基本信息
徐镇  男  博导  中国科学院水生生物研究所
电子邮件: zhenxu@ihb.ac.cn
通信地址: 湖北省武汉市武昌区东湖南路7号
邮政编码:

招生信息

   
招生专业
090801-水产养殖
071004-水生生物学
招生方向
鱼类病毒致病机制与免疫防控技术;鱼类抗病分子遗传机制与育种技术

教育背景

2006-09--2009-06   华中农业大学   博士
2003-09--2006-07   华中农业大学   硕士
1998-09--2002-06   山东农业大学   学士

工作经历

   
工作简历
2021-03~现在, 中国科学院水生生物研究所, 研究员
2015-01~2021-02,华中农业大学, 教授
2010-02~2014-12,美国宾夕法尼亚大学, 博士后
2009-08~2010-01,中国科学院水生生物研究所, 科研助理
社会兼职
2021-01-01-今,中国水产学会鱼病专业委员会, 副主任委员
2016-08-04-2020-08-27,省级科技特派员,

教授课程

水生动物免疫学
水产品品质与卫生检验
水生生物科学进展
水产养殖学概论
水生动物免疫学实验
水产科学研究进展
科学精神与水产研究

专利与奖励

   
专利成果
( 1 ) 一种水产养殖装置, 发明专利, 2021, 第 1 作者, 专利号: ZL202122056616.9

( 2 ) 一种恒温养殖系统, 实用新型, 2022, 第 1 作者, 专利号: CN215454792U

( 3 ) 谷氨酰胺在提高虹鳟生长性能中的应用, 发明专利, 2021, 第 1 作者, 专利号: CN113598286A

( 4 ) 一种适用于冷水性鱼类的简易疫苗浸泡装置, 发明专利, 2021, 第 1 作者, 专利号: CN215302366U

出版信息

   
发表论文
[1] Weiguang Kong, Gaofeng Cheng, Jiafeng Cao, Jiaqian Yu, Xinyou Wang, Zhen Xu. Ocular mucosal homeostasis of teleost fish provides insight into the coevolution between microbiome and mucosal immunity. MICROBIOME[J]. 2024, 第 6 作者12(1): 1-19, https://doaj.org/article/89e386fd48d14b9baaef6a4fc23744e3.
[2] 孔维光, 曹佳烽, 程高锋, 于永耀, 徐镇. 硬骨鱼类黏膜B细胞和免疫球蛋白研究进展. 科学通报[J]. 2023, 第 5 作者68(15): 1869-1883, http://lib.cqvip.com/Qikan/Article/Detail?id=7109915834.
[3] Jiafeng Cao, Haoyue Xu, Yongyao Yu, Zhen Xu. Regulatory roles of cytokines in T and B lymphocytes-mediated immunity in teleost fish. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY[J]. 2023, 第 4 作者  通讯作者  144: http://dx.doi.org/10.1016/j.dci.2022.104621.
[4] Song, Yun Jie, Zhang, Jie, Xu, Zhen, Nie, Pin, Chang, Ming Xian. Liver X Receptor LXRα Promotes Grass Carp Reovirus Infection by Attenuating IRF3-CBP Interaction and Inhibiting RLR Antiviral Signaling. JOURNAL OF IMMUNOLOGY[J]. 2023, 第 3 作者211(6): 1006-1019, https://journals.aai.org/jimmunol/article/211/6/1006/265825.
[5] Cao, Jiafeng, Ding, Liguo, Wang, Qingchao, Han, Guangkun, Qin, Dacheng, Cheng, Gaofeng, Dong, Zhaoran, Mu, Qingjiang, Kong, Weiguang, Liu, Xia, Yu, Yongyao, Xu, Zhen. Conserved Role of mTORC1 Signaling in B Cell Immunity in Teleost Fish. JOURNAL OF IMMUNOLOGY[J]. 2022, 第 12 作者  通讯作者  209(6): 1095-1107, 
[6] Dong, ZhaoRan, Mu, QingJiang, Kong, WeiGuang, Qin, DaCheng, Zhou, Yong, Wang, XinYou, Cheng, GaoFeng, Luo, YangZhi, Ai, TaoShan, Xu, Zhen. Gut mucosal immune responses and protective efficacy of oral yeast Cyprinid herpesvirus 2 (CyHV-2) vaccine in Carassius auratus gibelio. FRONTIERS IN IMMUNOLOGY[J]. 2022, 第 10 作者  通讯作者  13: http://dx.doi.org/10.3389/fimmu.2022.932722.
[7] Mu, Qingjiang, Dong, Zhaoran, Kong, Weiguang, Wang, Xinyou, Yu, Jiaqian, Ji, Wei, Su, Jianguo, Xu, Zhen. Response of immunoglobulin M in gut mucosal immunity of common carp (Cyprinus carpio) infected with Aeromonas hydrophila. FRONTIERS IN IMMUNOLOGY[J]. 2022, 第 8 作者  通讯作者  13: http://dx.doi.org/10.3389/fimmu.2022.1037517.
[8] Ding, Liguo, Han, Guangkun, Wang, Xinyou, Sun, Ruhan, Yu, Yongyao, Xu, Zhen. Gallbladder microbiota in early vertebrates provides evolutionary insights into mucosal homeostasis. FRONTIERS IN IMMUNOLOGY[J]. 2022, 第 6 作者  通讯作者  13: http://dx.doi.org/10.3389/fimmu.2022.1020413.
[9] Zhenyu Huang, Mengting Zhan, Gaofeng Cheng, Ruiqi Lin, Xue Zhai, Haiou Zheng, Qingchao Wang, Yongyao Yu, Zhen Xu. IHNV Infection Induces Strong Mucosal Immunity and Changes of Microbiota in Trout Intestine. VIRUSES[J]. 2022, 第 9 作者  通讯作者  14: https://doaj.org/article/42ded4ee4cdb40418deaae50ffdb920f.
