1.肿瘤相关突变型p53促癌功能获得（Gain-of-function）的机制研究

2.特异性靶向突变型p53信号通路的小分子化合物筛选及药理学研究

拟招收博士研究生1名、硕士研究生1名

100706-药理学

药理学
肿瘤生物学

2013-09--2018-10   美国新泽西州立罗格斯大学   博士研究生/药理学博士
2010-09--2012-12   山东大学医学院   硕士研究生/临床医学硕士
2004-09--2010-06   山东大学医学院   本科生/医学学士

   

2019-04~现在, 中国科学院昆明植物研究所, 研究员
2018-10~2019-03,美国罗格斯大学新泽西癌症研究所, 博士后
2011-12~2013-09,美国新泽西医学牙科大学, 访问学者

   

（1） 国家优秀自费留学生奖学金, , 国家级, 2017
（2） 美国国立卫生院F99基金, 院级, 2017
（3） 美国罗格斯大学Aaron Shatkin奖学金, 一等奖, 研究所（学校）, 2016
（4） 国家奖学金, 国家级, 2007
（5） 山东大学优秀学生奖学金, 一等奖, 研究所（学校）, 2007

   

[1] 肖龙高, 赵越勤, 丁骁, 刘晖, 朱光玉, 李彦茜, 严欢, 方欣, 赵逾涵, 刘海洋. Eudesmane-guaiane sesquiterpenoid dimers from Aucklandia costus trigger paraptosis-like cell death via ROS accumulation and MAPK hyperactivation. Chinese Journal of Natural Medicines[J]. 2024, 第 9 作者  通讯作者  
[2] 杨旭, 丁骁, 赵越勤, 汪印元, 董鲜祥, 牛振鹏, 谷志佳, 费继敏, 赵逾涵, 郝小江. Isowalsuranolide targets TrxR1/2 and triggers lysosomal biogenesis and autophagy via the p53-TFEB/TFE3 axis. Science China Life Sciences[J]. 2024, 第 9 作者  通讯作者  https://www.sciengine.com/SCLS/doi/10.1007/s11427-023-2563-6.
[3] 汪印元, 倪建成, 赵越勤, 杨旭, 牛振鹏, 杨杏芝, 董鲜祥, 赵逾涵, 郝小江, 丁骁. Iridoid glycosides from Morinda officinalis induce lysosomal biogenesis and promote autophagic flux to attenuate oxidative stress. Journal of Asian Natural Products Research[J]. 2023, 第 8 作者  通讯作者  26(5): 562-574, 
[4] Jinliang Li, Fengchao Li, Guoxing Wu, Furong Gui, Hongmei Li, Lili Xu, Xiaojiang Hao, Yuhan Zhao, Xiao Ding, Xiaoping Qin. Acetylcholinesterase inhibitory activity of sesquiterpenoids isolated from Laggera pterodonta. FRONTIERS IN PLANT SCIENCE[J]. 2023, 第 8 作者  通讯作者  14: https://doaj.org/article/59e82ba731984819bc8ce72b62a97753.
[5] Zhenpeng Niu, Guihua Tang, Xuenan Wang, Xu Yang, Yueqin Zhao, Yinyuan Wang, Qin Liu, Fan Zhang, Yuhan Zhao, Xiao Ding, Xiaojiang Hao. Trigonochinene E promotes lysosomal biogenesis and enhances autophagy via TFEB/TFE3 in human degenerative NP cells against oxidative stress. PHYTOMEDICINE[J]. 2023, 第 9 作者  通讯作者  http://dx.doi.org/10.1016/j.phymed.2023.154720.
[6] Yu, Hang, Li, Jinliang, Wu, Guoxing, Tang, Qingbo, Duan, Xiuan, Liu, Quanjun, Lan, Mingxian, Zhao, Yuhan, Hao, Xiaojiang, Qin, Xiaoping, Ding, Xiao. Antifeedant Mechanism of Dodonaea viscosa Saponin A Isolated from the Seeds of Dodonaea viscosa. MOLECULES[J]. 2022, 第 8 作者27(14): 
[7] Lan, Mingxian, Gao, Xi, Duan, Xiuan, Li, Hongmei, Yu, Hang, Li, Jinliang, Zhao, Yueqin, Hao, Xiaojiang, Zhao, Yuhan, Ding, Xiao, Wu, Guoxing. Nematicidal activity of tirotundin and parthenolide isolated from Tithonia diversifolia and Chrysanthemum parthenium. Journal of Environmental Science and Health, Part B[J]. 2022, 第 9 作者  通讯作者  57(1): 54-61, http://dx.doi.org/10.1080/03601234.2021.2022945.
