大学   理学博士
2005-10--2006-03   日本熊本大学   日本政府奖学金留学生
1999-08--2002-06   延边大学   理学硕士
1995-08--1999-07   延边大学   学士

   

生物化学与分子生物学前沿
延边大学化学前沿讲座
山东大学生命科学学院，酶与生物催化：从化学角度对金属酶的理性设计
海洋大学生命科学菁英班“生物能源前沿”

   

（1） 聚能英才奖教金, 研究所（学校）, 2023
（2） 青岛市科学技术奖自然科学二等奖, 二等奖, 市地级, 2022
（3） 第四批青岛市创新领军人才, , 市地级, 2018
（4） 中科院青岛生物能源所清源聚能奖教金, 研究所（学校）, 2018
（5） 四面体杂志年度十佳审稿人, 其他, 2012
（6） 日本政府奖学金, 国家级, 2005

[1] 丛志奇, 秦相全, 姜谊平. 一种激活酶催化反应的二肽双功能小分子化合物及其应用. CN: CN115073550A, 2022-09-20.
[2] 丛志奇, 马娜娜, 陈杰, 刘传飞. 一种人工光酶全细胞生物催化剂及其制备方法与应用. CN: CN115181713A, 2022-10-14.
[3] 丛志奇, 孔繁慧, 陈杰, 刘传飞. 一种催化靛蓝生物合成的P450突变酶. CN: CN115109758A, 2022-09-27.
[4] 丛志奇, 陈杰, 刘传飞. 一种催化乙苯等烷基苯及衍生物羟化的突变体及其应用. CN: CN113106074A, 2021-07-13.
[5] 丛志奇, 王曦翎, 姚富泉, 马娜娜, 陈杰, 刘传飞. 一种细胞色素P450BM3氧化酶突变体及其制备方法和应用. CN: CN112760298A, 2021-05-07.
[6] 丛志奇, 赵盼霞, 陈杰, 刘传飞, 马娜娜. 一种催化苯乙烯及其衍生物制备手性有机化合物的方法. CN: CN113106139A, 2021-07-13.
[7] 丛志奇, 陈杰, 陈置丰, 刘传飞. 一种协同选择性催化甲苯及类似物羟化的突变体及其应用. CN: CN113106073A, 2021-07-13.
[8] 丛志奇, 陈杰, 马娜娜, 陈置丰. 一种激活酶催化反应的双功能小分子化合物及其应用. CN: CN110128364A, 2019-08-16.
[9] 尹炳柱, 张春波, 丛志奇. 新型二介晶结构液晶化合物及合成方法. CN: CN1810924A, 2006-08-02.

   

