干细胞生物学（诱导多能干细胞、细胞类型转换）
神经生物学（神经干细胞、学习记忆、成瘾机制、动物行为）

招收对干细胞生物学和/或神经生物学有兴趣的博士、硕士
欢迎对干细胞生物学和/或神经生物学有兴趣的本科生来实验室实习

2005-08--2020-07   美国明尼苏达大学   博士
2001-09--2005-07   清华大学   学士

2010-至今 中国科学院广州生物医药与健康研究院 研究员
2010            美国明尼苏达大学药理系 博士后研究助理

9. 国家发明专利，脱氢抗坏血酸和2，3-二酮-L-古洛糖酸在细胞重编程中的应用，202310053420.5，2023-02-03，郑辉、梁丽宁、秦朝辉、周予晟、王晨晨，申请；

8. 国家发明专利，shTet1 慢病毒及其构建方法及其在神经干细胞增殖中的应用，202310079144.X，2023-02-08，郑辉、梁丽宁、王晨晨、周予晟、秦朝辉，申请；

7. PCT，组合物及其在提高维生素C抗肿瘤效果中的用途，PCT/CN2021/112737，2021-08-16，郑辉、李长朋、王付卉，申请；

6. 国家发明专利，一类可提高维生素C抗肿瘤效果的药物组合物，202011430939.3，2020-12-10，郑辉、李长朋、王付卉，申请；

5. 国家发明专利，纳络酮在调控Tet1蛋白DNA去甲基化酶活性的药物中的应用，201810491786.X，2018-05-22，郑辉、梁丽宁、陈金龙，申请；

4. 国家发明专利，一种提高体细胞向神经细胞转分化效率的方法，201710326824.1，2017-05-10，郑辉、杨肖、陈金龙、何松蔚，申请；

3. 国家发明专利，利用无血清培养基从成纤维细胞中获得神经细胞的方法，ZL201610952074.4，2016-11-03，2019-10-11（授权），郑辉、何松蔚、陈金龙，授权；

2. 国家发明专利，一种利用无血清培养基通过转分化获得神经细胞的方法，ZL201510289740.6，2015-06-17，2020-01-03（授权），郑辉、何松蔚，授权；

1. 国家发明专利，纳络酮用于制备提高空间学习记忆能力的药物中的应用，ZL201410393385.2，2014-11-05，2016-08-24（授权），郑辉、李文、何松蔚、孙昊，授权。

    [37] Liang L#, He M#, Zhang Y#, Wang C, Qin Z, Li Q, Yang T, Meng F, Zhou Y, Ge H, Song W, Chen S, Dong L, Ren Q, Li C, Guo L, Sun H, Zhang W, Pei D*, Zheng H* Unraveling the 2,3–diketo–L–gulonic acid–dependent and –independent impacts of L–ascorbic acid on somatic cell reprogramming. Cell & Bioscience. 2023 Nov 30;13(1):218. 共同通讯作者

[36] Li C*#, He J#, Meng F#, Wang F#, Sun H, Zhang H, Zhang M, Xu Q, Liang L, Li Y, Yang T, He M, Wang T, Lin J, Sun J, Huang Q, Guo L, Zhang X, Mai S*, Zheng H*. Nuclear Localization of TET2 Requires β-catenin Activation and Correlates with Favourable Prognosis in Colorectal Cancer. Cell Death & Disease. 2023 Aug 24;14(8):552. 共同通讯作者

[35] Li Y#, Yang T#, Cheng Y#, Hou J#, Liu Z, Zhao Y, Chen S, Qin Z, Wang C, Song W, Ge H, Li C, Liang L, Guo L, Sun H, Wu LP*, Zheng H*. Low glutaminase and glycolysis correlate with a high transdifferentiation efficiency in mouse cortex. Cell Proliferation. 2023 May;56(5):e13422. 共同通讯作者

    [34] Sun J#*, Yang J, Miao X, Loh HH, Pei D, Zheng H*. Proteins in DNA methylation and their role in neural stem cell proliferation and differentiation. Cell Regeneration. 2021 Mar 2;10(1):7. 共同通讯作者

    [33] Meng F#, Li Y, Sun H, Li C, Li Q, Law PY, Loh HH, Liang L*, Zheng H*. Naloxone Facilitates Contextual Learning and Memory in a Receptor-Independent and Tet1-Dependent Manner. Cellular and Molecular Neurobiology. 2021 Jul;41(5):1031-1038. 共同通讯作者