[10] Yu, Yongyao, Huang, Zhenyu, Kong, Weiguang, Dong, Fen, Zhang, Xiaoting, Zhai, Xue, Cheng, Gaofeng, Zhan, Mengting, Cao, Jiafeng, Ding, Liguo, Han, Guangkun, Takizawa, Fumio, Ding, Yang, Sunyer, J Oriol, Xu, Zhen. Teleost swim bladder, an ancient air-filled organ that elicits mucosal immune responses. CELL DISCOVERY[J]. 2022, 第 15 作者  通讯作者  8(1): http://dx.doi.org/10.1038/s41421-022-00393-3.
[11] Meng, Kaifeng, Lin, Xing, Liu, Hairong, Chen, Huijie, Liu, Fei, Xu, Zhen, Sun, Yonghua, Luo, Daji. Gonadal bacterial community composition is associated with sex-specific differences in swamp eels (Monopterus albus). FRONTIERS IN IMMUNOLOGY[J]. 2022, 第 6 作者13: http://dx.doi.org/10.3389/fimmu.2022.938326.
[12] Meng, KaiFeng, Ding, LiGuo, Wu, Sha, Wu, ZhengBen, Cheng, GaoFeng, Zhai, Xue, Sun, RuHan, Xu, Zhen. Interactions Between Commensal Microbiota and Mucosal Immunity in Teleost Fish During Viral Infection With SVCV. FRONTIERS IN IMMUNOLOGY[J]. 2021, 第 8 作者  通讯作者  12: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8058427/.
[13] Xu Zhen. Prevailing role of mucosal immunoglobulins and B cells in teleost skin immune responses to bacterial infection.. Journal of Immunology. 2021, 第 1 作者  通讯作者  
[14] Yu, YongYao, Ding, LiGuo, Huang, ZhenYu, Xu, HaoYue, Xu, Zhen. Commensal bacteria-immunity crosstalk shapes mucosal homeostasis in teleost fish. REVIEWS IN AQUACULTURE. 2021, 第 5 作者  通讯作者  13(4): 2322-2343, http://dx.doi.org/10.1111/raq.12570.
[15] Wang, Qingchao, Ji, Wei, Xu, Zhen. Current use and development of fish vaccines in China. FISH & SHELLFISH IMMUNOLOGY[J]. 2020, 第 3 作者  通讯作者  96: 223-234, http://dx.doi.org/10.1016/j.fsi.2019.12.010.
[16] Liu, Xia, Yu, Yongyao, Qin, Dacheng, Song, Zixi, Huang, Zhenyu, Meng, Kaifeng, Cao, Jiafeng, Xu, Fangzheng, Cheng, Gaofeng, Ji, Wei, Xu, Zhen. Expression analysis of taste receptor genes (T1R1, T1R3, and T2R4) in response to bacterial, viral and parasitic infection in rainbow trout, Oncorhynchus mykiss. FISH & SHELLFISH IMMUNOLOGY[J]. 2020, 第 11 作者  通讯作者  101: 176-185, http://dx.doi.org/10.1016/j.fsi.2020.03.055.
[17] Dong, Fen, Yin, Guangmei, Meng, Kaifeng, Xu, Haoyue, Liu, Xia, Wang, Qingchao, Xu, Zhen. IgT Plays a Predominant Role in the Antibacterial Immunity of Rainbow Trout Olfactory Organs. FRONTIERS IN IMMUNOLOGY[J]. 2020, 第 7 作者  通讯作者  11: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7701277/.
[18] Xu, Zhen, Takizawa, Fumio, Casadei, Elisa, Shibasaki, Yasuhiro, Ding, Yang, Sauters, Thomas J C, Yu, Yongyao, Salinas, Irene, Sunyer, J Oriol. Specialization of mucosal immunoglobulins in pathogen control and microbiota homeostasis occurred early in vertebrate evolution. SCIENCE IMMUNOLOGY[J]. 2020, 第 1 作者5(44): https://www.webofscience.com/wos/woscc/full-record/WOS:000519520300004.
[19] Xu Zhen. Mediation of mucosal immunoglobulins in buccal cavity of primitive vertebrate in antibacterial immunity. Frontiers in Immunology. 2020, 第 1 作者  通讯作者  
[20] Yu, Yongyao, Wang, Qingchao, Huang, Zhenyu, Ding, Liguo, Xu, Zhen. Immunoglobulins, Mucosal Immunity and Vaccination in Teleost Fish. FRONTIERS IN IMMUNOLOGY. 2020, 第 5 作者  通讯作者  11: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7566178/.