[1] Fan, Shengxian, Cong, Zhiqi. Emerging strategies for modifying cytochrome P450 monooxygenases into peroxizymes.. Accounts of Chemical Research[J]. 2024, 第 2 作者  通讯作者  https://doi.org/10.1021/acs.accounts.3c00746.
[2] Zhao, Panxia, Jiang, Yiping, Wang Qian, Chen Jie, Yao Fuquan, Cong, Zhiqi. Crucial gating residues govern the enhancement of peroxygenase activity in an engineered cytochrome P450 O-demethylase†. Chemical Science[J]. 2024, 第 6 作者  通讯作者  https://pubs.rsc.org/en/content/articlelanding/2024/sc/d4sc02418d.
[3] Zhao, Panxia, Kong, Fanhui, Jiang, Yiping, Qin, Xiangquan, Tian, Xiaoxia, Cong, Zhiqi. Enabling Peroxygenase Activity in Cytochrome P450 Monooxygenases by Engineering Hydrogen Peroxide Tunnels. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2023, 第 6 作者  通讯作者  http://dx.doi.org/10.1021/jacs.3c00195.
[4] Wang, Xiling, Lin, Xiaodan, Jiang, Yiping, Qin, Xiangquan, Ma, Nana, Yao, Fuquan, Dong, Sheng, Liu, Chuanfei, Feng, Yingang, Jin, Longyi, Xian, Mo, Cong, Zhiqi. Engineering Cytochrome P450BM3 Enzymes for Direct Nitration of Unsaturated Hydrocarbons. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2023, 第 12 作者  通讯作者  62(13): https://www.doi.org/10.1002/anie.202217678.
[5] Chen, Jie, Dong, Sheng, Fang, Wenhan, Jiang, Yiping, Chen, Zhifeng, Qin, Xiangquan, Wang, Cong, Zhou, Haifeng, Jin, Longyi, Feng, Yingang, Wang, Binju, Cong, Zhiqi. Regiodivergent and Enantioselective Hydroxylation of C-H bonds by Synergistic Use of Protein Engineering and Exogenous Dual-Functional Small Molecules. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2023, 第 12 作者  通讯作者  62(4): e202215088, 
[6] Qin, Xiangquan, Jiang, Yiping, Yao, Fuquan, Chen, Jie, Kong, Fanhui, Zhao, Panxia, Jin, Longyi, Cong, Zhiqi. Anchoring a Structurally Editable Proximal Cofactor-like Module to Construct an Artificial Dual-center Peroxygenase. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2023, 第 8 作者  通讯作者  http://dx.doi.org/10.1002/anie.202311259.
[7] Qin, Xiangquan, Jiang, Yiping, Chen, Jie, Yao, Fuquan, Zhao, Panxia, Jin, Longyi, Cong, Zhiqi. Co-Crystal Structure-Guided Optimization of Dual-Functional Small Molecules for Improving the Peroxygenase Activity of Cytochrome P450BM3. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES[J]. 2022, 第 7 作者  通讯作者  23(14): 
[8] Di, Siyu, Fan, Shengxian, Jiang, Fengjie, Cong, Zhiqi. A Unique P450 Peroxygenase System Facilitated by a Dual-Functional Small Molecule: Concept, Application, and Perspective. ANTIOXIDANTS[J]. 2022, 第 4 作者  通讯作者  11(3): http://dx.doi.org/10.3390/antiox11030529.
[9] Kong, Fanhui, Chen, Jie, Qin, Xiangquan, Liu, Chuanfei, Jiang, Yiping, Ma, Li, Xu, Huifang, Li, Shengying, Cong, Zhiqi. Evolving a P450BM3 Peroxygenase for the Production of Indigoid Dyes from Indoles. CHEMCATCHEM[J]. 2022, 第 9 作者  通讯作者  14(24): 
[10] Mahor, Durga, Cong, Zhiqi, Weissenborn, Martin J, Hollmann, Frank, Zhang, Wuyuan. Valorization of Small Alkanes by Biocatalytic Oxyfunctionalization. CHEMSUSCHEM. 2022, 第 2 作者15(9): http://dx.doi.org/10.1002/cssc.202101116.
[11] Zhao, Panxia, Chen, Jie, Ma, Nana, Chen, Jingfei, Qin, Xiangquan, Liu, Chuanfei, Yao, Fuquan, Yao, Lishan, Jin, Longyi, Cong, Zhiqi. Enabling highly (R)-enantioselective epoxidation of styrene by engineering unique non-natural P450 peroxygenases. CHEMICAL SCIENCE[J]. 2021, 第 10 作者  通讯作者  12(18): 6307-6314, http://dx.doi.org/10.1039/d1sc00317h.
[12] Zhang, Xuan, Jiang, Yiping, Chen, Qianqian, Dong, Sheng, Feng, Yingang, Cong, Zhiqi, Shaik, Sason, Wang, Binju. H-Bonding Networks Dictate the Molecular Mechanism of H2O2 Activation by P450. ACS CATALYSIS[J]. 2021, 第 6 作者  通讯作者  11(14): 8774-8785, http://dx.doi.org/10.1021/acscatal.1c02068.
