基本信息

赵江瑜  女  硕导  中国科学院新疆理化技术研究所
电子邮件: zhaojy@ms.xjb.ac.cn
通信地址: 乌鲁木齐市北京南路40-1号
邮政编码: 830011

研究领域

天然化合物的构效关系研究,有机化学

招生信息

   
招生专业
070303-有机化学
招生方向
天然化合物的构效关系,抗病毒活性研究

教育背景

2008-09--2011-12   中国科学院新疆理化技术研究所   博士
2004-09--2007-07   南开大学   硕士
2000-09--2004-07   忻州师范学院   本科
学历

研究生学历

学位
博士学位

工作经历

   
工作简历
2014-10~现在, 中国科学院新疆理化技术研究所, 副研究员
2012-03~2014-09,中国科学院新疆理化技术研究所, 助理研究员
2007-09~2008-07,新疆科技学校, 教师

专利与奖励

   
奖励信息
(1) 第十三届新疆自然科学优秀学术论文, 一等奖, 省级, 2014
(2) 第十二届新疆自然科学优秀学术论文, 二等奖, 省级, 2012
专利成果
( 1 ) 一枝蒿酮酸糖酯类衍生物及其制备方法和用途, 发明, 2012, 第 2 作者, 专利号: ZL201010191025.6
( 2 ) 含哌嗪环的一枝蒿酮酸酯类衍生物及其制备方法和用途, 发明, 2013, 第 2 作者, 专利号: ZL201010227465.2
( 3 ) 一枝蒿酮酸异恶唑酰胺类衍生物及其制备方法和用途, 发明, 2013, 第 2 作者, 专利号: ZL201110213499.0
( 4 ) 一枝蒿酮酸酯类衍生物及其制备方法和用途, 发明, 2014, 第 2 作者, 专利号: ZL201110213512.2
( 5 ) 一枝蒿酮酸含杂环酰胺类衍生物及其制备方法和用途, 发明, 2016, 第 3 作者, 专利号: ZL201310039406.6
( 6 ) 一枝蒿酮酸含杂环酯类衍生物及其制备方法和用途, 发明, 2016, 第 4 作者, 专利号: ZL201310039407.0
( 7 ) 一枝蒿酮酸含杂环和糖的酯类衍生物及其制备方法和用途, 发明, 2016, 第 4 作者, 专利号: ZL201310219905.3
( 8 ) 一种2,5-二氨基-3,4-噻吩二羧酸乙酯衍生物的制备方法和用途, 发明, 2016, 第 3 作者, 专利号: ZL201410302424.3
( 9 ) 异叶青兰有效部位的制备方法和用途, 发明, 2014, 第 5 作者, 专利号: ZL201310031267.2
( 10 ) 一枝蒿酮酸含杂环和糖的酰胺类衍生物及其制备方法和用途, 发明, 2016, 第 3 作者, 专利号: ZL201310248785.X