    [32] Zhang M#, Li Q, Yang T, Meng F, Lai X, Liang L, Li C, Sun H, Sun J, Zheng H*. Positive feedback between retinoic acid and 2-phospho-L-ascorbic acid trisodium salt during somatic cell reprogramming. Cell Regeneration. 2020 Oct 1;9(1):17. 通讯作者

    [31] Lai X#, Li Q#, Wu F, Lin J, Chen J*, Zheng H*, Guo L*. Epithelial-Mesenchymal Transition and Metabolic Switching in Cancer: Lessons From Somatic Cell Reprogramming. Frontiers in Cell and Developmental Biology. 2020 Aug 6;8:760.共同通讯作者

[30] Chen J#, Liang L#, Li Y, Zhang Y, Zhang M, Yang T, Meng F, Lai X, Li C, He J, He M, Xu Q, Li Q, Law PY, Loh HH, Pei D, Sun H*, Zheng H*. Naloxone regulates the differentiation of neural stem cells via a receptor-independent pathway. The FASEB Journal. 2020 Apr;34(4):5917-5930. 共同通讯作者

    [29] Liang L#, Chen J#, Li Y, Lai X, Sun H, Li C, Zhang M, Yang T, Meng F, Law PY, Loh HH, Zheng H*. Morphine and Naloxone Facilitate Neural Stem Cells Proliferation via a TET1-Dependent and Receptor-Independent Pathway. Cell Reports. 2020 Mar 17;30(11):3625-3631. 通讯作者

    [28] Sun H#, Yang X#, Liang L#, Zhang M#, Li Y, Chen J, Wang F, Yang T, Meng F, Lai X, Li C, He J, He M, Xu Q, Li Q, Lin L, Pei D*, Zheng H*. Metabolic switch and epithelial-mesenchymal transition cooperate to regulate pluripotency. The EMBO Journal. 2020 Apr 15;39(8):e102961. 共同通讯作者

    [27] He S#, Wang F#, Zhang Y#, Chen J, Liang L, Li Y, Zhang M, Yang X, Pang H, Li Y, Huang X, Qin D, Pei D, Sun H*, Zheng H*. Hemi-methylated CpG sites connect Dnmt1-knockdown-induced and Tet1-induced DNA demethylation during somatic cell reprogramming. Cell Discovery. 2019 Feb 12;5:11. 共同通讯作者

[26] Lin L#, Liang L#, Yang X#, Sun H, Li Y, Pei D, Zheng H*. The homeobox transcription factor MSX2 partially mediates the effects of bone morphogenetic protein 4 (BMP4) on somatic cell reprogramming. The Journal of Biological Chemistry. 2018 Sep 21;293(38):14905-14915. 通讯作者

[25] He S#, Sun H#, Lin L, Zhang Y, Chen J, Liang L, Li Y, Zhang M, Yang X, Wang X, Wang F, Zhu F, Chen J, Pei D, Zheng H*. Passive DNA demethylation preferentially up-regulates pluripotency-related genes and facilitates the generation of induced pluripotent stem cells. The Journal of Biological Chemistry. 2017 Nov 10;292(45):18542-18555. 通讯作者

    [24] He S#, Chen J#, Zhang Y#, Zhang M, Yang X, Li Y, Sun H, Lin L, Fan K, Liang L, Feng C, Wang F, Zhang X, Guo Y, Pei D*, Zheng H*. Sequential EMT-MET induces neuronal conversion through Sox2. Cell Discovery. 2017 May 30;3:17017.  共同通讯作者

[23] Liang L#, Sun H, Li L, Zheng H*. Transitions between mesenchymal and epithelial states and the concomitant gene expression changes. Science Foundation in China. 2016,24(1):50-62. 通讯作者

    [22] Li L#, He S, Zheng H*. The Abilities of ShDNMT1 to Promote Reprogramming are Enhanced by Vitamin C-recused Proliferation. China Biotechnology. 2016, 36(6): 1-8. 通讯作者

    [21] Sun H#, Liang L, Li Y, Feng C, Li L, Zhang Y, He S, Pei D, Guo Y*, Zheng H*. Lysine-specific histone demethylase 1 inhibition promotes reprogramming by facilitating the expression of exogenous transcriptional factors and metabolic switch. Scientific Reports. 2016 Aug 2;6:30903. 共同通讯作者