[13] Zhao, Panxia, Chen, Jie, Ma, Nana, Chen, Jingfei, Qin, Xiangquan, Liu, Chuanfei, Yao, Fuquan, Yao, Lishan, Jin, Longyi, Cong, Zhiqi. Enabling highly ( R )-enantioselective epoxidation of styrene by engineering unique non-natural P450 peroxygenases. CHEMICAL SCIENCE[J]. 2021, 第 10 作者  通讯作者  12(18): 6307-6314, http://dx.doi.org/10.1039/d1sc00317h.
[14] Zhang, Xuan, Jiang, Yiping, Chen, Qianqian, Dong, Sheng, Feng, Yingang, Cong, Zhiqi, Shaik, Sason, Wang, Binju. H-Bonding Networks Dictate the Molecular Mechanism of H 2 O 2 Activation by P450. ACS CATALYSIS[J]. 2021, 第 6 作者  通讯作者  11(14): 8774-8785, http://dx.doi.org/10.1021/acscatal.1c02068.
[15] Zhao, Panxia, Chen, Jie, Ma, Nana, Chen, Jingfei, Qin, Xiangquan, Liu, Chuanfei, Yao, Fuquan, Yao, Lishan, Jin, Longyi, Cong, Zhiqi. Enabling highly (R)-enantioselective epoxidation of styrene by engineering unique non-natural P450 peroxygenases dagger. CHEMICAL SCIENCE[J]. 2021, 第 10 作者  通讯作者  12(18): 6307-6314, http://dx.doi.org/10.1039/d1sc00317h.
[16] Ma, Nana, Fang, Wenhan, Liu, Chuanfei, Qin, Xiangquan, Wang, Xiling, Jin, Longyi, Wang, Binju, Cong, Zhiqi. Switching an Artificial P450 Peroxygenase into Peroxidase via Mechanism-Guided Protein Engineering. ACS CATALYSIS[J]. 2021, 第 8 作者  通讯作者  11(14): 8449-8455, http://dx.doi.org/10.1021/acscatal.1c02698.
[17] Jiang, Yihui, Wang, Chunlan, Ma, Nana, Chen, Jie, Liu, Chuanfei, Wang, Fang, Xu, Jiakun, Cong, Zhiqi. Regioselective aromatic O-demethylation with an artificial P450BM3 peroxygenase system. CATALYSIS SCIENCE & TECHNOLOGY[J]. 2020, 第 8 作者  通讯作者  10(5): 1219-1223, https://www.webofscience.com/wos/woscc/full-record/WOS:000536775400030.
[18] Wang, Xiling, Chen, Jie, Ma, Nana, Cong, Zhiqi. Selective Hydroxylation of Alkanes Catalyzed by Cytochrome P450 Enzymes. ACTA CHIMICA SINICA[J]. 2020, 第 4 作者  通讯作者  78(6): 490-503, http://dx.doi.org/10.6023/A20030086.
[19] 王曦翎, 陈杰, 马娜娜, 丛志奇. 细胞色素P450酶催化的烷烃选择性羟化. 化学学报[J]. 2020, 第 4 作者78(6): 490-503, http://lib.cqvip.com/Qikan/Article/Detail?id=7102530884.
[20] 丛志奇. 细胞色素P450酶催化的烷烃选择行羟化. 化学学报. 2020, 第 1 作者  通讯作者  
[21] Xu Jiakun, Wang Chunlan, Cong Zhiqi. Strategies for substrate-regulated P450 catalysis: from substrate engineering to co-catalysis.. CHEMISTRY (WEINHEIM AN DER BERGSTRASSE, GERMANY). 2019, 第 3 作者http://kns.cnki.net/KCMS/detail/detail.aspx?QueryID=0&CurRec=1&recid=&FileName=SJPDD7021155414D5D362CBB1B5E61D21BE4&DbName=SJPD_06&DbCode=SJPD&yx=&pr=&URLID=&bsm=.
[22] Chen, Jie, Kong, Fanhui, Ma, Nana, Zhao, Panxia, Liu, Chuanfei, Wang, Xiling, Cong, Zhiqi. Peroxide-Driven Hydroxylation of Small Alkanes Catalyzed by an Artificial P450BM3 Peroxygenase System. ACS CATALYSIS[J]. 2019, 第 7 作者  通讯作者  9(8): 7350-7355, https://www.webofscience.com/wos/woscc/full-record/WOS:000480503700077.
[23] Ariyasu, Shinya, Kodama, Yusaku, Kasai, Chie, Cong, Zhiqi, Stanfield, Joshua Kyle, Aiba, Yuichiro, Watanabe, Yoshihito, Shoji, Osami. Development of a High-Pressure Reactor Based on Liquid-Flow Pressurisation to Facilitate Enzymatic Hydroxylation of Gaseous Alkanes. CHEMCATCHEM[J]. 2019, 第 4 作者11(19): 4709-4714, https://www.webofscience.com/wos/woscc/full-record/WOS:000483567200001.
[24] Xu, Jiakun, Wang, Chunlan, Cong, Zhiqi. Strategies for Substrate-Regulated P450 Catalysis: From Substrate Engineering to Co-catalysis. CHEMISTRY-A EUROPEAN JOURNAL[J]. 2019, 第 3 作者  通讯作者  25(28): 6853-6863, 
[25] 丛志奇. Selective hydroxylation of naphthalene using the H2O2-dependent engineered P450BM3 driven by dual-functional small molecule. Journal of Porphyrins and Phthalocyanines. 2018, 第 1 作者  通讯作者  