[21] Kong, Weiguang, Yu, Yongyao, Dong, Shuai, Huang, Zhenyu, Ding, Liguo, Cao, Jiageng, Dong, Fen, Zhang, Xiaoting, Liu, Xia, Xu, Haoyue, Meng, Kaifeng, Su, Jianguo, Xu, Zhen. Pharyngeal Immunity in Early Vertebrates Provides Functional and Evolutionary Insight into Mucosal Homeostasis. JOURNAL OF IMMUNOLOGY[J]. 2019, 第 13 作者  通讯作者  203(11): 3054-3067, https://www.webofscience.com/wos/woscc/full-record/WOS:000497950400028.
[22] Xu Zhen. Immune responses of fish to Ichthyophthirius multifiliis (Ich): a model for understanding immunity against extracellular protozoans. Developmental & Comparative Immunology. 2019, 第 1 作者  通讯作者  
[23] Huang, Zhenyu, Yu, Yongyao, Dong, Shuai, Yin, Yaxing, Wang, Qingchao, Yu, Wei, Luo, Yanzhi, Xu, Jie, Zhang, Liqiang, Yu, Yunzhen, Ai, Taoshan, Xu, Zhen. Major histocompatibility complex class IIA and IIB genes of loach (Misgurnus anguillicaudatus): Molecular cloning and expression analysis in response to bacterial and parasitic challenge. AQUACULTURE[J]. 2019, 第 12 作者  通讯作者  500: 359-369, http://dx.doi.org/10.1016/j.aquaculture.2018.10.043.
[24] Xu Zhen. Convergent evolution of mucosal immune responses at the buccal cabity of teleost fish. iScience. 2019, 第 1 作者  通讯作者  
[25] Dong, Shuai, Ding, Liguo, Cao, Jiafeng, Liu, Xia, Xu, Haoyue, Meng, Kaifeng, Yu, Yongyao, Wang, Qingchao, Xu, Zhen. Viral-Infected Change of the Digestive Tract Microbiota Associated With Mucosal Immunity in Teleost Fish. FRONTIERS IN IMMUNOLOGY[J]. 2019, 第 9 作者  通讯作者  10: https://doaj.org/article/88b3c813081c45939928dac9b8f1ae8a.
[26] 黄贝, 陈善楠, 徐镇, 聂品. 斜带石斑鱼IgM、IgZ和IgD重链基因的克隆. 水产学报[J]. 2012, 第 3 作者36(7): 1000-1010, http://lib.cqvip.com/Qikan/Article/Detail?id=42734420.
[27] Wei, You Chuan, Pan, Ting Shuang, Chang, Ming Xian, Huang, Bei, Xu, Zhen, Luo, Ting Rong, Nie, P. Cloning and expression of Toll-like receptors 1 and 2 from a teleost fish, the orange-spotted grouper Epinephelus coioides. VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY[J]. 2011, 第 5 作者141(3-4): 173-182, http://dx.doi.org/10.1016/j.vetimm.2011.02.016.
[28] Huang, Bei, Qi, Zhi T, Xu, Zhen, Nie, Pin. Global characterization of interferon regulatory factor (IRF) genes in vertebrates: Glimpse of the diversification in evolution. BMC IMMUNOLOGY[J]. 2010, 第 3 作者11(1): http://dx.doi.org/10.1186/1471-2172-11-22.
[29] 王改玲, 骆彦萍, 孙宝剑, 徐镇, 许巧情, 聂品. 鳜免疫球蛋白D重链基因的克隆与表达分析. 中国水产科学[J]. 2010, 第 4 作者11-20, http://lib.cqvip.com/Qikan/Article/Detail?id=32759146.
[30] 徐镇, 昌明先, 齐志涛, 黄贝, 聂品. 中华鳖免疫球蛋白j链基因的克隆与表达. 2008年中国水产学会学术年会论文摘要集. 2009, 第 1 作者http://ir.ihb.ac.cn/handle/342005/14550.
[31] 齐志涛, 邹钧, 黄贝, 徐镇, 聂品. 非洲爪蟾γ-干扰素基因座细胞因子的克隆及比较分析. 2008年中国水产学会学术年会论文摘要集. 2009, 第 4 作者http://ir.ihb.ac.cn/handle/342005/14532.
[32] Xu, Zhen, Wang, Gai L, Nie, P. IgM, IgD and IgY and their expression pattern in the Chinese soft-shelled turtle Pelodiscus sinensis. MOLECULAR IMMUNOLOGY[J]. 2009, 第 1 作者46(10): 2124-2132, http://dx.doi.org/10.1016/j.molimm.2009.03.028.
[33] 黄贝, 聂品, 齐志涛, 徐镇. 脊椎动物干扰素调节因子(Irf)家族基因起源进化初探. 2008年中国水产学会学术年会论文摘要集. 2009, 第 4 作者http://ir.ihb.ac.cn/handle/342005/14516.
[34] Peng Ju-Li, Wang Xu-Zhen, Wang Ding, He Shun-Ping (clad@ihb.ac.cn). APPLICATION OF DNA BARCODING BASED ON THE MITOCHONDRIALCO1 GENE SEQUENCES IN CLASSIFICATION OF CULTER (PISCES: CYPRINIDAE). ACTA HYDROBIOLOGICA SINICA[J]. 2009, 33(2): 271-276, http://www.irgrid.ac.cn/handle/1471x/543659.

