病毒感染与致病的分子机制、病毒与宿主相互作用

   

071010-生物化学与分子生物学
071005-微生物学

病毒与天然免疫系统相互作用，病毒感染的分子机理
分子病毒学

2005-09--2011-06   中国科学院武汉病毒研究所   理学博士学位
2001-09--2005-06   湖北大学   学士学位

2005-09--2011-06   中国科学院武汉病毒研究所   理学博士学位
2001-09--2005-06   湖北大学   学士学位

 理学博士学位

2019-09~现在, 中国科学院武汉病毒研究所, 研究员
2013-09~2019-08,中国科学院武汉病毒研究所, 副研究员
2011-07~2013-08,中国科学院武汉病毒研究所, 助理研究员

2019-09~现在, 中国科学院武汉病毒研究所, 研究员
2013-09~2019-08,中国科学院武汉病毒研究所, 副研究员
2011-07~2013-08,中国科学院武汉病毒研究所, 助理研究员

分子生物学

   

[1] 王汉中, 柯贤良, 张万坡, 李红霞, 郑振华, 张振峰. 复制缺陷型抗EV71和CA16病毒双价疫苗的制备方法. CN: CN102284058A, 2011-12-21.

   

[1] Yuanjiu Miao, Yue Zheng, Ting Wang, Wenfu Yi, Nailou Zhang, Wanpo Zhang, Zhenhua Zheng. Breast milk transmission and involvement of mammary glands in tick-borne flavivirus infected mice. JOURNAL OF VIROLOGY[J]. 2024, 第 7 作者  通讯作者  98(3): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10949448/.
[2] Zhang, Nailou, Tan, Zhongyuan, Wei, Jinbo, Zhang, Sai, Liu, Yan, Miao, Yuanjiu, Ding, Qingwen, Yi, Wenfu, Gan, Min, Li, Chunjie, Liu, Bin, Wang, Hanzhong, Zheng, Zhenhua. Identification of novel anti-ZIKV drugs from viral-infection temporal gene expression profiles. EMERGING MICROBES & INFECTIONS[J]. 2023, 第 13 作者  通讯作者  12(1): http://dx.doi.org/10.1080/22221751.2023.2174777.
[3] Yixia Yang, Wenfu Yi, Feng Gong, Zhiyou Tan, Xiaoyun Shan, JingJing Qian, Conghua Xie, Xinghu Ji, Zhenhua Zheng, Zhike He. An all-in-one assay based on CRISPR/Cas13a and a DNA circuit for rapid and ultrasensitive detection of Echovirus 11. SENSORS AND ACTUATORS: B. CHEMICAL. 2023, 第 9 作者  通讯作者  388: http://dx.doi.org/10.1016/j.snb.2023.133851.
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[5] XuRui Shen, Rong Geng, Qian Li, Ying Chen, ShuFen Li, Qi Wang, Juan Min, Yong Yang, Bei Li, RenDi Jiang, Xi Wang, XiaoShuang Zheng, Yan Zhu, JingKun Jia, XingLou Yang, MeiQin Liu, QianChun Gong, YuLan Zhang, ZhenQiong Guan, HuiLing Li, ZhenHua Zheng, ZhengLi Shi, HuiLan Zhang, Ke Peng, Peng Zhou. ACE2-independent infection of T lymphocytes by SARS-CoV-2. SIGNAL TRANSDUCTION AND TARGETED THERAPY[J]. 2022, 第 21 作者7(1): http://dx.doi.org/10.1038/s41392-022-00919-x.
[6] Yang, Hang, Xu, Jingjing, Gong, Yujing, Tang, Yan, Li, Wuyou, Zheng, Zhenhua, Li, Yuhong, He, Jin, Wei, Hongping. Internal cell-penetrating peptide-mediated internalization enables a chimeric lysin to target intracellular pathogens. INTERNATIONAL JOURNAL OF PHARMACEUTICS[J]. 2021, 第 6 作者599: http://dx.doi.org/10.1016/j.ijpharm.2021.120449.
[7] Yang, Jieyu, Jing, Xuping, Yi, Wenfu, Li, XiaoDan, Yao, Chen, Zhang, Bo, Zheng, Zhenhua, Wang, Hanzhong, Gong, Peng. Crystal structure of a tick-borne flavivirus RNA-dependent RNA polymerase suggests a host adaptation hotspot in RNA viruses. NUCLEIC ACIDS RESEARCH[J]. 2021, 第 7 作者  通讯作者  49(3): 1567-1580, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7897508/.
