基本信息
赵潇 男 博导 国家纳米科学中心
电子邮件： zhaox@nanoctr.cn
通信地址： 北京市海淀区中关村北一条11号
邮政编码：
电子邮件： zhaox@nanoctr.cn
通信地址： 北京市海淀区中关村北一条11号
邮政编码：
招生信息
招生专业
0703J1-纳米科学与技术
083100-生物医学工程
083100-生物医学工程
招生方向
肿瘤疫苗
核酸载体
天然纳米颗粒
核酸载体
天然纳米颗粒
教育背景
2013-09--2016-06 天津医科大学 博士研究生学位
2010-09--2013-06 天津医科大学 硕士研究生学位
2005-09--2010-06 河南大学 学士学位
2010-09--2013-06 天津医科大学 硕士研究生学位
2005-09--2010-06 河南大学 学士学位
工作经历
工作简历
2016-08~2019-08,国家纳米科学中心, 博士后
专利与奖励
奖励信息
（1） 中国抗癌协会科技奖, 一等奖, 部委级, 2017
（2） 天津市科技进步奖, 一等奖, 省级, 2016
（2） 天津市科技进步奖, 一等奖, 省级, 2016
专利成果
（ 1 ） 一种脂质体-聚合物杂化纳米粒子及其制备方法和应用, 发明, 2016, 第 3 作者, 专利号: ZL201410164437.9
出版信息
发表论文
[1] Liu, Guangna, Ma, Nana, Cheng, Keman, Feng, Qingqing, Ma, Xiaotu, Yue, Yale, Li, Yao, Zhang, Tianjiao, Gao, Xiaoyu, Liang, Jie, Zhang, Lizhuo, Wang, Xinwei, Ren, Zhenhua, Fu, YangXin, Zhao, Xiao, Nie, Guangjun. Bacteria-derived nanovesicles enhance tumour vaccination by trained immunity. NATURE NANOTECHNOLOGY. 2023, 第 15 作者 通讯作者 http://dx.doi.org/10.1038/s41565-023-01553-6.
[2] Ma, Xiaotu, Liang, Xiaolong, Li, Yao, Feng, Qingqing, Cheng, Keman, Ma, Nana, Zhu, Fei, Guo, Xinjing, Yue, Yale, Liu, Guangna, Zhang, Tianjiao, Liang, Jie, Ren, Lei, Zhao, Xiao, Nie, Guangjun. Modular-designed engineered bacteria for precision tumor immunotherapy via spatiotemporal manipulation by magnetic field. NATURE COMMUNICATIONS[J]. 2023, 第 14 作者 通讯作者 14(1): http://dx.doi.org/10.1038/s41467-023-37225-1.
[3] Li, Qinglin, Zhang, Lizhuo, Lang, Jiayan, Tan, Zhuo, Feng, Qingqing, Zhu, Fei, Liu, Guangna, Ying, Zhangguo, Yu, Xuefei, Feng, He, Yi, Heqing, Wen, Qingliang, Jin, Tiefeng, Cheng, Keman, Zhao, Xiao, Ge, Minghua. Lipid-Peptide-mRNA Nanoparticles Augment Radioiodine Uptake in Anaplastic Thyroid Cancer. ADVANCED SCIENCE[J]. 2023, 第 15 作者 通讯作者 10(3): http://dx.doi.org/10.1002/advs.202204334.
[4] Xiaotu Ma, Xiaolong Liang, Yao Li, Qingqing Feng, Keman Cheng, Nana Ma, Fei Zhu, Xinjing Guo, Yale Yue, Guangna Liu, Tianjiao Zhang, Jie Liang, Lei Ren, Xiao Zhao, Guangjun Nie. Modular-designed engineered bacteria for precision tumor immunotherapy via spatiotemporal manipulation by magnetic field. NATURE COMMUNICATIONS[J]. 2023, 第 14 作者14(1): 1-22, http://dx.doi.org/10.1038/s41467-023-37225-1.