[8] Zhao, Yueqin, Yang, Xu, Fei, Jimin, Dong, Xianxiang, Wang, Yinyuan, Yang, Shan, Hao, Xiaojiang, Ding, Xiao, Zhao, Yuhan. Identification of limonoids from Walsura yunnanensis and evaluation of their cytotoxicity against cancer cell lines. FITOTERAPIA[J]. 2022, 第 9 作者  通讯作者  157: http://dx.doi.org/10.1016/j.fitote.2021.105120.
[9] ChunYuan Chang, Jianming Wang, Yuhan Zhao, Juan Liu, Xue Yang, Xuetian Yue, Huaying Wang, Fan Zhou, Juan M InclanRico, John J Ponessa, Ping Xie, Lanjing Zhang, Mark C Siracusa, Zhaohui Feng, Wenwei Hu. Tumor suppressor p53 regulates intestinal type 2 immunity. NATURE COMMUNICATIONS[J]. 2021, 第 3 作者12(1): http://dx.doi.org/10.1038/s41467-021-23587-x.
[10] Wei, Ruiran, Zhao, Yueqin, Wang, Juan, Yang, Xu, Li, Shunlin, Wang, Yinyuan, Yang, Xingzhi, Fei, Jimin, Hao, Xiaojiang, Zhao, Yuhan, Gui, Liming, Ding, Xiao. Tagitinin C induces ferroptosis through PERK-Nrf2-HO-1 signaling pathway in colorectal cancer cells. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES[J]. 2021, 第 10 作者  通讯作者  17(11): 2703-2717, http://dx.doi.org/10.7150/ijbs.59404.
[11] 王娟, 杨旭, 赵越勤, 丁骁, 夏海滨, 赵逾涵. Tagitinin F诱导MDA-MB-231细胞凋亡作用机制研究. 中南药学[J]. 2021, 第 6 作者19(5): 789-794, http://lib.cqvip.com/Qikan/Article/Detail?id=7104653388.
[12] Chan, Chang S, Sun, Yvonne, Ke, Hua, Zhao, Yuhan, Belete, Merzu, Zhang, Cen, Feng, Zhaohui, Levine, Arnold J, Hu, Wenwei. Genetic and stochastic influences upon tumor formation and tumor types in Li-Fraumeni mouse models. LIFE SCIENCE ALLIANCE[J]. 2021, 第 4 作者4(3): http://dx.doi.org/10.26508/lsa.202000952.
[13] Wang, Huaying, Wang, Jianming, Zhao, Yuhan, Zhang, Xiao, Liu, Juan, Zhang, Cen, Haffty, Bruce, Verzi, Michael, Zhang, Lanjing, Gao, Nan, Feng, Zhaohui, Hu, Wenwei. LIF is essential for ISC function and protects against radiation-induced gastrointestinal syndrome. CELL DEATH & DISEASE[J]. 2020, 第 3 作者11(7): https://doaj.org/article/63e12ea63a5440a1be11f08af02e3af6.
[14] Li, Mengyue, Gao, Xi, Lan, Mingxian, Liao, Xianbin, Su, Fawu, Fan, Liming, Zhao, Yuhan, Hao, Xiaojiang, Wu, Guoxing, Ding, Xiao. Inhibitory activities of flavonoids from Eupatorium adenophorum against acetylcholinesterase. PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY[J]. 2020, 第 7 作者170: http://dx.doi.org/10.1016/j.pestbp.2020.104701.
[15] Huaying Wang, Jianming Wang, Yuhan Zhao, Xiao Zhang, Juan Liu, Cen Zhang, Bruce Haffty, Michael Verzi, Lanjing Zhang, Nan Gao, Zhaohui Feng, Wenwei Hu. LIF is essential for ISC function and protects against radiation-induced gastrointestinal syndrome. CELL DEATH & DISEASE[J]. 2020, 第 3 作者11(7): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7385639/.
