赵建国 男 博导 动物研究所
电子邮件:zhaojg@ioz.ac.cn
通信地址:北京市朝阳区北辰西路1号院5号
办公电话:010-64806259
邮政编码:100101

研究领域

主要研究领域为1. 猪的基因组编辑; 2. 猪疾病模型建立和经济性状功能基因研究;3. 猪早期胚胎发育中的分子事件。通过建立高效的猪基因组编辑和功能基因组学分析平台,可以为生物医学研究和临床前转化提供理想的疾病模型,同时也可以为猪的经济性状改良和品系培育提供新的手段和解决思路。目前已经建立了包括人的色素性视网膜炎的疾病模型、听力缺陷小型猪疾病模型以及多个出生缺陷和帕金森猪疾病模型;创建了携带有人抗凝血因子9, Furin蛋白和α-抗胰蛋白酶的转基因猪。首次报道利用组蛋白去乙酰化抑制剂-Scriptaid大幅提高了在生物医学研究中具有广泛应用价值的-NIH近交系小型猪的克隆效率。首次报道了利用锌指核酶技术在大动物当中实现了GFP基因的高效敲除并且利用CRISPR/Cas9实现了猪基因组单一基因或者多个基因的同时编辑。

招生信息

   
招生专业
071008-发育生物学
招生方向
转基因动物
体细胞重编程
早期胚胎发育

工作经历

   
工作简历
2010-08--今 中国科学院动物研究所 研究员
2007-07--2010-08 University of Missouri-Columbia Research Assistant Professor
2005-11--2007-06 University of New Orleans Postdoc
2003-08--2005-11 上海交通大学医学遗传研究所 助理研究员

教授课程

生殖生物学

专利与奖励

   
专利成果
[1] 赵建国, 孙泽文, 张颖, 王霄, 秦国嵩, 姚婧. 突变基因及其用途. CN: CN114181944A, 2022-03-15.
[2] 赵建国, 王霄, 曹春伟, 海棠, 周琪, 王红梅, 张颖, 贾启涛, 郑千涛. 一种突变基因及其用于构建斑色鱼鳞癣小型猪模型的用途. CN: CN110846321B, 2021-11-19.
[3] 周琪, 赵建国, 海棠, 贾启涛, 曹春伟, 王红梅, 张颖, 郑千涛, 王霄. 一种突变基因及其用于构建蹼足病小型猪模型的用途. CN: CN110846330B, 2021-08-27.
[4] 郑爱华, 赵超越, 李虹悦, 张毓航, 金万洙, 赵建国. 基于水疱性口炎病毒载体的重组新型冠状病毒及其制备方法与应用. CN: CN112941038A, 2021-06-11.
[5] 赵建国, 郑千涛, 黄娇娇, 秦国嵩, 金万洙. 一种抗寒及瘦肉型转基因猪及其制备方法. CN: CN107182940A, 2017-09-22.
[6] 王红梅, 周琪, 赵建国, 孟安明, 曹春伟, 海棠, 祁蒙. 一种猪MITF基因突变的检测方法. CN: CN107034268B, 2017-08-11.
[7] 赵建国, 姚婧, 黄娇娇, 秦国嵩. 一种敲除猪DJ-1基因的细胞的构建方法及其应用. CN: CN107034192A, 2017-08-11.
[8] 何宏轩, 王玉田, 王承民, 贾亚雄, 马志军, 赵建国. 一种消毒剂及其制备方法和用途. CN: CN105519588A, 2016-04-27.

