源于中药的天然药物分子合成与结构优化：
以中药中已知或新发现的活性化合物为基础，结合生物药理靶向活性筛选手段，通过人工合成、合理药物设计进行活性分子的结构优化，确立活性化合物与靶点间的构效关系，为临床前及临床研究提供候选化合物，最终实现中药新药的创制。

招生专业方向：
有机化学；药物化学

2009-01--2010-01   迈阿密大学   博士后
2007-08--2009-01   夏威夷大学   博士后
2002-09--2007-07   中科院理化技术研究所   理学博士

1998/9-2002/7 本科毕业于山西大学化学化工学院；

2002/9-2007/7 中科院理化技术研究所获博士学位；

2007/8-2008/10 University of Hawaii 有机光化学博士后；

2008/10-2010/1 University of Miami 超分子有机光化学博士后。

2010年4月-2011年7月，就职于康龙化成（北京）新药有限公司，从事新型药物小分子的研究开发，任职有机合成高级研究员。

2011年7月，中国科学院大连化学物理研究所，任职副研究员，现主要从事天然药物分子的人工合成及结构优化。

2012-01~现在, 中科院大连化物所, 副研究员

发表文章：

14. Lai Wei, Tao Hou, Jiaqi Li, Xiuli Zhang, Han Zhou, Zhenyu Wang, Junxiang Cheng, Kaijing Xiang, Jixia Wang, Yaopeng Zhao,* and Xinmiao Liang*, Structure−Activity Relationship Studies of Coumarin-like Diacid Derivatives as Human G Protein-Coupled Receptor-35 (hGPR35) Agonists and a Consequent New Design Principle, J. Med. Chem. 2021, 64, 2634−2647.

13. Fangfang Xu , Yaopeng Zhao (co-first), Han Zhou , Chunzhi Li , Xiuli Zhang , Tao Hou , Lala Qu ,  Lai Wei , Jixia Wang* , Yanfang Liu* , Xinmiao Liang*, SAR Studies of 3-(4-(phenoxymethyl)phenyl)propanoic acid and N-phenylbenzenesulfonamide Derivatives as FFA4 Agonists; Bioorg. Med. Chem. Lett. 30 (2020) 127650.

12. Ji-Xia Wang, Yao-Peng Zhao (co-first), Na-Na Du, Yang Han, Hao Li, Rong Wang, Yang Xu, Yan-Fang Liu,* and Xin-Miao Liang, Scocycamides, a Pair of Macrocyclic Dicaffffeoylspermidines with Butyrylcholinesterase Inhibition and Antioxidation Activity from the Roots of Scopolia tangutica; Org. Lett. 2020, 22, 8240−8244.

11. Jinlin Peng,† Yaopeng Zhao,‡ Yulong Hong,† Robert S. Burkhalter,§ Carrie L. Hogue,§ Elizabeth Tran,† Lai Wei,‡ Lori Romeo,∥ Paula Dolley-Sonneville,∥ Zara Melkoumian,*,∥ Xinmiao Liang,*,‡ and Ye Fang*, Chemical Identity and Mechanism of Action and Formation of a Cell Growth Inhibitory Compound from Polycarbonate Flasks, Anal. Chem. 2018, 90, 4603−4610.

10. Jiao Zhao, Panpan Su, Yaopeng Zhao, Mingrun Li, Yan Yang, Qihua Yang* and Can Li*. “Systematic morphology and phase control of Mg-ptcda coordination polymers by Ostwald ripening and self-templating.” J. Mat. Chem., 2012, 22, 8470-8475.
9. Yao-Peng Zhao, Lan-Ying Yang, Charles J. Simmons and Robert S. H. Liu,* "The Role of Organic Glasses in cis/trans Photoisomerization at Low Temperatures”, Chem. Asian J., 2009, 4, 754-760. 
8. Yao-Peng Zhao, Lan-Ying Yang and Robert S. H. Liu,* “Designing Systems for One-Way trans to cis Photoisomerization for Solar Reactions”, Green Chem., 2009, 11, 837-842.
7. Yao-Peng Zhao, Xiao-Jun Wang, Jing-Jing Wang, Gang Si, Yan Liu, Chen-Ho Tung and Li-Zhu Wu,* “Tetrathiafulvalene derivatives bearing a crown ether with intramolecular charge transfer properties: synthesis and cation binding studies”, New J. Chem., 2009, 33, 813–817.
6. Nithyanandhan Jayaraj, Yao-Peng Zhao, Anand Parthasarathy, Mintu Porel, Robert S. H. Liu and V. Ramamurthy,* “Nature of Supramolecular Complexes Controlled by the Structure of the Guest Molecules: Formation of Octa Acid Based Capsuleplex and Cavitandplex” Langmuir, 2009, 25(18), 10575-10586.
5. Yan Geng, Xiao-Jun Wang, Bin Chen, Hai Xue, Yao-Peng Zhao, Shuittong Lee, Chen-Ho Tung, Li-Zhu Wu, “Semiconducting Neutral Microstructures Fabricated by Coordinative Self-Assembly of Intramolecular Charge-Transfer Tetrathiafulvalene Derivatives”, Chem. Eur. J. 2009, 15, 5124-5129.
4. Yao-Peng Zhao, Roger O. Campbell, Robert S. H. Liu,* “A Green Way to Hindered 7-cis-Isomers of Dienes and Trienes in the Vitamin A Series.”, Green Chem., 2008, 10, 1038-1042.
3. Yao-Peng Zhao, Li-Zhu Wu,* Gang Si, Yan Liu, Hai Xue, Li-Ping Zhang, Chen-Ho Tung,* “Synthesis, Electrochemistry, and Pb2+-Binding Studies of Tetrathiafulvalene Acetylene Derivatives”, J. Org. Chem. 2007, 72(10), 3632-3639.
2. Gang Si, Li-Zhu Wu,* Wen-Guang Wang, Jie Ding, Xu-Feng Shan, Yao-Peng Zhao, Chen-Ho Tung and Ming Xu, “Synthesis, structure and electrochemical property of diphenylacetypene-substituted diiron axadithiolates as active site of Fe-only hydrogenases”, Tetrahedron Lett., 2007, 48, 4775-4779.
1. Yao-Peng Zhao, Chun-Chang Zhao, Li-Zhu Wu,* Li-Ping Zhang, Chen-Ho Tung,* Yuan-Jiang Pan. “First Fluorescent Sensor for Fluoride Based on 2-Ureido-4[1H]-Pyrimidinone Quadruple Hydrogen-bonded AADD Supramolecular Assembly”, J. Org. Chem. 2006. 71(5). 2143-2146. 

 

译著及著作章节：
1. Robert S.H. Liu, Lan-Ying Yang, Yao-Peng Zhao, Akira Kawanabe, Hideki Dandori. “Supramolecular Photochemistry, Controlling Photochemical Processes”, ed. V.Ramamurthy and Yoshihisa Inoue, Wiley-VCH, Weinheim, 2011, Chapter.13, 547-570.
2. 国外优秀化学著作译丛——《超分子化学》,赵耀鹏, 孙震 译, «supramolecular chemistry» / [UK] Steed, J. W.; Atwood, J. L.化学工业出版社, 2006. 05.

负责科研项目：
1. 国家自然科学青年基金（2013/01-2015/12），“多相手性烯烃复分解反应钌基催化剂的设计与合成”，

2. 催化基础国家重点实验室自主研究课题（2012/06-2014/05），“多相手性钌基催化剂的制备及其对烯烃复分解不对称催化性能的研究 

3. 大连化物所2012年度博士科研探索课题（2013/02始），“分子光探针对纳米笼微环境的探测研究”