基本信息
赵逾涵  女  博导  中国科学院昆明植物研究所
电子邮件: zhaoyuhan@mail.kib.ac.cn
通信地址: 云南省昆明市蓝黑路132号
邮政编码:

研究领域

1.肿瘤相关突变型p53促癌功能获得(Gain-of-function)的机制研究

2.特异性靶向突变型p53信号通路的小分子化合物筛选及药理学研究

招生信息

拟招收博士研究生1名、硕士研究生1名

招生专业
100706-药理学
招生方向
药理学
肿瘤生物学

教育背景

2013-09--2018-10   美国新泽西州立罗格斯大学   博士研究生/药理学博士
2010-09--2012-12   山东大学医学院   硕士研究生/临床医学硕士
2004-09--2010-06   山东大学医学院   本科生/医学学士

工作经历

   
工作简历
2019-04~现在, 中国科学院昆明植物研究所, 研究员
2018-10~2019-03,美国罗格斯大学新泽西癌症研究所, 博士后
2011-12~2013-09,美国新泽西医学牙科大学, 访问学者

专利与奖励

   
奖励信息
(1) 国家优秀自费留学生奖学金, , 国家级, 2017
(2) 美国国立卫生院F99基金, 院级, 2017
(3) 美国罗格斯大学Aaron Shatkin奖学金, 一等奖, 研究所(学校), 2016
(4) 国家奖学金, 国家级, 2007
(5) 山东大学优秀学生奖学金, 一等奖, 研究所(学校), 2007