出版信息

   
发表论文
[1] 赵建国. One-step base editing in multiple genes by direct embryo injection for pig trait improvement. SCIENCE CHINA Life Sciences. 2021, [2] Yao, Jing, Wang, Yu, Cao, Chunwei, Song, Ruigao, Bi, Dengfeng, Zhang, Hongyong, Li, Yongshun, Qin, Guosong, Hou, Naipeng, Zhang, Nan, Zhang, Jin, Guo, Weiwei, Yang, Shiming, Wang, Yanfang, Zhao, Jianguo. CRISPR/Cas9-mediated correction of MITF homozygous point mutation in a Waardenburg syndrome 2A pig model. MOLECULAR THERAPY-NUCLEIC ACIDS[J]. 2021, 24: 986-999, http://dx.doi.org/10.1016/j.omtn.2021.04.009.
[3] Bi, Dengfeng, Yao, Jing, Wang, Yu, Qin, Guosong, Zhang, Yunting, Wang, Yanfang, Zhao, Jianguo. CRISPR/Cas13d-mediated efficient KDM5B mRNA knockdown in porcine somatic cells and parthenogenetic embryos. REPRODUCTION[J]. 2021, 162(2): 149-160, [4] Song, Ruigao, Liu, Keqiang, Wang, Yu, Qin, Guosong, Xiao, Meng, Liu, Yaping, Yang, Jun, Zong, Ruojun, Yan, Xinghui, Zheng, Qiantao, Zhang, Hongyong, Hou, Naipeng, Yao, Jing, Wang, Xiao, Wang, Yanfang, Zhao, Jianguo, Zhang, Xue. A pig model carrying heterozygous point mutation of NCSTN simulates familial acne inversa and reveals dysregulated cholesterol biosynthesis via the Notch-pAMPK-HMGCR pathway. SCIENCE BULLETIN. 2021, 66(23): 2343-2346, http://dx.doi.org/10.1016/j.scib.2021.05.022.
[5] 赵建国. Mitochondrial Uncoupling Protein-1 Antagonizes Atherosclerosis by Blocking NLRP3-Inflammasome-dependent Interleukin-1β production. Science Advances. 2021, [6] 毕登峰, 王煜, 姚婧, 赵建国. CRISPR/Cas13d介导猪胎儿成纤维细胞SUV39H1/SUV39H2基因敲降. 中国畜牧兽医[J]. 2021, 48(6): 1957-1966, http://lib.cqvip.com/Qikan/Article/Detail?id=7105024540.
[7] Wang, Yu, Bi, Dengfeng, Qin, Guosong, Song, Ruigao, Yao, Jing, Cao, Chunwei, Zheng, Qiantao, Hou, Naipeng, Wang, Yanfang, Zhao, Jianguo. Cytosine Base Editor (hA3A-BE3-NG)-Mediated Multiple Gene Editing for Pyramid Breeding in Pigs. FRONTIERS IN GENETICS[J]. 2020, 11: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7701296/.
[8] Li, Feifei, Wang, Danyang, Song, Ruigao, Cao, Chunwei, Zhang, Zhihua, Wang, Yu, Li, Xiaoli, Huang, Jiaojiao, Liu, Qiang, Hou, Naipeng, Xu, Bingxiang, Li, Xiao, Gao, Xiaomeng, Jia, Yan, Zhao, Jianguo, Wang, Yanfang. The asynchronous establishment of chromatin 3D architecture between in vitro fertilized and uniparental preimplantation pig embryos. GENOME BIOLOGY[J]. 2020, 21(1): http://dx.doi.org/10.1186/s13059-020-02095-z.
[9] 赵建国. Rnf20 deficiency in adipocyte impairs adipose tissue development and thermogenesis. protein cell. 2020, [10] 王煜, 宋瑞高, 赵建国, 王彦芳. 碱基编辑器介导的猪IGF2基因高效定点突变. 中国畜牧兽医[J]. 2020, 47(11): 3427-3435, http://lib.cqvip.com/Qikan/Article/Detail?id=7103246372.
[11] Ruigao SONG, Yu WANG, Yanfang WANG, Jianguo ZHAO. Base editing in pigs for precision breeding. FRONTIERS OF AGRICULTURAL SCIENCE AND ENGINEERING[J]. 2020, 7(2): 161-170, http://lib.cqvip.com/Qikan/Article/Detail?id=7102483705.
[12] Liu, Lulu, Wang, Yu, Liang, Xiaojuan, Wu, Xiao, Liu, Jiali, Yang, Shulin, Tao, Cong, Zhang, Jin, Tian, Jianhui, Zhao, Jianguo, Wang, Yanfang. Stearoyl-CoA Desaturase Is Essential for Porcine Adipocyte Differentiation. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES[J]. 2020, 21(7): https://doaj.org/article/19a125e138e1471898c1e52bbcc524a0.
[13] 潘建飞, 郑千涛, 陶聪, 赵建国, 王彦芳. 急性冷刺激后巴马猪背膘和腹股沟皮下脂肪组织的脂质组比较. 中国畜牧兽医[J]. 2020, 9(47): 2759-2766, http://lib.cqvip.com/Qikan/Article/Detail?id=7102893426.