[20] Liang L#, Sun H#, Zhang W, Zhang M, Yang X, Kuang R, Zheng H*. Meta-Analysis of EMT Datasets Reveals Different Types of EMT. PLoS One. 2016 Jun 3;11(6):e0156839. 通讯作者

[19] Huang Z#, Liang L#, Li L#, Xu M, Li X, Sun H, He S, Lin L, Zhang Y, Song Y, Yang M, Luo Y, Loh HH, Law PY, Zheng D*, Zheng H*. Opioid doses required for pain management in lung cancer patients with different cholesterol levels: negative correlation between opioid doses and cholesterol levels. Lipids in Health and Disease. 2016 Mar 8;15:47. 共同通讯作者

    [18] Chen J#, Li W, Li Y, He S, Li L, Liang L, Song Y, Qin D*, Zheng H*. MicroRNA-128-3p impaired water maze learning by suppressing Doublecortin expression in both wild type and Aβ-42 infused mice. Neuroscience Letters. 2016 Jul 28;626:79-85. 共同通讯作者

    [17] He S#, Guo Y, Zhang Y, Li Y, Feng C, Li X, Lin L, Guo L, Wang H, Liu C, Zheng Y, Luo C, Liu Q, Wang F, Sun H, Liang L, Li L, Su H, Chen J, Pei D*, Zheng H*. Reprogramming somatic cells to cells with neuronal characteristics by defined medium both in vitro and in vivo. Cell Regeneration. 2015 Dec 30;4:12. 共同通讯作者

[16] Zheng H#, Hutchins AP, Pan G, Li Y, Pei D*, Pei G*. Where cell fate conversions meet Chinese philosophy. Cell Research. 2014 Oct;24(10):1162-3. 第一作者

[15] Li X#, Pei D, Zheng H*. Transitions between epithelial and mesenchymal states during cell fate conversions. Protein Cell. 2014;5(8):580-91. 通讯作者

    [14] Li W#, He S#, Zhou Y, Li Y, Hao J, Zhou X, Wang F, Zhang Y, Huang Z, Li Z, Loh HH, Law PY, Zheng H*. Neurod1 modulates opioid antinociceptive tolerance via two distinct mechanisms. Biological Psychiatry. 2014 Nov 15;76(10):775-84. 通讯作者

    [13] Zheng H*#, Zhang Y, Li W, Loh HH, Law PY. NeuroD modulates opioid agonist-selective regulation of adult neurogenesis and contextual memory extinction. Neuropsychopharmacology. 2013 Apr;38(5):770-7. 第一作者+通讯作者

    [12] Zheng H*#, Loh HH, Law PY. Posttranslation modification of G protein-coupled receptor in relationship to biased agonism. Methods in Enzymology. 2013;522:391-408. 第一作者+通讯作者

[11] Liu X#, Sun H, Qi J, Wang L, He S, Liu J, Feng C, Chen C, Li W, Guo Y, Qin D, Pan G, Chen J, Pei D*, Zheng H*. Sequential introduction of reprogramming factors reveals a time-sensitive requirement for individual factors and a sequential EMT-MET mechanism for optimal reprogramming. Nature Cell Biology. 2013 Jul;15(7):829-38. 共同通讯作者

[10] Zheng H*#, Zou H, Liu X, Chu J, Zhou Y, Loh HH, Law PY. Cholesterol level influences opioid signaling in cell models and analgesia in mice and humans. Journal of Lipid Research. 2012 Jun;53(6):1153-62. 第一作者+通讯作者 

[9]           Zheng H*#, Pearsall EA, Hurst DP, Zhang Y, Chu J, Zhou Y, Reggio PH, Loh HH, Law PY. Palmitoylation and membrane cholesterol stabilize μ-opioid receptor homodimerization and G protein coupling. BMC Cell Biology. 2012 Mar 19;13:6. 第一作者+通讯作者   

[8]           Zheng H*#, Law PY, Loh HH. Non-Coding RNAs Regulating Morphine Function: With Emphasis on the In vivo and In vitro Functions of miR-190. Frontiers in Genetics. 2012 Jun 15;3:113. 第一作者+通讯作者   

[7]           Zheng H*#, Chu J, Zhang Y, Loh HH, Law PY. Modulating micro-opioid receptor phosphorylation switches agonist-dependent signaling as reflected in PKCepsilon activation and dendritic spine stability. The Journal of Biological Chemistry. 2011 Apr 8;286(14):12724-33. 第一作者+通讯作者