出版信息

   
代表性论文
[1] Zhao, Yueqin, Yang, Xu, Fei, Jimin, Dong, Xianxiang, Wang, Yinyuan, Yang, Shan, Hao, Xiaojiang, Ding, Xiao, Zhao, Yuhan. Identification of limonoids from Walsura yunnanensis and evaluation of their cytotoxicity against cancer cell lines. FITOTERAPIA[J]. 2022, 157: http://dx.doi.org/10.1016/j.fitote.2021.105120.
[2] Lan, Mingxian, Gao, Xi, Duan, Xiuan, Li, Hongmei, Yu, Hang, Li, Jinliang, Zhao, Yueqin, Hao, Xiaojiang, Zhao, Yuhan, Ding, Xiao, Wu, Guoxing. Nematicidal activity of tirotundin and parthenolide isolated from Tithonia diversifolia and Chrysanthemum parthenium. JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART B-PESTICIDES FOOD CONTAMINANTS AND AGRICULTURAL WASTES[J]. 2022, 57(1): 54-61, [3] ChunYuan Chang, Jianming Wang, Yuhan Zhao, Juan Liu, Xue Yang, Xuetian Yue, Huaying Wang, Fan Zhou, Juan M InclanRico, John J Ponessa, Ping Xie, Lanjing Zhang, Mark C Siracusa, Zhaohui Feng, Wenwei Hu. Tumor suppressor p53 regulates intestinal type 2 immunity. NATURE COMMUNICATIONS[J]. 2021, 12(1): http://dx.doi.org/10.1038/s41467-021-23587-x.
[4] Wei, Ruiran, Zhao, Yueqin, Wang, Juan, Yang, Xu, Li, Shunlin, Wang, Yinyuan, Yang, Xingzhi, Fei, Jimin, Hao, Xiaojiang, Zhao, Yuhan, Gui, Liming, Ding, Xiao. Tagitinin C induces ferroptosis through PERK-Nrf2-HO-1 signaling pathway in colorectal cancer cells. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES[J]. 2021, 17(11): 2703-2717, http://dx.doi.org/10.7150/ijbs.59404.
[5] Chan, Chang S, Sun, Yvonne, Ke, Hua, Zhao, Yuhan, Belete, Merzu, Zhang, Cen, Feng, Zhaohui, Levine, Arnold J, Hu, Wenwei. Genetic and stochastic influences upon tumor formation and tumor types in Li-Fraumeni mouse models. LIFE SCIENCE ALLIANCE[J]. 2021, 4(3): http://dx.doi.org/10.26508/lsa.202000952.
[6] Wang, Huaying, Wang, Jianming, Zhao, Yuhan, Zhang, Xiao, Liu, Juan, Zhang, Cen, Haffty, Bruce, Verzi, Michael, Zhang, Lanjing, Gao, Nan, Feng, Zhaohui, Hu, Wenwei. LIF is essential for ISC function and protects against radiation-induced gastrointestinal syndrome. CELL DEATH & DISEASE[J]. 2020, 11(7): https://doaj.org/article/63e12ea63a5440a1be11f08af02e3af6.
[7] Yang, Yang, KarsliUzunbas, Gizem, PoilletPerez, Laura, Sawant, Akshada, Hu, Zhixian Sherrie, Zhao, Yuhan, Moore, Dirk, Hu, Wenwei, White, Eileen. Autophagy promotes mammalian survival by suppressing oxidative stress and p53. GENES & DEVELOPMENT[J]. 2020, 34(9-10): 688-700, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7197357/.
[8] Li, Mengyue, Gao, Xi, Lan, Mingxian, Liao, Xianbin, Su, Fawu, Fan, Liming, Zhao, Yuhan, Hao, Xiaojiang, Wu, Guoxing, Ding, Xiao. Inhibitory activities of flavonoids from Eupatorium adenophorum against acetylcholinesterase. PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY[J]. 2020, 170: http://dx.doi.org/10.1016/j.pestbp.2020.104701.
[9] Huaying Wang, Jianming Wang, Yuhan Zhao, Xiao Zhang, Juan Liu, Cen Zhang, Bruce Haffty, Michael Verzi, Lanjing Zhang, Nan Gao, Zhaohui Feng, Wenwei Hu. LIF is essential for ISC function and protects against radiation-induced gastrointestinal syndrome. Cell Death & Disease. 2020, 11(7): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7385639/.
[10] Zhao, Yuhan, Wu, Lihua, Yue, Xuetian, Zhang, Cen, Wang, Jianming, Li, Jun, Sun, Xiaohui, Zhu, Yiming, Feng, Zhaohui, Hu, Wenwei. A polymorphism in the tumor suppressor p53 affects aging and longevity in mouse models. ELIFE[J]. 2018, 7: https://doaj.org/article/9722c0b879e543a2b2ec9c069840f726.
[11] WeiGang Qiu, Alla Polotskaia, Gu Xiao, Lia Di, Yuhan Zhao, Wenwei Hu, John Philip, Ronald C Hendrickson, Jill Bargonetti. Identification, validation, and targeting of the mutant p53-PARP-MCM chromatin axis in triple negative breast cancer. NPJ BREAST CANCER[J]. 2017, 3(1): http://dx.doi.org/10.1038/s41523-016-0001-7.