[14] Zhao, JianGuo, Wang, DongHui. beta-Selective Cu(II)-Catalyzed Dehydrogenative Enamination of Alkylbenzenes. ORGANIC LETTERS[J]. 2020, 22(24): 9473-9477, https://www.webofscience.com/wos/woscc/full-record/WOS:000607016900014.
[15] Jianfei Pan, Cong Tao, Chunwei Cao, Qiantao Zheng, Sin Man Lam, Guanghou Shui, Xuexue Liu, Kui Li, Jianguo Zhao, Yanfang Wang. Adipose lipidomics and RNA-Seq analysis revealed the enhanced mitochondrial function in UCP1 knock-in pigs. BBA - Molecular and Cell Biology of Lipids. 2019, 1864(10): 1375-1383, http://dx.doi.org/10.1016/j.bbalip.2019.06.017.
[16] Pan, Jianfei, Tao, Cong, Cao, Chunwei, Zheng, Qiantao, Lam, Sin Man, Shui, Guanghou, Liu, Xuexue, Li, Kui, Zhao, Jianguo, Wang, Yanfang. Adipose lipidomics and RNA-Seq analysis revealed the enhanced mitochondrial function in UCP1 knock-in pigs. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS[J]. 2019, 1864(10): 1375-1383, http://dx.doi.org/10.1016/j.bbalip.2019.06.017.
[17] Jianguo Zhao, Liangxue Lai, Weizhi Ji, Qi Zhou. Genome editing in large animals:current status and future prospects. 国家科学评论:英文版[J]. 2019, 6(3): 402-420, https://www.webofscience.com/wos/woscc/full-record/WOS:000473767700015.
[18] Zhang, Ying, Hong, Qianlong, Cao, Chunwei, Yang, Lizhu, Li, Yongshun, Hai, Tang, Zhang, Hongyong, Zhou, Qi, Sui, Ruifang, Zhao, Jianguo. A novel porcine model reproduces human oculocutaneous albinism type. CELL DISCOVERYnull. 2019, 5: http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000490007400001.
[19] Tao, Cong, Wang, Yajun, Zhao, Ying, Pan, Jianfei, Fan, Yiping, Liang, Xiaojuan, Cao, Chunwei, Zhao, Jianguo, Petris, Michael J, Li, Kui, Wang, Yanfang. Adipocyte-specific disruption of ATPase copper transporting alpha in mice accelerates lipoatrophy. DIABETOLOGIA[J]. 2019, 62(12): 2340-2353, https://www.webofscience.com/wos/woscc/full-record/WOS:000500998600016.
[20] Qiu, Jingtao, Zhang, Jinglin, Zhou, Yewen, Li, Xin, Li, Hongjiao, Liu, Jiali, Gou, Kemian, Zhao, Jianguo, Cui, Sheng. MicroRNA-7 inhibits melatonin synthesis by acting as a linking molecule between leptin and norepinephrine signaling pathways in pig pineal gland. JOURNAL OF PINEAL RESEARCH[J]. 2019, 66(3): https://www.webofscience.com/wos/woscc/full-record/WOS:000460583700005.
[21] Ji, XiaoJun, Chen, Wei, Wang, Xiao, Zhang, Yue, Liu, Qian, Guo, WeiWei, Zhao, JianGuo, Yang, ShiMing. Canalostomy is an ideal surgery route for inner ear gene delivery in big animal model. ACTA OTO-LARYNGOLOGICA[J]. 2019, 139(11): 939-947, https://www.webofscience.com/wos/woscc/full-record/WOS:000485163200001.
[22] Wang, Xiao, Cao, Chunwei, Li, Yongshun, Hai, Tang, Jia, Qitao, Zhang, Ying, Zheng, Qiantao, Yao, Jing, Qin, Guosong, Zhang, Hongyong, Song, Ruigao, Wang, Yanfang, Shui, Guanghou, Lam, Sin Man, Liu, Zhonghua, Wei, Hong, Meng, Anming, Zhou, Qi, Zhao, Jianguo. A harlequin ichthyosis pig model with a novel ABCA12 mutation can be rescued by acitretin treatment. JOURNAL OF MOLECULAR CELL BIOLOGY[J]. 2019, 11(12): 1029-1041, http://lib.cqvip.com/Qikan/Article/Detail?id=7100883412.
[23] 范一萍, 王晓梅, 贾启涛, 李成勃, 梁小娟, 曹春伟, 周磊, 陶聪, 赵建国, 刘剑锋, 王彦芳. 猪PRLR和FSHβ基因多态性检测及其与繁殖性状的关联分析. 中国畜牧兽医[J]. 2019, 46(3): 774-781, http://lib.cqvip.com/Qikan/Article/Detail?id=7001505133.
[24] 赵建国, 赖良学, 季维智, 周琪. Genome editing in large animals: current status and future prospects. National Science Review[J]. 2019, 6(3): 402–420-, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8291540/.