[5] Ma, Nana, Cheng, Keman, Feng, Qingqing, Liu, Guangna, Liang, Jie, Ma, Xiaotu, Chen, Zhiqiang, Lu, Yichao, Wang, Xinwei, He, Wei, Xu, Hu, Wu, Shan, Zou, Jiajia, Shi, Quanwei, Nie, Guangjun, Zhao, Xiao. Nanoscale Organization of TRAIL Trimers using DNA Origami to Promote Clustering of Death Receptor and Cancer Cell Apoptosis. SMALL[J]. 2023, 第 16 作者 通讯作者 19(23): http://dx.doi.org/10.1002/smll.202206160.
[6] Zhu, Fei, Yan, Na, Lu, Xukun, Xu, Junchao, Gu, Haiyan, Liang, Jie, Cheng, Keman, Wang, Xiaona, Ma, Xiaotu, Ma, Nana, Zhao, Xiao, Chen, Chunying, Nie, Guangjun. Cell-Reprogramming-Inspired Dynamically Responsive Hydrogel Boosts the Induction of Pluripotency via Phase-Separated Biomolecular Condensates. ADVANCED MATERIALS. 2023, 第 11 作者http://dx.doi.org/10.1002/adma.202211609.
[7] Liang, Jie, Zhu, Fei, Cheng, Keman, Ma, Nana, Ma, Xiaotu, Feng, Qingqing, Xu, Chen, Gao, Xiaoyu, Wang, Xinwei, Shi, Jian, Zhao, Xiao, Nie, Guangjun. Outer Membrane Vesicle-Based Nanohybrids Target Tumor-Associated Macrophages to Enhance Trained Immunity-Related Vaccine-Generated Antitumor Activity. ADVANCED MATERIALS. 2023, 第 11 作者 通讯作者 http://dx.doi.org/10.1002/adma.202306158.
[8] Xiaotu Ma, Xiaolong Liang, Yao Li, Qingqing Feng, Keman Cheng, Nana Ma, Fei Zhu, Xinjing Guo, Yale Yue, Guangna Liu, Tianjiao Zhang, Jie Liang, Lei Ren, Xiao Zhao, Guangjun Nie. Author Correction: Modular-designed engineered bacteria for precision tumor immunotherapy via spatiotemporal manipulation by magnetic field. NATURE COMMUNICATIONS[J]. 2023, 第 14 作者14(1): 1-1, http://dx.doi.org/10.1038/s41467-023-39906-3.
[9] Ma, Nana, Chen, Zhiqiang, Liu, Guangna, Yue, Yale, Li, Yao, Cheng, Keman, Ma, Xiaotu, Feng, Qingqing, Liang, Jie, Zhang, Tianjiao, Gao, Xiaoyu, Wang, Xinwei, Guo, Xinjing, Zhu, Fei, Nie, Guangjun, Zhao, Xiao. Normalizing the Immune Macroenvironment via Debulking Surgery to Strengthen Tumor Nanovaccine Efficacy and Eliminate Metastasis. ACS NANO. 2022, 第 16 作者 通讯作者
[10] Li, Yao, Ma, Xiaotu, Liu, Xiaoli, Yue, Yale, Cheng, Keman, Zhang, Qiang, Nie, Guangjun, Zhao, Xiao, Ren, Lei. Redox-Responsive Functional Iron Oxide Nanocrystals for Magnetic Resonance Imaging-Guided Tumor Hyperthermia Therapy and Heat- Mediated Immune Activation. ACS APPLIED NANO MATERIALS[J]. 2022, 第 8 作者 通讯作者 5(3): 4537-4549, http://dx.doi.org/10.1021/acsanm.2c00898.