[6]           Zheng H*#, Zeng Y, Zhang X, Chu J, Loh HH, Law PY. mu-Opioid receptor agonists differentially regulate the expression of miR-190 and NeuroD. Molecular Pharmacology. 2010 Jan;77(1):102-9. 第一作者+通讯作者

[5]           Zheng H*#, Zeng Y, Chu J, Kam AY, Loh HH, Law PY. Modulations of NeuroD activity contribute to the differential effects of morphine and fentanyl on dendritic spine stability. Journal of Neuroscience. 2010 Jun 16;30(24):8102-10. 第一作者+通讯作者

[4]           Zheng H*#, Loh HH, Law PY. Agonist-selective signaling of G protein-coupled receptor: mechanisms and implications. IUBMB Life. 2010 Feb;62(2):112-9. 第一作者+通讯作者

[3]           Zheng H*#, Chu J, Zeng Y, Loh HH, Law PY. Yin Yang 1 phosphorylation contributes to the differential effects of mu-opioid receptor agonists on microRNA-190 expression. The Journal of Biological Chemistry. 2010 Jul 16;285(29):21994-2002. 第一作者+通讯作者

[2]           Zheng H*#, Loh HH, Law PY. Beta-arrestin-dependent mu-opioid receptor-activated extracellular signal-regulated kinases (ERKs) Translocate to Nucleus in Contrast to G protein-dependent ERK activation. Molecular Pharmacology. 2008 Jan;73(1):178-90. 第一作者+通讯作者

[1]           Zheng H*#, Chu J, Qiu Y, Loh HH, Law PY. Agonist-selective signaling is determined by the receptor location within the membrane domains. Proceedings of the National Academy of Sciences of the United States of America. 2008 Jul 8;105(27):9421-6. 第一作者+通讯作者

2010. 10 Beijing Forest University, Beijing,China
Oral Presentation in ASBMB. Title: “Opioid, NeuroD, Adult Neurogenesis and Memory”, Hui Zheng, Ji Chu, Horace H. Loh and Ping-Yee Law”

2010. 09 Cold Spring Harbor Asia Conference, Suzhou,China
Oral Presentation Titled “NeuroD, Adult Neurogenesis and Memory” in “Reprogramming and Plasticity” section, “Molecular Switches & Genome Function in Stem Cells & Development”, Hui Zheng, Ji Chu, Horace H. Loh and Ping-Yee Law”

2010. 04 Experimental Biology 2010, Anaheim, CA
Poster Presentation in ASBMB. Title: “Yin Yang 1 Phosphorylation contributes to the differential effects of µ-opioid receptor agonists on miR-190 expression”, Hui Zheng, Ji Chu, Yan Zeng, Horace H. Loh and Ping-Yee Law”


2009. 10 Society of neuroscience annual meeting in Chicago, IL.
Poster Presentation Title: μ-opioid receptor modulates the stability of dendritic spines by agonist-selective regulation on NeuroD activity. Hui Zheng, Yan Zeng, Xiaoxiao Zhang, Ji Chu, Horace H. Loh and Ping-Yee Law

2009. 05 2nd Annual Biomedical Sciences Graduate Programs, Minneapolis, MN
Oral Presentation. Title: “Agonist-selective signaling of MOR” Hui Zheng, Horace H. Loh and Ping-Yee Law

2008.08 236th American Chemical Society National Meeting, Philadelphia, PA
Oral Presentation in a symposium: “Pharmacology: The Forgotten Art of Drug Discovery”. Title: “Agonist-Selective Signaling On mu-Opioid Receptor, Hui Zheng, Horace H. Loh and Ping-Yee Law”

2008.05 1st Annual Biomedical Sciences Graduate Programs, Minneapolis, MN
Poster Presentation. Title: “Agonist-selective signaling of MOR agonists, morphine and fentanyl, Hui Zheng, Horace H. Loh and Ping-Yee Law

2008.04 Experimental Biology 2008, San Diego, CA
Poster Presentation in Program: “G Protein II”, ASPET. Title: “Morphine and Etorphine activate same G protein but exhibit distinct pathways in μ-opioid receptor-mediated ERK1/2 activation, Hui Zheng, Horace H. Loh and Ping-Yee Law”