出版信息

   
发表论文
[1] Zhao, Bo, Ablajan, Nurfida, Zhao, JiangYu, Kodirova, D R, Sagdullaev, Sh Sh, Aisa, H A. Two new C-19-diterpenoid alkaloids from Aconitum smirnovii. PHYTOCHEMISTRY LETTERS[J]. 2020, 38: 96-100, http://dx.doi.org/10.1016/j.phytol.2020.05.007.
[2] Li, Gen, Obul, Mamateli, Zhao, Jiangyu, Liu, Geyu, Lu, Wei, Aisa, Haji Akber. Novel amides modified rupestonic acid derivatives as anti-influenza virus reagents. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS[J]. 2019, 29(19): http://dx.doi.org/10.1016/j.bmcl.2019.08.009.
[3] Obul, Mamateli, Wang, Xincheng, Zhao, Jiangyu, Li, Gen, Aisa, Haji Akber, Huang, Guozheng. Structural modification on rupestonic acid leads to highly potent inhibitors against influenza virus. MOLECULAR DIVERSITY[J]. 2019, 23(1): 1-9, https://www.webofscience.com/wos/woscc/full-record/WOS:000459517700001.
[4] 黄国正. Diversity-oriented synthesis of amide derivatives of tricyclic thieno[2,3-d]pyrimidin-4(3H)-ones and evaluation their influence on melanin synthesis in murine B16 cells. Heterocyclic Communications. 2018, [5] Nie, Li Fei, Bozorov, Khurshed, Huang, Guozheng, Zhao, Jiangyu, Niu, Chao, Aisa, Haji Akber. Design, synthesis, and toward a side-ring optimization of tricyclic thieno2,3-dpyrimidin-4(3H)-ones and their effect on melanin synthesis in murine B16 cells. PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS[J]. 2018, 193(10): 656-667, https://www.webofscience.com/wos/woscc/full-record/WOS:000457566000006.
[6] Yusuf, Abdullah, Zhao, Jiangyu, Wang, Bianlin, Aibibula, Paruke, Aisa, Haji Akber, Huang, Guozheng. Total synthesis of rupestine G and its epimers. ROYAL SOCIETY OPEN SCIENCE[J]. 2018, 5(3): http://ir.xjipc.cas.cn/handle/365002/5791.
[7] Zhao, B, Zhao, J Y, Sagdullaev, Sh Sh, Aisa, H A. DITERPENE ALKALOIDS FROM Aconitum smirnovii. CHEMISTRY OF NATURAL COMPOUNDS[J]. 2018, 54(4): 828-830, https://www.webofscience.com/wos/woscc/full-record/WOS:000440423000060.
[8] Ablajan, Nurfida, Zhao, Bo, Xue, Wenjuan, Ruzi, Zukela, Zhao, Jiangyu, Aisa, Haji Akber. Diterpenoid Alkaloids from Delphinium aemulans. NATURAL PRODUCT COMMUNICATIONS[J]. 2018, 13(11): 1429-1431, https://www.webofscience.com/wos/woscc/full-record/WOS:000456230000004.
[9] Xue, WenJuan, Zhao, Bo, Ruzi, Zukela, Zhao, JiangYu, Aisa, Haji Akber. Norditerpenoid alkaloids from Delphinium pseudoaemulans C. Y. Yang et B. Wang. PHYTOCHEMISTRY[J]. 2018, 156: 234-240, http://dx.doi.org/10.1016/j.phytochem.2018.09.010.
[10] Zhao Jiangyu. Structure–activity relationship studies of 1-(10-hydroxyalkyl) rupestonic acid methyl esters against influenza viruses. Bioorganic & Medicinal Chemistry Letters. 2017, [11] Bozorov, Khurshed, Zhao, Jiang Yu, Nie, Li Fei, Ma, HaiRong, Bobakulov, Khayrulla, Hu, Rui, Rustamova, Nigora, Huang, Guozheng, Efferth, Thomas, Aisa, Haji A. Synthesis and in vitro biological evaluation of novel diaminothiophene scaffolds as antitumor and antiinfluenza virus agents. Part. RSC ADVANCES[J]. 2017, 7(50): 31417-31427, https://www.webofscience.com/wos/woscc/full-record/WOS:000404076400032.
[12] Bozorov, Khurshed, Nie, Li Fei, Zhao, Jiangyu, Aisa, Haji A. 2-Aminothiophene scaffolds: Diverse biological and pharmacological attributes in medicinal chemistry. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRYnull. 2017, 140: 465-493, http://dx.doi.org/10.1016/j.ejmech.2017.09.039.
[13] Zhao, Jiangyu, Niu, Chao, Li, Gen, Aisa, Haji Akber. Synthesis of Rupestonic Acid Derivatives with Antiviral Activity. CHEMISTRY OF NATURAL COMPOUNDS[J]. 2017, 53(2): 276-283, http://ir.xjipc.cas.cn/handle/365002/4783.
[14] Khurshed Bozorov, JiangYu Zhao, Haji A Aisa. Recent advances in ipso-nitration reactions. ARKIVOC[J]. 2016, 41-66, [15] Niu, Chao, Yin, Li, Nie, Li Fei, Dou, Jun, Zhao, Jiang Yu, Li, Gen, Aisa, Haji Aker. Synthesis and bioactivity of novel isoxazole chalcone derivatives on tyrosinase and melanin synthesis in murine B16 cells for the treatment of vitiligo. BIOORGANIC & MEDICINAL CHEMISTRY[J]. 2016, 24(21): 5440-5448, http://dx.doi.org/10.1016/j.bmc.2016.08.066.
[16] Ma, LinLin, Wang, HuiQiang, Wu, Ping, Hu, Jin, Yin, JinQiu, Wu, Shuo, Ge, Miao, Sun, WenFang, Zhao, JiangYu, Aisa, Haji Akber, Li, YuHuan, Jiang, JianDoug. Rupestonic acid derivative YZH-106 suppresses influenza virus replication by activation of heme oxygenase-1-mediated interferon response. FREE RADICAL BIOLOGY AND MEDICINE[J]. 2016, 96(7): 347-361, http://dx.doi.org/10.1016/j.freeradbiomed.2016.04.021.
[17] Bozorov, Khurshed, Zhao, JiangYu, Elmuradov, Burkhon, Pataer, Apar, Aisa, Haji A. Recent developments regarding the use of thieno2,3-dpyrimidin-4-one derivatives in medicinal chemistry, with a focus on their synthesis and anticancer properties. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRYnull. 2015, 102(9): 552-573, http://dx.doi.org/10.1016/j.ejmech.2015.08.018.
[18] Gu, Dongyu, Yang, Yi, Chen, Qibin, Habasi, Madina, Zhao, Jiangyu, Aisa, Haji Akber. Identification of metabolites of rupestonic acid in rat urine by liquid chromatography combined with electrospray ionization quadrupole time-of-flight tandem mass spectrometry. BIOMEDICAL CHROMATOGRAPHY[J]. 2015, 29(4): 595-603, https://www.webofscience.com/wos/woscc/full-record/WOS:000352094800016.
[19] He, YaoWu, Dong, ChangZhi, Zhao, JiangYu, Ma, LinLin, Li, YuHuan, Aisa, Haji Akber. 1,2,3-Triazole-containing derivatives of rupestonic acid: Click-chemical synthesis and antiviral activities against influenza viruses. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY[J]. 2014, 76(4): 245-255, http://dx.doi.org/10.1016/j.ejmech.2014.02.029.
[20] Bozorov, Khurshed, Ma, HaiRong, Zhao, JiangYu, Zhao, HaiQing, Chen, Hua, Bobakulov, Khayrulla, Xin, XueLei, Elmuradov, Burkhon, Shakhidoyatov, Khusnutdin, Aisa, Haji A. Discovery of diethyl 2,5-diaminothiophene-3,4-dicarboxylate derivatives as potent anticancer and antimicrobial agents and screening of anti-diabetic activity: Synthesis and in vitro biological evaluation. Part 1. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY[J]. 2014, 84(9): 739-745, http://dx.doi.org/10.1016/j.ejmech.2014.07.065.
[21] Zhao, Jiangyu, Aisa, Haji Akber. Synthesis and anti-influenza activity of aminoalkyl rupestonates. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS[J]. 2012, 22(6): 2321-2325, http://dx.doi.org/10.1016/j.bmcl.2012.01.056.
[22] Zhao, Jiangyu, Aisa, Haji Akber. Synthesis of Novel Isoxazole Contained Rupestonic Acid Derivatives and in vitro Inhibitory Activity against Influenza Viruses A and B. CHINESE JOURNAL OF ORGANIC CHEMISTRY[J]. 2012, 32(2): 333-337, http://dx.doi.org/10.6023/cjoc1108081.