[11] Qingqing Feng, Xiaotu Ma, Keman Cheng, Guangna Liu, Yao Li, Yale Yue, Jie Liang, Lizhuo Zhang, Tianjiao Zhang, Xinwei Wang, Xiaoyu Gao, 聂广军, Xiao Zhao. Engineered Bacterial Outer Membrane Vesicles as Controllable Two-way Adaptors to Activate Macrophage Phagocytosis for Improved Tumor Immunotherapy. Advanced Materials[J]. 2022, 第 13 作者 通讯作者 34(40): e2206200,
[12] Zhao, Xiao, Li, Feng, Li, Yiye, Wang, Hai, Ren, He, Chen, Jing, Nie, Guangjun, Hao, Jihui. Co-delivery of HIF1 alpha siRNA and gemcitabine via biocompatible lipid-polymer hybrid nanoparticles for effective treatment of pancreatic cancer (vol 46, pg 13, 2015). BIOMATERIALS. 2022, 第 1 作者280: http://dx.doi.org/10.1016/j.biomaterials.2021.121296.
[13] Yue, Yale, Xu, Jiaqi, Li, Yao, Cheng, Keman, Feng, Qingqing, Ma, Xiaotu, Ma, Nana, Zhang, Tianjiao, Wang, Xinwei, Zhao, Xiao, Nie, Guangjun. Antigen-bearing outer membrane vesicles as tumour vaccines produced in situ by ingested genetically engineered bacteria. NATURE BIOMEDICAL EENGINEERING[J]. 2022, 第 10 作者 通讯作者 6(7): 898-909, http://dx.doi.org/10.1038/s41551-022-00886-2.
[14] Zhao, Xiao, Zhao, Ruifang, Nie, Guangjun. Nanocarriers based on bacterial membrane materials for cancer vaccine delivery. NATURE PROTOCOLS[J]. 2022, 第 1 作者17(10): 2240-2274, http://dx.doi.org/10.1038/s41596-022-00713-7.
[15] Ma, Xiaotu, Yao, Meinan, Gao, Yu, Yue, Yale, Li, Yao, Zhang, Tianjiao, Nie, Guangjun, Zhao, Xiao, Liang, Xiaolong. Functional Immune Cell-Derived Exosomes Engineered for the Trilogy of Radiotherapy Sensitization. ADVANCED SCIENCE[J]. 2022, 第 8 作者 通讯作者 9(23): http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000812466900001.
[16] Li, Yao, Ma, Xiaotu, Yue, Yale, Zhang, Kaiyue, Cheng, Keman, Feng, Qingqing, Ma, Nana, Liang, Jie, Zhang, Tianjiao, Zhang, Lizhuo, Chen, Zhiqiang, Wang, Xinwei, Ren, Lei, Zhao, Xiao, Nie, Guangjun. Rapid Surface Display of mRNA Antigens by Bacteria-Derived Outer Membrane Vesicles for a Personalized Tumor Vaccine. ADVANCED MATERIALS[J]. 2022, 第 14 作者 通讯作者 34(20): e2109984, http://dx.doi.org/10.1002/adma.202109984.
[17] Gao, Chao, Cheng, Keman, Li, Yao, Gong, Ruining, Zhao, Xiao, Nie, Guangjun, Ren, He. Injectable Immunotherapeutic Hydrogel Containing RNA-Loaded Lipid Nanoparticles Reshapes Tumor Microenvironment for Pancreatic Cancer Therapy. NANO LETTERS[J]. 2022, 第 5 作者 通讯作者 22(22): 8801-8809, http://dx.doi.org/10.1021/acs.nanolett.2c01994.
[18] Yue, Yale, Zhao, Xiao. Melanin-Like Nanomedicine in Photothermal Therapy Applications. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021, 第 2 作者 通讯作者 22(1): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7795111/.