[26] 马娜娜. Dual-Functional Small Molecules for Generating an Efficient Cytochrome P450BM3 Peroxygenase.. ANGEWANDTE CHEMIE (INTERNATIONAL ED. IN ENGLISH). 2018, 
[27] Ma, Nana, Chen, Zhifeng, Chen, Jie, Chen, Jingfei, Wang, Cong, Zhou, Haifeng, Yao, Lishan, Shoji, Osami, Watanabe, Yoshihito, Cong, Zhiqi. Dual-Functional Small Molecules for Generating an Efficient Cytochrome P450BM3 Peroxygenase. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2018, 第 10 作者  通讯作者  57(26): 7628-7633, https://www.webofscience.com/wos/woscc/full-record/WOS:000435766800004.
[28] Chen, Zhifeng, Chen, Jie, Ma, Nana, Zho, Haifeng, Cong, Zhiqi. Selective hydroxylation of naphthalene using the H2O2-dependent engineered P450BM3 driven by dual-functional small molecules. JOURNAL OF PORPHYRINS AND PHTHALOCYANINES[J]. 2018, 第 5 作者  通讯作者  22(9-10): 831-836, http://ir.qibebt.ac.cn/handle/337004/12205.
[29] Dr. Osami Shoji, Sota Yanagisawa, Joshua Kyle Stanfield, Kazuto Suzuki, Dr. Zhiqi Cong, Dr. Hiroshi Sugimoto, Prof. Dr. Yoshitsugu Shiro, Prof. Dr. Yoshihito Watanabe. Direct Hydroxylation of Benzene to Phenol by Cytochrome P450BM3 Triggered by Amino Acid Derivatives. ANGEWANDTE CHEMIE INTERNATIONAL EDITION. 2017, https://www.webofscience.com/wos/woscc/full-record/WOS:000434546000005.
[30] Shoji, Osami, Yanagisawa, Sota, Stanfield, Joshua Kyle, Suzuki, Kazuto, Cong, Zhiqi, Sugimoto, Hiroshi, Shiro, Yoshitsugu, Watanabe, Yoshihito. Direct Hydroxylation of Benzene to Phenol by Cytochrome P450BM3 Triggered by Amino Acid Derivatives. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2017, 第 5 作者56(35): 10324-10329, https://www.webofscience.com/wos/woscc/full-record/WOS:000434546000005.
[31] 丛志奇. 过氧化氢驱动的细胞色素犘４５０酶研究进展. 生物资源. 2017, 第 1 作者  通讯作者  
[32] 王曦翎, 陈杰, 陈置丰, 周海峰, 丛志奇. 过氧化氢驱动的细胞色素P450酶研究进展. 生物资源[J]. 2017, 第 5 作者39(2): 75-84, http://lib.cqvip.com/Qikan/Article/Detail?id=672189261.
[33] Cong, Zhiqi, Shoji, Osami, Kasai, Chie, Kawakami, Norifumi, Sugimoto, Hiroshi, Shiro, Yoshitsugu, Watanabe, Yoshihito. Activation of Wild-Type Cytochrorne P450BM3 by the Next Generation of Decoy Molecules: Enhanced Hydroxylation of Gaseous Alkanes and Crystallographic Evidence. ACS CATALYSIS[J]. 2015, 第 1 作者5(1): 150-156, https://www.webofscience.com/wos/woscc/full-record/WOS:000347513400019.
[34] 丛志奇. Activation of Wild-type Cytochrome P450BM3 by the Next Generation Decoy Molecules: Enhanced Hydroxylation of Gaseous Alkanes and Crystallographic Evidence. ACSCATAL. 2015, 第 1 作者
[35] Kawakami, Norifumi, Cong, Zhiqi, Shoji, Osami, Watanabe, Yoshihito. Highly efficient hydroxylation of gaseous alkanes at reduced temperature catalyzed by cytochrome P450BM3 assisted by decoy molecules. JOURNAL OF PORPHYRINS AND PHTHALOCYANINES[J]. 2015, 第 2 作者19(1-3): 329-334, https://www.webofscience.com/wos/woscc/full-record/WOS:000352644100030.
[36] Cong, Zhiqi, Kinemuchi, Haruki, Kurahashi, Takuya, Fujii, Hiroshi. Factors Affecting Hydrogen-Tunneling Contribution in Hydroxylation Reactions Promoted by Oxoiron(IV) Porphyrin pi-Cation Radical Complexes. INORGANIC CHEMISTRY[J]. 2014, 第 1 作者53(19): 10632-10641, https://www.webofscience.com/wos/woscc/full-record/WOS:000342856800079.
[37] Cong Zhiqi, Kinemuchi Haruki, Kurahashi Takuya, Fujii Hiroshi. Factors affecting hydrogen-tunneling contribution in hydroxylation reactions promoted by oxoiron(IV) porphyrin π-cation radical complexes.. INORGANIC CHEMISTRY. 2014, 第 1 作者
[38] 丛志奇. Synthesis, Charaterization and Reactivity of Hypochloritoiron(III) Porphyrin Complexes.. J. Am. Chem. Soc.. 2012, 第 1 作者