[8] Li, Penghui, Yao, Chen, Wang, Ting, Wu, Tong, Yi, Wenfu, Zheng, Yue, Miao, Yuanjiu, Sun, Jianhong, Tan, Zhongyuan, Liu, Yan, Zhang, Xiaowei, Wang, Hanzhong, Zheng, Zhenhua. Recovery of a Far-Eastern Strain of Tick-Borne Encephalitis Virus with a Full-Length Infectious cDNA Clone. VIROLOGICASINICA[J]. 2021, 第 13 作者  通讯作者  
[9] Ke, Xianliang, Li, Chunjie, Luo, Dan, Wang, Ting, Liu, Yan, Tan, Zhongyuan, Du, Mingyuan, He, Zhike, Wang, Hanzhong, Zheng, Zhenhua, Zhang, Yuan. Metabolic labeling of enterovirus 71 with quantum dots for the study of virus receptor usage. JOURNAL OF NANOBIOTECHNOLOGY[J]. 2021, 第 10 作者  通讯作者  19(1): http://dx.doi.org/10.1186/s12951-021-01046-5.
[10] Du, Mingyuan, Zheng, Jiao, Tian, Songbai, Liu, Yucheng, Zheng, Zhenhua, Wang, Hanzhong, Xia, Jianbo, Ji, Xinghu, He, Zhike. DNAzyme Walker for Homogeneous Detection of Enterovirus EV71 and CVB3. ANALYTICAL CHEMISTRY[J]. 2021, 第 5 作者93(13): 5606-5611, http://dx.doi.org/10.1021/acs.analchem.1c00335.
[11] Ke, Xianliang, Zhang, Yuan, Liu, Yan, Miao, Yuanjiu, Zheng, Caishang, Luo, Dan, Sun, Jianhong, Hu, Qinxue, Xu, Yi, Wang, Hanzhong, Zheng, Zhenhua. A Single Mutation in the VP1 Gene of Enterovirus 71 Enhances Viral Binding to Heparan Sulfate and Impairs Viral Pathogenicity in Mice. VIRUSES-BASEL[J]. 2020, 第 11 作者  通讯作者  12(8): http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000579055300001.
[12] DanLuo, ZhiXia, HengLi, DannaTu, TingWang, WeiZhang, LuPeng, WenfuYi, SaiZhang, JunhuaShu, HuiXu, YongLi, BuyunShi, ChengjiaoHuang, WenTang, ShunaXiao, XiaolanShu, YanLiu, YuanZhang, ShanGuo, ZhiYu, BaoxiangWang, YuanGao, QinxueHu, HanzhongWang, XiaohuiSong, HongMei, XiaoqinZhou, ZhenhuaZheng. Epidemiological, Clinical and Serological Characteristics of Children with Coronavirus Disease 2019 in Wuhan: A Single-centered, Retrospective Study. Virologica Sinica[J]. 2020, 第 29 作者  通讯作者  35(6): 861-867, https://www.virosin.org/article/doi/10.1007/s12250-020-00333-z.
[13] DanLuo, YuanjiuMiao, XianliangKe, ZhongyuanTan, ChunHu, PenghuiLi, TingWang, YuanZhang, JianhongSun, YanLiu, HanzhongWang, ZhenhuaZheng. Baculovirus Surface Display of Zika Virus Envelope Protein Protects against Virus Challenge in Mouse Model. Virologica Sinica[J]. 2020, 第 12 作者  通讯作者  35(5): 637-650, https://www.virosin.org/article/doi/10.1007/s12250-020-00238-x.
[14] Wang, Ting, Li, Penghui, Zhang, Yuan, Liu, Yan, Tan, Zhongyuan, Sun, Jianhong, Ke, Xianliang, Miao, Yuanjiu, Luo, Dan, Hu, Qinxue, Xu, Fuqiang, Wang, Hanzhong, Zheng, Zhenhua. In vivo imaging of Zika virus reveals dynamics of viral invasion in immune-sheltered tissues and vertical propagation during pregnancy. THERANOSTICS[J]. 2020, 第 13 作者  通讯作者  10(14): 6430-6447, https://www.webofscience.com/wos/woscc/full-record/WOS:000534615100023.