[19] Yue, Yale, Li, Fenfen, Li, Yao, Wang, Yazhou, Guo, Xinjing, Cheng, Zhaoxia, Li, Nan, Ma, Xiaotu, Nie, Guangjun, Zhao, Xiao. Biomimetic Nanoparticles Carrying a Repolarization Agent of Tumor-Associated Macrophages for Remodeling of the Inflammatory Microenvironment Following Photothermal Therapy. ACS NANO[J]. 2021, 第 10 作者 通讯作者 15(9): 15166-15179, http://dx.doi.org/10.1021/acsnano.1c05618.
[20] Chen, Long, Qin, Hao, Zhao, Ruifang, Zhao, Xiao, Lin, Liangru, Che, Yang, Lin, Yixuan, Li, Yao, Qin, Yuting, Li, Yiyi, Liu, Shaoli, Cheng, Keman, Chen, Hanqing, Shi, Jian, Anderson, Gregory J, Wu, Yan, Zhao, Yuliang, Nie, Guangjun. Bacterial cytoplasmic membranes synergistically enhance the antitumor activity of autologous cancer vaccines. SCIENCE TRANSLATIONAL MEDICINE[J]. 2021, 第 4 作者13(601): eabc2816, http://dx.doi.org/10.1126/scitranslmed.abc2816.
[21] Meng, Xiangda, Zhou, Wei, Sun, Zhuoyu, Han, Qi, Zhang, Jingkai, Zhang, Hongwen, Wang, Weijuan, Zhong, Min, Wang, Meiyan, Zhang, Junlan, Hao, Jing, Han, Han, Zhao, Xiao, Hu, Xingxing, Zhu, Xinlei, Li, Jianan, Wang, Tian, Huang, Yunli, Liao, Mengyu, Song, Yinting, Yan, Hua. Prevalence and causes of bilateral visual impairment in rural areas of Tianjin, China - The Tianjin Eye Study. ACTA OPHTHALMOLOGICA[J]. 2021, 第 13 作者99(2): E136-E143, http://dx.doi.org/10.1111/aos.14523.
[22] Han, Xuexiang, Cheng, Keman, Xu, Ying, Wang, Yazhou, Mm, Huan, Zhang, Yinlong, Zhao, Xiao, Zhao, Ruifang, Anderson, Gregory J, Ren, Lei, Nie, Guangjun, Li, Yiye. Modularly Designed Peptide Nanoprodrug Augments Antitumor Immunity of PD-L1 Checkpoint Blockade by Targeting Indoleamine 2,3-Dioxygenase. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2020, 第 7 作者142(5): 2490-2496, https://www.webofscience.com/wos/woscc/full-record/WOS:000512222700054.
[23] Li, Yao, Zhao, Ruifang, Cheng, Keman, Zhang, Kaiyue, Wang, Yazhou, Zhang, Yinlong, Li, Yujing, Liu, Guangna, Xu, Junchao, Xu, Jiaqi, Anderson, Gregory J, Shi, Jian, Ren, Lei, Zhao, Xiao, Nie, Guangjun. Bacterial Outer Membrane Vesicles Presenting Programmed Death 1 for Improved Cancer Immunotherapy via Immune Activation and Checkpoint Inhibition. ACS NANO[J]. 2020, 第 14 作者 通讯作者 14(12): 16698-16711, http://dx.doi.org/10.1021/acsnano.0c03776.
[24] Li, Yao, Zhao, Xiao, Liu, Xiaoli, Cheng, Keman, Han, Xuexiang, Zhang, Yinlong, Min, Huan, Liu, Guangna, Xu, Junchao, Shi, Jian, Qin, Hao, Fan, Haiming, Ren, Lei, Nie, Guangjun. A Bioinspired Nanoprobe with Multilevel Responsive T-1-Weighted MR Signal-Amplification Illuminates Ultrasmall Metastases. ADVANCED MATERIALS[J]. 2020, 第 2 作者32(4): https://www.webofscience.com/wos/woscc/full-record/WOS:000500726600001.