[39] Cong Zhiqi, Kurahashi Takuya, Fujii Hiroshi. Formation of iron(III) meso-chloro-isoporphyrin as a reactive chlorinating agent from oxoiron(IV) porphyrin π-cation radical.. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 2012, 第 1 作者
[40] Cong, Zhiqi, Kurahashi, Takuya, Fujii, Hiroshi. Formation of Iron(III) meso-Chloro-isoporphyrin as a Reactive Chlorinating Agent from Oxoiron(IV) Porphyrin pi-Cation Radical. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2012, 第 1 作者134(10): 4469-4472, https://www.webofscience.com/wos/woscc/full-record/WOS:000301990600005.
[41] Cong, Zhiqi, Kurahashi, Takuya, Fujii, Hiroshi. Oxidation of Chloride and Subsequent Chlorination of Organic Compounds by Oxoiron(IV) Porphyrin pi-Cation Radicals. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2011, 第 1 作者50(42): 9935-9939, https://www.webofscience.com/wos/woscc/full-record/WOS:000296207100030.
[42] 丛志奇. Oxidation of Chloride Ion and Subsequent Chlorination of Organic Compounds by Oxoiron(IV) Porphyrin π-Cation Radical Complexes.. Angew. Chem. Int. Ed.. 2011, 第 1 作者
[43] Cong, Zhiqi, Miki, Takumi, Urakawa, Osamu, Nishino, Hiroshi. Synthesis of Dibenzb,foxepins via Manganese(III)-Based Oxidative 1,2-Radical Rearrangement. JOURNAL OF ORGANIC CHEMISTRY[J]. 2009, 第 1 作者74(10): 3978-3981, http://dx.doi.org/10.1021/jo9002773.
[44] 张春波, 黄哲钢, 丛志奇, 尹炳柱. 含胆甾烯基结构的手性二介晶结构液晶化合物. 液晶与显示[J]. 2005, 第 3 作者20(5): 375-383, http://lib.cqvip.com/Qikan/Article/Detail?id=20261930.
[45] Chen, T, Liu, WJ, Cong, ZQ, Yin, BZ. Synthesis of novel dithia-crown ether annulated tetrathiafulvalene derivatives. CHINESE JOURNAL OF ORGANIC CHEMISTRY[J]. 2005, 25(5): 570-575, https://www.webofscience.com/wos/woscc/full-record/WOS:000228850100014.
[46] 张晓鹏, 丛志奇, 尹炳柱, 吴峰. 带取代卓酮基的中性生色氮杂15-完-5-丁烷的合成及其络合性质的研究. 延边大学学报. 自然科学版[J]. 2005, 第 2 作者31(1): 31-34, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=1898193&detailType=1.
[47] 张晓鹏, 丛志奇, 尹炳柱, 吴峰. 带取代革酮基的中性生色氮杂15-冠-5-醚的合成及其络合性质的研究. 延边大学学报：自然科学版[J]. 2005, 第 2 作者31(1): 31-34, http://lib.cqvip.com/Qikan/Article/Detail?id=15100311.
[48] 陈铁, 刘武军, 丛志奇, 尹炳柱. 新品研发辑要——新型四硫富瓦烯硫杂冠醚衍生物的合成. 化工中间体[J]. 2005, 第 3 作者58-58, http://lib.cqvip.com/Qikan/Article/Detail?id=20048155.
[49] Yin, BZ, Wen, QW, Chen, T, Liu, WJ, Cong, ZQ, Jin, LY, Wada, T, Saigo, K. Synthesis of nanoscale octathia 36-crown-12 annulated tetrathiafulvalene tetramers. CHINESE JOURNAL OF ORGANIC CHEMISTRY[J]. 2005, 25(2): 188-192, https://www.webofscience.com/wos/woscc/full-record/WOS:000226796200008.
[50] Yin, BZ, Wen, QW, Chen, T, Liu, WJ, Cong, ZQ, Jin, LY, Wada, T, Saigo, K. Synthesis of nanoscale octathia 36-crown-12 annulated tetrathiafulvalene tetramers. CHINESE JOURNAL OF ORGANIC CHEMISTRY[J]. 2005, 25(2): 188-192, https://www.webofscience.com/wos/woscc/full-record/WOS:000226796200008.
[51] 陈铁, 燕小梅, 丛志奇, 金龙一, 尹炳柱. 含TTF的氮硫杂冠醚的合成. 延边大学学报：自然科学版[J]. 2003, 第 3 作者29(3): 231-232, http://lib.cqvip.com/Qikan/Article/Detail?id=8419275.
[52] 尹炳柱, 丛志奇. 2，6—二氨基—1，3二氮杂Ao的简便合成. 化学试剂[J]. 2003, 第 2 作者25(1): 55-55, http://lib.cqvip.com/Qikan/Article/Detail?id=7455393.
[53] 丛志奇, 陈铁, 尹炳柱, 许桂花. 2—芳胺基—5—芳偶氮基草酮化合物的合成. 延边大学学报：自然科学版[J]. 2003, 第 1 作者29(2): 107-110,156, http://lib.cqvip.com/Qikan/Article/Detail?id=8044272.
[54] 丛志奇, 尹炳柱, 金龙一, 陈铁. 2-氯（上艹下卓）酮与Meldrum's acid的反应研究. 化学试剂[J]. 2003, 第 1 作者25(6): 321-322,366, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=1241199&detailType=1.
[55] 丛志奇, 胡永才. 2－酰胺基－6－芳偶氮基－1，3－二氮杂Ao的合成. 延边大学学报：自然科学版[J]. 2002, 第 1 作者28(4): 280-284, http://lib.cqvip.com/Qikan/Article/Detail?id=7471846.
[56] 丛志奇, 陈铁, 尹炳柱, 胡永才. 2－酰胺基－6－芳偶氮基－1，3－二氮杂薁的合成. 延边大学学报. 自然科学版[J]. 2002, 第 1 作者28(4): 282-284, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=1136765&detailType=1.