[12] Liu, Juan, Zhang, Cen, Zhao, Yuhan, Feng, Zhaohui. MicroRNA Control of p53. JOURNAL OF CELLULAR BIOCHEMISTRY[J]. 2017, 118(1): 7-14, https://www.webofscience.com/wos/woscc/full-record/WOS:000387809300001.
[13] Yue, Xuetian, Zhang, Cen, Zhao, Yuhan, Liu, Juan, Lin, Alan W, Tan, Victor M, Drake, Justin M, Liu, Lianxin, Boateng, Michael N, Li, Jun, Feng, Zhaohui, Hu, Wenwei. Gain-of-function mutant p53 activates small GTPase Rac1 through SUMOylation to promote tumor progression. GENES & DEVELOPMENT[J]. 2017, 31(16): 1641-1654, https://www.webofscience.com/wos/woscc/full-record/WOS:000411629600003.
[14] Juan Liu, Cen Zhang, Yuhan Zhao, Xuetian Yue, Hao Wu, Shan Huang, James Chen, Kyle Tomsky, Haiyang Xie, Christen A Khella, Michael L Gatza, Dajing Xia, Jimin Gao, Eileen White, Bruce G Haffty, Wenwei Hu, Zhaohui Feng. Parkin targets HIF-1α for ubiquitination and degradation to inhibit breast tumor progression. Nature Communications[J]. 2017, 8(1): 1-16, https://doaj.org/article/21615c60190c416990f49adb86754ecf.
[15] Yue, Xuetian, Zhao, Yuhan, Xu, Yang, Zheng, Min, Feng, Zhaohui, Hui, Wenwei. Mutant p53 in Cancer: Accumulation, Gain-of-Function, and Therapy. JOURNAL OF MOLECULAR BIOLOGYnull. 2017, 429(11): 1595-1606, http://dx.doi.org/10.1016/j.jmb.2017.03.030.
[16] Yue, Xuetian, Zhao, Yuhan, Zhang, Cen, Li, Jun, Liu, Zhen, Liu, Juan, Hu, Wenwei. Leukemia inhibitory factor promotes EMT through STAT3-dependent miR-21 induction. ONCOTARGET[J]. 2016, 7(4): 3777-3790, https://www.webofscience.com/wos/woscc/full-record/WOS:000369952400011.
[17] Zhang, Cen, Liu, Juan, Zhao, Yuhan, Yue, Xuetian, Zhu, Yu, Wang, Xiaolong, Wu, Hao, Blanco, Felix, Li, Shaohua, Bhanot, Gyan, Haffty, Bruce G, Hu, Wenwei, Feng, Zhaohui. Glutaminase 2 is a novel negative regulator of small GTPase Rac1 and mediates p53 function in suppressing metastasis. ELIFE[J]. 2016, 5: https://doaj.org/article/22c62ddb3b184de1ad1026ebb99b808a.
[18] Yue, Xuetian, Zhao, Yuhan, Huang, Grace, Li, Jun, Zhu, Junlan, Feng, Zhaohui, Hu, Wenwei. A novel mutant p53 binding partner BAG5 stabilizes mutant p53 and promotes mutant p53 GOFs in tumorigenesis. CELL DISCOVERY[J]. 2016, 2: 16039-, https://www.webofscience.com/wos/woscc/full-record/WOS:000414897800001.
[19] Zhang, Cen, Liu, Juan, Huang, Grace, Zhao, Yuhan, Yue, Xuetian, Wu, Hao, Li, Jun, Zhu, Junlan, Shen, Zhiyuan, Haffty, Bruce G, Hu, Wenwei, Feng, Zhaohui. Cullin3-KLHL25 ubiquitin ligase targets ACLY for degradation to inhibit lipid synthesis and tumor progression. GENES & DEVELOPMENT[J]. 2016, 30(17): 1956-1970, https://www.webofscience.com/wos/woscc/full-record/WOS:000384964600007.
[20] 赵逾涵. A novel mutant p53 binding partener BAG5 stabilizes mutant p53 and promotes mutant p53 GOFs in tumorigenesis.. Cell Discovery. 2016, [21] Zhang, Cen, Liu, Juan, Tan, Chunwen, Yue, Xuetian, Zhao, Yuhan, Peng, Jiaping, Wang, Xiaolong, Laddha, Saurabh V, Chan, Chang S, Zheng, Shu, Hu, Wenwei, Feng, Zhaohui. microRNA-1827 represses MDM2 to positively regulate tumor suppressor p53 and suppress tumorigenesis. ONCOTARGET[J]. 2016, 7(8): 8783-8796, https://www.webofscience.com/wos/woscc/full-record/WOS:000375618100027.
[22] Yuhan Zhao, Xuetian Yue, Wenwei Hu. Pontin, a novel interactor of mutant p53 that promotes mutant p53 gain of function. Molecular & Cellular Oncology. 2015, 3(2): [23] Xuetian Yue. BAG2 promotes tumorigenesis through enhancing mutant p53 protein levels and function. eLife Sciences Publications, Ltd. 2015, http://oa.las.ac.cn/oainone/service/browseall/read1?ptype=JA&workid=JA201904029098695ZK.
[24] Lihua Wu, Haiyang Yu, Yuhan Zhao, Cen Zhang, Jiabei Wang, Xuetian Yue, Qifeng Yang, Wenwei Hu. HIF-2α mediates hypoxia-induced LIF expression in human colorectal cancer cells. Oncotarget. 2015, 6(6): 4406-4417, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414199/.