[25] Xu, Ying, Han, Xuexiang, Li, Yiye, Min, Huan, Zhao, Xiao, Zhang, Yinlong, Qi, Yingqiu, Shi, Jian, Qi, Sheng, Bao, Yongping, Nie, Guangjun. Sulforaphane Mediates Glutathione Depletion via Polymeric Nanoparticles to Restore Cisplatin Chemosensitivity. ACS NANO[J]. 2019, 第 5 作者13(11): 13445-13455, http://dx.doi.org/10.1021/acsnano.9b07032.
[26] Liu, Guangna, Zhao, Xiao, Zhang, Yinlong, Xu, Junchao, Xu, Jiaqi, Li, Yao, Min, Huan, Shi, Jian, Zhao, Ying, Wei, Jingyan, Wang, Jing, Nie, Guangjun. Engineering Biomimetic Platesomes for pH-Responsive Drug Delivery and Enhanced Antitumor Activity. ADVANCED MATERIALS[J]. 2019, 第 2 作者31(32): http://dx.doi.org/10.1002/adma.201900795.
[27] Liu, Shaoli, Zhang, Yinlong, Zhao, Xiao, Wang, Jing, Di, Chunzhi, Zhao, Ying, Ji, Tianjiao, Cheng, Keman, Wang, Yongwei, Chen, Long, Qi, Yingqiu, Li, Suping, Nie, Guangjun. Tumor-Specific Silencing of Tissue Factor Suppresses Metastasis and Prevents Cancer-Associated Hypercoagulability. NANO LETTERS[J]. 2019, 第 3 作者19(7): 4721-4730, http://dx.doi.org/10.1021/acs.nanolett.9b01785.
[28] Liu, Xiaoli, Zheng, Jianjun, Sun, Wei, Zhao, Xiao, Li, Yao, Gong, Ningqiang, Wang, Yanyun, Ma, Xiaowei, Zhang, Tingbin, Zhao, LingYun, Hou, Yayi, Wu, Zhibing, Du, Yang, Fan, Haiming, Tian, Jie, Liang, XingJie. Ferrimagnetic Vortex Nanoring-Mediated Mild Magnetic Hyperthermia Imparts Potent Immunological Effect for Treating Cancer Metastasis. ACS NANO[J]. 2019, 第 4 作者13(8): 8811-8825, http://dx.doi.org/10.1021/acsnano.9b01979.
[29] Han, Xuexiang, Xu, Ying, Li, Yiye, Zhao, Xiao, Zhang, Yinlong, Min, Huan, Qi, Yingqiu, Anderson, Gregory J, You, Linhao, Zhao, Yuliang, Nie, Guangjun. An Extendable Star-Like Nanoplatform for Functional and Anatomical Imaging-Guided Photothermal Oncotherapy. ACS NANO[J]. 2019, 第 4 作者13(4): 4379-4391, http://dx.doi.org/10.1021/acsnano.8b09607.
[30] Lang, Jiayan, Zhao, Xiao, Qi, Yingqiu, Zhang, Yinlong, Han, Xuexiang, Ding, Yanping, Guan, Jiajing, Ji, Tianjiao, Zhao, Ying, Nie, Guangjun. Reshaping Prostate Tumor Microenvironment To Suppress Metastasis via Cancer-Associated Fibroblast Inactivation with Peptide Assembly-Based Nanosystem. ACS NANO[J]. 2019, 第 2 作者13(11): 12357-12371, http://dx.doi.org/10.1021/acsnano.9b04857.
[31] Lang, Jiayan, Zhao, Xiao, Wang, Xiuchao, Zhao, Ying, Li, Yiye, Zhao, Ruifang, Cheng, Keman, Li, Yao, Han, Xuexiang, Zheng, Xiaowei, Qin, Hao, Geranpayehvaghei, Marzieh, Shi, Jian, Anderson, Gregory J, Hao, Jihui, Ren, He, Nie, Guangjun. Targeted Co-delivery of the Iron Chelator Deferoxamine and a HIF1 alpha Inhibitor Impairs Pancreatic Tumor Growth. ACS NANO[J]. 2019, 第 2 作者 通讯作者 13(2): 2176-2189, http://dx.doi.org/10.1021/acsnano.8b08823.