   

（ 1 ） 基于金属酶催化C-H变换的分子设计（团队科研项目启动基金）, 负责人, 研究所自主部署, 2016-05--2019-04
（ 2 ） 肝代谢酶CYP1A2抑制剂的设计与合成, 参与, 地方任务, 2017-01--2020-12
（ 3 ） 理性设计P450甲烷单加氧酶及其分子机理研究, 负责人, 国家任务, 2018-01--2021-12
（ 4 ） 基于细胞色素P450酶的生物医药开发, 负责人, 地方任务, 2018-01--2020-12
（ 5 ） P450甲烷羟化酶的理性设计及应用潜力开发, 负责人, 研究所自主部署, 2018-04--2020-03
（ 6 ） 酶促手性芳基邻二醇化合物的氧化级联不对称合成, 负责人, 研究所自主部署, 2019-01--2021-12
（ 7 ） 青岛能源所一三五重点培育方向：碳-氢键选择性氧化P450酶的设计与应用, 负责人, 研究所自主部署, 2018-08--2020-12
（ 8 ） 中国科学院国际人才交流计划国际博士后项目, 负责人, 中国科学院计划, 2018-07--2020-04
（ 9 ） 中国科学院国际人才交流计划国际博士后项目, 负责人, 中国科学院计划, 2019-08--2021-07
（ 10 ） 高稳定性P450过加氧酶的分子基础与进化设计, 负责人, 国家任务, 2020-01--2023-12
（ 11 ） 木质素生物转化P450过加氧酶的人工分子设计研究, 负责人, 研究所自主部署, 2020-01--2021-12
（ 12 ） 多功能同功酶的实验室同源进化技术研究, 负责人, 其他国际合作项目, 2020-09--2022-08
（ 13 ） 新型酶分子机器的精确设计与构筑, 负责人, 研究所自主部署, 2023-07--2027-06
（ 14 ） 异戊二烯合成酶（IspS）催化机制解析与实验室进化, 负责人, 国家任务, 2023-02--2026-12
（ 15 ） 非天然P450元件创制与高附加值化合物生产, 负责人, 国家任务, 2023-12--2028-11
（ 16 ） 基于过氧化氢隧道工程的类固醇羟化P450过加氧酶的理性设计与分子机制研究, 负责人, 国家任务, 2024-01--2027-12