[25] Cao, Chunwei, Zhang, Ying, Jia, Qitao, Wang, Xiao, Zheng, Qiantao, Zhang, Hongyong, Song, Ruigao, Li, Yongshun, Luo, Ailing, Hong, Qianlong, Qin, Guosong, Yao, Jing, Zhang, Nan, Wang, Yanfang, Wang, Hongmei, Zhou, Qi, Zhao, Jianguo. An exonic splicing enhancer mutation in DUOX2 causes aberrant alternative splicing and severe congenital hypothyroidism in Bama pigs. DISEASE MODELS & MECHANISMS[J]. 2019, 12(1): https://doaj.org/article/d3b310007c4b4e3198ba488905667dd5.
[26] 秦国嵩, 赵建国, 黄娇娇. RepSox Increases Porcine Cloning Efficiency by Improving Pluripotency of Donor Nuclei. CELLULAR REPROGRAMMING[J]. 2019, 21(4): 181-186, http://dx.doi.org/10.1089/cell.2018.0064.
[27] Sun, Xiuyun, Wang, Jun, Yao, Xia, Zheng, Wen, Mao, Yang, Lan, Tianlong, Wang, Liguo, Sun, Yonghui, Zhang, Xinyi, Zao, Qiuye, Zhao, Jianguo, Xiao, RuiPing, Zhang, Xiuqin, Ji, Guangju, Rao, Yu. A chemical approach for global protein knockdown from mice to non-human primates. CELL DISCOVERY[J]. 2019, 5(1): https://doaj.org/article/c439f61958e9443ea9425c06101d3ee2.
[28] 张颖, 洪潜龙, 曹春伟, 杨丽珠, 李永顺, 海棠, 张洪勇, 周琪, 睢瑞芳, 赵建国. A novel porcine model reproduces human oculocutaneous albinism type II. Cell Discovery[J]. 2019, 5(1): 1-3, http://dx.doi.org/10.1038/s41421-019-0117-7.
[29] Huang, Jiaojiao, Wang, Yanfang, Zhao, Jianguo. CRISPR editing in biological and biomedical investigation. JOURNAL OF CELLULAR PHYSIOLOGYnull. 2018, 233(5): 3875-3891, https://www.webofscience.com/wos/woscc/full-record/WOS:000424644700016.
[30] Hongyong Zhang, Jiaojiao Huang, Zechen Li, Guosong Qin, Nan Zhang, Tang Hai, Qianlong Hong, Qiantao Zheng, Ying Zhang, Ruigao Song, Jing Yao, Chunwei Cao, Jianguo Zhao, Qi Zhou. Rescuing ocular development in an anophthalmic pig by blastocyst complementation. EMBO Molecular Medicine[J]. 2018, 10(12): n/a-n/a, https://doaj.org/article/0cc8f0970f30466584f98fde466fdfb2.
[31] Zhu, Nengbo, Zhao, Jianguo, Bao, Hongli. Iron catalyzed methylation and ethylation of vinyl arenes. CHEMICAL SCIENCE[J]. 2017, 8(3): 2081-2085, [32] White, Martyn K, Kaminski, Rafal, Young, WonBin, Roehm, Pamela C, Khalili, Kamel. CRISPR Editing Technology in Biological and Biomedical Investigation. JOURNAL OF CELLULAR BIOCHEMISTRY[J]. 2017, 118(11): 3586-3594, https://www.webofscience.com/wos/woscc/full-record/WOS:000411065300006.
[33] 黄娇娇, 曹春伟, 郑国民, 赵建国. 基因组编辑技术在猪遗传改良中的应用. 遗传[J]. 2017, 1078-1089, http://lib.cqvip.com/Qikan/Article/Detail?id=89679090504849554949484949.
[34] Wang Yanfang, Huang Jiaojiao, Zhao Jianguo. Gene engineering in swine for agriculture. JOURNAL OF INTEGRATIVE AGRICULTURE[J]. 2017, 16(12): 2792-2804, http://dx.doi.org/10.1016/S2095-3119(17)61766-0.
[35] Jia, Qitao, Cao, Chunwei, Tang, Hai, Zhang, Ying, Zheng, Qiantao, Wang, Xiao, Zhang, Rui, Wang, Xianlong, Luo, Ailing, Wei, Hong, Meng, Anming, Zhou, Qi, Wang, Hongmei, Zhao, Jianguo. A 2-bp insertion (c.67_68insCC) in MC1R causes recessive white coat color in Bama miniature pigs. JOURNAL OF GENETICS AND GENOMICS. 2017, 44(4): 215-217, http://dx.doi.org/10.1016/j.jgg.2017.02.003.
[36] Jia Qitao, Cao Chunwei, Tang Hai, Zhang Ying, Zheng Qiantao, Wang Xiao, Zhang Rui, Wang Xianlong, Luo Ailing, Wei Hong, Meng Anming, Zhou Qi, Wang Hongmei, Zhao Jianguo. A 2-bp insertion (c.67_68insCC) in MC1R causes recessive white coat color in Bama miniature pigs. Journal of Genetics and Genomics[J]. 2017, [37] Lin, Jun, Cao, Chunwei, Tao, Cong, Ye, Rongcai, Dong, Meng, Zheng, Qiantao, Wang, Chao, Jiang, Xiaoxiao, Qin, Guosong, Yan, Changguo, Li, Kui, Speakman, John R, Wang, Yanfang, Jin, Wanzhu, Zhao, Jianguo. Cold adaptation in pigs depends on UCP3 in beige adipocytes. JOURNAL OF MOLECULAR CELL BIOLOGY[J]. 2017, 9(5): 364-375, https://www.webofscience.com/wos/woscc/full-record/WOS:000417761200003.