[32] Xu, Jiaqi, Zhang, Yinlong, Xu, Junchao, Wang, Meifang, Liu, Guangna, Wang, Jing, Zhao, Xiao, Qi, Yingqiu, Shi, Jian, Cheng, Keman, Li, Yao, Qi, Sheng, Nie, Guangjun. Reversing tumor stemness via orally targeted nanoparticles achieves efficient colon cancer treatment. BIOMATERIALS[J]. 2019, 第 7 作者216: 119247, http://dx.doi.org/10.1016/j.biomaterials.2019.119247.
[33] Zhao, Xiao, Liu, Liang, Liang, Jiayan, Cheng, Keman, Wang, Yongwei, Li, Xueyan, Shi, Jian, Wang, Yanli, Nie, Guangjun. A CRISPR-Cas13a system for efficient and specific therapeutic targeting of mutant KRAS for pancreatic cancer treatment. CANCER LETTERS[J]. 2018, 第 1 作者431: 171-181, http://dx.doi.org/10.1016/j.canlet.2018.05.042.
[34] Cheng, Keman, Ding, Yanping, Zhao, Ying, Ye, Shefang, Zhao, Xiao, Zhang, Yinlong, Ji, Tianjiao, Wu, Huanhuan, Wang, Bin, Anderson, Gregory J, Ren, Lei, Nie, Guangjun. Sequentially Responsive Therapeutic Peptide Assembling Nanoparticles for Dual-Targeted Cancer Immunotherapy. NANO LETTERS[J]. 2018, 第 5 作者18(5): 3250-3258, http://www.corc.org.cn/handle/1471x/2177614.
[35] 赵潇, 颜华. 血管内皮生长因子在外伤性增生性玻璃体视网膜病变发病机制中的作用研究进展. 中华眼底病杂志[J]. 2018, 第 1 作者34(2): 187-190, http://lib.cqvip.com/Qikan/Article/Detail?id=674788833.
[36] Du, Chong, Qi, Yingqiu, Zhang, Yinlong, Wang, Yazhou, Zhao, Xiao, Min, Huan, Han, Xuexiang, Lang, Jiayan, Qin, Hao, Shi, Quanwei, Zhang, Zhengkui, Tian, Xiaodong, Anderson, Greg J, Zhao, Ying, Nie, Guangjun, Yang, Yinmo. Epidermal Growth Factor Receptor-Targeting Peptide Nanoparticles Simultaneously Deliver Gemcitabine and Olaparib To Treat Pancreatic Cancer with Breast Cancer 2 (BRCA2) Mutation. ACS NANO[J]. 2018, 第 5 作者12(11): 10785-10796, http://dx.doi.org/10.1021/acsnano.8b01573.
[37] Shi, Quanwei, Zhang, Yinlong, Liu, Shaoli, Liu, Guangna, Xu, Junchao, Zhao, Xiao, Anderson, Gregory J, Nie, Guangjun, Li, Suping. Specific tissue factor delivery using a tumor-homing peptide for inducing tumor infarction. BIOCHEMICAL PHARMACOLOGY[J]. 2018, 第 6 作者156: 501-510, http://dx.doi.org/10.1016/j.bcp.2018.09.020.
[38] Wang, Bin, Ding, Yanping, Zhao, Xiaozheng, Han, Xuexiang, Yang, Na, Zhang, Yinlong, Zhao, Ying, Zhao, Xiao, Taleb, Mohammad, Miao, Qing Robert, Nie, Guangjun. Delivery of small interfering RNA against Nogo-B receptor via tumor-acidity responsive nanoparticles for tumor vessel normalization and metastasis suppression. BIOMATERIALS[J]. 2018, 第 8 作者175: 110-122, http://dx.doi.org/10.1016/j.biomaterials.2018.05.034.