（1）Tuning peroxidase activity of artificial P450 peroxygenase by engineering redox-sensitive residues   生物催化法拉第讨论会   Fengjie Jiang, Zihan Wang   2024-05-22
（2）非天然P450过氧化酶的分子设计与选择性氧化   第二十届全国青年催化学术会议   2024-05-10
（3）双功能分子协同P450过氧化酶催化系统   中国化学会第33届学术年会   丛志奇   2023-06-17
（4）人工P450过氧化酶的催化多功能性拓展   第十二届化学生物学年会   丛志奇   2023-04-14
（5）Enzymatic divergent C-H hydroxylation by an engineered P450 peroxygenase system   2022-10-28
（6）人工P450过氧化酶的结构基础与催化多功能性   中国化学会第十五届生物无机化学会议   2021-10-24
（7）Design and Evolution of Artificial P450 Peroxyzymes   中国生物工程协会第五届青年科技论坛   2021-07-02
（8）Mechanism-Guided Design of a Unique P450 Peroxygenase System and Its Catalytic Applications   2019-12-15
（9）Modification of P450 Monooxygenase into its Peroxygenase Mode   中国化学会第十一届全国化学生物学学术会议   2019-11-18
（10）Mechanism-Guided Design of a Unique P450 Peroxygenase System and Its Catalytic Applications   2019-11-15
（11）Peroxide-Driven Hydroxylation of Gaseous Alkanes by Artificial P450 Peroxygenase System   2019-10-24
（12）Design of Artificial P450 Peroxygenase for Catalytic Oxidation of Non-Native Substrates   中国科协第383次青年科学家论坛：人工酶定向进化   2019-10-20
（13）Construction of Artificial P450 Peroxygenase for Oxidation of Non-Native Substrates   , 中国化学会第六届卟啉、酞菁及相关材料学术研讨会(NCPP-6)暨第一届亚洲卟啉、酞菁及相关材料学术会议（ACPP-1）   2019-08-23
（14）助催化策略协同蛋白质工程构建多功能P450过加氧酶催化剂   第十四届全国酶学学术讨论会   2019-08-11
（15）从化学角度对金属酶的理性设计   全国催化技术与应用暨催化研究交流研讨会   2019-01-23
（16）CONSTRUCTION OF ARTIFICIAL P450 PEROXYGENASE FOR CATALYTIC MONOOXYGENATION OF NON-NATIVE SUBSTRATES   2018-12-12
（17）人工P450过加氧酶的构建与催化应用   中国化学会第十四届全国生物无机化学会议论文模板   2018-10-18
（18）CONSTRUCTION OF AN ARTIFICIAL P450 PEROXYGENASE   长白山论坛   2018-08-25
（19）Hydroxylation of Small Alkanes by a P450-H2O2 System   中韩C1化学研讨会-大连   2018-08-23
（20）The Use of Dual-Functional Small Molecules in Generating Robust P450BM3 Peroxygenase Toward Oxidation of Unnatural Substrates    2018-06-24
（21）利用双功能小分子解除细胞色素P450酶的辅酶依赖   中国化学会第31届学术年会   2018-05-04
（22）双功能小分子驱动的P450过加氧酶及其催化应用   无机化学北大发展论坛   2018-01-13
（23）Metalloenzyme-based Bio&Biomimetic Oxidation   2017-10-18
（24）小分子协同P450酶催化C-H,C=C,C-S键选择性氧化   全国均相催化学术讨论会   2017-09-26
（25）化学调控细胞色素P450单加氧酶的催化功能与催化活性   中国化学会第十届全国化学生物学学术会议   2017-09-23
（26）化学干预与调控策略协同构筑面向合成应用的细胞色素P450生物催化剂   中国科协第316次青年科学家论坛   2017-09-14
（27）小分子协同调控P450单加氧酶的催化杂泛性   第13届全国酶学学术讨论会   2017-08-18
（28）高价态铁卟啉作为血红素氯过氧化物酶的机理探针   中国化学会第四届卟啉与酞菁学术研讨会   2017-07-09
（29）P450单加氧酶的化学活化策略与气态烷烃羟化   中国生物工程学会第二届青年科技论坛   2017-04-07
（30）小分子驱动P450单加氧酶选择性氧化气态烷烃   泰山学术论坛-生物无机化学与纳米材料专题   2016-11-04
（31）小分子驱动P450单加氧酶选择氧化气态烷烃   第十六届全国青年催化学术会议   2016-10-21
（32）氯过氧化物酶Hypochlorito-Iron(III) Porophyrin模型中间体的研究   中国化学会第十三届全国生物无机化学会议   2016-10-13
（33）Synergistic Effect of Decoy Molecule andSite-directed Mutation Leading to A P450   CONG, Zhiqi; SHOJI, Osami; KASAI, Chie; SUGIMOTO, Hiroshi; SHIRO, Yoshitsugu; WATANABE, Yoshihito   2016-03-24