[38] Wang, Liying, Cao, Chunwei, Wang, Fang, Zhao, Jianguo, Li, Wei. H2B ubiquitination: Conserved molecular mechanism, diverse physiologic functions of the E3 ligase during meiosis. NUCLEUS[J]. 2017, 8(5): 461-468, https://www.webofscience.com/wos/woscc/full-record/WOS:000418054400003.
[39] Hai, Tang, Guo, Weiwei, Yao, Jing, Cao, Chunwei, Luo, Ailing, Qi, Meng, Wang, Xianlong, Wang, Xiao, Huang, Jiaojiao, Zhang, Ying, Zhang, Hongyong, Wang, Dayu, Shang, Haitao, Hong, Qianlong, Zhang, Rui, Jia, Qitao, Zheng, Qiantao, Qin, Guosong, Li, Yongshun, Zhang, Tao, Jin, Weiwu, Chen, ZhengYi, Wang, Hongmei, Zhou, Qi, Meng, Anming, Wei, Hong, Yang, Shiming, Zhao, Jianguo. Creation of miniature pig model of human Waardenburg syndrome type 2A by ENU mutagenesis. HUMAN GENETICS[J]. 2017, 136(11-12): 1463-1475, http://dx.doi.org/10.1007/s00439-017-1851-2.
[40] 赵建国. Creation of miniature pig model of human Waardenburg syndrome type 2A by ENU mutageneis. Human genetics. 2017, [41] Zheng Qiantao, Lin Jun, Huang Jiaojiao, Zhang Hongyong, Zhang Rui, XueYing Zhang, Cao Chunwei, Catherine Hambly, Qin Guosong, Yao Jing, Song Ruigao, Jia Qitao, Wang Xiao, YongShun Li, Zhang Nan, ZhengYu Piao, Ye Rongcai, John RSpeakman, Wang Hongmei, Zhou Qi, Wang Yanfang, Jin Wanzhu, Zhao Jianguo. Reconstitution of UCP1 Using CRISPR/Cas9 in the White Adipose Tissue of Pigs Decreases Fat Deposition and Improves Thermogenic Capacity. PNAS[J]. 2017, 114(45): E9474-E9482, http://ir.ioz.ac.cn/handle/000000/13129.
[42] Zheng, Qiantao, Lin, Jun, Huang, Jiaojiao, Zhang, Hongyong, Zhang, Rui, Zhang, Xueying, Cao, Chunwei, Hambly, Catherine, Qin, Guosong, Yao, Jing, Song, Ruigao, Jia, Qitao, Wang, Xiao, Li, Yongshun, Zhang, Nan, Piao, Zhengyu, Ye, Rongcai, Speakman, John R, Wang, Hongmei, Zhou, Qi, Wang, Yanfang, Jin, Wanzhu, Zhao, Jianguo. Reconstitution of UCP1 using CRISPR/Cas9 in the white adipose tissue of pigs decreases fat deposition and improves thermogenic capacity. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2017, 114(45): E9474-E9482, https://www.webofscience.com/wos/woscc/full-record/WOS:000414631200009.
[43] Hai, Tang, Cao, Chunwei, Shang, Haitao, Guo, Weiwei, Mu, Yanshuang, Yang, Shulin, Zhang, Ying, Zheng, Qiantao, Zhang, Tao, Wang, Xianlong, Liu, Yu, Kong, Qingran, Li, Kui, Wang, Dayu, Qi, Meng, Hong, Qianlong, Zhang, Rui, Wang, Xiupeng, Jia, Qitao, Wang, Xiao, Qin, Guosong, Li, Yongshun, Luo, Ailing, Jin, Weiwu, Yao, Jing, Huang, Jiaojiao, Zhang, Hongyong, Li, Menghua, Xie, Xiangmo, Zheng, Xuejuan, Guo, Kenan, Wang, Qinghua, Zhang, Shibin, Li, Liang, Xie, Fei, Zhang, Yu, Weng, Xiaogang, Yin, Zhi, Hu, Kui, Cong, Yimei, Zheng, Peng, Zou, Hailong, Xin, Leilei, Xia, Jihan, Ruan, Jinxue, Li, Hegang, Zhao, Weiming, Yuan, Jing, Liu, Zizhan, Gu, Weiwang, Li, Ming, Wang, Yong, Wang, Hongmei, Yang, Shiming, Liu, Zhonghua, Wei, Hong, Zhao, Jianguo, Zhou, Qi, Meng, Anming. Pilot study of large-scale production of mutant pigs by ENU mutagenesis. ELIFE[J]. 2017, 6: https://doaj.org/article/cf41846c1164446c96c69e5c95f2b662.