科研活动

   
科研项目
( 1 ) 中国科学院率先行动“****”A类项日,现代农业:鱼类黏膜免疫, 负责人, 中国科学院计划, 2021-01--2023-12
( 2 ) 鱼类黏膜B细胞吞噬、抗原递呈功能及其 分子机制的研究, 负责人, 国家任务, 2021-01--2024-12
( 3 ) 大黄鱼免疫球蛋白IgM和IgT在抗刺激隐核虫感染中的功能研究, 参与, 国家任务, 2020-01--2023-12
( 4 ) 鱼类B和T淋巴细胞在细菌感染过程中的免疫应答规律与互作机制的研究, 负责人, 国家任务, 2019-01--2022-12
( 5 ) 水产动物精准营养及其代谢调控机制一水产动物免疫应答的营养调控机制, 负责人, 国家任务, 2018-12--2022-12
( 6 ) 水产动物疫病发 生的分子基础与免疫机制病原诱导的适应性免疫应答的细胞与分子机制, 参与, 国家任务, 2018-12--2022-12
( 7 ) 生命科学:鱼类免疫学, 负责人, 国家任务, 2017-01--2019-12
( 8 ) 湖北省“楚天学者”主讲教授-华中农业大学高层次人才启动经费、鱼类免疫学, 负责人, 地方任务, 2015-08--2020-06
( 9 ) 鱼类黏膜免疫, 负责人, 国家任务, 2023-01--2027-12
( 10 ) 大宗水产动物重大病毒病害致病机理与高效防控技术, 负责人, 中国科学院计划, 2023-11--2028-11
( 11 ) 鱼类抗病毒感染的黏膜免疫机制与高效疫苗设计, 负责人, 地方任务, 2023-07--2026-06
( 12 ) 抗出血病性状遗传多样性评估与新种质鉴定, 负责人, 国家任务, 2023-09--2025-12
参与会议
(1)Adaptive Immunity & Vaccines   2019-11-01
(2)Mucosal Immunoglobulin IgT Plays a Key role In The Oral Immunity of Teleosts   2019-06-16
(3)Mucosal Immunity   2018-06-17

指导学生

现指导学生

徐皓月  博士研究生  071004-水生生物学  

王紫璇  硕士研究生  086000-生物与医药  

蔡畅  硕士研究生  071004-水生生物学  

林睿琪  硕士研究生  071004-水生生物学  

李雨晴  博士研究生  090801-水产养殖  

杨鹏  博士研究生  090801-水产养殖