[39] Qi, Yingqiu, Min, Huan, Mujeeb, Ayeesha, Zhang, Yinlong, Han, Xuexiang, Zhao, Xiao, Anderson, Greg J, Zhao, Ying, Nie, Guangjun. Injectable Hexapeptide Hydrogel for Localized Chemotherapy Prevents Breast Cancer Recurrence. ACS APPLIED MATERIALS & INTERFACES[J]. 2018, 第 6 作者10(8): 6972-6981, http://www.corc.org.cn/handle/1471x/2178096.
[40] Zhao, Xiao, Wang, Xiuchao, Sun, Wei, Cheng, Keman, Qin, Hao, Han, Xuexiang, Lin, Yu, Wang, Yongwei, Lang, Jiayan, Zhao, Ruifang, Zheng, Xiaowei, Zhao, Ying, Shi, Jian, Hao, Jihui, Miao, Qing Robert, Nie, Guangjun, Ren, He. Precision design of nanomedicines to restore gemcitabine chemosensitivity for personalized pancreatic ductal adenocarcinoma treatment. BIOMATERIALS[J]. 2018, 第 1 作者158: 44-55, http://dx.doi.org/10.1016/j.biomaterials.2017.12.015.
[41] Ji, Tianjiao, Lang, Jiayan, Wang, Jing, Cai, Rong, Zhang, Yinlong, Qi, Feifei, Zhang, Lijing, Zhao, Xiao, Wu, Wenjing, Hao, Jihui, Qin, Zhihai, Zhao, Ying, Nie, Guangjun. Designing Liposomes To Suppress Extracellular Matrix Expression To Enhance Drug Penetration and Pancreatic Tumor Therapy. ACS NANO[J]. 2017, 第 8 作者11(9): 8668-8678, http://dx.doi.org/10.1021/acsnano.7b01026.
[42] Li, Suping, Zhang, Yinlong, Wang, Jing, Zhao, Ying, Ji, Tianjiao, Zhao, Xiao, Ding, Yanping, Zhao, Xiaozheng, Zhao, Ruifang, Li, Feng, Yang, Xiao, Liu, Shaoli, Liu, Zhaofei, Lai, Jianhao, Whittaker, Andrew K, Anderson, Gregory J, Wei, Jingyan, Nie, Guangjun. Nanoparticle-mediated local depletion of tumour-associated platelets disrupts vascular barriers and augments drug accumulation in tumours. NATURE BIOMEDICAL ENGINEERING[J]. 2017, 第 6 作者1(8): 667-679, https://www.webofscience.com/wos/woscc/full-record/WOS:000418858400001.
[43] Zhao, Xiao, Wang, Xiuchao, Fang, Lijun, Lan, Chungen, Zheng, Xiaowei, Wang, Yongwei, Zhang, Yinlong, Han, Xuexiang, Liu, Shaoli, Cheng, Keman, Zhao, Ying, Shi, Jian, Guo, Jiayi, Hao, Jihui, Ren, He, Nie, Guangjun. A combinatorial strategy using YAP and pan-RAF inhibitors for treating KRAS-mutant pancreatic cancer. CANCER LETTERS[J]. 2017, 第 1 作者402: 61-70, http://dx.doi.org/10.1016/j.canlet.2017.05.015.
[44] Zhao, Xiao, Yang, Keni, Zhao, Ruifang, Ji, Tianjiao, Wang, Xiuchao, Yang, Xiao, Zhang, Yinlong, Cheng, Keman, Liu, Shaoli, Hao, Jihui, Ren, He, Leong, Kam W, Nie, Guangjun. Inducing enhanced immunogenic cell death with nanocarrier-based drug delivery systems for pancreatic cancer therapy. BIOMATERIALS[J]. 2016, 第 1 作者102: 187-197, http://dx.doi.org/10.1016/j.biomaterials.2016.06.032.