[15] Sun, Jianhong, Zhang, Wanpo, Tan, Zhongyuan, Zheng, Caishang, Tang, Yan, Ke, Xianliang, Zhang, Yuan, Liu, Yan, Li, Penghui, Hu, Qinxue, Wang, Hanzhong, Mao, Panyong, Zheng, Zhenhua. Zika virus promotes CCN1 expression via the CaMKII alpha-CREB pathway in astrocytes. VIRULENCE[J]. 2020, 第 13 作者  通讯作者  11(1): 113-131, http://dx.doi.org/10.1080/21505594.2020.1715189.
[16] 王倩云, 彭晖, 郑振华, 芦宝静. 蜱传脑炎病毒感染小鼠脑组织单核细胞趋化蛋白1（MCP-1）、CD68和核因子κB（NF-κB）表达增加. 细胞与分子免疫学杂志[J]. 2020, 第 3 作者36(1): 9-13, http://lib.cqvip.com/Qikan/Article/Detail?id=7102046646.
[17] Wang, JiaJia, Zheng, Caishang, Jiang, YongZhong, Zheng, Zhenhua, Lin, Miao, Lin, Yi, Zhang, ZhiLing, Wang, Hanzhong, Pang, DaiWen. One-Step Monitoring of Multiple Enterovirus 71 Infection-Related MicroRNAs Using Core-Satellite Structure of Magnetic Nanobeads and Multicolor Quantum Dots. ANALYTICAL CHEMISTRY[J]. 2020, 第 4 作者92(1): 830-837, https://www.webofscience.com/wos/woscc/full-record/WOS:000506719400072.
[18] Qin, Fujun, Xu, Congrui, Hu, Jia, Lei, Chengfeng, Zheng, Zhenhua, Peng, Ke, Wang, Hanzhong, Sun, Xiulian. Dissecting the Cell Entry Pathway of Baculovirus by Single-Particle Tracking and Quantitative Electron Microscopic Analysis. JOURNAL OF VIROLOGY[J]. 2019, 第 5 作者93(8): 
[19] Wei, Chunyu, Zheng, Caishang, Sun, Jianhong, Luo, Dan, Tang, Yan, Zhang, Yuan, Ke, Xianliang, Liu, Yan, Zheng, Zhenhua, Wang, Hanzhong. Viperin Inhibits Enterovirus A71 Replication by Interacting with Viral 2C Protein. VIRUSES-BASEL[J]. 2019, 第 9 作者  通讯作者  11(1): https://www.webofscience.com/wos/woscc/full-record/WOS:000459132000013.
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[24] Chunyu Wei, Caishang Zheng, Jianhong Sun, Dan Luo, Yan Tang, Yuan Zhang, Xianliang Ke, Yan Liu, Zhenhua Zheng, Hanzhong Wang. Viperin Inhibits Enterovirus A71 Replication by Interacting with Viral 2C Protein. VIRUSES[J]. 2018, 第 9 作者11(1): https://doaj.org/article/3023cba250524876836c0e971e95ff73.
[25] Ke, Xianliang, Zhang, Yuan, Zheng, Fangliang, Liu, Yan, Zheng, Zhenhua, Xu, Yi, Wang, Hanzhong. SpyCatcher-SpyTag mediated in situ labelling of progeny baculovirus with quantum dots for tracking viral infection in living cells. CHEMICAL COMMUNICATIONS[J]. 2018, 第 5 作者54(10): 1189-1192, http://www.corc.org.cn/handle/1471x/2373342.
[26] Li, Penghui, Ke, Xianliang, Wang, Ting, Tan, Zhongyuan, Luo, Dan, Miao, Yuanjiu, Sun, Jianhong, Zhang, Yuan, Liu, Yan, Hu, Qinxue, Xu, Fuqiang, Wang, Hanzhong, Zheng, Zhenhua. Zika Virus Attenuation by Codon Pair Deoptimization Induces Sterilizing Immunity in Mouse Models. JOURNAL OF VIROLOGY[J]. 2018, 第 13 作者  通讯作者  92(17): http://dx.doi.org/10.1128/JVI.00701-18.
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已指导学生

唐妍  硕士研究生  085238-生物工程  

韦春雨  硕士研究生  071010-生物化学与分子生物学  

苗元玖  硕士研究生  085238-生物工程  

现指导学生

姚琛  硕士研究生  071010-生物化学与分子生物学  

隋妍  硕士研究生  071005-微生物学  

郑月  硕士研究生  071005-微生物学  

张赛  硕士研究生  071010-生物化学与分子生物学