[25] Zhao, Y, Zhang, C, Yue, X, Li, X, Liu, J, Yu, H, Belyi, V A, Yang, Q, Feng, Z, Hu, W. Pontin, a new mutant p53-binding protein, promotes gain-of-function of mutant p53. CELL DEATH AND DIFFERENTIATION[J]. 2015, 22(11): 1824-1836, https://www.webofscience.com/wos/woscc/full-record/WOS:000362438500010.
[26] Liu, Juan, Zhang, Cen, Lin, Meihua, Zhu, Wei, Liang, Yingjian, Hong, Xuehui, Zhao, Yuhan, Young, Ken H, Hu, Wenwei, Feng, Zhaohui. Glutaminase 2 negatively regulates the PI3K/AKT signaling and shows tumor suppression activity in human hepatocellular carcinoma. ONCOTARGET[J]. 2014, 5(9): 2635-2647, https://www.webofscience.com/wos/woscc/full-record/WOS:000336966600025.
[27] Li, Xiaoyan, Yang, Qifeng, Yu, Haiyang, Wu, Lihua, Zhao, Yuhan, Zhang, Cen, Yue, Xuetian, Liu, Zhen, Wu, Hao, Haffty, Bruce G, Feng, Zhaohui, Hu, Wenwei. LIF promotes tumorigenesis and metastasis of breast cancer through the AKT-mTOR pathway. ONCOTARGET[J]. 2014, 5(3): 788-801, https://www.webofscience.com/wos/woscc/full-record/WOS:000332701300019.
[28] Yu, Haiyang, Yue, Xuetian, Zhao, Yuhan, Li, Xiaoyan, Wu, Lihua, Zhang, Cen, Liu, Zhen, Lin, Kevin, XuMonette, Zijun Y, Young, Ken H, Liu, Juan, Shen, Zhiyuan, Feng, Zhaohui, Hu, Wenwei. LIF negatively regulates tumour-suppressor p53 through Stat3/ID1/MDM2 in colorectal cancers. NATURE COMMUNICATIONS[J]. 2014, 5: https://www.webofscience.com/wos/woscc/full-record/WOS:000343982800007.
[29] Zhao, Yuhan, Yu, Haiyang, Hu, Wenwei. The regulation of MDM2 oncogene and its impact on human cancers. ACTA BIOCHIMICA ET BIOPHYSICA SINICAnull. 2014, 46(3): 180-189, https://www.webofscience.com/wos/woscc/full-record/WOS:000332100100003.
[30] Zhang, Cen, Liu, Juan, Liang, Yingjian, Wu, Rui, Zhao, Yuhan, Hong, Xuehui, Lin, Meihua, Yu, Haiyang, Liu, Lianxin, Levine, Arnold J, Hu, Wenwei, Feng, Zhaohui. Tumour-associated mutant p53 drives the Warburg effect. NATURE COMMUNICATIONS[J]. 2013, 4: https://www.webofscience.com/wos/woscc/full-record/WOS:000329396500021.
[31] Zheng, Tongsen, Wang, Jiabei, Zhao, Yuhan, Zhang, Cen, Lin, Meihua, Wang, Xiaowen, Yu, Haiyang, Liu, Lianxin, Feng, Zhaohui, Hu, Wenwei. Spliced MDM2 isoforms promote mutant p53 accumulation and gain-of-function in tumorigenesis. NATURE COMMUNICATIONS[J]. 2013, 4: 2996-2996, https://www.webofscience.com/wos/woscc/full-record/WOS:000329398400001.
[32] Kong, Xiaoli, Moran, Meena S, Zhao, Yuhan, Yang, Qifeng. Inhibition of metadherin sensitizes breast cancer cells to AZD6244. CANCER BIOLOGY & THERAPY[J]. 2012, 13(1): 43-49, https://www.webofscience.com/wos/woscc/full-record/WOS:000300356900005.
[33] Feng, Zhaohui, Liu, Lianxin, Zhang, Cen, Zheng, Tongsen, Wang, Jiabei, Lin, Meihua, Zhao, Yuhan, Wang, Xiaowen, Levine, Arnold J, Hu, Wenwei. Chronic restraint stress attenuates p53 function and promotes tumorigenesis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2012, 109(18): 7013-7018, https://www.webofscience.com/wos/woscc/full-record/WOS:000303602100054.
[34] Li, Xiaoyan, Xu, Bing, Moran, Meena S, Zhao, Yuhan, Su, Peng, Haffty, Bruce G, Shao, Changshun, Yang, Qifeng. 53BP1 functions as a tumor suppressor in breast cancer via the inhibition of NF-kappa B through miR-146a. CARCINOGENESIS[J]. 2012, 33(12): 2593-2600, https://www.webofscience.com/wos/woscc/full-record/WOS:000311903500033.
[35] Zhao, Yuhan, Kong, Xiaoli, Li, Xiaoyan, Yan, Shi, Yuan, Cunzhong, Hu, Wenwei, Yang, Qifeng. Metadherin Mediates Lipopolysaccharide-Induced Migration and Invasion of Breast Cancer Cells. PLOS ONE[J]. 2011, 6(12): https://doaj.org/article/d887ee1d40f146b7b783a91541a64247.

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