科研活动

   
科研项目
( 1 ) 一枝蒿酮酸衍生物的合成及初步的抗流感病毒药效学研究, 主持, 国家级, 2015-01--2017-12
( 2 ) 中国科学院青年创新促进会成员, 主持, 部委级, 2015-01--2018-12
( 3 ) 一枝蒿碱的全合成及衍生物的抗流感病毒活性研究, 主持, 省级, 2015-01--2017-12
( 4 ) 栽培植物汇总C20二萜类生物碱的分离纯化及活性研究, 主持, 国家级, 2017-01--2018-12
( 5 ) 一枝蒿酮酸衍生物的抗病毒活性及构效关系研究, 主持, 部委级, 2012-09--2016-08
( 6 ) 中国科学院中亚药物研发中心, 参与, 部委级, 2013-01--2020-12
( 7 ) 中亚干旱区天然产物研究, 主持, 部委级, 2016-01--2020-12
( 8 ) 一枝蒿酮酸衍生物的成药性研究, 参与, 省级, 2013-01--2015-12
( 9 ) 一枝蒿酮酸衍生物的合成及生物活性研究, 参与, 省级, 2009-06--2011-12
( 10 ) 维药一枝蒿抗病毒药效及其代谢研究, 参与, 国家级, 2012-01--2014-12
( 11 ) 靶向Pgp肿瘤MDR逆转剂个性化先导化合物的发现研究, 参与, 部委级, 2018-01--2019-12

指导学生

现指导学生

陈磊  硕士研究生  070303-有机化学