[45] Song, Xiao, Ding, Yanping, Liu, Gang, Yang, Xiao, Zhao, Ruifang, Zhang, Yinlong, Zhao, Xiao, Anderson, Gregory J, Nie, Guangjun. Cancer Cell-derived Exosomes Induce Mitogen-activated Protein Kinase-dependent Monocyte Survival by Transport of Functional Receptor Tyrosine Kinases. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2016, 第 7 作者291(16): 8453-8464, http://dx.doi.org/10.1074/jbc.M116.716316.
[46] Ji, Tianjiao, Li, Suping, Zhang, Yinlong, Lang, Jiayan, Ding, Yanping, Zhao, Xiao, Zhao, Ruifang, Li, Yiye, Shi, Jian, Hao, Jihui, Zhao, Ying, Nie, Guangjun. An MMP-2 Responsive Liposome Integrating Antifibrosis and Chemotherapeutic Drugs for Enhanced Drug Perfusion and Efficacy in Pancreatic Cancer. ACS APPLIED MATERIALS & INTERFACES[J]. 2016, 第 6 作者8(5): 3438-3445, http://www.corc.org.cn/handle/1471x/2176565.
[47] Li, Feng, Zhao, Xiao, Wang, Hai, Zhao, Ruifang, Ji, Tianjiao, Ren, He, Anderson, Gregory J, Nie, Guangjun, Hao, Jihui. Multiple Layer-by-Layer Lipid-Polymer Hybrid Nanoparticles for Improved FOLFIRINOX Chemotherapy in Pancreatic Tumor Models. ADVANCED FUNCTIONAL MATERIALS[J]. 2015, 第 2 作者25(5): 788-798, http://dx.doi.org/10.1002/adfm.201401583.
[48] Xiao Zhao, Feng Li, Yiye Li, Hai Wang, He Ren, Jing Chen, Guangjun Nie, Jihui Hao. Co-delivery of HIF1α siRNA and gemcitabine via biocompatible lipid-polymer hybrid nanoparticles for effective treatment of pancreatic cancer. BIOMATERIALS. 2015, 第 1 作者46: 13-25, http://dx.doi.org/10.1016/j.biomaterials.2014.12.028.
[49] Gao, Chuntao, Li, Shasha, Zhao, Tiansuo, Chen, Jing, Ren, He, Zhang, Huan, Wang, Xiuchao, Lang, Mingxiao, Liu, Jingcheng, Gao, Song, Zhao, Xiao, Sheng, Jun, Yuan, Zhanna, Hao, Jihui. SCF, Regulated by HIF-1 alpha, Promotes Pancreatic Ductal Adenocarcinoma Cell Progression. PLOS ONE[J]. 2015, 第 11 作者10(3): https://www.webofscience.com/wos/woscc/full-record/WOS:000351987300239.
[50] Zhao, Xiao, Li, Feng, Li, Yiye, Wang, Hai, Ren, He, Chen, Jing, Nie, Guangjun, Hao, Jihui. Co-delivery of HIF1 alpha siRNA and gemcitabine via biocompatible lipid-polymer hybrid nanoparticles for effective treatment of pancreatic cancer. BIOMATERIALS[J]. 2015, 第 1 作者46: 13-25, http://dx.doi.org/10.1016/j.biomaterials.2014.12.028.
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科研活动
科研项目
（ 1 ） 基于铁代谢调控的多层杂化纳米载体联合药物输运体系治疗胰腺癌的疗效研究, 主持, 国家级, 2019-01--2021-12
（ 2 ） 中科院高层次人才引进计划, 主持, 部委级, 2019-10--2022-10
（ 2 ） 中科院高层次人才引进计划, 主持, 部委级, 2019-10--2022-10