[44] Zhang, Ying, Xue, Yuanyuan, Cao, Chunwei, Huang, Jiaojiao, Hong, Qianlong, Hai, Tang, Jia, Qitao, Wang, Xianlong, Qin, Guosong, Yao, Jing, Wang, Xiao, Zheng, Qiantao, Zhang, Rui, Li, Yongshun, Luo, Ailing, Zhang, Nan, Shi, Guizhi, Wang, Yanfang, Ying, Hao, Liu, Zhonghua, Wang, Hongmei, Meng, Anming, Zhou, Qi, Wei, Hong, Liu, Feng, Zhao, Jianguo. Thyroid hormone regulates hematopoiesis via the TR-KLF9 axis. BLOOD[J]. 2017, 130(20): 2161-2170, http://dx.doi.org/10.1182/blood-2017-05-783043.
[45] 赵建国, 郑千涛. 一石两鸟:白色脂肪中重构有功能的UCP1降低猪的脂肪沉积同时提高猪的体温调节能力. 遗传[J]. 2017, 1112-1113, http://lib.cqvip.com/Qikan/Article/Detail?id=89679090504849554949484952.
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[60] Shan, Lei, Wu, Qi, Li, Yuli, Shang, Haitao, Guo, Kenan, Wu, Jiayan, Wei, Hong, Zhao, Jianguo, Yu, Jun, Li, MengHua. Transcriptome Profiling Identifies Differentially Expressed Genes in Postnatal Developing Pituitary Gland of Miniature Pig. DNA RESEARCH[J]. 2014, 21(2): 207-216, https://www.webofscience.com/wos/woscc/full-record/WOS:000339897500009.
[61] Miles, Edward L, OGorman, Chad, Zhao, Jianguo, Samuel, Melissa, Walters, Eric, Yi, YoungJoo, Sutovsky, Miriam, Prather, Randall S, Wells, Kevin D, Sutovsky, Peter. Transgenic pig carrying green fluorescent proteasomes. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2013, 110(16): 6334-6339, https://www.webofscience.com/wos/woscc/full-record/WOS:000318041500031.
[62] Zhu, Jiayi, Yang, Qing, Cao, Liyan, Dou, Xiujing, Zhao, Jianguo, Zhu, Weijuan, Ding, Fan, Bu, Rie, Suo, Siqingaowa, Ren, Yudong, Li, Guangxing, Ren, Xiaofeng. Development of porcine rotavirus vp6 protein based ELISA for differentiation of this virus and other viruses. VIROLOGY JOURNAL[J]. 2013, 10(1): 91-91, http://dx.doi.org/10.1186/1743-422X-10-91.
[63] Wang, YaPeng, Qi, ShuTao, Wei, Yanchang, Ge, ZhaoJia, Chen, Lei, Hou, Yi, Ouyang, YingChun, Schatten, Heide, Zhao, JianGuo, Sun, QingYuan. Knockdown of UCHL5IP causes abnormalities in gamma-tubulin localisation, spindle organisation and chromosome alignment in mouse oocyte meiotic maturation. REPRODUCTION FERTILITY AND DEVELOPMENT[J]. 2013, 25(3): 495-502, https://www.webofscience.com/wos/woscc/full-record/WOS:000315718900005.
[64] Miao, YiLiang, Zhang, Xia, Zhao, JianGuo, Spate, Lee, Zhao, MingTao, Murphy, Clifton N, Prather, Randall S, Sun, QingYuan, Schatten, Heide. Effects of griseofulvin on in vitro porcine oocyte maturation and embryo development. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS[J]. 2012, 53(7): 561-566, https://www.webofscience.com/wos/woscc/full-record/WOS:000307362500009.
[65] Whyte, Jeffrey J, Zhao, Jianguo, Wells, Kevin D, Samuel, Melissa S, Whitworth, Kristin M, Walters, Eric M, Laughlin, M Harold, Prather, Randall S. Gene Targeting With Zinc Finger Nucleases to Produce Cloned eGFP Knockout Pigs. MOLECULAR REPRODUCTION AND DEVELOPMENTnull. 2011, 78(1): 2-2, https://www.webofscience.com/wos/woscc/full-record/WOS:000287110900003.
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[71] 赵建国. Association analysis of SNPs in the chicken UCP gene with growth and body composition traits. Canadian Journal of Animal Science. 2006, [72] Zhao, JG, Li, H, Wang, YX, Meng, H. The expression characterization of chicken uncoupling protein gene. ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES[J]. 2005, 18(11): 1552-1556, http://www.corc.org.cn/handle/1471x/2052164.
[73] 李志辉, 王启贵, 赵建国, 王宇祥, 李辉. 类胰岛素生长因子Ⅱ(IGF2)基因多态性与鸡体脂性状的相关研究. 中国农业科学[J]. 2004, 37(4): 600-604, http://lib.cqvip.com/Qikan/Article/Detail?id=9719784.
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科研活动