[16] Yang, Yang, KarsliUzunbas, Gizem, PoilletPerez, Laura, Sawant, Akshada, Hu, Zhixian Sherrie, Zhao, Yuhan, Moore, Dirk, Hu, Wenwei, White, Eileen. Autophagy promotes mammalian survival by suppressing oxidative stress and p53. GENES & DEVELOPMENT[J]. 2020, 第 6 作者34(9-10): 688-700, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7197357/.
[17] Zhao, Yuhan, Wu, Lihua, Yue, Xuetian, Zhang, Cen, Wang, Jianming, Li, Jun, Sun, Xiaohui, Zhu, Yiming, Feng, Zhaohui, Hu, Wenwei. A polymorphism in the tumor suppressor p53 affects aging and longevity in mouse models. ELIFE[J]. 2018, 第 1 作者7: https://doaj.org/article/9722c0b879e543a2b2ec9c069840f726.
[18] WeiGang Qiu, Alla Polotskaia, Gu Xiao, Lia Di, Yuhan Zhao, Wenwei Hu, John Philip, Ronald C Hendrickson, Jill Bargonetti. Identification, validation, and targeting of the mutant p53-PARP-MCM chromatin axis in triple negative breast cancer. NPJ BREAST CANCER[J]. 2017, 第 5 作者3(1): http://dx.doi.org/10.1038/s41523-016-0001-7.
[19] Liu, Juan, Zhang, Cen, Zhao, Yuhan, Feng, Zhaohui. MicroRNA Control of p53. JOURNAL OF CELLULAR BIOCHEMISTRY[J]. 2017, 第 3 作者118(1): 7-14, https://www.webofscience.com/wos/woscc/full-record/WOS:000387809300001.
[20] Juan Liu, Cen Zhang, Yuhan Zhao, Xuetian Yue, Hao Wu, Shan Huang, James Chen, Kyle Tomsky, Haiyang Xie, Christen A Khella, Michael L Gatza, Dajing Xia, Jimin Gao, Eileen White, Bruce G Haffty, Wenwei Hu, Zhaohui Feng. Parkin targets HIF-1α for ubiquitination and degradation to inhibit breast tumor progression. NATURE COMMUNICATIONS[J]. 2017, 第 3 作者8(1): 1-16, https://doaj.org/article/21615c60190c416990f49adb86754ecf.
[21] Yue, Xuetian, Zhao, Yuhan, Xu, Yang, Zheng, Min, Feng, Zhaohui, Hui, Wenwei. Mutant p53 in Cancer: Accumulation, Gain-of-Function, and Therapy. JOURNAL OF MOLECULAR BIOLOGY. 2017, 第 2 作者429(11): 1595-1606, http://dx.doi.org/10.1016/j.jmb.2017.03.030.
[22] Yue, Xuetian, Zhang, Cen, Zhao, Yuhan, Liu, Juan, Lin, Alan W, Tan, Victor M, Drake, Justin M, Liu, Lianxin, Boateng, Michael N, Li, Jun, Feng, Zhaohui, Hu, Wenwei. Gain-of-function mutant p53 activates small GTPase Rac1 through SUMOylation to promote tumor progression. GENES & DEVELOPMENT[J]. 2017, 第 3 作者31(16): 1641-1654, https://www.webofscience.com/wos/woscc/full-record/WOS:000411629600003.
[23] Yue, Xuetian, Zhao, Yuhan, Zhang, Cen, Li, Jun, Liu, Zhen, Liu, Juan, Hu, Wenwei. Leukemia inhibitory factor promotes EMT through STAT3-dependent miR-21 induction. ONCOTARGET[J]. 2016, 第 2 作者7(4): 3777-3790, https://www.webofscience.com/wos/woscc/full-record/WOS:000369952400011.
[24] Yue, Xuetian, Zhao, Yuhan, Huang, Grace, Li, Jun, Zhu, Junlan, Feng, Zhaohui, Hu, Wenwei. A novel mutant p53 binding partner BAG5 stabilizes mutant p53 and promotes mutant p53 GOFs in tumorigenesis. CELL DISCOVERY[J]. 2016, 第 2 作者2: 16039, https://www.webofscience.com/wos/woscc/full-record/WOS:000414897800001.