（34）Activation of Wild-type Cytochrome P450BM3 by the 2nd-generation of Decoy Molecules: Hydroxylation of Small Alkanes and Mechanism   2015-07-24
（35）Construction of Small Alkane Hydroxylase by P450BM3-decoy Molecule System   Cong, Zhiqi; Shoji, Osami; Kasai, Chie; Sugimoto, Hiroshi; Shiro, Yoshitsugu; Watanabe, Yoshihito   2015-03-27
（36）Powerful Activation of Cytochrome P450BM3 by Second-Generation Decoy Molecules and the Hydroxylation of Small Alkanes    Cong, Zhiqi; Shoji, Osami; Kasai, Chie; Sugimoto, Hiroshi; Shiro, Yoshitsugu; Watanabe, Yoshihito   2014-11-15
（37）Arousal of Wild-type Cytochrome P450 by second-generation decoy molecules: toward the hydroxylation of gaseous alkanes   2014-09-24
（38）“Hydroxylation of gaseous alkanes catalyzed by Wild-type Cytochrome P450: Development of Second-Generation Decoy Molecules and Studies of Reaction mechanism based on crystal structure analysis”    Cong, Zhiqi; Shoji, Osami; Kasai, Chie; Sugimoto, Hiroshi; Shiro, Yoshitsugu; Watanabe, Yoshihito   2014-09-11
（39） “New Generation of Decoy Molecules to Powerfully Activate Cytochrome P450BM3 for Small Alkanes Hydroxylation”    Cong, Zhiqi; Shoji, Osami; Kasai, Chie; Sugimoto, Hiroshi; Shiro, Yoshitsugu; Watanabe, Yoshihito   2014-03-26
（40） “Synthesis, Charaterization and Reactivity of Hypochlorite-Iron(III) Porphyrin Complexes.”   CONG, Zhiqi; YANAGISAWA, Sachiko; KURAHASHI, Takuya; OGURA, Takashi; FUJII, Hiroshi   2012-11-16
（41） “Synthesis and Chlorinating Reactivity of Iron(III) meso-Chloro-Isoporphyrins.”    CONG, Zhiqi; KURAHASHI, Takuya; FUJII, Hiroshi   2012-09-21
（42）“Oxidation of Chloride Ion by Compound I Model Complex and Related Chlorination of Organic Compounds.”   CONG, Zhiqi; KURAHASHI, Takuya; FUJII, Hiroshi   2011-11-04
（43） “Hydrogen Tunneling Effect on Alkane Hydroxylation by High-valent Oxoiron porphyrin Model Complexes.”   CONG, Zhiqi; KURAHASHI, Takuya; FUJII, Hiroshi   2011-03-26
（44） “Hydrogen Tunneling Effect on Hydrocarbon Hydroxylation by Oxoiron(IV) Porphyrin π-Cation Radical Complexes.”    CONG, Zhiqi; FUJII, Hiroshi   2010-11-10
（45）“Synthesis of Dibenz[b,f]oxepins from 2-(9-Xanthenyl)malonate.”    CONG, Zhiqi; NISHINO, Hiroshi   2008-03-26

1. 低碳酶催化，日本名古屋大学渡边研究室

2. 金属酶分子机理与小分子活化，日本奈良女子大学藤井研究室

已指导学生

马娜娜  硕士研究生  085238-生物工程  

赵盼霞  硕士研究生  085238-生物工程  

陈杰  博士研究生  071010-生物化学与分子生物学  

马娜娜  博士研究生  071010-生物化学与分子生物学  

林晓丹  硕士研究生  085238-生物工程  

孔繁慧  博士研究生  071010-生物化学与分子生物学  

狄思宇  硕士研究生  086000-生物与医药  

江凤杰  硕士研究生  071010-生物化学与分子生物学  

现指导学生

范圣贤  博士研究生  071010-生物化学与分子生物学  

赵盼霞  博士研究生  071010-生物化学与分子生物学  

陈小琼  硕士研究生  086000-生物与医药  

张洲  硕士研究生  071010-生物化学与分子生物学  

张瑾  硕士研究生  086000-生物与医药  

汪子涵  博士研究生  071010-生物化学与分子生物学