   
科研项目
(1) 5hmc在猪早期胚胎发育和体细胞重编程中的研究,主持,部委级,2012-01--2016-12
(2) 规模化创造循环系统小型猪疾病模型,主持,部委级,2012-01--2015-12
(3) 功能性蛋白和mRNA介导的体细胞重编程,主持,院级级,2011-06--2015-05
(4) 用人工诱变的方法规模化挖掘猪的基因资源,主持,院级级,2011-01--2012-12
(5) 小分子化合物对体细胞核移植重编程作用机制的研究,主持,部委级,2011-01--2015-12
(6) 利用化学诱变创制出生缺陷等模型猪,主持,国家级,2011-01--2014-12
(7) 转基因技术改良荣昌猪脂肪性状及体细胞重编程机理,主持,院级级,2010-04--2013-04
参与会议
(1) Genetic modifications in pigs for biomedicine,2015-07,Tang Hai
(2) 猪的遗传修饰和疾病模型的构建,全球华人遗传学大会暨全国第十三次医学遗传学学术会议,2014-10,Xianlong Wang
(3) Genetic modifications in pigs for creation of human disease models,2014-10,Chunwei Cao

指导学生

已指导学生

黄娇娇  博士研究生  071008-发育生物学  

王亚朋  博士研究生  071008-发育生物学  

祁蒙  硕士研究生  071008-发育生物学  

罗霭玲  硕士研究生  071008-发育生物学  

现指导学生

杨锦修  博士研究生  071008-发育生物学  

张颖  博士研究生  071008-发育生物学  

张洪勇  硕士研究生  071008-发育生物学  

贾启涛  博士研究生  071008-发育生物学  

张蕊  硕士研究生  071008-发育生物学  

郑千涛  博士研究生  071008-发育生物学  

王霄  博士研究生  071008-发育生物学