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[26] 赵逾涵. A novel mutant p53 binding partener BAG5 stabilizes mutant p53 and promotes mutant p53 GOFs in tumorigenesis.. Cell Discovery. 2016, 第 1 作者
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[29] Yuhan Zhao, Xuetian Yue, Wenwei Hu. Pontin, a novel interactor of mutant p53 that promotes mutant p53 gain of function. MOLECULAR & CELLULAR ONCOLOGY. 2015, 第 1 作者3(2): 
[30] Xuetian Yue. BAG2 promotes tumorigenesis through enhancing mutant p53 protein levels and function. ELIFE SCIENCES PUBLICATIONS, LTD. 2015, http://oa.las.ac.cn/oainone/service/browseall/read1?ptype=JA&workid=JA201904029098695ZK.
[31] Wu, Lihua, Yu, Haiyang, Zhao, Yuhan, Zhang, Cen, Wang, Jiabei, Yue, Xuetian, Yang, Qifeng, Hu, Wenwei. HIF-2α mediates hypoxia-induced LIF expression in human colorectal cancer cells. ONCOTARGET[J]. 2015, 第 3 作者6(6): 4406-4417, http://dx.doi.org/10.18632/oncotarget.3017.
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[33] Liu, Juan, Zhang, Cen, Lin, Meihua, Zhu, Wei, Liang, Yingjian, Hong, Xuehui, Zhao, Yuhan, Young, Ken H, Hu, Wenwei, Feng, Zhaohui. Glutaminase 2 negatively regulates the PI3K/AKT signaling and shows tumor suppression activity in human hepatocellular carcinoma. ONCOTARGET[J]. 2014, 第 7 作者5(9): 2635-2647, http://dx.doi.org/10.18632/oncotarget.1862.
[34] Li, Xiaoyan, Yang, Qifeng, Yu, Haiyang, Wu, Lihua, Zhao, Yuhan, Zhang, Cen, Yue, Xuetian, Liu, Zhen, Wu, Hao, Haffty, Bruce G, Feng, Zhaohui, Hu, Wenwei. LIF promotes tumorigenesis and metastasis of breast cancer through the AKT-mTOR pathway. ONCOTARGET[J]. 2014, 第 5 作者5(3): 788-801, https://www.webofscience.com/wos/woscc/full-record/WOS:000332701300019.
[35] Yu, Haiyang, Yue, Xuetian, Zhao, Yuhan, Li, Xiaoyan, Wu, Lihua, Zhang, Cen, Liu, Zhen, Lin, Kevin, XuMonette, Zijun Y, Young, Ken H, Liu, Juan, Shen, Zhiyuan, Feng, Zhaohui, Hu, Wenwei. LIF negatively regulates tumour-suppressor p53 through Stat3/ID1/MDM2 in colorectal cancers. NATURE COMMUNICATIONS[J]. 2014, 第 3 作者5: https://www.webofscience.com/wos/woscc/full-record/WOS:000343982800007.
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[41] Feng, Zhaohui, Liu, Lianxin, Zhang, Cen, Zheng, Tongsen, Wang, Jiabei, Lin, Meihua, Zhao, Yuhan, Wang, Xiaowen, Levine, Arnold J, Hu, Wenwei. Chronic restraint stress attenuates p53 function and promotes tumorigenesis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2012, 第 7 作者109(18): 7013-7018, https://www.webofscience.com/wos/woscc/full-record/WOS:000303602100054.
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